Gene 16201 (Tetrahymena)
16201
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 16201.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 16201.AA | Ciliate-C7 | 113-275 | 65 | 1.4e-107 | 345.85 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 113-275 Range on HMM: 1-164/164 Sequence Identity: 65% (107 aa) FKYIGQGKQGLVFLAKELSTNRRFAIKGLHVRDSQGKIFQETFDQAQQEINMLEKCKGSTYVVNLLKKIEGKEFIYLVLSECQ-GTLSELIEKSPNKKLN |...|||.||||.|||. .||.|.||||..|||.||.|.|....|.|||||.|..||.| |||.||...||..||||||.||| |||...||...||.|| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN ELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKTSGYGMNQYL |.||||||||||.||..|||..|. ||||||||||||||||||.|.|||| ||. |.| .||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Pkinase | 16201.AA | Pkinase | 110-260 | 27 | 1.5e-23 | 84.31 | Pfam | 1-159 (293) | Show / Hide |
Range on Protein: 110-260 Range on HMM: 1-159/293 Sequence Identity: 27% (45 aa) FSDFKYIGQGKQGLVFLAKELSTNRRFAIKGLHVRDSQGKIFQE---TFDQAQQEINMLEKCKGSTYVVNLLKKIEGKEFIYLVLSECQG-----TLSEL . . ||.| | |..... .|....|.| . .|. . |. . .|| .. .. .. ..| |. | | ||.|. |.| |... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY IEKSPNKKL--NELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNA----VVSDLGLA |. . .... | ...|.. |..|| ..||...| ||| .||||| ||. ..| ||| ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA |
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| Kinase | 16201.AA | Ciliate-E1 | 116-298 | 19 | 7.9e-22 | 68.1 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 116-298 Range on HMM: 1-202/202 Sequence Identity: 19% (40 aa) IGQGKQGLVFLAKELSTN-RRFAIKGLHVRDSQGKIFQETFDQAQQEIN-MLEKCKGSTYVVNLLKKIEGKE--FIYLVLSECQGTLSELIE-------- ||.| ...|| || ..| . |.| ... . |..|.. ..|.. ... |. |...... |. .. ...... .|. .| . .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYN---QNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW ---KSPNKKLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKTSGYGMNQYLGNWLFQAPECY--------DPNKFQ .. ....... .. .... .|| .|... | |.|..||||. .|| | .|.|... | . . . ... .. ||.| ...| QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKIN DYADEY | | YKSDIY |
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| Kinase | 16201.AA | AGC | 110-260 | 23 | 1.3e-21 | 51.25 | In-house | 1-202 (395) | Show / Hide |
Range on Protein: 110-260 Range on HMM: 1-202/395 Sequence Identity: 23% (47 aa) FSDFKYIGQGKQGLVFLAKEL------STNRRFAIKGLHVRD--------SQGKIFQE-TFDQ----AQQEINMLEKCKG---------STYVVN-LLKK | | ||.| | |.|... .|.. .|.| | .. . .. | . .| ..| |.||||.. . ..|. | FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHW-KQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYS IEGKEF--IYLVLSECQ----------G-TLSELIEKS-PNKKLNELSAIKYAKD-------IAEGLLHIHS-QKCISND-LKMDNILIDYNGNAVVSDL . |. .|.|. .. | | . . .....| | || |. .| ..|| .. | | || .|||.| .|. .| FQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF GLA ||. GLC |
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| Kinase | 16201.AA | Ciliate-E2-Unclassified | 110-287 | 19 | 1.5e-21 | 71.58 | In-house | 1-239 (352) | Show / Hide |
Range on Protein: 110-287 Range on HMM: 1-239/352 Sequence Identity: 19% (46 aa) FSDFKYIGQGKQGLVFLAKELSTNRRFAIKGLHVRDSQG-KIFQETFDQAQQEINMLEKCK------------------GSTYVVNLLKKIEGKEFIYLV . | |||| .| |..... ... .|.| ... .. |. .. . .|.. ... | . ..|... . |. ||.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LSEC-QGTLSELIEKSPN---------------KKLNELSAI-----KYAKDIAEGLLHIHSQK-CISNDLKMDNILIDYNG---NAVVSDLGLADSLTK . | .|.|.. |.|... |.. | |. .|.. | .|| ..|... .| |.| .|||.| || . ..|.|.. . . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ TSGYG--------------MNQYLGNWLFQ----APECYD ... |.. |. .. |||... NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ |
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| Kinase | 16201.AA | CAMK | 115-284 | 15 | 1.2e-20 | 62.58 | In-house | 1-290 (425) | Show / Hide |
Range on Protein: 115-284 Range on HMM: 1-290/425 Sequence Identity: 15% (45 aa) YIGQGKQGLVFLAKELSTN------------RRFAIKGLHVRDSQGKI----------------------FQETFDQAQQEINMLEKCKG------STYV .|.| | |.|... .|. ...||| . . ..| ... .. ..||... |..| . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNLLKKIEG-------------------KEFIYLVL---SECQGT-----LSELIEKSPN-------------KKLNELSAIKYAKDIAEGLLHIHSQKC ..|. .| ....|.|. |.| | . | . .. ....| | .| . |.... ..||.. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI ISNDLKMDNILIDYN-----------------GNAVVSDLGLADSLTKTSGYG----------------------MNQYLGNWLFQA-PE . ||| .|||.|.| .| ..| |.| ... ... |. . | . | || VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE |
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| Kinase | 16201.AA | STE | 110-284 | 19 | 3.6e-19 | 64.43 | In-house | 1-232 (359) | Show / Hide |
Range on Protein: 110-284 Range on HMM: 1-232/359 Sequence Identity: 19% (46 aa) FSDFKYIGQGKQGLVFLAKEL------STNRR---------FAIKGLHVRDSQ-----------GKIFQETFDQAQQEINMLEKCKG-STYVVNLLKKIE . . . ||.| | |..|. .|.. .||| ....... ....| ..| ..||... ||. . ..|. . . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF GK-------EFIYLVLSECQ-GTLSELIE-K-SPNKKLN----------ELSAIKYAKDIAEG-LLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLAD . . ..... . |.|...|. | ...| || | ......| .| | ..||.. | |.| .|||. . .| |.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG SLTK---------------TSGYGMNQYLGNWLFQAPE .||. |.. | | . ||| QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE |
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| Kinase | 16201.AA | Ciliate-E2 | 110-284 | 18 | 1.1e-18 | 60.74 | In-house | 1-257 (365) | Show / Hide |
Range on Protein: 110-284 Range on HMM: 1-257/365 Sequence Identity: 18% (49 aa) FSDFKYIGQGKQGLVFLAKELSTNRRFA--------------------IKGLHVRDSQGKIFQETFDQAQQEIN----------MLEKCKGSTYVVNLLK . | |||| .| |...| .....|| |. . . ....... .. .||| .||. . . ..... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMYE KIE--GKEFIYLVLSECQG-TLSELIEKSPNK---------KLNELSAIKYAKDIAE---------------GLLHIHSQK-CISNDLKMDNILIDYNGN . .. ||||. ||| .| ..|.... | ...| .... | |.. .| ..||.. .| |.| .|||. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- AVVSDLGLADSLT----------------------KTSGY--------GMNQYLGNWLFQAPE ..|.||. .. .|.|| |...|. ..||| IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE |
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| Kinase | 16201.AA | STE20 | 110-266 | 23 | 9.6e-18 | 61.67 | In-house | 1-174 (288) | Show / Hide |
Range on Protein: 110-266 Range on HMM: 1-174/288 Sequence Identity: 23% (43 aa) FSDFKYIGQGKQGLVFLAKELSTNRR----FAIKGLHVRDS---QGKIFQETFDQAQQEINMLEKCKGSTYVVNLLKKIEGK----EFIYLVLSECQG-T . ... |||| | |..| . .|.. ||| . ... | . .. |.||... .|| . ..|. . . . ...| |.| . YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGS LSELIE---KSPNK----KLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTK----T |..... | .. ..|| ... .|| ..||...| |.| ||||.. .|.. .| |.. .||| | LTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDT |
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| Kinase | 16201.AA | CAMKL | 114-260 | 26 | 2.7e-17 | 51.62 | In-house | 5-176 (297) | Show / Hide |
Range on Protein: 114-260 Range on HMM: 5-176/297 Sequence Identity: 26% (45 aa) KYIGQGKQGLVFLAKE-LSTNRRFAIKGLHVR----DSQGKIF------QETFDQAQQEINMLEKCK--GSTYVVNLLKKIEGKEF------IYLVLSEC | .|.| | | ||. . |... ||| .. . | . | . ..||. ... . . .. |. || .|. ||||. | KTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYC QGT---LSELIEKSPNKK--LNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNG--NAVVSDLGLA .| | . |.| .... . | | .| . | ... ..||.. . |.| .|||.|.|| |. ..| |.. SGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS |
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| Kinase | 16201.AA | IRE | 182-259 | 29 | 2.8e-17 | 56.06 | In-house | 63-170 (292) | Show / Hide |
Range on Protein: 182-259 Range on HMM: 63-170/292 Sequence Identity: 29% (32 aa) EGKEFIYLVLSECQGTLSELIEK--------------SPNKKLN--------ELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDY--------NGN |...|.|| |. |||.|....|. ||..| .. .. .|....|| | |||. . .||| ||||.. |. EDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNNNNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNR AVVSDLGL .. ||.|| FMISDFGL |
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| Kinase | 16201.AA | S_TKc | 110-427 | 17 | 7.3e-16 | 55.71 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 110-427
Range on HMM: 1-231/231
Sequence Identity: 17% (59 aa)
FSDFKYIGQGKQGLVFLAKELSTNRRFAIKGLHVRDSQGKIFQETFDQAQQEINMLEKCKGSTYVVNLLKKIEGKEFIYLVLSECQG---TLSELIEKSP
. . ||.| | |..... .|.|..||| .. .....||..|.| . ..|.|. .. ...|.|. | | .| ..|.| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NKK----LNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKTSGYGMNQYLGNWLFQAPECYDPNKFQDYADEYQKLG
.. ..| | .|.. |...| ..||.. | ||| .|||.| . ..| ||| | . . | . |||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----------------
LNISTKPTI-KSECFSLGNQQSQLFAYKYLSTLINYXQIDIQILRQLDIQFDKMFNKYQGYLIYLMVQDFKSTLMFKKHLPLNYSNEFEQFTYKNQLKFI
. . |. |.| | |. . . ...... ..| .
-----GYGKCKCDWWSCG-----CILYEMLCGYPPFP-QMQMMFKKIG---------------------------------------------SPEAKDF
INGLTQFKPEDRLSIKDVLI-----ILKGII
|... |. ||.|... ..| . .
IRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 16201.AA | TyrKc | 110-345 | 17 | 3e-06 | -120.82 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 110-345 Range on HMM: 1-280/280 Sequence Identity: 17% (53 aa) FSDFKYIGQGKQGLVFLAKELSTNRRFAIKGLHVRDSQGKIFQETFDQAQQEINMLEKC-KGSTYVVNLLKKIEGK-------EFIYLVL-SECQGTLSE . | .| | | |.... . |.| |. .| | .|.... | . .|.|. . . | ...|. . | | . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDF---MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD LIEKSPNKKLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKT------SGYGMNQY--LGN------WLFQAPECY . |. .| |. .... .||.| ..||..|| || |.|.. |. . .|| ||. .. . | . . |. |. |||| YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM--APECI DPNKF---------------------QDYADEYQKLGLNISTKPTIKSECFSLGNQQ--------SQLFAYKYLSTLINY--------XQIDIQIL . .|| | | .. |. |. .|. . |. .. .. .| .... NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF |
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| TMF_DNA_bd | 16201.AA | TMF_DNA_bd | 484-534 | 36 | 0.000935 | 16.45 | Pfam | 24-75 (75) | Show / Hide |
Range on Protein: 484-534 Range on HMM: 24-75/75 Sequence Identity: 36% (19 aa) LSKQQQGQDAIISQLRQSNIQLEQQIKSLK-DIQKQLENELKALRNQKVQLE ||||.. . ..| .||. | .||.||..|| . . .|| |. |.. . . | LSKQELKHNNTIKKLRKKNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE |
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