Gene 13633 (Tetrahymena)

13633

Species: Tetrahymena
Alias: TTHERM_00197650, PreTt13633, 13633, 17.m00240, 870
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
13633.AA Protein None 432 None Fasta, JSON
13633.kin_dom Protein Kinase Domain None 175 None Fasta, JSON
13633.NA RNA None 1299 None Fasta, JSON

Protein domain

Protein domains of 13633.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13633.AA Ciliate-C7 13-175 78 5.1e-118 379.8 In-house 1-164 (164) Show / Hide 
Range on Protein: 13-175
Range on HMM: 1-164/164
Sequence Identity: 78% (128 aa)

FRFLGKGAQGLVLLAKNQKTQMRYAIKGVQVKDLYGNLSYGIYSKVKQEIDILQQCRGSPYVVSLLDSFEGKQFVYLVLNECQ-GTLTEIIERNQNKRLN
|||||.|.||||||||.|||.||||||||||.|  ||.   |. .|.|||.||.||..|||||.||..|||.||.|||||||| |||..|||||||||||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

EISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTDKSDYSSNQYM
|||||||||||..||||||||||.|||||||||||||||||||.||||||.||.||.|. ||||
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM
Pkinase 13633.AA Pkinase 10-178 28 3.4e-30 107.85 Pfam 1-171 (293) Show / Hide 
Range on Protein: 10-178
Range on HMM: 1-171/293
Sequence Identity: 28% (52 aa)

YSDFRFLGKGAQGLVLLAKNQKTQMRYAIKGVQVKDLYGNLSYG---IYSKVKQEIDILQQCRGSPYVVSLLDSFEGKQFVYLVLNECQG-----TLTEI
|   | .|.|. | | ......|. ..|.| . ...   .  .    .     .|| |.. . ..|..| |.|.|| |. .|.|.  |.|      | ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IERNQNKRL--NEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNA----VVSDFGLADKLTDKSDYSSNQYMGNF
|.. .....   |  ...|.. | .||.|.||....  ||| .||||| ||.      ..||||| ..     | .|. |  |
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTF
Kinase 13633.AA AGC 13-160 25 8.2e-29 70.29 In-house 1-202 (395) Show / Hide 
Range on Protein: 13-160
Range on HMM: 1-202/395
Sequence Identity: 25% (51 aa)

FRFL---GKGAQGLVLLAKNQ------KTQMRYAIKGVQ----VKDLYGNLSYGIYSK--------VKQEIDILQQCRG---------SPYVVS-LLDSF
|.||   |||. | | |..         |.  ||.| ..    ....  |    ...         |..| .||..|..         .|..|. |  ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EGKQF--VYLVLNECQ----------G-TLTEIIERN-QNKRLNEISAIKYAKD-------ITEGLYYIHS-KNCLVND-LKMDNILIDYNGNAVVSDFG
. |.   .|.|.  ..          |  |  ..    ...|..|  |  ||         |. .| |.|| ..    | || .|||.| .|.   .|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LA
|.
LC
S_TKc 13633.AA S_TKc 10-279 21 3.4e-28 100.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-279
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

YSDFRFLGKGAQGLVLLAKNQKTQMRYAIKGVQVKDLYGNLSYGIYSKVKQEIDILQQCRGSPYVVSLLDSFEGKQFVYLVLNECQG---TLTEIIERNQ
|   | .|||| | | .... ||. ..||| .               ....||.||..  . |..| |.|.|.  ...|.|.  | |   .| ..|....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NKR----LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTDKSDYSSNQYMGNFIYQAPECYDPTDK-----------
 ..    ..|  | .|.. | ..| |.||.. .  ||| .|||.|   .  ..||||| .|        . . |   | |||   . .|           
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCI

----IIGKVYYDEYQKLGVKVKQEPRYIIYSLVQGIDFQLVFNKHRPLNYDSEFQNFVYRKQLKQLIDELTQFVPKNRLSIKEALI-----ILKGII
    . |.  ..              . .. ..                           ...|..|. . |. |..|... |||       .   .
LYEMLCGYPPFP------------QMQMMFKKIG-------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13633.AA CAMK 15-184 18 4.9e-28 86.84 In-house 1-290 (425) Show / Hide 
Range on Protein: 15-184
Range on HMM: 1-290/425
Sequence Identity: 18% (54 aa)

FLGKGAQGLVLLAKNQKTQ------------MRYAIKGVQVKDLYGNL----------------------SYGIYSKVKQEIDILQQCRG------SPYV
 ||.|. | | |... .|.             ..||| .  | | ..                       .     .|..||.|.....|       | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSLLDSFEG-------------------KQFVYLVL---NECQGT------LTEIIERNQN------------KRLNEISAIKYAKDITEGLYYIHSKNC
..|.. .|                    ....|.|.     |.|       .  |.|. ..            .|..|  | .| . | ... |.||.| 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LVNDLKMDNILIDYN-----------------GNAVVSDFGLADKLTDKSDYS----------------------SNQYMGNFIYQA-PE
   ||| .|||.|.|                 .|  ..|||.| |.......                        . . |   | | ||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE
Kinase 13633.AA CAMKL 10-160 25 3.2e-25 77.33 In-house 1-176 (297) Show / Hide 
Range on Protein: 10-160
Range on HMM: 1-176/297
Sequence Identity: 25% (46 aa)

YSDFRFLGKGAQGLVLLAKN-QKTQMRYAIKGVQ--VKDLYGNLS--------YGIYSKVKQEIDILQQCR--GSPYVVSLLDSFEGKQF------VYLV
|   . ||||. | | ||.. . |. ..||| .    . .  . .             ....|| |... .  . | ...|.. .| ...      .|||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LNECQGT---LTEIIERNQNKR--LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNG--NAVVSDFGLA
.  |.|    | . |... ..|  . |  | .| . | ....|.||..    |.| .|||.|.||  |. ..|||..
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS
Kinase 13633.AA Ciliate-E1 16-201 19 3.1e-24 76.03 In-house 1-202 (202) Show / Hide 
Range on Protein: 16-201
Range on HMM: 1-202/202
Sequence Identity: 19% (39 aa)

LGKGAQGLVLLAKNQKTQ-MRYAIKGVQVKDLYGNLSYGIYSKVKQEIDILQQCRGSPYVVSLLDSFEGKQ--FVYLVLNECQGTLTEIIE---------
.|.| ...|. ||.|...   .|.| ..... |   .  .... |... |..  ..  |.. ..| .. .|  . ......|. .|.. ..         
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNH--FQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

--RNQNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTDKSDYSSNQYMGNFIYQAPECYD-----PTDKIIGKV
  ..... ...   .. .... .|| ..|..| .  |.|..||||. .|| | .|||....|  ........      |. ||.|      . .. . . 
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINY

YYDEY
 .| |
KSDIY
Kinase 13633.AA Ciliate-E2-Unclassified 10-187 21 4.5e-24 80.41 In-house 1-239 (352) Show / Hide 
Range on Protein: 10-187
Range on HMM: 1-239/352
Sequence Identity: 21% (51 aa)

YSDFRFLGKGAQGLVLLAKNQKTQ----MRYAIKGVQVKDLYGNLSYGIYSKVKQEIDILQ---------------QCRGSPYVVSLLDSFEGKQFVYLV
|   . .|.|..| | .... |..    | |..|  ..|... . .  ...  ..|. ...               .   .|..| ... |. || .|.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LNEC-QGTLTEIIE---------------RNQNKRLNEISAI-----KYAKDITEGLYYIHSKN-CLVNDLKMDNILIDYNG---NAVVSDFGLADKLTD
.  | .|.| ..|.               ..|.|.. |  |.     .|.. | .|| |.|.|| ..  |.| .|||.| ||   .  ..|||.. |. .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

K--------------SDYSSNQYMGNFIYQ----APECYD
               ..  ... .|. .|.    |||...
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ
Kinase 13633.AA Ciliate-E2 10-184 21 1.1e-23 78.13 In-house 1-257 (365) Show / Hide 
Range on Protein: 10-184
Range on HMM: 1-257/365
Sequence Identity: 21% (56 aa)

YSDFRFLGKGAQGLVLLAKNQKTQMRYAIK-------------GVQVKDLYGNLS-YGIYSKVKQEIDILQQCR---------------GSPYVVSLLDS
|   . .|.|..| | ..|. |.| ..|||             .|..|  . .         .||||.|... .                .|... . ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--GKQFVYLVLNECQG-TLTEIIERN----------QNKRLNEISAIKYAKDITE---------------GLYYIHSKN-CLVNDLKMDNILIDYNGN
|.   .. .|||.  ||| .| ..|. |          . |...|  .... | |..               .| |.|||| ..  |.| .|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

AVVSDFGLADKLTDKSDYSS------------------------------NQYMGNFIYQAPE
  ..||||. |..|.... .                              |.. |.  |.|||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE
Kinase 13633.AA STE 10-184 21 2.2e-23 79.49 In-house 1-232 (359) Show / Hide 
Range on Protein: 10-184
Range on HMM: 1-232/359
Sequence Identity: 21% (50 aa)

YSDFRFLGKGAQGLVLLAKNQK---------------TQMRYAIKGVQVKDL-----------YGNLSYGIYSKVKQEIDILQQCRG-SPYVVSLLDSFE
. . ...|||| | | .|.| |               |. ..||| . ...            . |    .  ....||.|...|.  .|..|  .....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GK-------QFVYLVLNECQ-GTLTEIIE------RNQN------KRLNEISAIKYAKDITEG-LYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLAD
 .       . .....  .  |.|..||.      ...|      .|..|   ......| .| |||.||..    |.| .|||.     .  .|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KLTD---------------KSDYSSNQYMGNFIYQAPE
.|||                ..  .|   |   . |||
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase 13633.AA CMGC 10-160 18 3.7e-23 72.15 In-house 1-251 (513) Show / Hide 
Range on Protein: 10-160
Range on HMM: 1-251/513
Sequence Identity: 18% (48 aa)

YSDFRFLGKGAQGLVLLAKNQKTQMR--------------YAIKGVQVKDLYGNLSY------GIYSKVKQEIDILQQCR----------------GSPY
|   . .|.|. | |  .....|. .              .||| .  .  | .         |. ..   || ||.. .                  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVSLLDSFEGKQ-----------------FVYLVLNECQGTLTEIIERNQ-------NKRLNEIS------------AIKYA------KDITEGLY--YI
.|.|.|.|  |.                  .|||   .. .| ..|..||       .. |.|                ..       . | .||   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSKN--CLVNDLKMDNILIDYNGNA--------------------VVSDFGLA
||..   .  |||  ||||. |.                       . |||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 13633.AA ULK 10-184 23 3.1e-21 70.96 In-house 1-221 (329) Show / Hide 
Range on Protein: 10-184
Range on HMM: 1-221/329
Sequence Identity: 23% (53 aa)

YSDFRFLGKGAQGLVLLAKNQKTQMRYAIKGVQVKDLYGNLSYGIYSK-----------VKQEIDILQQCR---GSPY----VVSLLDSFEGKQF--VYL
|.  . ||||. | |  ..|.||. .|. . | .| .   ... . ..           .|.||.|...     ....    .| |.| || ...  .|.
YCLNHCLGKGSFGKVYKGRNKKTK-DYVNEKVACKMI--DKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI

VLNECQG-TLTEIIERNQN--------KRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAV------------VSDFGLADKLTDK--
..  |.| .| ..|..|..        |||.|  ||.. |.| .|. ..|..|.   |.| .||||. .                ..|||.| ....   
IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNM

SDYSSNQYM------GNFIYQAPE
..     .       |  .| ||.
EQQMMMTCVNEKRLCGTPLYMAPQ
Kinase 13633.AA TyrKc 10-275 18 2.3e-07 -103.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

YSDFRFLGKGAQGLVLLAKNQKTQMRYAIKGVQVKDLYGNLSYGIYSKVKQEIDILQQC-RGSPYVVSLL-DSFEG-------KQFVYLVLNECQGTLTE
 .  . || || | | ...     .  |.| ..                 .|. |. .     | .| |.    ..       ..   ..   . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

IIERNQNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTDK------SDYSSNQY--MGN--FIYQ--APECYDP
 . ....| |.    .... .| .|  |.|||||   ||   |.|.. |. . .|||||. ...|.      .|| . .    |.  . .   ||||   
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

TDKI-------------------IGKVYYDE-YQKLGVKVKQEPRYIIYSLVQGIDFQLVFNKHRPLNYDSE-----FQNFVYRKQLKQLIDELTQFVPK
 ...                    |.  | .  |.     . ... .|  . ||        .  | .|  .         .|.   ||      .. |.
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-----MMSNQEVIEYVKQGY-----RMPQPPNDY--PMSFVCCPDEMYQ-IMKQCW----HEDPE

NRLSIKEALIIL
.| . .|   ..
DRPTFSEIHECF
Kinase 13633.AA CMGC 230-272 12 0.007952 4.08 In-house 451-508 (513) Show / Hide 
Range on Protein: 230-272
Range on HMM: 451-508/513
Sequence Identity: 12% (8 aa)

NKHRPLNYDSEFQNFVYR---------------------KQLKQLIDELTQFVPKNRLSIKEAL
.. .  ..   ...| ..                     .|.  |.. . |. |..|.....||
DD-N-NKK---AMVF-NWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQAL
Kinase 13633.AA CAMK 241-272 28 0.069368 1.05 In-house 390-420 (425) Show / Hide 
Range on Protein: 241-272
Range on HMM: 390-420/425
Sequence Identity: 28% (9 aa)

FQNFVYRKQLKQLIDELTQFVPKNRLSIKEAL
|..    .. |.||  . |  |..|..|...|
FHH-FVSQECKDLIRKMLQVDPEKRMTIEQCL
Kinase 13633.AA Ciliate-E2 230-272 13 0.175604 0.83 In-house 300-360 (365) Show / Hide 
Range on Protein: 230-272
Range on HMM: 300-360/365
Sequence Identity: 13% (8 aa)

NKHRPLNYDSEF-------------QNFVYRKQLKQLIDE----LTQFVPKNRLS-IKEAL
.|  ........              ..   .. |.||      . |  |..|.. ....|
IKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase 13633.AA Pkinase 250-272 26 6.355852 0.81 Pfam 266-288 (293) Show / Hide 
Range on Protein: 250-272
Range on HMM: 266-288/293
Sequence Identity: 26% (6 aa)

LKQLIDELTQFVPKNRLSIKEAL
.|..|. . .. || |......|
CKDFIKWCLCKDPKKRPTAEQIL