Gene 13106 (Tetrahymena)
13106
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 13106.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 13106.AA | Ciliate-C7 | 71-233 | 46 | 4.9e-90 | 288.87 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 71-233 Range on HMM: 1-164/164 Sequence Identity: 46% (77 aa) FKYLGAGNQGCVLLALDNANKFRYAIKGFQIKDKSGQVFEDDRIACEKEADLLLKMSDQPNNLRLFKKLEGDLMIYLVLNECK-GTLKDLIQQ-QGGKLN |..||.|.||.|||| |.....||||||.|..||.|....| ......|...| ...|.|....|....||. .||||||||. |||...|.. | .|| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN IYSTIKYSKDIAENLYYIHKNRFIVQDIKPDNILIDYNNNAVVADFGMGNKLIEMDNYYAQDSFQ ..|.|||.||||..|||||.....|.|.| ||||||||.||||.|||....|.... .|...... EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKS-KYQINQYM |
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| Kinase | 13106.AA | Ciliate-E2 | 68-340 | 17 | 1.6e-19 | 63.7 | In-house | 1-360 (365) | Show / Hide |
Range on Protein: 68-340 Range on HMM: 1-360/365 Sequence Identity: 17% (65 aa) YSNFKYLGAGNQGCVLLALDNANKFRYAIK-------------GFQIKDKSGQVFEDDRIACEKEADLLLK----------------MSDQPNNLRLFKK | | .| ||.|.| .. . .. ..||| ...|| . ... . | | . ... . || .... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC LE--GDLMIYLVLNECKG-TLKDLIQQQGGK----------LNIYSTIKYSKDIAE---------------NLYYIHKNR-FIVQDIKPDNILIDYNNNA . | ||||. |.| .|.|.|... | .... ....| |.. | |.|.. | ||||.|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I VVADFGMGNKLIEMDNYYAQ-----------------------------DSFQGNSLFSPPEVQNFYEDYYEQINKNNSKKIKNTPSKRGDCFSFGYLMY ..|||. |. . ... . ... |. . .||. | ...|. | . .. .. | .|.| ..| KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILN-GKKYDNQ-------QKQKGYDYKCDIWSLGVILY YLIFGESKLLFYISQKNKELEFPQFQDDEK----------EFPFKFQLKKLILG----LTRFIPNERTK-LQEVL ...||. .. .|.....||... ... . . | || . |..| ...| EMLFGKPPF--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL |
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| Kinase | 13106.AA | CAMKL | 68-221 | 28 | 7.5e-17 | 50.16 | In-house | 1-180 (297) | Show / Hide |
Range on Protein: 68-221 Range on HMM: 1-180/297 Sequence Identity: 28% (53 aa) YSNFKYLGAGNQGCVLLALD-NANKFRYAIKGFQIKDKSGQVF-------------EDDRIACEKEADLLLKMS--DQPNNLRLFKKLEGDLM------I | | || |. | | ||.. .. ..||| | ||.. |.| ..|. .. ... || .|. .| . . | YRIGKTLGKGSFGKVKLATHIRTTGEKVAIK---IIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKI YLVLNECKGT---LKDLIQQQG---GKLNIYSTIKYSKDIAENLYYIHKNRFIV-QDIKPDNILIDYNN--NAVVADFGMGNKLI |||. | | | | |...| |.. . .| . | . ..|.|... || ||||.|||.|.|. |. ..|||..|. . YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDENGNNNIKIIDFGFSNMYR |
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| Kinase | 13106.AA | CAMK | 73-251 | 18 | 2.3e-16 | 48.55 | In-house | 1-311 (425) | Show / Hide |
Range on Protein: 73-251
Range on HMM: 1-311/425
Sequence Identity: 18% (58 aa)
YLGAGNQGCVLLALDNANK------------FRYAIKGFQI----------------KDKSGQVF------EDDRIACEKEADLLLKMS------DQPNN
|| |. | | |. . .. ..||| .|||.. . || ..| ... |.. | ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
LRLFKKLEG-------------------DLMIYLVL---NECKGT-----LKDLIQQQGG--------------KLNIYSTIKYSKDIAENLYYIHKNRF
..|. | | ..|.|. | | | | |...|. ... . .| . |.. . |.|..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
IVQDIKPDNILIDYN-----------------NNAVVADFGMGNKLIEMDNYY---------------------AQDSFQGNSLFSP-PEVQNFY-----
. |.||.|||.|.| || ..|||. ||... .|.. | | . . ||| |
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM
-------EDYY
..||
QNATDEEKPYY
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| Kinase | 13106.AA | S_TKc | 68-347 | 19 | 3.6e-16 | 60.26 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 68-347
Range on HMM: 1-231/231
Sequence Identity: 19% (57 aa)
YSNFKYLGAGNQGCVLLALDNANKFRYAIKGFQIKDKSGQVFEDDRIACEKEADLLLKMSDQPNNLRLFKKLEGDLMIYLVLNECKG---TLKDLIQQQG
| . .| | |.| .. .. . ..||| . ..| ..| | . || .|. . .|.|. | | .|.|.|...|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
GK-----LNIYSTIKYSKDIAENLYYIHKNRFIVQDIKPDNILIDYNNNAVVADFGMGNKLIEMDNYYAQDSFQGNSLFSPPEVQNFYEDYYEQINKNNS
.. .. . .| . |.. | |.|....| |.||.|||.| . ..|||. .| ..| | . .|||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---------------
KKIKNTPSK-RGDCFSFGYLMYYLIFGESKLLFYISQKNKELEFPQFQDDEKEFPFKFQLKKLILGLTRFIPNERTKLQEVLI-----ALKGMV
.| . | |.| ..| .. |. | .. .. ..| .| .. .. |..| |.| .. .
-----GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 13106.AA | Pkinase | 68-286 | 23 | 4.3e-16 | 57.99 | Pfam | 1-209 (293) | Show / Hide |
Range on Protein: 68-286
Range on HMM: 1-209/293
Sequence Identity: 23% (54 aa)
YSNFKYLGAGNQGCVLLALDNANKFRYAIKGFQIKDKSGQVFEDDRIACEKEADLLLKMSDQPNNLRLFKKLEGDLMIYLVLNECKG-----TLKDLIQ-
| . .|.|. ||| .. . . ..|.| . .... .. . .| . |. ..... . || .||. | . ||.|. | | |.|.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST
QQGGKL--NIYSTIKYSKDIAENLYYIHKNRFIVQDIKPDNILIDYNNNA----VVADFGMGNKLIEMDNYYAQDSFQGNSLFSPPEVQNFYEDYYEQIN
...|.. ..| . |.. |.|.|....| |.||.||||| |.. ..||| .. |. ..| | . . .|||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV------------
KNNSKKIK--NTPSKRGDCFSFGYLMYYLIFGE
|. . ... | .|.| ..|....|.
------IRGGQYYGPKVDMWSCGCILYEMLCGR
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| Kinase | 13106.AA | Ciliate-E1 | 74-262 | 21 | 1.8e-14 | 43.87 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 74-262 Range on HMM: 1-202/202 Sequence Identity: 21% (44 aa) LGAGNQGCVLLALDNANK-FRYAIKGFQIKDKSGQVFEDDRIACEKEADLLLKMSDQPNNLRLFKKLEGDLM-IY-LVLNECKGTLKDLIQ--------- .|.| .. |. | . |. .|.| ....... |. ..| | || ....| . . . ... .. |. |. .....|. .||| .| IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEI---KEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ ---QQGGKLNIYSTIKYSKDIAENLYYIHKNRFIVQDIKPDNILIDYNNNAVVADFGMGNKLIEMDNYYAQDSFQGNSLFSPPEVQ--NFYEDYYEQINK |. ..... .. ... . | ..| ...| .||||.||||. ..| | .||| . .|.. .|.. | . . ... .|.... . | ...|. . QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKIN NNSKKI .| . YKSDIY |
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| Kinase | 13106.AA | Ciliate-E2-Unclassified | 68-340 | 18 | 1.5e-12 | 39.89 | In-house | 1-347 (352) | Show / Hide |
Range on Protein: 68-340
Range on HMM: 1-347/352
Sequence Identity: 18% (67 aa)
YSNFKYLGAGNQGCVLLALDNANKFRY-----AIKGFQIKDKSGQVFEDDRIACEKEADL---------------LLKMSDQPNNLRLFKKLEGDLMIYL
| | .| |..|.| .. .. .| | ..| ..|.|. . . . . ..|| .|.... |. ...| . . ||.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI
VLNECKG-TLKDLIQQQGG----------------KLNIYSTI-----KYSKDIAENL-YYIHKNRFIVQDIKPDNILIDYNN---NAVVADFGMGNKLI
|. |.| .|.. |..... .. . .. .| . | . | |..||| .| ||||.|||.| |. . ..||| |..
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ
EMDNYYAQD--------------SFQGNSLFS----PPEVQNFYEDYYEQINKNNSKKIKNTPSKRGDCFSFGYLMYYLIFGESKLLFYISQKNK-----
...|.. . .| |. . .||| . . . . |..|.| ..|...||. . || ....
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-------------YKCDIWSLGVILYEMLFGY--YPFYDNNCEQHQQLI
--------ELEFPQFQ-DDEKEFP----------FKFQLKKLIL----GLTRFIPNERTKLQEVL
.... | . . . .|| .. | .| . ||.| ....|
TQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
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| Kinase | 13106.AA | GIN4 | 122-216 | 32 | 1.3e-11 | 32.98 | In-house | 86-181 (293) | Show / Hide |
Range on Protein: 122-216 Range on HMM: 86-181/293 Sequence Identity: 32% (32 aa) LLLKMSDQPNNLRLFKKLEGDLMIYLVLNEC-KGTLKDLIQQQGGKLNIYSTIKYSKDIAENLYYIHKNRFIVQDIKPDNILIDYNNN-AVVADFGM ...|. . || .||. | . .|||| || | ... .. |.| |.| . | . . | | . |.||.|.|.| .| .||||| VIMKLISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDH-GPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGM |
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| Kinase | 13106.AA | NuaK | 179-218 | 47 | 1.6e-11 | 26.02 | In-house | 108-147 (252) | Show / Hide |
Range on Protein: 179-218 Range on HMM: 108-147/252 Sequence Identity: 47% (19 aa) IAENLYYIHKNRFIVQDIKPDNILIDYNNNAVVADFGMGN |. ..| ||.| . | | ||| | |.|| .||||. | IVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSN |
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| Kinase | 13106.AA | Dicty4-Unclassified | 153-216 | 41 | 5.8e-11 | 33.74 | In-house | 86-155 (263) | Show / Hide |
Range on Protein: 153-216 Range on HMM: 86-155/263 Sequence Identity: 41% (29 aa) KGTLKDLIQ------QQGGKLNIYSTIKYSKDIAENLYYIHKNRFIVQDIKPDNILIDYNNNAVVADFGM ||.| .| || ||. ||| ||| . . | || ||| |||.| ..|. .||||. KGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGI |
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| Kinase | 13106.AA | Ciliate-E2b | 68-215 | 27 | 6.2e-11 | 29.64 | In-house | 1-147 (272) | Show / Hide |
Range on Protein: 68-215
Range on HMM: 1-147/272
Sequence Identity: 27% (42 aa)
YSNFKYLGAGNQGCVLLALD-NANKFRYAIKGFQIKDKSGQVFEDDRIACEKEADLLLKMSDQPNNLRLFKKLEGDLMIYLVLNECKGT-LKDLIQQQG-
| || |. | | | . | ||.| ... . | | . . ||. .|.. . |. .... | .|... |.| | |.| ..|
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNME-KHMLQEKN---VLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGR
GKLNIYSTIKYSKDIAENLYYIHKNRFIVQDIKPDNILIDYNNNAVVADFG
|. | | . | .| | |.. | |||| ||..|.. .|.|
LLLSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMG
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| Kinase | 13106.AA | TyrKc | 68-293 | 17 | 2.7e-05 | -136.97 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 68-293 Range on HMM: 1-280/280 Sequence Identity: 17% (50 aa) YSNFKYLGAGNQGCVLLALDNANKFRYAIKGFQIKDKSGQVFEDDRIACEKEADLLLKM-SDQPNNLRLFKKLEGD-------LMIYLVLNECK-GTLKD . | || |. | | .. . |.| . | . .|| .. | . || .||. . ...|. .. | ||| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD LIQQQGGKLNIYSTIKYSKDIAENLYYIHKNRFIVQDIKPDNILIDYNNNAVVADFGMGNKLIEMD-------NYYAQDS-FQGNSLF----SPPEVQNF .. ..||. .... .||. |.|....| |. |.|.. |. . ..|||. . |. | || . . .|.... .||. |. YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY Y-----------------------EDYYE-----QINKNNSKKIKNT--PSKRGD--------CFSFGYLMYYLIFGE--------SKLLFYI . . |.. |. ...|. . . . | . | . | | . .. GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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