Gene 11466 (Tetrahymena)
11466
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 11466.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 11466.AA | Ciliate-C7 | 42-232 | 57 | 4.8e-102 | 327.88 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 42-232
Range on HMM: 1-164/164
Sequence Identity: 57% (109 aa)
LDFQGQGAQGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVLTECLGIYHSLPSKFYSIHLLM
. | |||.||||.|||...|| ||||||. ..|...|.|| |..||||||..|.|||.|||| .|||..||...|.|||.||.|
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQG----------------
HKLNGISRQKIGTLSDIIKNTQNQRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAVVSDFGFADNLTQQSGYAFDEYK
|||..||...||.||||.||||| ||||.|||.||||.|.|||||||||||||||||||.||| ||||||.|.|....|
-----------GTLNQIIERNQNKRLNEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM
|
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| Kinase | 11466.AA | Ciliate-E2-Unclassified | 46-244 | 16 | 1.1e-15 | 50.87 | In-house | 8-239 (352) | Show / Hide |
Range on Protein: 46-244
Range on HMM: 8-239/352
Sequence Identity: 16% (42 aa)
GQGAQGLVVLAKEKSTNKRYAIKGIPIKDSKD-NVDQVILGQVQQEIQMLNQCK------------------GSPYVANLLHKIEGNDYIFLVLTECLG-
|||..| | ....|.... ||.| . . ... . . . .|.. .|. | .|.. .... . ..|..|. | |
GQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGG
--------------IYHSLPSKFYSIHLLMHKLNGISRQKIGTLSDIIKNTQNQRLNELSAIK------YTKDIAEGLYFIHSKK-CLVNDLKMDNILID
. |. .|..... . ..| |.. | .|| ..|.|. .. |.| .|||.|
DLWQYIKKRKKQKQK----------------------------GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFD
YNG---NAVVSDFGFADNLTQQSGYAFDEY---------------KGNIIFQ----APECYD
|| . ..|||.. .. |.... .. |..... |||...
NNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ
|
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| Kinase | 11466.AA | Ciliate-E2 | 153-252 | 17 | 1.2e-15 | 50.16 | In-house | 119-281 (365) | Show / Hide |
Range on Protein: 153-252
Range on HMM: 119-281/365
Sequence Identity: 17% (30 aa)
GTLSDIIKNT----------QNQRLNELSAIKYTKDIAE---------------GLYFIHSKK-CLVNDLKMDNILIDYNGNAVVSDFGFADNLTQQSG-
|.| |.||| . ....| .....| |.. .| ..|||. .. |.| .|||. ..|||.. ......
GDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQN
-------YAFDEYK-----------------------GNIIFQAPECYD--P-----------SKFDIYS
. . . | |. ..||| . . | ||.|
RTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS
|
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| Kinase | 11466.AA | STE-Unique | 153-217 | 34 | 2.8e-14 | 46.59 | In-house | 379-457 (616) | Show / Hide |
Range on Protein: 153-217 Range on HMM: 379-457/616 Sequence Identity: 34% (27 aa) GTLSDIIKNTQN-------QRLNELSAIKYTKDIAEGLYFIHSKK--CLVNDLKMDNILIDYNG-----NAVVSDFGFA |||..|||.. | . | .|.||. |.||| ..||.. . ||| .||... | .....||| | GTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHA |
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| S_TKc | 11466.AA | S_TKc | 39-357 | 19 | 2.3e-13 | 19.06 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 39-357
Range on HMM: 1-231/231
Sequence Identity: 19% (65 aa)
MMNLDFQGQGAQGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVLTECLGIYHSLPSKFYSIH
|. |.|| | | ....|.|....||| |. ....|||.| . . |.. .|. .. |....|. | |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDG-------------
LLMHKLNGISRQKIGTLSDIIKNTQNQR----LNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAVVSDFGFADNLTQQSGYAFDEYKGN
|.| |.||. . .. ..| | .|.. |...| ..||.. . ||| .|||.| . ..|||.| | . . |
------------DLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGT
IIFQAPECYDPSKFDIYSEEYKNLGVAVKQKPSQRVFYRQKLINIIKIYNINL-KSEACSLGYLLYTMISGFQANLVFSKHQPLQYNADFQNLAYEKQLR
. ||| . |. |.| .|| |..| |... |... ....
PWYMAPEVL----------------------------------------GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG-SPEAK
YIIDGLTKFIPRERLKVKEALI---------VL
.|... .. |..|. . ||| .
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 11466.AA | Ciliate-A2 | 46-98 | 33 | 1.1e-11 | 37.05 | In-house | 1-56 (272) | Show / Hide |
Range on Protein: 46-98 Range on HMM: 1-56/272 Sequence Identity: 33% (19 aa) GQGAQGLVVLAKEK--STNKRYAIKGIPIKDSKDN-VDQVILGQVQQEIQMLNQCK |||. |.|...... |. |||| ..| |..| ..| | . . |.| | |. GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCN |
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| Kinase | 11466.AA | Pkinase | 153-217 | 33 | 1.1e-11 | 42.35 | Pfam | 85-159 (293) | Show / Hide |
Range on Protein: 153-217 Range on HMM: 85-159/293 Sequence Identity: 33% (25 aa) G----TLSDIIKNTQNQRL--NELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNA----VVSDFGFA | |.|.|. .. .. | ...| . |..||...||.... ||| .||||| ||. ..|||.| GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA |
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| Kinase | 11466.AA | ULK | 153-217 | 28 | 4.3e-11 | 35.04 | In-house | 105-189 (329) | Show / Hide |
Range on Protein: 153-217 Range on HMM: 105-189/329 Sequence Identity: 28% (24 aa) GTLSDIIKNTQN--------QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAV------------VSDFGFA |.|...||. .. .||.| ||.. |.|..|. ..|.... |.| .||||. . ..||||| GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 11466.AA | CAMK | 46-122 | 16 | 4.6e-11 | 31.17 | In-house | 3-140 (425) | Show / Hide |
Range on Protein: 46-122 Range on HMM: 3-140/425 Sequence Identity: 16% (23 aa) GQGAQGLVVLAKEKSTN------------KRYAIKGIPIKDSKDNV----------------------DQVILGQVQQEIQMLNQCKG------SPYVAN |.|. | | |...|.|. ...||| |. | ||.. ... . .|..||.......| | . . GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK LLHKIEG-------------------NDYIFLVL--TE |.. .| ......|. .| LYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIME |
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| Kinase | 11466.AA | ULK | 153-217 | 28 | 1.3e-09 | 30.36 | In-house | 102-185 (324) | Show / Hide |
Range on Protein: 153-217 Range on HMM: 102-185/324 Sequence Identity: 28% (24 aa) GTLSDIIKNTQN-------QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAV------------VSDFGFA |.|...||. .. .||.| ||.. |.|..|. ..|.... |.| .|||| . ..||||| GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 11466.AA | STE | 153-221 | 29 | 3.6e-09 | 28.64 | In-house | 122-198 (359) | Show / Hide |
Range on Protein: 153-221 Range on HMM: 122-198/359 Sequence Identity: 29% (24 aa) GTLSDIIK---NTQN---------QRLNELSAIKYTKDIAEG-LYFIHSKKCLVNDLKMDNILIDYNGNAVVSDFGFADNLT |.|.|||| ... .|..| ......| .| ||..||.. |.| .|||. . .|||.. .|| GSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLT |
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| Kinase | 11466.AA | CAMK | 158-241 | 19 | 7.1e-09 | 23.99 | In-house | 155-290 (425) | Show / Hide |
Range on Protein: 158-241
Range on HMM: 155-290/425
Sequence Identity: 19% (27 aa)
IIKNTQN------------QRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYN-----------------GNAVVSDFGFADNLTQQS----
|...... |..| | .| . |.... ..||.. ||| .|||.|.| .| ..||||| ... .
IVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFM
------------------GYAFDEYKGNIIFQA-PE
| . .. | . | ||
CSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE
|
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| Kinase | 11466.AA | STE-Unique | 40-107 | 22 | 2.8e-08 | 24.93 | In-house | 1-67 (616) | Show / Hide |
Range on Protein: 40-107 Range on HMM: 1-67/616 Sequence Identity: 22% (15 aa) MNLDFQGQGAQGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLL . .. |.|. | |.... |....|.||| |..| || . . ||. . .. ........ NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLH-HQNIVKYY |
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| Kinase | 11466.AA | STE20 | 46-107 | 28 | 4.2e-08 | 26.04 | In-house | 8-70 (288) | Show / Hide |
Range on Protein: 46-107 Range on HMM: 8-70/288 Sequence Identity: 28% (19 aa) GQGAQGLVVLAKEKSTNKR----YAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQCKGSPYVANLL |||. | | .| .|.|.. .||| ..... .. | . .|.||....||| .|.. . . GQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNE--QDEWEDIQKEISIMKQCK-HPNIVKYY |
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| Kinase | 11466.AA | STE | 40-107 | 16 | 4.6e-08 | 24.68 | In-house | 1-96 (359) | Show / Hide |
Range on Protein: 40-107 Range on HMM: 1-96/359 Sequence Identity: 16% (16 aa) MNL-DFQGQGAQGLVVLAKEK------STNKR---------YAIKGIPIKDSK-----------DNVDQVILGQVQQEIQMLNQCKG-SPYVANLL . .. |.|| | |..|. . .|.. .||| ....... .|... .. |...||.....|. .|.. . . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYY |
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| Kinase | 11466.AA | STE20 | 153-222 | 29 | 6.8e-08 | 25.25 | In-house | 93-169 (288) | Show / Hide |
Range on Protein: 153-222 Range on HMM: 93-169/288 Sequence Identity: 29% (23 aa) GTLSDIIKN--TQNQ-----RLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAVVSDFGFADNLTQ |.|.||.|. . .. ..|| .... .|| ..||... |.| ||||.. .|.. .|||.. ||. GSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTK |
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| Kinase | 11466.AA | ULK | 46-120 | 19 | 1.4e-07 | 22.58 | In-house | 8-99 (329) | Show / Hide |
Range on Protein: 46-120 Range on HMM: 8-99/329 Sequence Identity: 19% (18 aa) GQGAQGLVVLAKEKST----NKRYAIKGIPIK-DSKDNVD---QVILGQVQQEIQMLNQCK---GSPY----VANLLHKIEGN--DYIFLVL |.|. | | .. | | |. .|.| |... ...| . |... ....||. . . | .... . |.. | ..|.... GKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM |
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| Kinase | 11466.AA | ULK | 46-120 | 22 | 1.6e-07 | 22.87 | In-house | 8-96 (324) | Show / Hide |
Range on Protein: 46-120 Range on HMM: 8-96/324 Sequence Identity: 22% (20 aa) GQGAQG-LVVLAKEKST---NKRYAIKGIP---IKDSKDNVD-QVILGQVQQEIQMLNQCK--GSPY--VANLLHKIEGN--DYIFLVL |.|. | | .. | | |. .|.| |. ....| . . |... . ..||| . . | .|. . |.. | ..|.... GKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM |
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| Kinase | 11466.AA | Ciliate-A2 | 155-217 | 30 | 2.9e-07 | 21.6 | In-house | 85-150 (272) | Show / Hide |
Range on Protein: 155-217 Range on HMM: 85-150/272 Sequence Identity: 30% (20 aa) LSDIIKNTQNQR--LNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGN-AVVSDFGFA |.| |. |||. ... ...... | ... .|.| . ||. ||||| ... .. |||.| LQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLA |
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| Kinase | 11466.AA | Pkinase | 46-120 | 29 | 3e-06 | 23.41 | Pfam | 8-79 (293) | Show / Hide |
Range on Protein: 46-120 Range on HMM: 8-79/293 Sequence Identity: 29% (23 aa) GQGAQGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVI--LGQVQQEIQMLNQCKGSPYVANLLHKIEGNDYIFLVL |.|. | | ....|.|.|..|.| |. .. |...|| | .|||... . ..|.. |.. | .|.| .|. GSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVM |
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| TyrKc | 11466.AA | TyrKc | 39-317 | 14 | 9e-05 | -145.47 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 39-317
Range on HMM: 1-280/280
Sequence Identity: 14% (49 aa)
MMNLDFQGQGAQGLVVLAKEKSTNKRYAIKGIPIKDSKDNVDQVILGQVQQEIQMLNQC-KGSPYVANLLHKIEGN-------DYIFLV--------LTE
.. | || | |.... | |.| . . .|.... . . | . .|. . . ...| | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
CLGIYHSLPSKFYSIHLLMHKLNGISRQKIGTLSDIIKNTQNQRLNELSAIKYTKDIAEGLYFIHSKKCLVNDLKMDNILIDYNGNAVVSDFGFADNLTQ
| .. |. ... .||.| ..|||.| || |.|.. |. . .|||| . ...
YLRKHRPK------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYD
Q--SGYAFDEYK------GN--IIFQ--APECYDPSKFDIYSE------------EYKNLGVAVKQKPSQRV----FYRQKLINIIKIYNINLKSEA---
.| . | |. |. . |||| .. .... | .| |.| . | .|. .| . . .
DDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYG----QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP
-----CSLGYLLYTMISGFQA---------NLVFSKHQPL
|. | . .. .. |. .
MSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI----HECF
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| Kinase | 11466.AA | Ciliate-E2 | 46-68 | 43 | 0.010508 | 5.09 | In-house | 8-30 (365) | Show / Hide |
Range on Protein: 46-68 Range on HMM: 8-30/365 Sequence Identity: 43% (10 aa) GQGAQGLVVLAKEKSTNKRYAIK |||..| | ..| ....|..||| GQGNFGSVYKCKVWKVQKQFAIK |
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