Gene 21061 (Tetrahymena)
21061
Group:
Other
Family:
Ciliate-C6
Sequence
Protein domains of 21061.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 21061.AA | Ciliate-C6 | 497-770 | 43 | 8.99999999999e-177 | 593.55 | In-house | 1-306 (306) | Show / Hide |
Range on Protein: 497-770 Range on HMM: 1-306/306 Sequence Identity: 43% (132 aa) ILEDKSLGRGTFGSVFECIEKPSKIALMKDIAQEQ------------------------LQEVYLLDRLQVYPNVIRLINYFYLPDKQLFIILELAQSSL |....|||.|.||.|..|..|...|....||.|.. ..|...|..|..|.|||...|||..|..|..|.|.||.|.| INYRDSLGSGSFGQVYKCKNKHKQIIKNMDILQQMPDYYACKQIHMTQQMSFENQMSQIFHEIEVLEKLKKYENVIKMQNYFIEPNRQTYIVLDLAESTL EQEIQERIKEVNNFYFKQEINIFSFNVKKKHYTKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIAND--TYKLSDFGAARQLSLEDFYRQN-THV ...||.....||||||||||||||||.|..|....||..||||||....|..|...|.|||.||.||||..| .|.|||||.|.||....|.|.| .|. QDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEFTRNNDIHM GSLKWMSPEMREGVEQNNIIQ----KYKLNYYQCDVFSLGLILMRMVTLEHIDGVNTDEEMKNFKVKRMMEKRKDLG-AEFLKVIEDMLIFDLKTRIDMS |.|||||||.||...|.|..| .....|..||.||||.||..|.||..|..||.||.|||.|...|....||.. .|..|....||......|.||| GTLKWMSPELREMKKQYNQHQDDNSNQQIDYFKCDIFSLGMILLYMLTLSDISQVNCDEFMKNQKIRIMKNMCKDISYKEIIKLVSKMLETNPDHRPDMS AFKVRI ... | ILIQTI |
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| Kinase | 21061.AA | Pkinase | 497-777 | 19 | 1.2e-24 | 88.2 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 497-777
Range on HMM: 1-293/293
Sequence Identity: 19% (66 aa)
ILEDKSLGRGTFGSVFECIEKPS------KIALMKDIAQEQLQ------EVYLLDRLQVYPNVIRLINYFYLPDKQLFIILELAQS-----SLE----QE
. . .|.|.||.|..|..| . || ... ...| |.... ||. ||..||. .|. .. . ...|... .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST-
IQERIKEVNNFYFKQEINIFSFNVKKKHY--TKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIA-NDTY----KLSDFGAARQLSLEDFYRQNTH
... . . .|. ....|| . .|. . | ||||||.|||| |.. |..||| |.|.. . .. .|
-----------------------WRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNSMTTF
VGSLKWMSPEMREGVEQNNIIQKYKLNYYQCDVFSLGLILMRMVTLEHI-DGV----NTDEEMKNFKVKRMMEKRKDLG---------------------
.|.. .|.|| |.... . .|..|.|.|| |.. . . .| | ...|. .. ... . . |
CGTPWYMAPEV---------IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHN
--AEFLKVIEDMLIFDLKTRIDMSAFKVRIEAIIKD--M
|....|...| .| | |. .| | .. .
WSEECKDFIKWCLCKDPKKRPT-------AEQILQHPWF
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| Kinase | 21061.AA | Ciliate-E2 | 497-716 | 20 | 2.5e-22 | 73.45 | In-house | 1-294 (365) | Show / Hide |
Range on Protein: 497-716 Range on HMM: 1-294/365 Sequence Identity: 20% (65 aa) ILEDKSLGRGTFGSVFEC--IEKPSKIA--------------------------LMKDIAQEQLQEVYLLDRLQV---------------YPNVIRLINY . | .|.|.||||..| .... ..| ..|. ....|| ... ... ||.|... . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FYL-PDKQLFIILELAQS-SLEQEIQER-IKEVNNFYFKQEINIFSFNVKKKHYTKDEILDFCKQIGF---------------LIRDLHNKQAITHRDLK |. |. .....|..| .|.. |... .|. ... . | .| ||... ||| .. ||.| | |||.| FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE----------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIK PQNILIANDTYKLSDFGAARQLSLE------------------------------DFYRQNTHVGSLKWMSPEMREGVEQNNIIQKYKLNYYQCDVFSLG |.|||. |..||| ..... . . .|| .|.. |.||. .| . .| || | |.||..||| PENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ-QKQKGYDYKCDIWSLG LILMRMVTLEH || .|.. .. VILYEMLFGKP |
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| Kinase | 21061.AA | ULK | 497-708 | 24 | 5.4e-21 | 70.08 | In-house | 1-246 (329) | Show / Hide |
Range on Protein: 497-708 Range on HMM: 1-246/329 Sequence Identity: 24% (66 aa) ILEDKSLGRGTFGSVFECIEKPS----------KIAL---MKDIAQE---------QLQEVYLLDRL-----QVY--PNVIRLINYFYLPD-KQLFIILE . .. || |.|| |.. . | . |. . |. . .| .|. .. .| . ||...|. .|. .. . ..||.| YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME LAQS-SLEQEIQERIK-----EVNNFYFKQEINIFSFNVKKKHYTKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIAND-------------TYK . . ||| |... | | .||. . .|.. |.||| ..|| .. | |||.||||||| |. ..| YCNGGDLEQYIKKNKKLPEDTE-----------------EKKRLSEQEAIQFFKQILNGFKELHKHN-IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLK LSDFGAARQLSLE--DFYRQNTHV------GSLKWMSPEMREGVEQNNIIQKY--KLNYY-Q-CDVFSLGLIL ..||| |.... . . | | |. |.|. |.|. . .|| ||..||| |. IADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQ---------ILQGQGEQKPYYDYKCDIWSLGCIF |
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| Kinase | 21061.AA | CAMK | 502-708 | 18 | 3.4e-20 | 61.12 | In-house | 1-324 (425) | Show / Hide |
Range on Protein: 502-708 Range on HMM: 1-324/425 Sequence Identity: 18% (60 aa) SLGRGTFGSVFECIEKPS-------------KIALMKDIA---------------------------------QEQ--LQEVYLLDRLQV------YPNV ||||.|| |..||.| . . .| | .. ..|. .. .|| ||. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI IRLINYFY------------LPDK-------QLFIIL---ELAQSS-LEQEIQERIKEVNNFYFKQEINIFSFNVKKKHYTKDEILDFCKQIGFLIRDLH |.|. .. .| ...... |... | ... ..|.| ..... . | . .....| .| . .|| .. .| IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF-D-QFDIV-ERGRFTEREARRYFRQICSAVHYCH NKQAITHRDLKPQNILIAND------------------TYKLSDFGAARQLSLEDFYR----------------------QNTHVGSLKWMS-PEMREGV .. | |||||| |||. .. . |..||| |... . .. .| .|.. |. ||. .| SHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGK EQNNIIQKY-----KLNY-YQCDVFSLGLIL . | . | | ..||. |.| || GHCNMQ--NATDEEKPYYGPKCDMWSCGVIL |
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| Kinase | 21061.AA | Ciliate-E2-Unclassified | 497-713 | 20 | 1.5e-19 | 64.47 | In-house | 1-265 (352) | Show / Hide |
Range on Protein: 497-713
Range on HMM: 1-265/352
Sequence Identity: 20% (58 aa)
ILEDKSLGRGTFGSVFECIEKPSK-------IALMKDIAQEQL----------QEVYLLD-------------RLQVYPNVIRLINYFYL-PDKQLFIIL
| .|.| ||.|..|..| | . .....| | .|. . |. |. ... ... .. ..|..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM
ELA-QSSLEQEIQERIK--EVNNFYFKQEINIFSFNVKKKHYTKDEIL-----DFCKQIGFLIRDLHNKQAITHRDLKPQNILIAND----TYKLSDFGA
|.. . .|.| |..| | .. .| . ..|. | ... ....|| . || |. | |||.||.|||. |. |..|||
EYCEGGDLWQYIKKRKKQKQK-------GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGI
AR--------------QLSLEDFYRQNTHVGSLKWM----SPEMREGVEQNNIIQKYKLNYYQCDVFSLGLILMRMVT
.. ... .. ...| .|.. | .||. .| .... |.||..||| || |..
SKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA------YKCDIWSLGVILYEMLF
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| Kinase | 21061.AA | ULK | 497-708 | 24 | 1e-18 | 63.08 | In-house | 1-242 (324) | Show / Hide |
Range on Protein: 497-708 Range on HMM: 1-242/324 Sequence Identity: 24% (66 aa) ILEDKSLGRGTFG-SVFECIEKPS-----KIAL-------MKDIAQE---------QLQEVYLLDRLQ--VYPN--VIRLINYFYLPD-KQLFIILELAQ . .. || |.|| |.. . | . ..| |... .| . .|. .. | || ...|. .|. .. . ..||.|. . YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN S-SLEQEIQERIK----EVNNFYFKQEINIFSFNVKKKHYTKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIANDT-------------YKLSDF ||| |... | | .|| . .|.. |.||| ..||... | |||.||||||| |.. .|..|| GGDLEQYIKKNKKLPETE-----------------EKKRLSEQEAIQFFKQICNGFKELHKHN-IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF GAARQLSL--EDFYRQNTHV------GSLKWMSPEMREGVEQNNIIQKY--KLNYY-Q-CDVFSLGLIL | |... .. | | |. |.|. |.|. . .|| ||..||| |. GFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQ---------ILQGQGEQKPYYDYKCDIWSLGCIF |
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| Kinase | 21061.AA | STE | 623-716 | 30 | 3.5e-17 | 57.32 | In-house | 168-266 (359) | Show / Hide |
Range on Protein: 623-716 Range on HMM: 168-266/359 Sequence Identity: 30% (35 aa) LHNKQAITHRDLKPQNILIANDTYKLSDFGAARQLSL---------------EDFYRQNTHVGSLKWMSPEM--REGVEQNNIIQKYKLNYY--QCDVFS ||... | |||.||.|||. ||.||| . ||. . || ||. ||.||. ..| . . | .||. | LHSHH-IIHRDIKPANILL----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R-------DKGYDTKCDIWS LGLILMRMVTLEH ||. .. |.| .. LGCTIIEMATGKP |
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| Kinase | 21061.AA | TKL | 623-708 | 22 | 8.4e-17 | 57.04 | In-house | 148-279 (364) | Show / Hide |
Range on Protein: 623-708 Range on HMM: 148-279/364 Sequence Identity: 22% (30 aa) LHN-------KQAITHRDLKPQNILIANDT---------------YKLSDFGAARQLSLEDFYRQNTH------------------VGSLKWMSPEMREG ||. | .| |||||..|||. .. |..||| .| .| . . . .|.. ||.||. .| LHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRG VEQNNI-------IQKYKLNYYQCDVFSLGLIL .... ..... . .|||.| |..| QMNYTEKVGIDEFCKGFEYS-EKCDVYSFGIVL |
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| Kinase | 21061.AA | Ciliate-A1 | 593-709 | 31 | 2.3e-16 | 52.15 | In-house | 87-219 (301) | Show / Hide |
Range on Protein: 593-709 Range on HMM: 87-219/301 Sequence Identity: 31% (43 aa) NIFSFNVKKKHYTKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIA-NDTYKLSDFGAARQLSLED-----------------FYRQNTHVGSLKW | | . ... |.|| ..| || . |.| .. | ||||||||||| | .|. |.| .|| | |.| NLFNYCYQNDYMKKEEIYEICYQIIEGYADIH-DHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYY MSPEMREGVEQNNIIQKYKLNYYQCDVFSLGLILM |||| . . |. | | |..|||.|.. MSPEQYQMHYRDQMFIENKI-YKQSDMYSLGCIIC |
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| Kinase | 21061.AA | S_TKc | 497-774 | 21 | 4.2e-16 | 59.3 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 497-774
Range on HMM: 1-231/231
Sequence Identity: 21% (61 aa)
ILEDKSLGRGTFGSVFECIEKP-SKIALMKDIAQEQLQEVYLLDRLQVYPNVIRLINYFYLPDKQLFIILELAQS---SLEQEIQERIKEVNNFYFKQEI
. .|.|.||.|. |..| .| .| | . ..|. .| . ||...|. .|. . |....|.. .| . |..| .. ..|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP-----
NIFSFNVKKKHYTKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIANDTYKLSDFGAARQLSLEDFYRQNTHVGSLKWMSPEMREGVEQNNIIQKY
.. .. ...|| . .|.. | ||||||.|||. . . |..||| |||| .| .|.. .|.||.
-----------FPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL------------
KLNYYQCDVFSLGLILMRMVTLEHIDGVNTDEEMKNFKVKRMMEKRKDLGAEFLKVIEDMLIFDLKTRIDMSAFKV-----RIEAII
. .. ||. |.| || |.. . . .. .|. . |.. |. .| .| . |. .. .
GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 21061.AA | TyrKc | 497-770 | 18 | 2.4e-11 | -39.34 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 497-770
Range on HMM: 1-280/280
Sequence Identity: 18% (59 aa)
ILEDKSLGRGTFGSVFECIEKPSKIALMKDIA----QEQLQEVYLLDRL-QVYPNVIRLINYFYLP------DKQLFIILELAQS-SLEQEIQERIKEVN
| .| ||.| || |.... | | . .. ..| .. .| ||..||. . . ...|.|..|.. .| . .... ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--
NFYFKQEINIFSFNVKKKHYTKDEILDFCKQIGFLIRDLHNKQAITHRDLKPQNILIANDT-YKLSDFGAARQLSLE-------DFYRQ----NTH-VGS
. .. |.|| || . || | . |||| |.|.... | |||| .| . . | ||. ... .
-------------------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP
LKWMSPEMREGVEQNNIIQKYKLNYYQCDVFSLGLILMRMVTLEHIDGVN------TDEEMKNFKVKR-MMEKRKD--------LGAEFLKVIEDMLIFD
..||.|| .|. . ||.| | . . |. . ...|. .. .. .|.. .. .| ..... .|
IRWMAPECI----------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHED
LKTRIDMSAFKVRI
. | .|. . ..
PEDRPTFSEIHECF
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| Kinase | 21061.AA | CMGC | 623-658 | 31 | 8.4e-11 | 30.77 | In-house | 198-255 (513) | Show / Hide |
Range on Protein: 623-658 Range on HMM: 198-255/513 Sequence Identity: 31% (18 aa) LHNKQ-AITHRDLKPQNILIANDTY---------------------KLSDFGAARQLS .| . | ||||||.|||| ... |. ||| ||... CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYH |
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| Kinase | 21061.AA | CMGC | 497-577 | 17 | 1.2e-07 | 20.2 | In-house | 1-146 (513) | Show / Hide |
Range on Protein: 497-577 Range on HMM: 1-146/513 Sequence Identity: 17% (25 aa) ILEDKSLGRGTFGSVFECIEKPS---------------KIALMKDIA------QEQ------------LQEVYLLDRLQ---------------VYPN-V .| .|.||.| |..|. | . .| .| | |.. | |. .| .|. .| . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI IRLINYFYLPD----------------KQLFIILELAQSSLEQEIQ ..|...|| .. ..|... |. . .| | |. VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIK |
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| Kinase | 21061.AA | STE | 498-567 | 14 | 1e-06 | 19.83 | In-house | 1-118 (359) | Show / Hide |
Range on Protein: 498-567
Range on HMM: 1-118/359
Sequence Identity: 14% (17 aa)
LED-KSLGRGTFGSVFECIEK-------------------PSKIALMK---------------------DIAQEQLQEVYLLDRLQV-YPNVIRLINYFY
.|. . .|.|.||.|. .. . | |. .. |. |.|. .. ... ||... . ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
LP------DKQLFIILEL
| .|.|..|.
KEGHNHKNDDELWICMEY
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| Kinase | 21061.AA | Pkinase_Tyr | 497-520 | 37 | 0.004598 | 11.0 | Pfam | 1-24 (270) | Show / Hide |
Range on Protein: 497-520 Range on HMM: 1-24/270 Sequence Identity: 37% (9 aa) ILEDKSLGRGTFGSVFECIEKPSK | .| ||.| ||.|.... |... ITFGKKLGEGAFGEVYKGTWKGDP |
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| Kinase | 21061.AA | Pkinase_Tyr | 623-678 | 38 | 0.013013 | 9.47 | Pfam | 127-184 (270) | Show / Hide |
Range on Protein: 623-678 Range on HMM: 127-184/270 Sequence Identity: 38% (23 aa) LHNKQAITHRDLKPQNILIA-NDTYKLSDFGAARQLSLEDFY-RQNT-HVGSLKWMSPE |..|. . |||| |.|.. | . | .||| || . .| | |. . |||.|| LESKN-CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPE |
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| Kinase | 21061.AA | TKL | 503-512 | 50 | 0.062623 | 2.75 | In-house | 1-10 (364) | Show / Hide |
Range on Protein: 503-512 Range on HMM: 1-10/364 Sequence Identity: 50% (5 aa) LGRGTFGSVF .|.|.|| |. IGSGGFGEVY |
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