Gene 15449 (Tetrahymena)
15449
Group:
Other
Family:
Ciliate-C6
Sequence
Protein domains of 15449.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 15449.AA | Ciliate-C6 | 48-318 | 68 | 2.9e-205 | 688.18 | In-house | 1-306 (306) | Show / Hide |
Range on Protein: 48-318 Range on HMM: 1-306/306 Sequence Identity: 68% (210 aa) LDYRDSLGSGSFGQVFKVKNKYKGIIKNPDILQNMPDYYACKQIHISQDG--ENQNSQIFHEIEVLEKLKKYENVIKLQNYIIE-ERATYLVLDLAESTL ..|||||||||||||.|.|||.| ||||.||||.|||||||||||..|.. |||.|||||||||||||||||||||.|||.|| .|.||.||||||||| INYRDSLGSGSFGQVYKCKNKHKQIIKNMDILQQMPDYYACKQIHMTQQMSFENQMSQIFHEIEVLEKLKKYENVIKMQNYFIEPNRQTYIVLDLAESTL QDEINSKQVN------------------SEKFDESEIVKFLIQIGKTLALIYIEEGIAHRDIKPSNILIKDQ--NFYLSDFGCAEKLFESEGARKN-LVM ||.|..|| | .|.|||.|||.|..|||||||.||.|..|||||||||||||.|. |.||||||||..||.||..|.| ..| QDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEFTRNNDIHM GTLKWMSPELREMKK----------NQVVDYFKSDIFSFGMLLLYMLTLSDISSVNTDEFTKNQKIRIMKIYCKGIS-KEIILLTSKMLETNPDNRPDAG ||||||||||||||| ||..||||.||||.||.|||||||||||.||.|||.||||||||| .||.|| ||||.|.|||||||||.|||.. GTLKWMSPELREMKKQYNQHQDDNSNQQIDYFKCDIFSLGMILLYMLTLSDISQVNCDEFMKNQKIRIMKNMCKDISYKEIIKLVSKMLETNPDHRPDMS IIINTI |.|.|| ILIQTI |
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Kinase | 15449.AA | Pkinase | 48-318 | 20 | 1.9e-33 | 119.33 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 48-318 Range on HMM: 1-293/293 Sequence Identity: 20% (63 aa) LDYRDSLGSGSFGQVFKVKNKYKGIIKNPDILQNMPDYYACKQIHISQDGENQNSQIFH--EIEVLEKLKKYENVIKLQNYIIEERATYLVLDLAESTLQ . .||||||.|.| ..| |. .|.|.| . . .... . .. ||... .| . .|...| . ... |.|....| .| YHIGRKIGSGSFGCVYKCHHKGTGK------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY DEINSK----QVNSEKF--DESEIVKFLIQIGKTLALIYIEEGIAHRDIKPSNILIK-DQNF----YLSDFGCAEKLFESEGARKNLVMGTLKWMSPELR . . .. .| .| |. ... || . |. .. .|| |||.||.||||. . . ..|||.|... . . . . ||. .|.||. -VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV- EMKKN-QVVDYFKSDIFSFGMLLLYMLT----LSDI----SSVNTDEFTKNQKIRIMKIYCK--------------------GISKEIILLTSKMLETNP . . . |.|..|.| .| .||. .. . .. .. .. . .. . . .|.| . . ...|. .| ---IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP DNRPDAGIIINT--I || | | . . KKRPTAEQILQHPWF |
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Kinase | 15449.AA | S_TKc | 48-326 | 23 | 6.2e-31 | 110.0 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 48-326 Range on HMM: 1-231/231 Sequence Identity: 23% (67 aa) LDYRDSLGSGSFGQVFKVKNKYKGIIKNPDILQNMPDYYACKQIHISQDGENQNSQIFHEIEVLEKLKKYENVIKLQNYIIEERATYLVLDLAES---TL . . .|.|.||.|.|...| ..|.|.|. .| ||..|.| . .|..|| .. . |.|..... .| YEILRKIGKGAFGKVYKCRHKK------------TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL QDEINSKQVNS--EKFDESEIVKFLIQIGKTLALIYIEEGIAHRDIKPSNILIKDQNFYLSDFGCAEKLFESEGARKNLVMGTLKWMSPELREMKKNQVV | | ... . .|.| .. ... || . |. . || |||.||.|||. . . ..||| | .| . . ||. .|.||. FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL------GY DYFKSDIFSFGMLLLYMLT----LSDISSVNTDEFTKNQKIRIMKIYCKGISKEIILLTSKMLETNPDNRPDAGIIINTIQDIE-NNFK ...|.|. |.| .| ||. . | ...|. . |.| . . .|.|. .|..|| | . . .|| . GKCKCDWWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 15449.AA | STE | 48-261 | 22 | 1.4e-29 | 101.64 | In-house | 1-263 (359) | Show / Hide |
Range on Protein: 48-261 Range on HMM: 1-263/359 Sequence Identity: 22% (62 aa) LDYRDSLGSGSFGQVFKVKNKYKGIIKNPDILQ----NMPDYYACKQIHISQDG---------------ENQNSQIFHEIEVLEKLKK-YENVIKLQNYI .. . .|.|.||.|.| .|. ...| . . .. ...| ||...... ... || .||... |... .|..| . WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY IEER-------ATYLVLDLAE-STLQDEINSK----QVNS------EKFDESEIVKFLIQIGKTLA-LIYIE-EGIAHRDIKPSNILIKDQNFYLSDFGC . | .... . . .| | |..| . .. .|.||.| ... || . | |.. .| ||||||.|||. |.|||. FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQI--LKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGV AEKLFES--------------EGA-RKNLVMGTLKWMSPELREMKKNQ-VVDY-FKSDIFSFGMLLLYMLT . .| .| .. . | . || ||.|| . .. . .| .|.|| |.| ... |.| CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT |
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Kinase | 15449.AA | Ciliate-E2 | 48-311 | 20 | 1.9e-25 | 84.3 | In-house | 1-356 (365) | Show / Hide |
Range on Protein: 48-311 Range on HMM: 1-356/365 Sequence Identity: 20% (73 aa) LDYRDSLGSGSFGQVFKVKNKYKGI-----IKNPDILQNMP---DYYACKQIHISQDGENQNSQIFHEIEVLEKLK---------------KYENVIKLQ . .|.|.||.|.|.|.. .. |.. ... . .... |.. . . .|| ||. || .. ... . |.||. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY NYII--EERATYLVLDLAES-TLQDEINSKQVNS-------EKFDESEIVKFLIQIGKTL-------------ALIYIEE-G-IAHRDIKPSNILIKDQN . . . |||..... .|.| |.... .. ..|.| || .. || . || |. . . | ||||||.|||. ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- FYLSDFGCAE---------------KLFESEGARKNLVMG----------------TLKWMSPELREMKK-----NQVVDYFKSDIFSFGMLLLYMLTL- ..||| . |.. . ... | |. |.|| ..|| .| .|.||.|.|..| .||. IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK ---SDISSVNTDEFTKNQKIRIMKIYCK--------GISKEIILLTSK----MLETNPDNRPD-A .. . .| ..... . |. .|.| . | .| ||. .|..|.. . PPFQQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGW |
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Kinase | 15449.AA | ULK | 46-261 | 23 | 7.4e-25 | 83.75 | In-house | 1-251 (329) | Show / Hide |
Range on Protein: 46-261 Range on HMM: 1-251/329 Sequence Identity: 23% (61 aa) YELDYRDSLGSGSFGQVFKVKNKYKGIIKNPDILQNMPDYYACKQIHIS-QDGENQNSQ-------IFHEIEVLEKLK-------KYENVIKLQNYIIEE |.|. . ||.||||.|.| .| .... | .| ..|||.| .. .. .|.... . ||... ||| . .|..|| . . YCLNHC--LGKGSFGKVYKGRN----KKTK-D-YVN--EKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETS --RATYLVLDLAES-TLQDEINSKQV------NSEKFDESEIVKFLIQIGKTLALIYI-EEGIAHRDIKPSNILIKDQNFY-------------LSDFGC .|..... . .|.. |. .. . .. |.|...|..|| .. .. ...| ||||||.||||.. . . ..||| NHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQI--LNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGF AEKLFES--EGARKNLVM------GTLKWMSPELREMK-KNQVVDYFKSDIFSFGMLLLYMLT | .. .. | . || |.|.. . . ... . .|.||.|.|... .||. AKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY |
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Kinase | 15449.AA | ULK | 46-308 | 21 | 7.7e-24 | 81.51 | In-house | 1-312 (324) | Show / Hide |
Range on Protein: 46-308 Range on HMM: 1-312/324 Sequence Identity: 21% (69 aa) YELDYRDSLGSGSFG-QVFKVKNKYKGIIKNPDILQNMPDYYACKQIHISQDGENQNS--------QIFHEIEVLEKLK--KYEN--VIKLQNYIIEE-- |.|. . ||.|||| .|.| .|| .. |.|||.| ... ...| .. ||... ||| | .| ..|| . . YCLNHC--LGKGSFGVKVYKGRNKKTNT---------QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH RATYLVLDLAES-TLQDEINSKQV-----NSEKFDESEIVKFLIQIGKTLALIYI-EEGIAHRDIKPSNILIKDQNFY-------------LSDFGCAEK .|..... . .|.. |. .. . .. |.|...|..|| .. .. ...| ||||||.||||.. . . ..||| | . NNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQI--CNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH LFE-SEGARKN-------LVMGTLKWMSPELREMK-KNQVVDYFKSDIFSFGMLLLYMLTLS------DISSV--NTDEFTK-------NQKIRIMKI-- ... .. . .. .. || |.|.. . . ... . .|.||.|.|... .||. . . . . .. . .. | . VDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKP -YCKGISKEIILLTSKMLETNPDNR . . ||.|.. | ..||. ... | PKDPKISPECKDLIRRMLQYDEKDR |
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Kinase | 15449.AA | CAMK | 53-261 | 20 | 9.4e-24 | 72.8 | In-house | 1-329 (425) | Show / Hide |
Range on Protein: 53-261 Range on HMM: 1-329/425 Sequence Identity: 20% (69 aa) SLGSGSFGQVFKVKNK-YKGIIKNPDILQNMPDYYACKQIHIS--QD------------------------GENQNSQIFHEIEVLEKLKK------YEN ||.||||.|.....| .| .. |. | . .|.| | . .| .. ....|||.. ||.. .| TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN VIKLQNYIIE-------------------ERATYLVL---DLAEST-----LQDEINSKQVNSEK-----------FDESEIVKFLIQIGKTLALIYIEE .||| .. .. |.|. .... | | | .. ..|. |.|.| .. || |. |. . IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQI--CSAVHYCHS -GIAHRDIKPSNILIKDQNF---------------Y---LSDFGCAEKLFESE----------------------GARKNLVMGTLKWMS-PELREMKK- .|.|||.|| |||. | | . ..||| | |....| | . . ||. |. ||. . |. HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH -------NQVVDY--FKSDIFSFGMLLLYMLT .. .| .|.|. | | .| ||. CNMQNATDEEKPYYGPKCDMWSCGVILYIMLC |
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Kinase | 15449.AA | CMGC | 48-206 | 18 | 6.2e-22 | 68.03 | In-house | 1-249 (513) | Show / Hide |
Range on Protein: 48-206 Range on HMM: 1-249/513 Sequence Identity: 18% (47 aa) LDYRDSLGSGSFGQVFKVKNKYKGIIK---NPDILQNMPDYYACKQIHISQDGENQNS----------QIFHEIEVLEKLK---------------KYEN . . .|.|..|.|.| ..| . | . . ..| | | . |.| .. ||. |..|. | .| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQ-AHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN -VIKLQNYIIEER-----------------ATYLVLDLAESTLQDEINSKQV-----NSEKFDESE------------IVKFL------IQIGKTLALIY ..||.... . ||| .. . .| . | ..| . ...| . | .|. || . |.| | NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY IEEG---IAHRDIKPSNILIKDQNF---------------------YLSDFG . | |||.||.|||| ... . ||| CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG |
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Kinase | 15449.AA | TKL | 54-318 | 15 | 1.6e-21 | 74.23 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 54-318 Range on HMM: 1-364/364 Sequence Identity: 15% (61 aa) LGSGSFGQVFKVKNKYKGIIKNPDILQNMP----DYYACKQIHISQ-DGENQNSQI---------------------FHEIEVLEKLKK--YENVIKLQN .|||.||.|.| | . | | | | |.... . | .. ||| |.|.|.. ... .|.... IGSGGFGEVYKGKWRGWGG-KC-------PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMG YIIEERA-------------TYLVLDLA-ESTLQDEINSKQVNSEKFDESEIVKFLIQIGKTLALIYIEE---------GIAHRDIKPSNILIKDQN--- | .... ..| ... .| . .. . .... ..| ... | .|.|||.|..|||... . YCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDI--ARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNV ------------FYLSDFGCAEKLFESEG------------------ARKNLVMGTLKWMSPELREMKKN------------QVVDYFKSDIFSFGMLLL ..||| . ...|.. ... . ||. ||.||. ... | . |.|..|||..| SNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW YMLTLSDISSVNTDEFTKNQK------IRIMKIY--------------------CKGISKEIILLTSKMLETNPDNRPDAGIIINTI .|| . |. .. . .|... |. . .... | . ...|..|| . |. .. EILTRCR---PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | 15449.AA | Ciliate-E1 | 54-250 | 22 | 8.2e-21 | 64.75 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 54-250 Range on HMM: 1-202/202 Sequence Identity: 22% (49 aa) LGSGSFGQVFKVKNKYKGIIKNPDILQNMPDYYACKQIHISQDGENQNSQIFHEIEVLEKLKKYENVIKLQNYIIEERA--TYLVLDLAESTLQDEIN-- .|.|||..||| |.. ... .... .... .. ......| ...... .||....|....||. . . ....... . .|.|... IGNGSFSIVFKAKQQNNNYNQVAQKII---------NCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH -------SKQVNSEKFDESEIVKFLIQIGKTLALIYIEEGIAHRDIKPSNILIKDQ-NFYLSDFGCAEKLFESEGARKNLVMGTLKWMSPELRE-----M ..| | .|.. .... .|. . |. ... .| ||||||.||||..| |. ..|||.. .| ... .. | . .|| . NRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQ-YNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEH KKNQVVDYFKSDIF .||| ..| ||||. NKNQKINY-KSDIY |
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Kinase | 15449.AA | NAK | 48-206 | 24 | 3.5e-17 | 53.81 | In-house | 1-171 (299) | Show / Hide |
Range on Protein: 48-206 Range on HMM: 1-171/299 Sequence Identity: 24% (43 aa) LDYRDSLGSGSFGQVFKVKNKYKGIIKNPDILQNMPDYYACKQIHISQDGENQNSQIFHEIEVLEKLKKYENVIKLQN-YIIEER------ATYLVLDLA . . |..| |..|..|.. | ... | . .. || | . |....|... .. .|||...||.. .|.... .| |.. . .|.. . YTVEKYLAEGGFSYVYLVQDNYINHPDN---PNSNGEKYALKRM-ICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYC ES-TLQDEINSKQ-VNSEKFDESEIVKFLIQIGKTLALI-YIEE--GIAHRDIKPSNILIK----DQNFYLSDFG . .|.|..|... . .| | ||.... .. . .. . .. .|.|||||. |||.. | |. | ||| CHGSLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFG |
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Kinase | 15449.AA | TyrKc | 48-318 | 16 | 3.8e-12 | -26.3 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 48-318 Range on HMM: 1-280/280 Sequence Identity: 16% (50 aa) LDYRDSLGSGSFGQVFKVKNKYKGIIKNPDILQNMPDYYACKQIHISQDGENQNSQIFHEIEVLEKL-KKYENVIKLQNYIIEE-------RATYLVLDL . . ||.| ||.|.| . | | | .. . . .|.... || .. .|...| ..... ..|. . ITLGKKLGEGAFGEVYKGTWK---------------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY AE-----STLQDEINSKQVNSEKFDESEIVKFLIQIGKTLALIYIEEGIAHRDIKPSNILIKDQN-FYLSDFGCAEKLFES-------EGARKN---LVM .. . |.. . . .. ..| .|| . . . .. |||. |.|..... |||| . .. . . || MPHGDLKDYLRKHRPK-------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK --GTLKWMSPELREMKKNQVVDYFKSDIFSFGMLL--LYMLTLSDISS-----VNTDEFTKNQKIR-IMKIYCKG-------ISKEIILLTSKMLETNPD ..||.|| | . .|||..||| .. .. . . . .. .| .. | . |.. . ..|. . .. . .|. TMLPIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE NRPDAGIIINTI .|| |. . DRPTFSEIHECF |
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Kinase | 15449.AA | NAK | 290-318 | 27 | 0.00123 | 7.92 | In-house | 271-299 (299) | Show / Hide |
Range on Protein: 290-318 Range on HMM: 271-299/299 Sequence Identity: 27% (8 aa) SKEIILLTSKMLETNPDNRPDAGIIINTI |.... | ..||...|..||. ..| . SQQMHDLIRYMLTPDPEQRPNIYQVLNQL |