Gene 15448 (Tetrahymena)
15448
Group:
Other
Family:
Ciliate-C6
Sequence
Protein domains of 15448.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 15448.AA | Ciliate-C6 | 183-453 | 67 | 4.4e-204 | 684.27 | In-house | 1-306 (306) | Show / Hide |
Range on Protein: 183-453 Range on HMM: 1-306/306 Sequence Identity: 67% (208 aa) INYRDSLGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIHMIQDG--ENQSSQIFHEIEVLEKLKKYENVIKLQNYIIE-ERATYLVLDLAESTL |||||||| ||.|||.|.|||.|.||||.||||.|||||||||||| |.. |||.|||||||||||||||||||||.|||.|| .|.||.||||||||| INYRDSLGSGSFGQVYKCKNKHKQIIKNMDILQQMPDYYACKQIHMTQQMSFENQMSQIFHEIEVLEKLKKYENVIKMQNYFIEPNRQTYIVLDLAESTL QDEINNKQAN------------------LEKFDESEIVKFLSQIGKTLALIQIEEGIAHRDIKPSNILIKDQ--NFYLSDFGCAEKLFEQEGARKN-LVM ||.|..|||| .|.|||.|||.|..|||||||.|..|..|||||||||||||.|. |.||||||||..||..|..|.| ..| QDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEFTRNNDIHM GTLKWMSPELKEMKK----------NQVVDYFKSDIFSFGMLLLYMLTLSDISSVNSDEFTKSQKIRIMKDYCKGIS-KEIILLTSKMLETNPDNRPDAA ||||||||||.|||| ||..||||.||||.||.|||||||||||.||.|||.|.|||||||..||.|| ||||.|.|||||||||.|||.. GTLKWMSPELREMKKQYNQHQDDNSNQQIDYFKCDIFSLGMILLYMLTLSDISQVNCDEFMKNQKIRIMKNMCKDISYKEIIKLVSKMLETNPDHRPDMS IIINTI |.|.|| ILIQTI |
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Kinase | 15448.AA | S_TKc | 183-451 | 23 | 3.3e-29 | 104.27 | SMART | 1-220 (231) | Show / Hide |
Range on Protein: 183-451 Range on HMM: 1-220/231 Sequence Identity: 23% (64 aa) INYRDSLGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIHMIQDGENQSSQIFHEIEVLEKLKKYENVIKLQNYIIEERATYLVLDLAES---TL . .| |..|.|.|...| ..|.|.|. .| ||..|.| . .|..|| .. . |.|..... .| YEILRKIGKGAFGKVYKCRHKK------------TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL QDEINNKQANL--EKFDESEIVKFLSQIGKTLALIQIEEGIAHRDIKPSNILIKDQNFYLSDFGCAEKLFEQEGARKNLVMGTLKWMSPELKEMKKNQVV | | ... . .|.| .. ... || . |. . || |||.||.|||. . . ..||| | .| . . ||. .|.||. FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL------GY DYFKSDIFSFGMLLLYMLT----LSDISSVNSDEFTKSQKIRIMKDYCKGISKEIILLTSKMLETNPDNRPDAAIIIN ...|.|. |.| .| ||. . .... .||. |.| . . .|.|. .|..|| | . . GKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQ |
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Kinase | 15448.AA | Pkinase | 183-453 | 20 | 4.1e-28 | 100.49 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 183-453 Range on HMM: 1-293/293 Sequence Identity: 20% (63 aa) INYRDSLGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIHMIQDGENQSSQIFH--EIEVLEKLKKYENVIKLQNYIIEERATYLVLDLAES--- . .| ||.|.|.| ..| . .|.|.| . ... . .. ||... .| . .|...| . ... |.|....| YHIGRKIGSGSFGCVYKCHHKGTGK------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY --TLQDEIN-NKQANLEKFDESEIVKFLSQIGKTLALIQIEEGIAHRDIKPSNILIK-DQNF----YLSDFGCAEKLFEQEGARKNLVMGTLKWMSPELK | | | .. .. |.| |. ... || . |. . .|| |||.||.||||. . . ..|||.|... . . . . ||. .|.||. VMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV- EMKKN-QVVDYFKSDIFSFGMLLLYMLT----LSDI----SSVNSDEFTKSQKI-RIMKDYCKGIS-------------------KEIILLTSKMLETNP . . . |.|..|.| .| .||. .. . .. .. . . ... |. . .| .| . . ...|. .| ---IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP DNRPDAAIIINT--I || |. | . . KKRPTAEQILQHPWF |
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Kinase | 15448.AA | STE | 184-396 | 22 | 4.5e-25 | 85.56 | In-house | 1-263 (359) | Show / Hide |
Range on Protein: 184-396 Range on HMM: 1-263/359 Sequence Identity: 22% (60 aa) NYR-DSLGIGSYGQVFKVKNKYKDIIKNPDILQ----NMPDYYACKQIHMIQDG---------------ENQSSQIFHEIEVLEKLKK-YENVIKLQNYI . . .| |..|.|.| .|. ...| . . .. ...| ||... .. ... || .||... |... .|..| . WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY IEER-------ATYLVLDLAE-STLQDEIN---NKQANLE-------KFDESEIVKFLSQIGKT-LALIQIEEGIAHRDIKPSNILIKDQNFYLSDFGCA . | .... . . .| | |. .. .| .|.||.| ... || | |... | ||||||.|||. |.|||.. FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL----VKLCDFGVC EKLFEQ--------------EGA-RKNLVMGTLKWMSPELKEMKKNQ-VVDY-FKSDIFSFGMLLLYMLT .| . .. . | . || ||.|| . .. . .| .|.|| |.| ... |.| GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT |
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Kinase | 15448.AA | ULK | 183-396 | 22 | 5.7e-23 | 77.09 | In-house | 1-251 (329) | Show / Hide |
Range on Protein: 183-396 Range on HMM: 1-251/329 Sequence Identity: 22% (58 aa) INYRDSLGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIH---MIQDGEN-----QSSQIFHEIEVLEKLK-------KYENVIKLQNYIIEE-- .. .. || ||.|.|. | ...... | .| ..|||.| |.|. . . .. ||... ||| . .|..|| . . YCLNHCLGKGSFGKVY----KGRNKKTK-D-YVN--EKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH RATYLVLDLAES-TLQDEINNKQA------NLEKFDESEIVKFLSQIGKTLALIQI-EEGIAHRDIKPSNILIKDQNFY-------------LSDFGCAE .|..... . .|.. |.... . .. |.|...|. || .. . ...| ||||||.||||.. . . ..||| | NNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQI--LNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK KLFEQ--EGARKNLVM------GTLKWMSPELKEMK-KNQVVDYFKSDIFSFGMLLLYMLT .. . | . || |.|.. . . ... . .|.||.|.|... .||. HVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY |
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Kinase | 15448.AA | ULK | 183-396 | 22 | 2.3e-22 | 76.23 | In-house | 1-247 (324) | Show / Hide |
Range on Protein: 183-396 Range on HMM: 1-247/324 Sequence Identity: 22% (58 aa) INYRDSLGIGSYG-QVFKVKNKYKDIIKNPDILQNMPDYYACKQIH---MIQDGEN-----QSSQIFHEIEVLEKLK--KYEN--VIKLQNYIIEE--RA .. .. || ||.| .|.| .|| .. |.|||.| |... . . .. ||... ||| | .| ..|| . . YCLNHCLGKGSFGVKVYKGRNKKTNT---------QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNN TYLVLDLAES-TLQDEINNKQA-----NLEKFDESEIVKFLSQIGKTLALIQI-EEGIAHRDIKPSNILIKDQNFY-------------LSDFGCAEKLF .|..... . .|.. |.... . .. |.|...|. || .. . ...| ||||||.||||.. . . ..||| | ... IYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQI--CNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVD E-QEGARKN-------LVMGTLKWMSPELKEMK-KNQVVDYFKSDIFSFGMLLLYMLT . .. . .. .. || |.|.. . . ... . .|.||.|.|... .||. NNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY |
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Kinase | 15448.AA | Ciliate-E2 | 183-451 | 19 | 3.1e-22 | 73.11 | In-house | 1-361 (365) | Show / Hide |
Range on Protein: 183-451 Range on HMM: 1-361/365 Sequence Identity: 19% (74 aa) INYRDSLGIGSYGQVFKVKNKYKDI-----IKNPDILQNMP---DYYACKQIHMIQDGENQSSQIFHEIEVLEKLK---------------KYENVIKLQ .. .| |..|.|.|.|.. .. |.. ... . .... |.. | . .|| ||. || .. ... . |.||. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY NYII--EERATYLVLDLAES-TLQDEINNK---------QANLEKFDESEIVKFLSQIGK---------------TLALIQIEEGIAHRDIKPSNILIKD . . . |||..... .|.| |.|. . ..|.| || .. || . | . . | ||||||.|||. ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-- QNFYLSDFGCAE---------------KLFEQEGARKNLVMG----------------TLKWMSPELKEMKK-----NQVVDYFKSDIFSFGMLLLYMLT ..||| . |.. . . ... | |. |.|| ..|| .| .|.||.|.|..| .||. --IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF L----SDISSVNSDEFTKSQKIRIMKDYCK--------GISKEIILLTSK----MLETNPDNRPD-AAIIIN .. . .| . ... .. |. .|.| . | .| ||. .|..|.. . |.| GKPPFQQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN |
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Kinase | 15448.AA | TKL | 189-453 | 14 | 5.6e-21 | 72.28 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 189-453 Range on HMM: 1-364/364 Sequence Identity: 14% (57 aa) LGIGSYGQVFKVKNKYKDIIKNPDILQNMP----DYYACKQIHMIQ-DGENQSSQI---------------------FHEIEVLEKLKK--YENVIKLQN .| |..|.|.| | . . | | | |.... . | .. .|| |.|.|.. ... .|.... IGSGGFGEVYKGKWRGWGG-KC-------PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMG YIIEERA-------------TYLVLDLA-ESTLQDEINNKQANLEKFDESEIVKFLSQIGKTLALIQIEE-------GIAHRDIKPSNILIKDQN----- | .... ..| ... .| . .. . .... .| . .. .. .|.|||.|..|||... . YCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSN ----------FYLSDFGCAEKLFEQEG------------------ARKNLVMGTLKWMSPEL--KEMKKNQVV---------DYF-KSDIFSFGMLLLYM ..||| . ... .. ... . ||. ||.||. ..|. .. | .|. |.|..|||..| . YMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI LTLSDISSVNSDEFTKSQK------IRIMKDY--------------------CKGISKEIILLTSKMLETNPDNRPDAAIIINTI || . .|. ... . .|... |. . .... | . ...|..|| . |. .. LTRCR---PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | 15448.AA | CAMK | 188-396 | 19 | 1.3e-20 | 62.51 | In-house | 1-329 (425) | Show / Hide |
Range on Protein: 188-396 Range on HMM: 1-329/425 Sequence Identity: 19% (65 aa) SLGIGSYGQVFKVKNK-YKDIIKNPDILQNMPDYYACKQIHM----------------IQDGENQS----------SQIFHEIEVLEKLKK------YEN || ||.|.|.....| . .. |. | . .|.| | |.. .... ....|||.. ||.. .| TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN VIKLQNYIIE-------------------ERATYLVL---DLAEST-----LQDEINNKQANLEK-----------FDESEIVKFLSQIGKTLALIQIEE .||| .. .. |.|. .... | | | . . |. |.|.| .. || .. . IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN GIAHRDIKPSNILIKDQNF---------------Y---LSDFGCAEKLFEQE----------------------GARKNLVMGTLKWMS-PELKEMKK-- |.|||.|| |||. | | . ..||| | |... | | . . ||. |. ||. . |. -IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC ------NQVVDY--FKSDIFSFGMLLLYMLT .. .| .|.|. | | .| ||. NMQNATDEEKPYYGPKCDMWSCGVILYIMLC |
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Kinase | 15448.AA | CMGC | 183-341 | 18 | 2.8e-18 | 55.79 | In-house | 1-249 (513) | Show / Hide |
Range on Protein: 183-341 Range on HMM: 1-249/513 Sequence Identity: 18% (46 aa) INYRDSLGIGSYGQVFKVKNKYKDIIK---NPDILQNMPDYYACKQIH---MIQD------GENQSSQIFHEIEVLEKLK---------------KYEN- . .| |.||.|.| ..| . | . . ..| | | . . ... .. .. ||. |..|. | .| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQ-AHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VIKLQNYIIEER-----------------ATYLVLDLAESTLQDEINNKQA-----NLEKFDESE------------IVKFL------SQIGKTLA--LI ..||.... . ||| .. . .| . | |.| . ...| . | .|. || . |. . IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC QIEEG-IAHRDIKPSNILIKDQNF---------------------YLSDFG | | |||.||.|||| ... . ||| HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG |
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Kinase | 15448.AA | Ciliate-E1 | 189-385 | 22 | 1.4e-17 | 54.09 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 189-385 Range on HMM: 1-202/202 Sequence Identity: 22% (48 aa) LGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIHMIQDGENQSSQIFHEIEVLEKLKKYENVIKLQNYIIEERA--TYLVLDLAESTLQDEIN-- .| ||...||| |.. ... .... ... ... ... ..| ...... .||....|....||. . . ....... . .|.|... IGNGSFSIVFKAKQQNNNYNQVAQKII---------NCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH -------NKQANLEKFDESEIVKFLSQIGKTLALIQIEEGIAHRDIKPSNILIKDQ-NFYLSDFGCAEKLFEQEGARKNLVMGTLKWMSPELKE-----M .| | .|.. .... |. . |. ... .| ||||||.||||..| |. ..|||.. .| ... .. | . .|| . . NRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQ-YNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEH KKNQVVDYFKSDIF .||| ..| ||||. NKNQKINY-KSDIY |
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Kinase | 15448.AA | NAK | 183-341 | 24 | 1.7e-14 | 44.73 | In-house | 1-171 (299) | Show / Hide |
Range on Protein: 183-341 Range on HMM: 1-171/299 Sequence Identity: 24% (42 aa) INYRDSLGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIHMIQDGENQSSQIFHEIEVLEKLKKYENVIKLQN-YIIEER------ATYLVLDLA . . |. | ...|..|.. | ... | . .. || | . ....|.. .. .|||...||.. .|.... .| |.. . .|.. . YTVEKYLAEGGFSYVYLVQDNYINHPDN---PNSNGEKYALKRM-ICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYC ES-TLQDEINNKQ-ANLEKFDESEIVKFLSQIGKTLALI-QIEE--GIAHRDIKPSNILIK----DQNFYLSDFG . .|.|..|... .. .| | ||....... . .. . |. .|.|||||. |||.. | |. | ||| CHGSLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFG |
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Kinase | 15448.AA | TyrKc | 183-453 | 15 | 1.5e-11 | -36.06 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 183-453 Range on HMM: 1-280/280 Sequence Identity: 15% (49 aa) INYRDSLGIGSYGQVFKVKNKYKDIIKNPDILQNMPDYYACKQIHMIQDGENQSSQIFHEIEVLEKL-KKYENVIKLQNYIIEE-------RATYLVLDL | . || | .|.|.| . | | | .. . .|.... || .. .|...| ..... ..|. . ITLGKKLGEGAFGEVYKGTWK---------------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY AE-----STLQDEINNKQANLEKFDESEIVKFLSQIGKTLALIQIEEGIAHRDIKPSNILIKDQN-FYLSDFGCAEKLFEQ-------EGARKN---LVM .. . |.. .. . .. ..| || . . . .. |||. |.|..... |||| . .. . . || MPHGDLKDYLRKHRPK-------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK --GTLKWMSPELKEMKKNQVVDYFKSDIFSFGMLL--LYMLTLSDISS-----VNSDEFTKSQKIRIMKDYCKG--------ISKEIILLTSKMLETNPD ..||.|| | . .|||..||| .. .. . . . .. .| . | . . . . ..|. . .. . .|. TMLPIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE NRPDAAIIINTI .|| . |. . DRPTFSEIHECF |
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Kinase | 15448.AA | NAK | 425-453 | 27 | 0.000157 | 10.95 | In-house | 271-299 (299) | Show / Hide |
Range on Protein: 425-453 Range on HMM: 271-299/299 Sequence Identity: 27% (8 aa) SKEIILLTSKMLETNPDNRPDAAIIINTI |.... | ..||...|..||. . ..| . SQQMHDLIRYMLTPDPEQRPNIYQVLNQL |