Gene 7492 (Tetrahymena)

7492

Species: Tetrahymena
Alias: 7492, TTHERM_01469350, PreTt07492, 406.m00010, 78
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C5

Sequence

Name Sequence Type Origin Length Description Download
7492.AA Protein None 697 None Fasta, JSON
7492.kin_dom Protein Kinase Domain None 242 None Fasta, JSON
7492.NA RNA None 2094 None Fasta, JSON

Protein domain

Protein domains of 7492.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 7492.AA Ciliate-C5 230-489 90 1.4e-194 646.31 In-house 1-260 (260) Show / Hide 
Range on Protein: 230-489
Range on HMM: 1-260/260
Sequence Identity: 90% (235 aa)

IYLTSYISQGGYGCVFEAKYNEEIVAVKCSKPKFEKIKEEEKIMQLLKDTPYVFKSIEEFLNEKKTKYYQISKKYQCNLKDIMQSFFDQKKTLPLNQIVG
|||||||||||.||||||||||||||||||||.|||||||||||.||||||||||||||||||||.|||||||.|.||||||||||||||||||||||.|
IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG

FAIHMSTVFEKIQQNNMIHSDIKPENILYNSQEQCFNLCDYGESKLFKEGSKTYNLKGFTRKYAAPEITDDNGFFKIQYDIYGLGIILLELTLGKFLEDG
|||.||||||||||||.||||.|||||||.|||.||||||||||| ||.|||||.||||||||||||||||||||.|.|||||||||||||||||||||.
FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDDNGFFNIKYDIYGLGIILLELTLGKFLEDE

DCTFIRKGKLPNYLSKNALYQDINQIIIKMLEILPNNRIDSFGLTKQLNQLRLKLESQFI
||||||.||||||.||||||||||||||||||..|.||||||.||||||.||||||||||
DCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI
Kinase 7492.AA Ciliate-E1 236-411 24 1.7e-26 83.44 In-house 1-202 (202) Show / Hide 
Range on Protein: 236-411
Range on HMM: 1-202/202
Sequence Identity: 24% (50 aa)

ISQGGYGCVFEAKYNEE--------IVAVKC--SKPKFEKIKEEEK-IMQLLKDTPYVFKSIEEFLNEKKTKYYQISKKYQCNLKDIMQ---------SF
|..|... ||.||...         |. ...  .. .|.....|.. ||. .|   |... |. .  ..   ...|  ...|.||| .|         ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

FDQKKTLPLNQIVGFAIHMSTVFEKIQQNNMIHSDIKPENILYNSQEQCFNLCDYGESKLFKEGSKT-YNLKGFTRKYAAPEIT-------DDNGFFKIQ
  ... .   |..  ....   .. ..|.| ||.||||.|||.|.|   ...|| | ||..|. ..  .. ||.| .|. ||         ..|   ...
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK

YDIY
.|||
SDIY
Kinase 7492.AA Ciliate-B2 231-414 28 4.9e-20 43.72 In-house 2-197 (197) Show / Hide 
Range on Protein: 231-414
Range on HMM: 2-197/197
Sequence Identity: 28% (57 aa)

YLTSYISQGGYGCVFEAKYNEEI------VAVKCSKP----KFEKIKEEEKIMQLLKDTPYVFKSIEEFLNEKKTKYYQISKKYQCNLKDIMQSFFDQKK
||. || .|| | ..|  |  ..      .|.|          | | .| |||...    .| | |. .  ... .   |  | .| ||. .|    |.|
YLCKYINKGGCGFICEG-YKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVL-IMEKCECSLKQELQKIQKQQK

TLPLNQIVGFAIHMSTVFEKIQQNNMIHSDIKPENILYNSQEQCFNLCDYGESKLFKEGSKTYNLKGFTRKYAAPE-ITDD---NGFFKIQY--DIYGLG
  . . ..     .     ..  .| .| ||||.|||  .... . .||.| | . |      . |||| ||| || . .|       .|..  ||| .|
CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGN-YVYCDFGISSIKK-DNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG
Kinase 7492.AA C8 234-417 22 8.2e-17 54.97 In-house 5-226 (226) Show / Hide 
Range on Protein: 234-417
Range on HMM: 5-226/226
Sequence Identity: 22% (50 aa)

SYISQGGYGCVFEAKYNEE--IVAVKCSKPKFE-KIKEEEKIMQLLKDTPYVFKSIEEFLNEKKTKYYQISKK----YQ-----------CNLKD-----
 |.|.|.|| | .||  ..   .. |  | . . .|...|.||. .. .| ||.  . . ||....| . ..      .           | ...     
QYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYE-MPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCE

-----IMQSFFDQKKTLPLNQIVGFAIHMSTVFEKIQQNNMIHSDIKPENIL-YNSQEQC--FNLCDYGESKLFKEGSKTYNLKGF----TRKYAAPEIT
     . . . .... .. ..    || |    . |.. |..| ||||.|.| . .|..     ||| |..   ..  . .  | .    | .| |||| 
QNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIE

DD----NGFFKIQYDIYGLGIIL
 .    . ...|| |.. .|..|
KKQDNQYKQYRIQSDLFSVGLVL
Kinase 7492.AA Ciliate-E3 343-421 38 4.1e-16 47.02 In-house 121-202 (202) Show / Hide 
Range on Protein: 343-421
Range on HMM: 121-202/202
Sequence Identity: 38% (32 aa)

QNNMIHSDIKPENILYNSQEQ--CFNLCDYGESK-LFKEG--SKTYNLKGFTRKYAAPEITDDNGFFKIQYDIYGLGIILLELT
. | |||||||.|||  . .       || |||| | |.   . |.   |.|  |||||. .|.. ..   |.| .| ....| 
EKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQY-QGWTPFYAAPEQ-NDQQQISKESDYYSVGAVFCQLC
Kinase 7492.AA Pkinase 238-426 23 3.7e-15 54.66 Pfam 9-211 (293) Show / Hide 
Range on Protein: 238-426
Range on HMM: 9-211/293
Sequence Identity: 23% (50 aa)

QGGYGCVFEAKYNEE--IVAVKCSKPKFEKIKE--------EEKIMQLLKDTPYVFKSIEEFLNEKKTKYYQISKKYQCNLKDIMQSF----FDQKKTL-
.|..|||....   .  |||||. | . || ..        | .||. | . |.. . .. | .  |...| .    .. |.  |  |     ...... 
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFY

-PLNQIVGFAIHMSTVFEKIQQNNMIHSDIKPENILYNSQEQC---FNLCDYGESKL--FKEGSKTYNLKGFTRKYAAPEITDDNGFFKIQYDIYGLGII
 . ...  ..  .    | . ... || |.||||||.... ..   . .|| | .|.     .| .. . | |. |.|||.  ..       |....|.|
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEVIRGGQYYGPKVDMWSCGCI

LLELTLGKFL
| |. .|...
LYEMLCGRPP
Kinase 7492.AA S_TKc 230-480 18 4.9e-15 43.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 230-480
Range on HMM: 1-231/231
Sequence Identity: 18% (50 aa)

IYLTSYISQGGYGCVFEAKYNE--EIVAVKCSKPKFEKIKEEEKIMQLLKDTPYVFKSIEEFLNEKKTKYYQISKKYQC---NLKDIMQSFFDQK--KTL
  .   | .|..|.|. .. ..  .|||.|. |   |.|. | .|..   . |.. | .. | .   ...| .         .|.|....   ..  . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLNQIVGFAIHMSTVFEKIQQNNMIHSDIKPENILYNSQEQCFNLCDYGESKLFKEGSKTYNLKGFTRKYAAPEITDDNGFFKI-QYDIYGLGIILLELT
|  ..  ..  .    | . ... || |.|||||| ..   .  .|| | ....       .    |. | |||.      .     |.. .|.|| |. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

LGKFLEDGDCTFIRKGKLPNYLSKNALYQDINQIIIKMLEILPNNRIDSFGLTK------QLNQL
 |. . . .   . |  .          ..  ..| |.|.  |..|.    . .      .   .
CGYPPFP-QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 7492.AA CMGC 230-397 14 1.6e-14 43.24 In-house 1-296 (513) Show / Hide 
Range on Protein: 230-397
Range on HMM: 1-296/513
Sequence Identity: 14% (43 aa)

IYLTSYISQGGYGCVFEAKY----------------NEEIVAVKCSKPKFEKIK---------------EEEKIMQLLK----------------DTPYV
    ..| .| || |....                 ..||||.|  | .|...                 | ||.. |.                . ...
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

FKSIEEFLNEK---------------KTKYYQISKKYQCNLKDIMQSFF------------------------DQKKTLPLNQIVGFAIHMSTVFE--KI
 | .. |  ..                 . | .    ...|......                           ..| ... .|  ..  . .  .   .
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

QQNN--MIHSDIKPENILYNSQEQCF-------------------NLCDYGESKLFKEG---------------------SKTYNLKGFTRKYAAPEI
 ...   || |.|||||| |.. ...                    .|| | .. . .                      ...|     || | ||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI
Kinase 7492.AA Ciliate-E2-Unclassified 230-469 18 3.5e-13 42.09 In-house 1-342 (352) Show / Hide 
Range on Protein: 230-469
Range on HMM: 1-342/352
Sequence Identity: 18% (64 aa)

IYLTSYISQGGYGCVFEAKYNEE-------------IVAVKCSKPKFEKIKEEEKIMQLLK------------------DTPYVFKSIEEFLNEKKTKYY
  .   | |||.|.|.... ...             |...|  . |   |. |.|.|. .|                  . |.. | ...|  ..| . |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCF--QDKQNIY

QISKKY-QCNLKDIMQSF----------FDQKKT---LPLNQIV-----GFAIHMSTVFEKIQQNN-MIHSDIKPENILYNSQEQ--CFNLCDYGESKLF
 .  .  . .|.......          |...|.   .. .|..      .. .    .|.. ..|  || ||||||||.... .  .  ..|.| ||  
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

KE---------------GSKTYNLKGFTRKYA----APEITDDNGFFK---IQYDIYGLGIILLELTLGKFLEDGDCTFI-------------RKGKLPN
..                .. .. .  |  |     |||. . ..  .   .. ||..||.|| |.  |..  .. .  .             ||  . |
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

YLSKNALYQDIN-----------------QIIIKMLEILPNNRID
 . ||  ..  .                 ... |||.  ||.||.
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRIT
Kinase 7492.AA MSK 347-420 32 3.3e-12 37.55 In-house 123-203 (277) Show / Hide 
Range on Protein: 347-420
Range on HMM: 123-203/277
Sequence Identity: 32% (27 aa)

IHSDIKPENILYNSQ--EQCFNLCDYGESKLFKEGSKTYNLKG--FTRKYAAPEITD----DNGFFKIQYDIYGLGIILLEL
|| |.||||||. ..  .    | | | ..|| . .... .|   ||  |.|||. .     .| .  . |...||.|| ..
IHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQ-DEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTM
Kinase 7492.AA Ciliate-E2 230-469 19 3.7e-12 38.02 In-house 1-354 (365) Show / Hide 
Range on Protein: 230-469
Range on HMM: 1-354/365
Sequence Identity: 19% (70 aa)

IYLTSYISQGGYGCVFEA-------------------------KYNEEIVAVKCSKPK-FEKIKEEEKIMQLLK---------------DTPYVFKSIEE
. .   | ||..|.|...                         |..  |.|.|. |..  | || |..||. ..               . |.. | .| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FLNEKKTKYYQISKKYQC-NLKDIMQ---SFFDQK----KTLPLNQIVGFAIHMSTVF---------------EKIQQNN-MIHSDIKPENILYNSQEQC
| .......| .   .|  .|.|...    .....    | . ...|  .  .   .|               | . ..|  || ||||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FNLCDYGESKLFK---------------------EGSKTYNLKGF------------TRKYAAPEITDDNGF--------FKIQYDIYGLGIILLELTLG
  ..| | || ..                     ... .|.   .            |  | ||||    .            . ||. ||.|| |.  |
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMD--QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

KFLEDGDCTFIRKGKL--PNYLSKNALYQDIN---------------QIIIK----MLEILPNNRID
|.        | ..|.  |.. . .  .| ..               ..| |    ||.  |..||.
KPPF---QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT
Kinase 7492.AA TKL 345-424 18 3.3e-11 36.6 In-house 160-286 (364) Show / Hide 
Range on Protein: 345-424
Range on HMM: 160-286/364
Sequence Identity: 18% (23 aa)

NMIHSDIKPENILYNSQEQ-------------CFNLCDYGESKLFKEGSK-------------------TYNLKGFTRKYAAPEITDDNGFFKIQY----
..|| |.|..||| ..  .             |  .||.| |. ... ..                   | . .. |  . |||. .......  .    
PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE

-----------DIYGLGIILLELTLGK
           |.|  ||.| |.  ..
FCKGFEYSEKCDVYSFGIVLWEILTRC
Kinase 7492.AA TKL 236-277 19 6.1e-07 21.03 In-house 1-81 (364) Show / Hide 
Range on Protein: 236-277
Range on HMM: 1-81/364
Sequence Identity: 19% (16 aa)

ISQGGYGCVFEAKYNE----------EIVAVKCSKPKF-----------------------------EKIKEEEKIMQLLK
| .||.|.|. .|..           . ||||  | .                              .. .||| ||....
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSR
Kinase 7492.AA TyrKc 230-471 16 1e-06 -115.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 230-471
Range on HMM: 1-280/280
Sequence Identity: 16% (51 aa)

IYLTSYISQGGYGCVFEAKYNEEIVAVKCSK--PKFEKIKEEEKIMQLL-KDTPYVFK----SIEE------------------------FLNEKKTKYY
| |   .  | .| |...... . ||||. |     | . .| .||  | .. | . .     ...                        .| ... |  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

QISKKYQCNLKDIMQSFFDQKKTLPLNQIVGFAIHMSTVFEKIQQNNMIHSDIKPENILYNSQEQCFNLCDYGESKLFKEG------SKTY------NLK
                       |.. . . |..  .   | . ..| || |.   |.|....  .   .| | |.  ...      ...|      . |
-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

G-FTRKYAAPEITDDNGFFKIQYDIYGLGIILLEL-TLGKFLEDGD----------CTFIRKG---KLPNYL-------SKNALYQDINQIIIK------
. .  .  |||   . | | .. |..  |. . |. |.|.    |.            ....|   . | .           ..|| . |          
TMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

-MLEILPNNRIDSF
 . ||     .. |
TFSEI-----HECF