Gene 25224 (Tetrahymena)

25224

Species: Tetrahymena
Alias: 336.m00014, PreTt25224, TTHERM_01344670, 1153, 25224, n.25224
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C5

Sequence

Name Sequence Type Origin Length Description Download
25224.AA Protein None 422 None Fasta, JSON
25224.kin_dom Protein Kinase Domain None 242 None Fasta, JSON
25224.NA RNA None 2256 None Fasta, JSON

Protein domain

Protein domains of 25224.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 25224.AA Ciliate-C5 70-329 94 2.9e-197 655.3 In-house 1-260 (260) Show / Hide 
Range on Protein: 70-329
Range on HMM: 1-260/260
Sequence Identity: 94% (245 aa)

IYLTSYISQGGNGCVFEAKYNEEIVAVKCSKPKFEKIKEEEKIMKLLKDTPYVFKTIEEFLNEKKTKYYQISKKYSCNLKDIMQSFFDQKKTLPLNQIVG
|||||||||||.||||||||||||||||||||.||||||||||||||||||||||.|||||||||.|||||||.||||||||||||||||||||||||.|
IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG

FAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDGSKTYNLKGFTRKYAAPEIKEDNGFFNIKYDIYGLGIILLELTLGKFLEDG
|||||||||||||||||||||.||||||||||||||||||||||||||||||||.|||||||||||||..|||||||||||||||||||||||||||||.
FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDDNGFFNIKYDIYGLGIILLELTLGKFLEDE

DCAFIRNGKLPNYISKNALYQDINQIIIKMLEKTPQNRIDSFGLTKQLNELRIKLESQFI
||.||||||||||||||||||||||||||||||.||||||||.|||||||||.|||||||
DCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI
Kinase 25224.AA Ciliate-E1 76-251 25 7.9e-28 87.84 In-house 1-202 (202) Show / Hide 
Range on Protein: 76-251
Range on HMM: 1-202/202
Sequence Identity: 25% (53 aa)

ISQGGNGCVFEAKYNEE--------IVAVKC--SKPKFEKIKEEEK-IMKLLKDTPYVFKTIEEFLNEKKTKYYQISKKYSCNLKDIMQ---------SF
|..|. . ||.||...         |. ...  .. .|.....|.. ||| .|   |... |. .  ..   ...|  ...|.||| .|         ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

FDQKKTLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDGSKT-YNLKGFTRKYAAPEIK-------EDNGFFNIK
  ... .   |..  ..|.   .. ..|.|.||.||||.|||...| . ...|| | || .|  ..  .. ||.| .|. || .       ..|   |.|
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK

YDIY
.|||
SDIY
Kinase 25224.AA Ciliate-B2 71-254 30 1.9e-21 47.1 In-house 2-197 (197) Show / Hide 
Range on Protein: 71-254
Range on HMM: 2-197/197
Sequence Identity: 30% (60 aa)

YLTSYISQGGNGCVFEAKYNEEI------VAVKCSKP----KFEKIKEEEKIMKLLKDTPYVFKTIEEFLNEKKTKYYQISKKYSCNLKDIMQSFFDQKK
||. || .|| | ..|  |  ..      .|.|          | | .| ||||..    .| |.|. .  ... .   |  |  | ||. .|    |.|
YLCKYINKGGCGFICEG-YKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVL-IMEKCECSLKQELQKIQKQQK

TLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDGSKTYNLKGFTRKYAAPE-IKED-----NGFFNIKYDIYGLG
  . . ..    |.     ..  .| .| ||||.|||  .|.  . .||.| | | |      . |||| ||| || ...|         . . ||| .|
CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF-MQNGNYVYCDFGIS-SIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG
Kinase 25224.AA Pkinase 78-308 22 1.5e-18 66.64 Pfam 9-282 (293) Show / Hide 
Range on Protein: 78-308
Range on HMM: 9-282/293
Sequence Identity: 22% (62 aa)

QGGNGCVFEAKYNEE--IVAVKCSKPKFEKIKE--------EEKIMKLLKDTPYVFKTIEEFLNEKKTKYYQISKKYSCNLKDIMQSF----FDQKKTL-
.|. |||....   .  |||||. | . || ..        | .||| | . |.. .... | .  |...| .     . |.  |  |     ...... 
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFY

-PLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKC---FNLCDYGESKS--FKDGSKTYNLKGFTRKYAAPEIKEDNGFFNIKYDIYGLGII
 . ...  .. |.    | . ... || |.||||||.|..  .   . .|| | .|      .| .. . | |. |.|||.  ..     | |....|.|
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEVIRGGQYYGPKVDMWSCGCI

LLELTLGKFLEDGD--------CAFIRNGKLPNYISKNALY---------------------QDINQIIIKMLEKTPQNRI
| |. .|... .|.         . |.. . | . .                          ..  ..| ..|.| |. |.
LYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase 25224.AA C8 74-257 22 4.5e-17 55.89 In-house 5-226 (226) Show / Hide 
Range on Protein: 74-257
Range on HMM: 5-226/226
Sequence Identity: 22% (51 aa)

SYISQGGNGCVFEAKYNEE--IVAVKCSKPKFE-KIKEEEKIMKLLKDTPYVFKTIEEFLNEKKTKYYQISKK----YS-----------CNLKD-----
 |.|.|. | | .||  ..   .. |  | . . .|...|.||| .. .| ||.  . . ||....| . ..      |           | ...     
QYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYE-MPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCE

-----IMQSFFDQKKTLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENIL-YDSQEKC--FNLCDYGESKSFKDGSKTYNLKGF----TRKYAAPEIK
     . . . .... .. ..    ||||    . |.. | .| ||||.|.| . .|..     ||| |..   ..  . .  | .    | .| |||| 
QNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIE

ED----NGFFNIKYDIYGLGIIL
..    . ...|. |.. .|..|
KKQDNQYKQYRIQSDLFSVGLVL
Kinase 25224.AA Ciliate-E2-Unclassified 70-265 20 1.1e-16 54.36 In-house 1-268 (352) Show / Hide 
Range on Protein: 70-265
Range on HMM: 1-268/352
Sequence Identity: 20% (55 aa)

IYLTSYISQGGNGCVFEAKYNEE-------------IVAVKCSKPKFEKIKEEEKIMK----------------LLKDTPYVFKTIEEFLNEKKTKYYQI
  .   | |||.|.|.... ...             |...|  . |   |. |.|.|.                .|.. |  |.  ...  ..| . | .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

SKKY-SCNLKDIMQSF----------FDQKKT---LPLNQIV-----GFAIQMSTVFEKIQQNN-LIHSDIKPENILYDSQEK--CFNLCDYGESKSFKD
  .    .|.......          |...|.   .. .|..      .. |    .|.. ..|  || ||||||||.|.. |  .  ..|.| ||  ..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

---------------GSKTYNLKGFTRKYA----APEIKEDNGFFN---IKYDIYGLGIILLELTLGKF
                .. .. .  |  |     |||. . ..  .   .| ||..||.|| |.  |..
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY
Kinase 25224.AA S_TKc 70-328 21 1.3e-15 52.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 70-328
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

IYLTSYISQGGNGCVFEAKYNE--EIVAVKCSKPKFEKIKEEEKIMKLLKDTPYVFKTIEEFLNEKKTKYYQISKKYSC---NLKDIMQSFFDQK--KTL
  .   | .|. |.|. .. ..  .|||.|. |   |.|. | .|.|   . |.. | .. | .   ...| .    .    .|.|....   ..  . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDGSKTYNLKGFTRKYAAPEIKEDNGFFNI-KYDIYGLGIILLELT
|  ..  .. |.    | . ... || |.|||||| |.   .  .|| | .. .       .    |. | |||.      ..  | |.. .|.|| |. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

LGKFLEDGDCAFIRNGKLPNYISKNALYQDINQIIIKMLEKTPQNRIDSFGLTKQLNELRIKLESQF
 |. . . . . . .  .          ..  ..| |.|.| |..|.    . .  .|. ||.   |
CGYPPFP-QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQ--DEWDIKCHPWF
Kinase 25224.AA CMGC 70-237 14 5.1e-15 44.88 In-house 1-296 (513) Show / Hide 
Range on Protein: 70-237
Range on HMM: 1-296/513
Sequence Identity: 14% (43 aa)

IYLTSYISQGGNGCVFEAKY----------------NEEIVAVKCSKPKFEKIK---------------EEEKIMKLLK----------------DTPYV
    ..| .|  | |....                 ..||||.|  | .|...                 | ||.| |.                . ...
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

FKTIEEFLNEK---------------KTKYYQISKKYSCNLKDIMQSFF------------------------DQKKTLPLNQIVGFAIQMSTVFE--KI
 | .. |  ..                 . | .     ..|......                           ..| ... .|  .. |. .  .   .
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

QQNN--LIHSDIKPENILYDSQEKCF-------------------NLCDYGESKSFKDG---------------------SKTYNLKGFTRKYAAPEI
 ...   || |.|||||| ... ...                    .|| | .... .                      ...|     || | ||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI
Kinase 25224.AA Ciliate-E3 183-261 37 5.3e-15 43.5 In-house 121-202 (202) Show / Hide 
Range on Protein: 183-261
Range on HMM: 121-202/202
Sequence Identity: 37% (31 aa)

QNNLIHSDIKPENILYDSQEK--CFNLCDYGESKSFKDGS-KTYNL-KGFTRKYAAPEIKEDNGFFNIKYDIYGLGIILLELT
. |.|||||||.||| |. .       || ||||  .     |  .  |.|  |||||.  |.. .    |.| .| ....| 
EKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQ-NDQQQISKESDYYSVGAVFCQLC
Kinase 25224.AA Ciliate-E2 70-309 18 7.8e-14 43.86 In-house 1-354 (365) Show / Hide 
Range on Protein: 70-309
Range on HMM: 1-354/365
Sequence Identity: 18% (71 aa)

IYLTSYISQGGNGCVFEA-------------------------KYNEEIVAVKCSKPK-FEKIKEEEKIMKLLK---------------DTPYVFKTIEE
. .   | ||. |.|...                         |..  |.|.|. |..  | || |..||. ..               . |.. | .| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FLNEKKTKYYQISKKYSC-NLKDIMQ---SFFDQK----KTLPLNQIVGFAIQMSTVF---------------EKIQQNN-LIHSDIKPENILYDSQEKC
| .......| .   ..  .|.|...    .....    | . ...|  .  |   .|               | . ..|  || ||||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FNLCDYGESKSFKDG---------SKTYNLKG-----------------------FTRKYAAPEIKEDNGF--------FNIKYDIYGLGIILLELTLGK
  ..| | || ..|          .| |   .                        |  | |||| .  .          . | ||. ||.|| |.  ||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

FLEDGDCAFIRNGKLPNYISKNA--------------------------LYQDINQIIIK----MLEKTPQNRID
.                .. .                            . |.  ..| |    ||.| |..||.
PPF--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT
Kinase 25224.AA TKL 185-264 20 7e-12 39.07 In-house 160-286 (364) Show / Hide 
Range on Protein: 185-264
Range on HMM: 160-286/364
Sequence Identity: 20% (26 aa)

NLIHSDIKPENILYDS-------------QEKCFNLCDYGESKSFK-------------------DGSKTYNLKGFTRKYAAPEIKEDNGFFNIKY----
..|| |.|..||| |.              . |  .||.| |....                   ...|| . .. |  . |||. ....... |.    
PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE

-----------DIYGLGIILLELTLGK
           |.|  ||.| |.  ..
FCKGFEYSEKCDVYSFGIVLWEILTRC
Kinase 25224.AA STE 183-260 27 3.9e-08 24.94 In-house 170-261 (359) Show / Hide 
Range on Protein: 183-260
Range on HMM: 170-261/359
Sequence Identity: 27% (27 aa)

QNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKD-----------------GSKTYNLKGFTRKYAAPEIKEDNGF-----FNIKYDIYGLGIILLEL
... || |||| |||         ||| | .... |                 ..|.. . |    . |||. . ||       ..| ||. ||. ..|.
SHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 25224.AA TyrKc 70-317 16 4e-07 -107.47 SMART 1-280 (280) Show / Hide 
Range on Protein: 70-317
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

IYLTSYISQGGNGCVFEAKYNEEIVAVKCSK--PKFEKIKEEEKIMKLL-KDTPYVFK-----TIE-----------------------EFLNEKKTKYY
| |   .  |  | |...... . ||||. |     | . .| .||. | .. | . .     | .                       ..| ... |  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

QISKKYSCNLKDIMQSFFDQKKTLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDG------SKTY------NLK
                       |.. . . |..| .   | . ..|.|| |.   |.|....  .   .| | |.  .|.      ...|      . |
-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

G-FTRKYAAPEIKEDNGFFNIKYDIYGLGIILLEL-TLGKFLEDGD----------CAFIRNGKLPNYISKNA------LYQDINQIIIKMLEKTPQNRI
. .  .  |||   . | |..| |..  |. . |. |.|.    |.           .....|. .     .         ... ||. .  .  | .| 
TMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

DSFGLTKQL
    . ...
TFSEIHECF
Kinase 25224.AA TKL 76-117 18 6e-06 17.5 In-house 1-83 (364) Show / Hide 
Range on Protein: 76-117
Range on HMM: 1-83/364
Sequence Identity: 18% (15 aa)

ISQGGNGCVFEAKYNE----------EIVAVKCSKP-------------------------------KFEKIKEEEKIMKLLK
| .|| |.|. .|..           . ||||  |                                 .....|| ..|. |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLR
Kinase 25224.AA STE 71-122 17 1.4e-05 15.83 In-house 1-92 (359) Show / Hide 
Range on Protein: 71-122
Range on HMM: 1-92/359
Sequence Identity: 17% (16 aa)

YLT-SYISQGGNGCVFEAKYN-----------------EEIVAVKCSK---------------------PKFEKIKEEEKIMKLLKD-TPYV
.   . | .|. | |. |...                  ||.|.|  .                      ....|..| |||| ...  |..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNI