Gene 2009 (Tetrahymena)

2009

Species: Tetrahymena
Alias: PreTt02009, TTHERM_01333150, 2009, 729, 331.m00012
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C5

Sequence

Name Sequence Type Origin Length Description Download
2009.AA Protein None 621 None Fasta, JSON
2009.kin_dom Protein Kinase Domain None 260 None Fasta, JSON
2009.NA RNA None 1866 None Fasta, JSON

Protein domain

Protein domains of 2009.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2009.AA Ciliate-C5 85-344 90 4.1e-195 648.07 In-house 1-260 (260) Show / Hide 
Range on Protein: 85-344
Range on HMM: 1-260/260
Sequence Identity: 90% (234 aa)

IYLTSYISQGRQGCVFEAKYNEEIVAVKCSKPIFQKIEEEQKILKLLKDTPYVLKSIEEFLNEKKSKYYQISKKYSCNLKEIMQSFFNQRKPLPLNQIVG
||||||||||..|||||||||||||||||||| |.||.||.||.|||||||||.|||||||||||||||||||.||||||.||||||.|.|.||||||.|
IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG

FAIQMSTVFEKIQQNNLVHSDVKPENILYDSQEKCFNLCDYGDSKSFKDGSKTYDLKAFTRKYAAPELFDDNGFFNIKYDIYGLGIILLELTLGKFLENE
|||||||||||||||||.||||||||||||||||||||||||.||||||||||||||.|||||||||. |||||||||||||||||||||||||||||.|
FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDDNGFFNIKYDIYGLGIILLELTLGKFLEDE

DCTFIRNGELPNYISKNALFQDINQIIVQMLEIMPQNRIDSFELTKQLNNLRLKLESQFI
||||||||.||||||||||.|||||||..|||.||||||||||||||||.||||||||||
DCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI
Kinase 2009.AA Ciliate-E1 91-266 25 5.5e-25 78.47 In-house 1-202 (202) Show / Hide 
Range on Protein: 91-266
Range on HMM: 1-202/202
Sequence Identity: 25% (52 aa)

ISQGRQGCVFEA---KYNEEIVAVKCSKPIFQ--------KIEEEQKILKLLKDTPYVLKSIEEFLNEKKSKYYQISKKYSCNLKEIMQ---------SF
|..| .. ||.|   ..|.. ||.|  . .|.        .|.|..||.| .|   |... |. .  ..   ...|  ...|.||. .|         ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

FNQRKPLPLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENILYDSQEKCFNLCDYGDSKSFKDGSKT-YDLKAFTRKYAAPELF-------DDNGFFNIK
 .. . .   |..  ..|.   .. ..|.|. |.| ||.|||...| . ...|| | || .|  ..  .. | .| .|. ||         ..|   |.|
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK

YDIY
.|||
SDIY
Kinase 2009.AA S_TKc 85-338 19 7.2e-16 55.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 85-338
Range on HMM: 1-231/231
Sequence Identity: 19% (51 aa)

IYLTSYISQGRQGCVFEAKYNE--EIVAVKCSKPIFQKIEEEQKILKLLKDTPYVLKSIEEFLNEKKSKYYQISKKYSC---NLKEIMQSFFNQRKP--L
  .   | .|  |.|. .. ..  .|||.|. |   ..|. | .|||   . |.. | .. | .   ...| .    .    .|......   ....  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENILYDSQEKCFNLCDYGDSKSFKDGSKTYDLKAFTRKYAAPELFDDNGFFNI-KYDIYGLGIILLELT
|  ..  .. |.    | . ... .| |.|||||| |.   .  .|| | .. .       .    |. | |||..     ..  | |.. .|.|| |. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

LGKF-LENEDCTFIRNGELPNYISKNALFQDINQIIVQMLEIMPQNRIDSFELTK---QLNNLRLK
 |.   . .. . ...             ..  ..| ..|.  |..|.   |. .     ..    
CGYPPFP-QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2009.AA Ciliate-E2-Unclassified 85-280 19 3.9e-15 48.97 In-house 1-268 (352) Show / Hide 
Range on Protein: 85-280
Range on HMM: 1-268/352
Sequence Identity: 19% (52 aa)

IYLTSYISQGRQGCVFEAKYNEE-------------IVAVKCSKPIFQKIEEEQKILKLLK------------------DTPYVLKSIEEFLNEKKSKYY
  .   | || .|.|.... ...             |...|  .     |  |.|... .|                  . |...| ...|  ..| . |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCF--QDKQNIY

QISKKY-SCNLKEIMQSF-------------FNQRKPLPLNQIV-----GFAIQMSTVFEKIQQNN-LVHSDVKPENILYDSQEK--CFNLCDYGDSKSF
 .  .    .|.......              .||| .. .|..      .. |    .|.. ..|  .| | ||||||.|.. |  .  ..|.| ||  
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

KD---------------GSKTYDLKAFTRKYA----APELFDDNGFFN---IKYDIYGLGIILLELTLGKF
..                .. .. .. |  |     |||... ..  .   .| ||..||.|| |.  |..
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY
Kinase 2009.AA Ciliate-B2 86-269 27 1.4e-14 30.6 In-house 2-197 (197) Show / Hide 
Range on Protein: 86-269
Range on HMM: 2-197/197
Sequence Identity: 27% (54 aa)

YLTSYISQGRQGCVFEAKYNEEI------VAVKCSKP----IFQKIEEEQKILKLLKDTPYVLKSIEEFLNEKKSKYYQISKKYSCNLKEIMQSFFNQRK
||. || .| .| ..|  |  ..      .|.|          . |..| ||.|..    .| | |. .  ... .   |  |  | ||. .|    |.|
YLCKYINKGGCGFICEG-YKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVL-IMEKCECSLKQELQKIQKQQK

PLPLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENILYDSQEKCFNLCDYGDSKSFKDGSKTYDLKAFTRKYAAPELFDDN------GFFNIKYDIYGLG
  . . ..    |.     ..  .| .| |.||.|||  .|.  . .||.| | | |        | || ||| ||  ..          . . ||| .|
CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF-MQNGNYVYCDFGIS-SIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG
Kinase 2009.AA CMGC 85-281 14 6.2e-14 41.25 In-house 1-342 (513) Show / Hide 
Range on Protein: 85-281
Range on HMM: 1-342/513
Sequence Identity: 14% (49 aa)

IYLTSYISQGRQGCVFEAKY----------------NEEIVAVKCSKPIFQKIEEEQ----------------KILKLLK----------------DTPY
    ..| .|  | |....                 ..||||.|  |  | . |...                |||| |.                . ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VLKSIEEFLNEK---------------KSKYYQISKKYSCNLKEIMQSFF------------------------NQRKPLPLNQIVGFAIQMSTVFE--K
..| .. |  ..                 . | .     ..|......                          .. | ... .|  .. |. .  .   
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IQQNN--LVHSDVKPENILYDSQEKCF-------------------NLCDYGDSKSFKDG---------------------SKTYDLKAFTRKYAAPELF
. ...   .| | |||||| ... ...                    .|| | .... .                      ...|     || | |||. 
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

DDN---------GFFNIKYDIYGLGIILLELTLG--------KFL
            . .. . |. ..| |. |. .|        | |
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPL
Kinase 2009.AA Ciliate-E2 85-335 16 6.2e-13 40.72 In-house 1-365 (365) Show / Hide 
Range on Protein: 85-335
Range on HMM: 1-365/365
Sequence Identity: 16% (62 aa)

IYLTSYISQGRQGCVFEA-------------------------KYNEEIVAVKCS--KPIFQKIEEEQKI--------------LKLLKDTPYVLKSIEE
. .   | || .|.|...                         |..  |.|.|.   . |.|.  |.. .              .. . . |...| .| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FLNEKKSKYYQISKKYSC-NLKEIMQSFFNQR-------KPLPLNQIVGFAIQMSTVF---------------EKIQQNN-LVHSDVKPENILYDSQEKC
| .......| .   ..  .|.......  .|       |.. ...|  .  |   .|               | . ..|  .| | ||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FNLCDYGDSKSFKD-----------GSKTYDL---------------------KAFTRKYAAPELFDDNGF--------FNIKYDIYGLGIILLELTLGK
  ..| | || ..|           . ...                        . |  | ||| .   .          . | ||. ||.|| |.  ||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

F---LENEDCTFIRNGELPNYISKNALFQDIN------------QIIVQ----MLEIMPQNRIDSFELTKQLNNL
.    ....| .  . . ..   .. . | ..            ..| .    ||.  |..||...|  ..   .
PPFQQQIKQCKIDFPCPEWQKD-TQ-CIQ-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 2009.AA Pkinase 93-281 23 2.3e-12 44.79 Pfam 9-211 (293) Show / Hide 
Range on Protein: 93-281
Range on HMM: 9-211/293
Sequence Identity: 23% (50 aa)

QGRQGCVFEAKYNEE--IVAVKCSKPIFQKIEE--------EQKILKLLKDTPYVLKSIEEFLNEKKSKYYQISKKYSCNLKEIMQSF----FNQRKPL-
.|  |||....   .  |||||. |   .| ..        | .|.| | . |.... .. | .  |...| .     . |.  |  |      ..... 
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFY

-PLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENILYDSQEKC---FNLCDYGDSKSF-KDGSKTYDLKAFTRKYAAPELFDDNGFFNIKYDIYGLGIIL
 . ...  .. |.    | . ... .| |.||||||.|..  .   . .|| | .| |    .  ..  . |. |.|||.  ..     | |....|.||
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL

LELTLGKFL
 |. .|...
YEMLCGRPP
Kinase 2009.AA C8 89-272 21 2.7e-12 39.09 In-house 5-226 (226) Show / Hide 
Range on Protein: 89-272
Range on HMM: 5-226/226
Sequence Identity: 21% (48 aa)

SYISQGRQGCVFEAKYNEE--IVAVKCSKPIFQ-KIEEEQKILKLLKDTPYVLKSIEEFLNEKKSKYYQISKK----YS-----------CNLKE-----
 |.|.|  | | .||  ..   .. |  |   . .|.....| | .. .| |..  . . ||.. .| . ..      |           | ..|     
QYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYE-MPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCE

-----IMQSFFNQRKPLPLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENIL-YDSQEKC--FNLCDYGDSKSFKDGSKTYDLKAF----TRKYAAPELF
     . . . |. .... ..    ||||    . |.. | .| |.||.|.| . .|..     ||| | .   ..  . .  | .    | .| |||  
QNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIE

DD----NGFFNIKYDIYGLGIIL
 .    . ...|. |.. .|..|
KKQDNQYKQYRIQSDLFSVGLVL
Kinase 2009.AA Ciliate-C8 157-272 23 2.8e-12 40.62 In-house 94-238 (238) Show / Hide 
Range on Protein: 157-272
Range on HMM: 94-238/238
Sequence Identity: 23% (34 aa)

KKYS--CNLKEIMQSFFNQRKPLPLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENIL-YDSQEKCFN--LCD------YGDSKSFKDGSKTYDLKA--F
.| .  ||||.  . . .. ...  ..    ||||  .   . ..| .| | ||.|.| ...|.. .   |||       | .   ..    |  |    
EKCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKG

TRKY-----------AAPELFDD-----NGFFNIKYDIYGLGIIL
|  |            |||. ..     . .| .| |.| .|..|
TDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 2009.AA TKL 200-279 19 1.9e-11 37.52 In-house 160-286 (364) Show / Hide 
Range on Protein: 200-279
Range on HMM: 160-286/364
Sequence Identity: 19% (25 aa)

NLVHSDVKPENILYDS-------------QEKCFNLCDYGDSKSFK-------------------DGSKTYDLKAFTRKYAAPELFDDNGFFNIKY----
...| | |..||| |.              . |  .||.| |....                   ...||   .  |  . |||......... |.    
PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE

-----------DIYGLGIILLELTLGK
           |.|  ||.| |.  ..
FCKGFEYSEKCDVYSFGIVLWEILTRC
Kinase 2009.AA CAMK 198-272 19 2.2e-11 32.19 In-house 197-324 (425) Show / Hide 
Range on Protein: 198-272
Range on HMM: 197-324/425
Sequence Identity: 19% (25 aa)

QNNLVHSDVKPENILYDSQEKCFN----------------LCDYGDSKSFKDG-----------------------SKTYDLKAFTRKYAA-PELFDD--
..| || | ||||||.|. .. ..                ..| | .. |..|                        . .     |  |.| ||..    
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG

-----------NGFFNIKYDIYGLGIIL
           .   . | |.  .|.||
HCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 2009.AA TyrKc 85-332 16 1.4e-07 -100.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 85-332
Range on HMM: 1-280/280
Sequence Identity: 16% (51 aa)

IYLTSYISQGRQGCVFEAKYNEEIVAVKCSK--PIFQKIEEEQKILKLL-KDTPYVLK----SIEE------------------------FLNEKKSKYY
| |   .  |  | |...... . ||||. |     . . .| .|.. | .. | ...     ...                        .| ... |  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

QISKKYSCNLKEIMQSFFNQRKPLPLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENILYDSQEKCFNLCDYGDSKSFKDG------SKTYD------LK
                       |.. . . |..| .   | . ..|..| |    |.|....  .   .| | |.  .|.      ...|.       |
-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

A-FTRKYAAPELFDDNGFFNIKYDIYGLGIILLEL-TLGKFLENED--CTFIRNGELPNYISKN------AL---------FQDINQIIVQMLEIMPQNR
. .  .  ||| . . | |..| |..  |. . |. |.|.    ..    .. | |. .|. .       .           ... ||. |  .  | .|
TMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR

IDSFELTKQL
    |. ...
PTFSEIHECF
Kinase 2009.AA TKL 91-132 16 4.5e-07 21.53 In-house 1-83 (364) Show / Hide 
Range on Protein: 91-132
Range on HMM: 1-83/364
Sequence Identity: 16% (14 aa)

ISQGRQGCVFEAKYNE----------EIVAVKCSKP-------------------------------IFQKIEEEQKILKLLK
| .|. |.|. .|..           . ||||  |                                .....||| .... |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLR
Kinase 2009.AA CAMK 90-153 11 0.006562 4.41 In-house 1-133 (425) Show / Hide 
Range on Protein: 90-153
Range on HMM: 1-133/425
Sequence Identity: 11% (15 aa)

YISQGRQGCVFEAKYNEEI--------------VAVKC--------------------------------SKPIFQKIEEEQKILKLLK------DTPYV
 . .|. | |....  .                ||.|                                 .    .... | .|.|.|.      | | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKSIEEFLNEK-----------------KSKYY
.| .| . ...                 ....|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMY