Gene 18408 (Tetrahymena)
18408
Group:
Other
Family:
Ciliate-C5
Sequence
Protein domains of 18408.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 18408.AA | Ciliate-A8 | 112-121 | 40 | 0.387343 | 0.63 | In-house | 1-10 (151) | Show / Hide |
Range on Protein: 112-121 Range on HMM: 1-10/151 Sequence Identity: 40% (4 aa) YKFQRIFEQN ||.|.. |.. YKYQKVLEKG |
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Kinase | 18408.AA | Ciliate-C5 | 147-285 | 83 | 5.2e-96 | 316.58 | In-house | 1-138 (260) | Show / Hide |
Range on Protein: 147-285 Range on HMM: 1-138/260 Sequence Identity: 83% (116 aa) IYLTSFISQGSFGCVFEAKYKEEIVAVKCSRVNLEKIKEEEDILILLKDTPYVFKSIENFLNETKSIYYQITKRYLCSLKDIMKNFFYQKKITLPLNQII |||||.||||.|||||||||.|||||||||..|.|||||||.|. |||||||||||||.||||.|| ||||.||| |.|||||..||.||| |||||||| IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKK-TLPLNQII GFAIQMSTVFQKIQEKNLIHSDVKPENILYDSQEKCFIL ||||||||||.|||..|||||||||||||||||||||.| GFAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNL |
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Kinase | 18408.AA | Ciliate-E1 | 153-284 | 21 | 1.7e-16 | 50.59 | In-house | 1-150 (202) | Show / Hide |
Range on Protein: 153-284 Range on HMM: 1-150/202 Sequence Identity: 21% (33 aa) ISQGSFGCVFEA--------KYKEEIVAVKCSRV--NLEKIKEEED-ILILLKDTPYVFKSIENFLNETKSIYYQITKRYLCSLKDIMK--------NFF |..|||. ||.| .... |. ... .. .......|.. |. .| |... |. . . |...|. . ||||| .. . . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC YQKKITLPLNQIIGFAIQMSTVFQKIQEKNLIHSDVKPENILYDSQEKCFI |... . |.. ..|. .. .. .|.||.| ||.|||...|... . QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVY |
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Kinase | 18408.AA | CMGC | 147-279 | 14 | 7.5e-10 | 27.6 | In-house | 1-220 (513) | Show / Hide |
Range on Protein: 147-279 Range on HMM: 1-220/513 Sequence Identity: 14% (33 aa) IYLTSFISQGSFGCVFEAKYKE----------------EIVAVKCSRVNLEKIK---------------EEEDILILLK----------------DTPYV . | .|..| |.... |. ||||.| . . ... | || |. . ... YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI FKSIENFLNET---------------KSIYYQITKRYLCSLKDIMKNFF--YQK---------------------KITLPLNQIIGFAIQMSTVFQ--KI | .. | . | .. ..|....|| || . ... .| .. |. . . VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC QEKN--LIHSDVKPENILYDSQ .. || | |||||| ... HSHWGNIIHRDLKPENILINHN |
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Kinase | 18408.AA | Ciliate-E3 | 233-286 | 35 | 1.4e-08 | 23.22 | In-house | 94-146 (202) | Show / Hide |
Range on Protein: 233-286 Range on HMM: 94-146/202 Sequence Identity: 35% (19 aa) FYQKKITLPLNQIIGFAIQMSTVFQKIQEKNLIHSDVKPENILYDSQEKCFILQ ... . . .| |. .||. | |||.|||| ||.||| |. . |.. YIK-QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIK |
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Kinase | 18408.AA | Ciliate-A8 | 260-284 | 56 | 2.9e-08 | 25.4 | In-house | 127-151 (151) | Show / Hide |
Range on Protein: 260-284 Range on HMM: 127-151/151 Sequence Identity: 56% (14 aa) QEKNLIHSDVKPENILYDSQEKCFI |||. ||.|.||.|||| ... || QEKGIIHCDIKPQNILYSWSKNQFI |
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Kinase | 18408.AA | STKR | 147-174 | 37 | 5e-08 | 21.75 | In-house | 1-32 (312) | Show / Hide |
Range on Protein: 147-174 Range on HMM: 1-32/312 Sequence Identity: 37% (12 aa) IYLTSFISQGSFGCVFEAKYKE----EIVAVK | |. | .| .|.|. .|... | |||| IQLIECIGKGRYGEVWKGKWRGNGEKETVAVK |
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Kinase | 18408.AA | Gdt | 147-190 | 32 | 1e-07 | 22.48 | In-house | 1-55 (289) | Show / Hide |
Range on Protein: 147-190 Range on HMM: 1-55/289 Sequence Identity: 32% (18 aa) IYLTSFISQGSFGCVFEAKYKEEIVAVK---CSRVN--------LEKIKEEEDIL | . .|||.|| |. ... |||| . || ..|. | ||| IDFKEYCSQGTFGMVYKGIWRSSQVAVKMFKHHYVNYTKTYSQSCDEIYREMDIL |
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Kinase | 18408.AA | S_TKc | 147-361 | 16 | 1.4e-07 | -65.75 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 147-361 Range on HMM: 1-231/231 Sequence Identity: 16% (44 aa) IYLTSFISQGSFGCVFEAKYKE--EIVAVKCSRVNLEKIKEEEDILILLKDTPYVFKSIENFLNETKSIYYQITKRYL--CSLKDIMKNFFYQKK-ITLP . | .|.||.|. .. |. .|||.|. . |.|. | .|| . |.. | .. | . ...| .|.|..|. .... .| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP LNQIIGFAIQMSTVFQKIQEKNLIHSDVKPENILYDSQEKCFILQNLLFDQLKLT---------------------VVIKLDQLSWLEHAAVNR-KV--- .. .. |. . . ... || |.|||||| |. ..|.. |. .. |. E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------HIKICDFGLARQLTTFCGTPWYMAPEVL------------GYGKCKCDWW ----------VGSIPTSSAFFLLQNQVILSCEVL----LFFAKKIANRKQYQKFLK--------KIK .| | . ... ... | |.. . | ..| . |. SCGCILYEMLCGYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 18408.AA | Type2 | 147-174 | 39 | 1.5e-07 | 20.78 | In-house | 1-33 (315) | Show / Hide |
Range on Protein: 147-174 Range on HMM: 1-33/315 Sequence Identity: 39% (13 aa) IYLTSFISQGSFGCVFEAKYKEE-----IVAVK | | |..| ||||. |..... .|||| IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVK |
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Kinase | 18408.AA | TKL | 153-194 | 17 | 3.4e-07 | 21.99 | In-house | 1-81 (364) | Show / Hide |
Range on Protein: 153-194 Range on HMM: 1-81/364 Sequence Identity: 17% (14 aa) ISQGSFGCVFEAKYKE----------EIVAVKCSRVNL-----------------------------EKIKEEEDILILLK | .|.||.|. .|.. . |||| ... .. .||| |..... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSR |
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Kinase | 18408.AA | Pkinase | 147-279 | 25 | 0.000115 | 17.58 | Pfam | 1-144 (293) | Show / Hide |
Range on Protein: 147-279 Range on HMM: 1-144/293 Sequence Identity: 25% (37 aa) IYLTSFISQGSFGCVFEAKYKEE--IVAVKCSRVNLEKIKE--------EEDILILLKDTPYVFKSIENFLNETKSIYYQITKRYLCSLKDIMKNFFYQK . . . | .||||||.... | . |||||. .. || .. | |. | . |.. . .. | . |. .| .. . |. | | | . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIS ---KITL--PLNQIIGFAIQMSTVFQKIQEKNLIHSDVKPENILYDSQ . .. . .... .. |. . . ... || |.||||||.|.. TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNN |
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Kinase | 18408.AA | ULK | 236-275 | 37 | 0.000116 | 12.29 | In-house | 123-162 (329) | Show / Hide |
Range on Protein: 236-275 Range on HMM: 123-162/329 Sequence Identity: 37% (15 aa) KKITLPLNQIIGFAIQMSTVFQKIQEKNLIHSDVKPENIL .| .|. ...| | .| |. ....| || | ||.||| EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNIL |
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Kinase | 18408.AA | ULK | 147-194 | 26 | 0.000185 | 11.58 | In-house | 1-68 (329) | Show / Hide |
Range on Protein: 147-194 Range on HMM: 1-68/329 Sequence Identity: 26% (18 aa) IYLTSFISQGSFGCVFEAK-YKE-----EIVAVKC------SRVNLE--------KIKEEEDILILLK ..| . .|||| |.... | |.||.| .. | | .| | .|. || YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLK |
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Kinase | 18408.AA | TyrKc | 147-357 | 13 | 0.000711 | -159.98 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 147-357 Range on HMM: 1-280/280 Sequence Identity: 13% (40 aa) IYLTSFISQGSFGCVFEAKYKEEIVAVKCSR--VNLEKIKEEEDILILL-KDTPYVFKSIENFLN--------ETKSIYYQIT-----KRYLCSLKDIMK | | . | || |.....| . ||||. . .| . .| |. | .. | . . . . | | | || . .. ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-- NFFYQKKITLPLNQIIGFAIQMSTVFQKIQEKNLIHSDVKPENILYDSQE---------KCFILQN-------LLFD-----QLK--LTV------VIKL |.. . . |..| . . . .||.|| | |.|.... .| . . | | . .|. ---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY D----------------------QLSWLEHA---AVNRKVVGSIPTSSAFFLLQN----------QVILSCEVLLFFAKKIANR---KQYQKFL | . . . |. |. . . .| . . . . . . ..| .. ... GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 18408.AA | TKL | 262-278 | 47 | 0.043162 | 3.34 | In-house | 159-175 (364) | Show / Hide |
Range on Protein: 262-278 Range on HMM: 159-175/364 Sequence Identity: 47% (8 aa) KNLIHSDVKPENILYDS ...|| | |..||| |. PPIIHRDLKSKNILVDE |
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Kinase | 18408.AA | Ciliate-E3 | 147-164 | 27 | 0.277091 | 0.11 | In-house | 1-18 (202) | Show / Hide |
Range on Protein: 147-164 Range on HMM: 1-18/202 Sequence Identity: 27% (5 aa) IYLTSFISQGSFGCVFEA . . .|.|| |. | YTVQQILGCGQFGRVYKA |