Gene 9190 (Tetrahymena)
9190
Group:
Other
Family:
Ciliate-C3
Sequence
Protein domains of 9190.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 9190.AA | Ciliate-C3 | 611-748 | 82 | 8e-93 | 314.68 | In-house | 1-140 (140) | Show / Hide |
Range on Protein: 611-748 Range on HMM: 1-140/140 Sequence Identity: 82% (115 aa) FIVKKVKLVENKESIVALKQSKDDGNDYLKQQMREISILSNLPKNNLLIKYVGHQKNEKQFQIFLEYFEGITLEKFLQELY--KQQQDQNHKDLKLQKLQ ||||||||.|||...|||||.....|||.||||||||||||||||||.|.|||||||.|||||||||||| |||||..|.| |..|||||||||||||| FIVKKVKLKENKDRKVALKQPQEEQNDYSKQQMREISILSNLPKNNLIIQYVGHQKNNKQFQIFLEYFEGQTLEKFINEIYDNKKYQDQNHKDLKLQKLQ ISKQILQAIEYLHEYNIVHGDIKFTNILINSKGEIKIIDF |||||||||.||||.|||||||||.|||||||.||||||| ISKQILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF |
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| Kinase | 9190.AA | Ciliate-E2 | 600-785 | 21 | 5.9e-22 | 72.13 | In-house | 1-286 (365) | Show / Hide |
Range on Protein: 600-785 Range on HMM: 1-286/365 Sequence Identity: 21% (62 aa) YEELEEISRSQF-IVKKVKLVENKE----------------------SIVALKQSKDDGNDYLKQ---QMREIS----------ILSNLPKNNLLIKYVG |. .. | . .| .|.|.| .... .|.|.|. | .. ..|| .|||| ||..| ... .||.. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQL-NHPNIIKMYE HQK--NEKQFQIFLEYFEGITLEKFLQELYKQQ-----QDQNHKDLKLQKLQISKQILQ---------------AIEYLHEYN-IVHGDIKFTNILINSK . . ... . . .||..| .|...... .|.. . . .. . ..|.||||| |.||||. | |.| ||| |||. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--- GEIKIIDFSESSFMVEE----------------------------------------TLGYTRG----YDA-----KDNVNTRYVDYYSLGILL |||||| | . .. |.|| . | . . .|..|||..| --IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL |
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| Kinase | 9190.AA | Ciliate-E2-Unclassified | 600-785 | 22 | 8e-20 | 65.46 | In-house | 1-260 (352) | Show / Hide |
Range on Protein: 600-785
Range on HMM: 1-260/352
Sequence Identity: 22% (58 aa)
YEELEEISRSQF-IVKKVKLVENKESIVALKQSKDDGNDYLKQQ------MREISILSNLP------------------KNNLLIKYVGHQKNEKQFQIF
|. .. | . .| .|.|.. ..| . |.|. |. .. ||. |.|. .. |. .. ...|.. . .... . |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV
LEYFEGITLEKFLQELYKQ--------QQDQNHKDLKLQKLQ------ISKQILQAIEYLHEYN-IVHGDIKFTNILINSKG---EIKIIDFSESS----
.||.|| .|...... || .. .. | . |. . . .||||..||||. | |.| ||| |||....| .||||||. |.
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
----------------FMVEETLGYTRGYD--------AKDNVNTRY----VDYYSLGILL
.. | | .| . . . .|..|||..|
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL
|
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| Kinase | 9190.AA | CMGC | 600-748 | 17 | 1.1e-15 | 47.1 | In-house | 1-248 (513) | Show / Hide |
Range on Protein: 600-748 Range on HMM: 1-248/513 Sequence Identity: 17% (45 aa) YEELEEISRSQF-IVKKVKLVENK-------------ESIVALKQSKDDGNDYLKQQ------------MREISILSNL------------------PKN || .. | . . .| | . ... . |||.| | . . .. |||.|| .| ..| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN NLLIKYVGHQKNEK---------------QFQIFLEYFEGITLEKFLQELYKQQQ--DQNHKDLKLQKLQ---------------IS------KQILQAI . .... . ||.. .. . || ... | .. |..| .|. . ..| . .. .|||... IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEY-----MDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGL E--YLHEYN--IVHGDIKFTNILINSK--------------------GEIKIIDF . |.| . |.| |.| |||||.. |..||.|| KLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDF |
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| Kinase | 9190.AA | MARK | 711-748 | 57 | 3.5e-15 | 46.26 | In-house | 111-150 (262) | Show / Hide |
Range on Protein: 711-748 Range on HMM: 111-150/262 Sequence Identity: 57% (23 aa) KQILQAIEYLHEYNIVHGDIKFTNILINSKG--EIKIIDF .||. |..|.|. |||| ||| |||| ..| |||||| RQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDF |
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| Kinase | 9190.AA | Ciliate-E8 | 712-751 | 50 | 3.7e-15 | 43.79 | In-house | 97-138 (138) | Show / Hide |
Range on Protein: 712-751 Range on HMM: 97-138/138 Sequence Identity: 50% (21 aa) QILQAIEYLHEYNIVHGDIKFTNILINS--KGEIKIIDFSES ||. |. ||| ||.| |.| |||. |||||| | QIMDAFCYLHNNNIIHCDFKLNNILVQRNDDTKIKIIDFGFS |
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| Kinase | 9190.AA | MKC | 709-748 | 57 | 5.8e-15 | 52.58 | In-house | 107-146 (260) | Show / Hide |
Range on Protein: 709-748 Range on HMM: 107-146/260 Sequence Identity: 57% (23 aa) ISKQILQAIEYLHEYNIVHGDIKFTNILINSKGEIKIIDF . | .||...|||| |||| |.| || .|..||||.||| VCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDF |
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| Kinase | 9190.AA | STE | 600-748 | 23 | 9.6e-15 | 48.6 | In-house | 1-191 (359) | Show / Hide |
Range on Protein: 600-748 Range on HMM: 1-191/359 Sequence Identity: 23% (46 aa) YEELEEISRSQFI-VKKVKLV------ENKES--------IVALKQSK-DDGN----------------DYLKQQMREISILSNLPK-NNLLIKYVGHQK .| .|.| . | | | . . ...| |.| || . .. | . ..| ..||.|.... . .|| |. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF NE-------KQFQIFLEYFEGITLEKFLQELYKQQQDQNHKD-----LKLQKL-QISKQILQA-IEYLHEYNIVHGDIKFTNILINSKGEIKIIDF .| . |..|| .| .|...... |. ....||. .. . . | .|||.. .|||. .|.| ||| |||. .|..|| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDF |
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| Kinase | 9190.AA | Ciliate-E9 | 709-748 | 43 | 1.1e-14 | 42.96 | In-house | 116-156 (298) | Show / Hide |
Range on Protein: 709-748 Range on HMM: 116-156/298 Sequence Identity: 43% (18 aa) ISKQILQAIEYLHEYN-IVHGDIKFTNILINSKGEIKIIDF . ||.. .|||.| | | | |.| |.||. . ..||.|| YFKQLIDSIEYMHQYQNICHRDLKPENMLIDKNYNMKICDF |
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| Kinase | 9190.AA | CAMKL | 711-748 | 52 | 3.3e-14 | 41.58 | In-house | 134-173 (297) | Show / Hide |
Range on Protein: 711-748 Range on HMM: 134-173/297 Sequence Identity: 52% (21 aa) KQILQAIEYLHEYNIVHGDIKFTNILINSKG--EIKIIDF .||. |..|.|. .||| ||| |||. ..| |||||| RQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDF |
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| Kinase | 9190.AA | Pkinase | 613-748 | 25 | 9.4e-13 | 46.18 | Pfam | 15-156 (293) | Show / Hide |
Range on Protein: 613-748 Range on HMM: 15-156/293 Sequence Identity: 25% (39 aa) VKKVKLVENKESIVALKQSKDDGNDYLKQQM----REISILSNLPKNNLLIKYVGHQKNEKQFQIFLEYFEGI----TLEKFLQELYKQQQDQNHKDL-- |.| . . . . |||.|. | .... |.| .||.|. .| . ... . ... . .|| || | ... ..|. . VYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-------WRHGCFYF KLQKLQ-ISKQILQAIEYLHEYNIVHGDIKFTNILINSKGEI----KIIDF . .. . .|||...||.|. .|.| |.| ||||...|.| ||.|| SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF |
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| Kinase | 9190.AA | S_TKc | 600-859 | 19 | 6.8e-12 | -2.54 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 600-859 Range on HMM: 1-231/231 Sequence Identity: 19% (55 aa) YEELEEISRSQFIVKKVKLVENKE--SIVALKQSKDDGNDYLKQQMREISILSNLPKNNLLIKYVGHQKNEKQFQIFLEYFEG--ITLEKFLQELYKQQQ || |..| . | ||... .|. |||.|. | .. .|||.||.. . ..|. .. . . . ...|| .| .| ..... .. YEILRKIGKGAF--GKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL D--QNHKDLKLQKLQISKQILQAIEYLHEYNIVHGDIKFTNILINSKGEIKIIDFSESSFMVEETLGYTRGY---DAKDNVNTRYVDYYSLGILLIRIFY . . . . . .||..|.||.|. .|.| |.| |||... .|||.|| . .. |. |. | ... .| .|.|..|. .. RFPFPE-HARF----YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLC QGDF--EIVCNCQEEGKICETQRQECKQKYIQKYGQIIDYNENTQNTDIIQDCLFRVEN--IICHLTYD-------HPPV | . .. .. . . . |.|. || . . . . || . -GYPPFP------QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 9190.AA | TyrKc | 600-842 | 17 | 5.6e-08 | -93.64 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 600-842 Range on HMM: 1-280/280 Sequence Identity: 17% (51 aa) YEELEEISRSQF-IVKKVKLVENKESIVALKQSKDDGNDYLKQQMREISILSNL-PKNNLLIKYVGHQKNE-------KQFQIFLEYFEGITLEKFLQEL . .... . .| .| | .. || | |.| .. |||..|...| ... ... .| . .. | .|| .. | ..|.. ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH YKQQQDQNHKDLKLQKLQISKQILQAIEYLHEYNIVHGDIKFTNILINSKGEIKIIDFSESSFMVEE------TLGYTRGY--DAK-------------- .. ..|... || . ||||. |..| |. |.|..... .|| || | . .. . |. ..| RPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN DNVNTRYVDYYSLGILL------IRIFYQG------DFEIVCNCQEEGKICETQRQ-------ECKQKYIQKYGQIIDYNENT-QNTDIIQDCL ... | | .| |... | | . . | .. ..|. . .| .. | | ... . . | .|. YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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