Gene 15976 (Tetrahymena)
15976
Group:
Other
Family:
Ciliate-C3
Sequence
Protein domains of 15976.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 15976.AA | Ciliate-C3 | 700-838 | 81 | 1.8e-93 | 316.85 | In-house | 1-140 (140) | Show / Hide |
Range on Protein: 700-838 Range on HMM: 1-140/140 Sequence Identity: 81% (114 aa) FVVKIVELKGNEG-SIVLKQPQEEQNDYSQQQMREISILSNLPKNNLIIEYKGHSKNKKYFQIFLEYYEGKTLLSFINEINDNKKYKDQNHKDLKLRKLQ |.||.|.||.|.. ...||||||||||||.|||||||||||||||||||.|.||.||.|.|||||||.||.||..|||||.|||||.|||||||||.||| FIVKKVKLKENKDRKVALKQPQEEQNDYSKQQMREISILSNLPKNNLIIQYVGHQKNNKQFQIFLEYFEGQTLEKFINEIYDNKKYQDQNHKDLKLQKLQ ISKQILQAIDYLHEHNIVHGDIKLSNILINSQDKIKIIDF |||||||||||||||||||||||.|||||||.|.|||||| ISKQILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF |
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| Kinase | 15976.AA | Ciliate-E2 | 728-875 | 20 | 1.8e-21 | 70.43 | In-house | 61-286 (365) | Show / Hide |
Range on Protein: 728-875
Range on HMM: 61-286/365
Sequence Identity: 20% (48 aa)
QQQMREISILSNLP---------------KNNLIIEYKGHSK--NKKYFQIFLEYYEGKTLLSFIN--EINDNKKYKDQNHKDLKLRKLQ-ISKQILQ--
.|...||.|. . ... ||... . . ..... . .||..|..|...|. .. |.. . | ..... . |.|||||
EQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGF
-------------AIDYLHEHN-IVHGDIKLSNILINSQDKIKIIDFSESGFLAEE----------------------------------------TIGY
|. |||. | |.| |||..|||. |||||| | .. .. | ||
KTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGY
TIG--YDAKDNL-------KTRYIDYYSLGILL
. |.. . .|..|||..|
MAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
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| Kinase | 15976.AA | CAMKL | 755-838 | 28 | 2.8e-17 | 51.56 | In-house | 93-173 (297) | Show / Hide |
Range on Protein: 755-838 Range on HMM: 93-173/297 Sequence Identity: 28% (27 aa) NKKYFQIFLEYYEGKT--LLSFINEINDNKKYKDQNHKDLKLRKLQIS------KQILQAIDYLHEHNIVHGDIKLSNILINSQD--KIKIIDF . |......|| .| |. .| . . . .... . .||. |..|.|.|.||| |||. |||. ... .|||||| T-KKIYLVMEYCSGGEMDLFDYIVKHGHRR------------GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDF |
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| Kinase | 15976.AA | AGC | 802-838 | 41 | 1.3e-16 | 37.99 | In-house | 161-199 (395) | Show / Hide |
Range on Protein: 802-838 Range on HMM: 161-199/395 Sequence Identity: 41% (16 aa) QILQAIDYLHE-HNIVHGD-IKLSNILINSQDKIKIIDF .|. |..|||. ..|.| | .|. |||.... ||. || CIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF |
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| Kinase | 15976.AA | MARK | 801-838 | 55 | 3.5e-16 | 49.57 | In-house | 111-150 (262) | Show / Hide |
Range on Protein: 801-838 Range on HMM: 111-150/262 Sequence Identity: 55% (22 aa) KQILQAIDYLHEHNIVHGDIKLSNILINSQD--KIKIIDF .||. |. |.|..|||| |||. |||| .. .|||||| RQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDF |
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| Kinase | 15976.AA | Ciliate-E2-Unclassified | 688-841 | 22 | 8.9e-16 | 51.23 | In-house | 1-194 (352) | Show / Hide |
Range on Protein: 688-841 Range on HMM: 1-194/352 Sequence Identity: 22% (43 aa) YDEKETINSISQFVVKIVELKGNEGSIVLKQPQEEQNDYSQQQM-------REISILSNLP------------------KNNLIIEYKGHSKNKKYFQIF | ..|.. .. .|. .. | . . .. ...|.|.|. .|. .. |. .. .|. . . ..|... | YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LEYYEGKTLLSFINEIND-----NKKYKDQNH-KDLKLRKLQ------ISKQILQAIDYLHEHN-IVHGDIKLSNILINSQD---KIKIIDFSES .|| ||..|. .|.. . | ....... | . .. . . .||||...|||. | |.| |||..|||.... .||||||. | MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS |
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| Kinase | 15976.AA | CAMK | 801-838 | 38 | 1.3e-15 | 46.05 | In-house | 186-240 (425) | Show / Hide |
Range on Protein: 801-838 Range on HMM: 186-240/425 Sequence Identity: 38% (21 aa) KQILQAIDYLHEHNIVHGDIKLSNILINSQD-----------------KIKIIDF .||..|..|.|.||||| |.|. |||... . .|||||| RQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF |
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| Kinase | 15976.AA | Ciliate-E8 | 802-841 | 54 | 2.8e-15 | 44.19 | In-house | 97-138 (138) | Show / Hide |
Range on Protein: 802-841 Range on HMM: 97-138/138 Sequence Identity: 54% (23 aa) QILQAIDYLHEHNIVHGDIKLSNILINS--QDKIKIIDFSES ||. |. ||| ||.| |.|| |||. ||||||| | QIMDAFCYLHNNNIIHCDFKLNNILVQRNDDTKIKIIDFGFS |
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| Kinase | 15976.AA | TKL | 746-838 | 18 | 4.4e-15 | 50.77 | In-house | 87-198 (364) | Show / Hide |
Range on Protein: 746-838 Range on HMM: 87-198/364 Sequence Identity: 18% (24 aa) IIEYKG---HSKN----------KKYFQIFLEYYEGKTLLSFINEINDNKKYKDQNHKDLKLRKLQISKQILQAIDYLHEHN--------IVHGDIKLSN |. ..| ... .... | ||..| .||.... ........| ....||| .| |.| |.| .| IVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN ILINSQDK--------------IKIIDF ||... . .|| || ILVDENWTNVSNYMYNPNADWCCKICDF |
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| Kinase | 15976.AA | Pkinase | 701-838 | 23 | 8.3e-15 | 53.43 | Pfam | 14-156 (293) | Show / Hide |
Range on Protein: 701-838
Range on HMM: 14-156/293
Sequence Identity: 23% (36 aa)
VVKIVELKGNEGSIVLKQPQEEQNDYSQQQM----REISILSNLPKNNLIIEYKGHSKNKKYFQIFLEYYEGK----TLLSFINEINDNKKYKDQNHKDL
.|.. ||.. ..|. . .. ...| .||.|. .| . |..... .|.. . .|| || | ..| ..|. .
CVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---------WRHGCF
--KLRKLQ-ISKQILQAIDYLHEHNIVHGDIKLSNILINSQDKI----KIIDF
. .. . .|||....|.|...|.| |.|..||||.... | ||.||
YFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF
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| Kinase | 15976.AA | CMGC | 714-838 | 16 | 7.1e-14 | 41.06 | In-house | 41-248 (513) | Show / Hide |
Range on Protein: 714-838
Range on HMM: 41-248/513
Sequence Identity: 16% (36 aa)
IVLKQPQEEQNDYSQQQ------------MREISILSNLP-----------------KNNLI--IEYKGHSKNK--------------KYFQIFLEYYEG
. .| ... . |.. |||.|| .| .||.. ... |.... ... . || .
VAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMD-
KTLLSFINEIND-----NKKYKDQNH-------------KDLKLRKLQISKQILQAID--YLHEHN--IVHGDIKLSNILINSQ----------------
..|. .| . .. .... .. | | . . ....|||.... |.| |. |.| |.| .|||||..
HDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMI-HIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNP
----DKIKIIDF
...||.||
CQKNGRLKICDF
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| Kinase | 15976.AA | S_TKc | 688-951 | 18 | 7.8e-14 | 25.97 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 688-951 Range on HMM: 1-231/231 Sequence Identity: 18% (52 aa) YDEKETINSISQFVVKIVELKGNEGSIVLKQPQEEQNDYSQQQMREISILSNLPKNNLIIEYKGHSKNKKYFQIFLEYYEG--KTLLSFINEINDNKKYK |. ..| . . .|. . |. .|. .. .|||.||.. . |. .... . ... ...|| .| .|...| . . ..... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF DQNHKDLKLRKLQISKQILQAIDYLHEHNIVHGDIKLSNILINSQDKIKIIDFSESGFLAEETIGYTIGY---DAKDNLKTR-YIDYYSLGILLIIIFY- . . . . .||..|..|.|.|.|.| |.| .|||... |||.|| . .| |. | | .. .| .|.|..|.. .. PFPE-HARF----YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCG --SFQIEILCNCGEKKKCKMQNHEEFILQAISKMDEQRKNQYSQIFFDQIKSLLNDQPYLRQTQRQKCE-------QKYF |. ... ... | |. . | |. .|. | | | . . .| YPPFP-----------------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 15976.AA | TyrKc | 694-951 | 16 | 2.3e-07 | -103.61 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 694-951 Range on HMM: 1-280/280 Sequence Identity: 16% (49 aa) INSISQF------VVKIVELKGNEGSIVLKQPQEEQNDYSQQQMREISILSNL-PKNNLIIEYKGHSKNK-------KYFQIFLEYYEGKTLLSFINEIN | . . .| ..| | .|. . |||..|...| ... |. | . . | .|| .. |.... . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR DNKKYKDQNHKDLKLRKLQISKQILQAIDYLHEHNIVHGDIKLSNILINSQDKIKIIDFSESGFLAEETIGY------TIGYDAKD--NLKT-RYIDYYS .. .|... || . .|||..|..| |. |.|.... .|| || |. . . . |..| . || | .. PK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG----LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA LGILLIIIF------YSFQIEI--LCNCGEKKKCK-----MQNHEEFILQAISKMDEQRKNQY---------SQIFFDQIKSLLNDQPYLRQTQRQKCEQ . . .| .|| . . .. |.. | | | ... . . . .. .. .. .. .|. . .| | | .. PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE--VIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--H KYF ..| ECF |
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