Gene 27962 (Tetrahymena)

27962

Species: Tetrahymena
Alias: TTHERM_00632930, 23, 90.m00126, PreTt27962, 27962
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: Ciliate-C1

Sequence

Name Sequence Type Origin Length Description Download
27962.AA Protein None 484 None Fasta, JSON
27962.kin_dom Protein Kinase Domain None 275 None Fasta, JSON
27962.NA RNA None 1455 None Fasta, JSON

Protein domain

Protein domains of 27962.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 27962.AA Ciliate-C1 11-285 47 6.2e-259 682.18 In-house 1-328 (328) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-328/328
Sequence Identity: 47% (157 aa)

YRLGKTLGKGYQAKVKICYAPNNK-VYAVKIFKR-------------------THSEEKNTKALIQEAGHLTQLK-HENLVNLVEILKKEQYIKKNGETY
....||.|.||..||..|..|||. |||||.||.                   ||..|........|..||..|| |.|.||.|.|....||.||||.||
MKIMKTIGHGYTCKVFYCKMPNNQKVYAVKQFKNEYTSQQQLTFKDSSSPRENTHHSESCMQDHNNEIKHLQELKNHPNIVNMVQIIREIQYDKKNGQTY

YTMGIVLELCTKGELFDYLLHSGK-FTEEQTRYYFKQLISGLQYLHTNNVCHRDLKPENILLDENFNLKIADFGFS----------ARLDGKDGSGFLKS
..|.||.|.|..||||||..|.|. |.||..||||.|||...||.|.||.|||||||||||||||||||||||||.          .....|||......
CFMCIVFEYCSNGELFDYIAHKGPLFNEELARYYFHQLINVIQYIHQNNICHRDLKPENILLDENFNLKIADFGFAQFLNSASSQNTLSKQKDGEKMNHN

-------------------SLGTEGYMAPEINEKKAYIGSAVDLFSAGIILFIMFTGHPPFHK-ALDSDPYYKLLITDRNSTFWEAHSRNK-EKGFFSND
                   ..|||||||||..||..|.||.||.|..|.|||.|..||||||| |..|||||......|....|..|..|. ...||||.
TSSTECSDASSDESHWLYVCMGTEGYMAPELHEKQRYCGSKVDIFACGVILFCMVHGHPPFHKIAHPSDPYYRFFCENRYHQYWQCHQKNYGQHNFFSNE

FMNLINSILAYEPQNRITLAELISHPWM
||.|||..|||.||.||||.|...|||.
FMDLINQMLAYNPQKRITLQEIKCHPWY
Kinase 27962.AA CAMK 16-285 24 3.9e-97 313.55 In-house 1-425 (425) Show / Hide 
Range on Protein: 16-285
Range on HMM: 1-425/425
Sequence Identity: 24% (104 aa)

TLGKGYQAKVKICYAP-NN------------KVYAVKIFKRT--------------------------HSEEKNTKALIQEAGHLTQ-------LKHENL
|||.|  .||| |.   ..            . .|.|| ...                          . ..|. | . .|   . .       |.|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLVEILKKEQYIKKNGET---------YYT----MGIVL---ELCTKGEL----FDYLLHS---------------GKFTEEQTRYYFKQLISGLQYLH
..| |.   ..|.| |  |         . |    | .|.   |.|. |||    |||.                  |.|||...|.||.|..|...|.|
IKLYEVYEDPHYFK-N--TNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH

TNNVCHRDLKPENILLDEN-----------------FNLKIADFGFSARLDGKDGSG---------------------FLKSSLGTEGYMA-PEINEK--
 .|..||||||||||||.|                 .|.||.||||....|.....                       .| . || .||| ||. ..  
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG

-----------KAYIGSAVDLFSAGIILFIMFTGHPPFHKALDSDPY---------YKLLITDRNSTFWEAHSRNKE------------------KGFFS
           | |.| ..|  |.|.||.|| .|.|||    |.. .         |.|.   ..  ..  ..  ..                  . |.|
HCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVS

NDFMNLINSILAYEPQNRITLAELISHPWM
 . ..||...| ..|..|.|...  .||||
QECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 27962.AA S_TKc 11-285 28 5.2e-82 279.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-231/231
Sequence Identity: 28% (82 aa)

YRLGKTLGKGYQAKVKICYAPN-NKVYAVKIFKRTHSEEKNTKALIQEAGHLTQLKHENLVNLVEILKKEQYIKKNGETYYTMGIVLELCTK--GELFDY
|......|||  .||. |.  . ....|.|| |         . ...|   | . .|.|.|.| ..                . .|.|.|    |.||||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----------DHLYMVMEYCDGDLGDLFDY

LLHSGK------FTEEQTRYYFKQLISGLQYLHTNNVCHRDLKPENILLDENFNLKIADFGFSARLDGKDGSGFLKSSLGTEGYMAPEINEKKAYIGS-A
. . |.      |.| ..|.|..|....|.|.| ....|||||||||||||  ..||.|||....|         ..  ||  |||||.       |  .
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCK

VDLFSAGIILFIMFTGHPPFHKALDSDPYYKLLITDRNSTFWEAHSRNKEKGFFSNDFMNLINSILAYEPQNRITLAELIS-------HPWM
.|  | |.||..|..| |||.   . .  .|..                     | .. ..|. .| ..|..|.|  |.         |||.
CDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 27962.AA CAMKL 11-285 32 1e-81 260.5 In-house 1-297 (297) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-297/297
Sequence Identity: 32% (101 aa)

YRLGKTLGKGYQAKVKICYA-PN-NKVYAVKIFK--RTHSEEKNTKA-----------LIQEAGHLTQLK---HENLVNLVEILKKEQYIKKNGETYYTM
||.|||||||  .||| .    . .. .|.|| .  ..  .....|            . .|.  . .|.   |.| . | |..  ...   . ||   .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEH---DIET-KKI

GIVLELCTKGE--LFDYLL-HS---GKFTEEQTRYYFKQLISGLQYLHTNNVCHRDLKPENILLDENF--NLKIADFGFSARLDGK-DGSG-FLKSSLGT
 .|.|.|  ||  ||||.  |    |...|...| ||.|..|...|.| ....|||.||||||||||   |.||.|||||.  . . .|.| .|| . |.
YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGS

EGYMAPEINEK--KAYIGSAVDLFSAGIILFIMFTGHPPFHKA-----LDSDPYYKLLITDRNSTFWEAHSRNKEKGFFSNDFMNLINSILAYEPQNRIT
  |||||| ..  | |.| .||  |.|.||. | .|. ||  .      ...  |..... .  ...  ..      . | |  .|| ..|   |  |.|
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWY------HVS-DCRDLIRKMLQVNPEKRPT

LAELISHPWM
. .. .||||
IHQIMNHPWM
Kinase 27962.AA Pkinase 11-285 27 6.3e-77 266.68 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-293/293
Sequence Identity: 27% (85 aa)

YRLGKTLGKGYQAKVKICYAPNN-KVYAVKIFKRTHSEEKNTKALIQ--EAGHLTQLKHENLVNLVEILKKEQYIKKNGETYYTMGIVLELCTKG----E
|..|...|.|  ..|..|.  .. |..||||.|. | ...  ....   |.  .  |.|.| | | ..          .  .|   .|.|.| .|    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-------KDHIY---MVMEYCEGGLYVMD

LFDYLL--HSGKF--TEEQTRYYFKQLISGLQYLHTNNVCHRDLKPENILLDENFNL----KIADFGFSARLDGKDGSGFLKSSLGTEGYMAPEINEKKA
||||.    .|.|  .|.. . |..|...||.|.| ....||||||||||.|.| ..    ||.|||... .|    .. ...  || .|||||.  .  
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQ

YIGSAVDLFSAGIILFIMFTGHPPFHKA------LDSDPYYKLLITDRNSTFWEAHSRNKEKGFFS-----------NDFMNLINSILAYEPQNRITLAE
|.|..|| .|.|.||..|..|.|||  .       .   ... . ..  . ... .|.  .. |.             ..  .|...|.. |. |.| ..
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LISHPWM
.  |||.
ILQHPWF
Kinase 27962.AA Ciliate-E9 11-285 32 2.9e-72 230.39 In-house 1-298 (298) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-298/298
Sequence Identity: 32% (97 aa)

YRLGKTLGKGYQAKVKICYAPNNKV-YAVKIFKRTHSEE-KNTKALIQEAGHLTQLKHE-NLVNLVEILKKEQYIKKNGETYYTMGIVLELCTKGELFDY
||...  ..| |  ||       .  ||.||.|     .   .| .. |   | |.. . ... |  |.    |.|  |       || |    |.||| 
YRVHRNIAQGTQGQVKLAIDMQTRKKYAIKIMKHQQMNDEMFFKYFQREMNILNQVQPHRYIIQLQDICYNINYMKCHGQKFTINYIVMEYANNGCLFDL

L-LHSGKFTEEQTRYYFKQLISGLQYLHTNN-VCHRDLKPENILLDENFNLKIADFGFSARLDGKDGSGF------LKSSLGTEGYMAP----EINEKKA
.  | .|| |.  .||||||| .  |.|    .|||||||||.|.|.|.|.|| |||.||..    .          |.  ||  |  |    .    . 
ISMHTEKFNENVAKYYFKQLIDSIEYMHQYQNICHRDLKPENMLIDKNYNMKICDFGMSAQCRNDKTQVIGNLQCQPKENHGTNQYNPPNNQQQQYQGIK

YIGSAVDLFSAGIILFIMFTGHPPFHKALDSDP--------YYK--LLITDRNSTFWEAHSRNKEKGFFSNDFMNLINSILAYEPQNRITLAELISHPWM
| | ..|.||||.|||.| ..  ||     ..         ||    .  |  . ||.    | ..   ...|. ..|. |  .|||||...|...||||
YNGQKFDIFSAGCILFMMVMNQYPFFHTNCYNDTTIDKIWQYYRIFFFCMDNCQNFWDQFIYN-YRP-EEQEFIDMMNWMLQQDPQNRISIQEIRMHPWM
Kinase 27962.AA Ciliate-E2 11-285 22 1.2e-66 227.75 In-house 1-365 (365) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-365/365
Sequence Identity: 22% (89 aa)

YRLGKTLGKGYQAKVKIC--YAPNN----------------------KVYAVKIFKRTHSEEKNT-KALIQEAGHLT-----------QLKHENLVNLVE
| . | .|.| ...|. |  .  ..                      | ||.||.|    |...  . ...|  .             ||.| |.....|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

ILK--KEQYIKKNGETYYTMGIVLELCTKGELFDYLLHS-----------GKFTEEQTRYYFKQLIS---------------GLQYLHTNN-VCHRDLKP
  .  ....|           .|.|.|  |.||||. ..           ..|||.. .|..||...               .|.||| .| ..|||.||
CFQEKDDNNIY----------LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP

ENILLDENFNLKIADFGFSARLDGKDG-------SGFLKSSL-----------------------GTEGYMAPEINEKKAY--------IGSAVDLFSAG
||||.     .||.|||.| ..| .         .. ..                          || ||||||| ..| |         . ..|..|.|
ENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG

IILFIMFTGHPPFHKALDSDPYYKLLITDRNSTFWEAHSRNK---------EKGFFSNDFMNLINS----ILAYEPQNRIT-LAELISHPWM
.||..| .| |||             | . .  | .......         ..   |.. ..||.     .| ..|..|||   ... |||.
VILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 27962.AA AGC 94-285 22 7.2e-66 168.32 In-house 110-395 (395) Show / Hide 
Range on Protein: 94-285
Range on HMM: 110-395/395
Sequence Identity: 22% (67 aa)

IVLELCT---------KG-ELFDYLL---HSGKFTEEQTRYYFKQ-------LISGLQYLHT-NNVCHRD-LKPENILLDENFNLKIADFGFSARLDGKD
.|.|..           | ||| .|    ..|.|.||..|.|. .       ....|.|||  ... ||| ||||||||||. ..|..|||.. .. ...
FVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDG

GSGF------------------------------------------------LKSSLG--TEGYMAPEINEKKAYIGSAVDLFS--AGIILFIMFTGHPP
. |.                                                 ..  |  |  ||||||       | |.|  |   |.... | ||.||
EKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLMYEMLTGYPP

FHKALDSDPYYKLLITDRNSTFWEAHSRN---KEK--------------GFFSNDFMNLINSILAYEPQNRIT----------LAELISHPWM
|.   . .   .   .... .|    ...   ..|               .||.. ..||.  |  .| .|..            |. .||| 
FYGDNPQE-NRH-PFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 27962.AA Ciliate-E2-Unclassified 11-285 24 5e-61 209.06 In-house 1-352 (352) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-352/352
Sequence Identity: 24% (89 aa)

YRLGKTLGKGYQAKVKIC------------YAPNNKVYAVKIFKRTHSEEKNTKALIQEAG-------------HLTQLKHENLVNLVEILKKEQYIKKN
|...|..|.| ..||. |            |.  ...|..|. .. . |..| .  ...                | ...|...|..... ...|.|   
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY--

GETYYTMGIVLELCTKGELFDYLLHSGK-----------------FTEEQTR-----YYFKQLISGLQYLHTNN-VCHRDLKPENILLDEN---FNLKIA
        ||.|.|  |.|..|. ...|                 |||.|..     .||.|...||.||| .| ..|||.||||||.|.|   ...||.
--------IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKII

DFGFSARLDGKDGSG-------------FLKSSLGTEGYM----APEINEKKAYIGS---AVDLFSAGIILFIMFTGHPPFHKALDSDPY----------
|||.| ...  ...               ...  || .||    |||. ... | .|   ..| .| |.||. | .| .||    . . .          
DFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNA

----YKLLITDRNSTFWEAHSRN--KEKGFFSNDFMN-LINSILAYEPQNRITLAELISHPWM
    ..  | ..|  | ..  ..  |   .   || | |. ..| . | .|||. ... |||.
YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 27962.AA MARK 11-220 35 2.1e-59 192.87 In-house 1-206 (262) Show / Hide 
Range on Protein: 11-220
Range on HMM: 1-206/262
Sequence Identity: 35% (79 aa)

YRLGKTLGKGYQAKVKICY-APNNKVYAVKIFKRTHSEE-KNTKALIQEAGHLTQLKHENLVNLVEILK--KEQYIKKNGETYYTMGIVLELCTKGELFD
|...||.|.|  |||| .   . .. .|.|| ...   . .. | .  |.  . .|.|.| . | ..     ||          .  ...|.. .|||.|
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQH---------QIYLIMEYASGGELYD

YLLHS--GKFTEEQTRYYFKQLISGLQYLHTNNVCHRDLKPENILLDENF--NLKIADFGFSARL--DGKDGSGFLKSSLGTEGYMAPEINEKKAYIGSA
|.     |. .|| .| .|.|..|...|.| .|..|||.||||||.|||   | ||.|||||..   . |     |..  ||  |||||| .|| | | .
YIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK-----LNTFCGTPPYMAPEIFLKKPYDGPK

VDLFSAGIILFIMFTGHPPF
||  | |..|..| .|. ||
VDIWSLGVVLYFMVCGYFPF
Kinase 27962.AA AMPK 11-220 38 1.3e-55 163.59 In-house 1-200 (254) Show / Hide 
Range on Protein: 11-220
Range on HMM: 1-200/254
Sequence Identity: 38% (83 aa)

YRLGKTLGKGYQAKVKICY--APNNKVYAVKIFKRTHSEEKNTKALIQ-EAGHLTQLKHENLVNLVEILKKEQYIKKNGETYYTMGIVLELCTKGELFDY
| .|||.|.|   |||. .    ..|| |.||  ..   .. ..  || |   |  ..| ... | |..          ||   . .|.|  . ||||||
YIIGKTIGEGTFGKVKMGTHILTGEKV-AIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVI---------IETPTDIFMVMEYVSGGELFDY

LLHSGKFTEEQTRYYFKQLISGLQYLHTNNVCHRDLKPENILLDENFNLKIADFGFSARLDGKDGSGFLKSSLGTEGYMAPEINEKKAYIGSAVDLFSAG
    |. .|.... .|.| |||. |.| ... ||||||||.|||.| |.||.||| |     |||  ||| . |   | |||. . | | |  ||. | |
IVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMM--KDG-EFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCG

IILFIMFTGHPPF
.||. |  |  ||
VILYAMLCGYLPF
Kinase 27962.AA ULK 11-285 24 1.6e-54 187.43 In-house 1-324 (324) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-324/324
Sequence Identity: 24% (83 aa)

YRLGKTLGKGYQAKVKICYA---PN---NKVYAVKIFKRTHSEEKNTK--------ALIQEAGHLTQLK---HEN--LVNLVEILKKE----QYIKKNGE
| | . ||||  . || . .    .   |...|.|.  .    .|. .         |..|   . .||   |.|   | | ....       |      
YCLNHCLGKGSFG-VKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIY------

TYYTMGIVLELCTKGELFDYLLHSGK---------FTEEQTRYYFKQLISGLQYLHTNNVCHRDLKPENILLDENFN------------LKIADFGFSAR
      |..|.|  | |..|.   .|         ..|.... .|||...|...|| .|. |||.||.|||. ...             ||||||||.  
------IIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH

LDG-KDGSGFLKSSL------GTEGYMAPEINE---KKAYIG-SAVDLFSAGIILFIMFTGHPPFHKALDSDPY------------YKLLITDRNSTFWE
.|        ... .      ||  ||||.| .   ..   . . .|..| |.|.. | .| .|| .   .| |            ....| ...  |  
VDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPK

AHSRNKEKGFFSNDFMNLINSILAYEPQNRITLAELISHPWM
      .   .|... .||   | |..  ||.  |...|||.
PP----KDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 27962.AA Pkinase_Tyr 11-162 27 1.8e-16 56.43 Pfam 1-156 (270) Show / Hide 
Range on Protein: 11-162
Range on HMM: 1-156/270
Sequence Identity: 27% (45 aa)

YRLGKTLGKGYQAKVKICYAP-----NNKVYAVKIFKRTHSEEKN--TKALIQEAGHLTQL-KHENLVNLVEILK-KEQYIKKNGETYYTMGIVLELCTK
 ..||.||.|   .|. ...      ..   |||. |  .. ...   .....||  ..|| .|.|.|.|. .   ... .         . ||.|.. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--------QIYIVMEYMPH

GELFDYLLH----SGKFTEEQTRYYFKQLISGLQYLHTNNVCHRDLKPENILLDENFNLKIADFG
| | |||       ...| ..   .  |  .|..||. .|  ||||   |.|..||.  ||.|||
GDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 27962.AA TyrKc 11-285 22 7.7e-14 1.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-285
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

YRLGKTLGKGYQAKVKICYAPNNKVYAVKIFKRTHSEEKNTKALIQEAGHLTQL--KHENLVNLVEILKKEQYIKKNGETY---YTMGIVLELCTKGELF
 .|||.|| |   .|  . .      |||  |  .      .....||  ...|  .|.|.|.|. .  ...        .     . ||.|.. .| | 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN------FMYIEPLMIVMEYMPHGDLK

DYL-LHSGKFTEEQTRYYFKQLISGLQYLHTNNVCHRDLKPENILLDENFNLKIADFGFSARLDGKDGS----GFLKSSL--GTEG-----YMAPEINEK
|||  | .|.. ..  ..  |  .| .||| .|. ||||   |.|..||.  ||.||| |  .. .| .       ...   |. .      ||||   .
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

KAYIGSAVDLFSAGIILFIMFT-GHPPFHK-----ALDSDPYYKLLITDRNSTFWEAHSRNKEKGF----FSNDFMNLINSILAYEPQNRITLAELISHP
. .  .. | .| |. .. .|| | .|          ... . ..   .|     ..     .        . .  ... .  ...| .| | .|.  | 
GKF-TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY----P--MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HE

WM
 .
CF
Kinase 27962.AA AGC 11-72 18 1.9e-08 16.42 In-house 1-96 (395) Show / Hide 
Range on Protein: 11-72
Range on HMM: 1-96/395
Sequence Identity: 18% (18 aa)

YRLGKTLGKGYQAKVKICYA-------PNNKVYAVKIFKRTH--------SEEKNTKA--------LIQEAGHLTQLK----------HENLVN-L
... |..|||   ||  .          ..|.||.|. |  |         .|..  .        . .|   |....          | ..|. |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKIL
Kinase 27962.AA AMPK 253-285 36 1.9e-08 21.24 In-house 222-254 (254) Show / Hide 
Range on Protein: 253-285
Range on HMM: 222-254/254
Sequence Identity: 36% (12 aa)

FFSNDFMNLINSILAYEPQNRITLAELISHPWM
|.|..  .||...|   |..|||  ..  ||| 
FLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase 27962.AA MARK 260-285 46 8.6e-08 21.74 In-house 237-262 (262) Show / Hide 
Range on Protein: 260-285
Range on HMM: 237-262/262
Sequence Identity: 46% (12 aa)

NLINSILAYEPQNRITLAELISHPWM
|||...|   |  |.|. |. .||||
NLIQRLLTVNPEERPTIEEIMKHPWM