Gene 9436 (Tetrahymena)

9436

Species: Tetrahymena
Alias: PreTt09436, 9.m00457, TTHERM_00128720, 9436, 3699.m00165, 539
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-B1

Sequence

Name Sequence Type Origin Length Description Download
9436.AA Protein None 421 None Fasta, JSON
9436.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
9436.NA RNA None 1266 None Fasta, JSON

Protein domain

Protein domains of 9436.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 9436.AA Ciliate-B1 13-268 47 4.8e-159 534.67 In-house 1-290 (290) Show / Hide 
Range on Protein: 13-268
Range on HMM: 1-290/290
Sequence Identity: 47% (137 aa)

YSNIELIGQGAISQVFKA-----TKENKIFAVKILTSKTIGG--NQNRYWKNEIEIITQLQKNLKA-------SPCPYITQIYDVFQENESAFIVNEYCD
|.....||||||||||..     .......|||..|..|...  .||.|...|.|||..|.|....       |||..|..||||.|......|..|||.
YQQNNVIGQGAISQVFYGQFCQNQQCQQEVAVKKITKQTQDNDKQQNKYYQQELEIIQCLIKKMNNNKISCQSSPCDHICNIYDVIQCQQQYYIIMEYCE

QGDLYNFIQKCHQHLNHFSLAIMMKQLIEGIIYLHERKIIHRDLKPENILVA---------YQDNVYVLKITDFG-ISSQDE-LTKSQVGTVNYMAPEII
||||||.|..|||...|........|...||.|||..||.||||||||||..         .|.|.|..|||||| ...|.|  ..|.|||.|||||||.
QGDLYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEYMMQSCVGTINYMAPEIL

R-SQQYDKSVDIWSFGCIAYEIITNEQLFQ--AQSQFEVARKIINFQYQ--SKHFINQDLFEIIE----QCLQVDQNKRITSDAILDKLN
. .|||||.|||||||||.||||||||||.  ...|.|||..|.|||..  ..||.|....||..    .|||.|...|||.|.|.|.| 
NFNQQYDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIRNFQCCDYQCHFQNNIYQEIQQLIQKYCLQPDPENRITIDQIIDRLM
Kinase 9436.AA S_TKc 13-271 30 3.4e-76 260.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-231/231
Sequence Identity: 30% (84 aa)

YSNIELIGQGAISQVFKATKEN--KIFAVKILTSKTIGGNQNRYWKNEIEIITQLQKNLKASPCPYITQIYDVFQENESAFIVNEYCDQ--GDLYNFIQK
|  ...||.|| ..|.|... .  .|.|.||.          .  ..||.|  .         .|.| ..|||||. .. ..| ||||.  |||. .|.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

CHQH-----LNHFSLAIMMKQLIEGIIYLHERKIIHRDLKPENILVAYQDNVYVLKITDFGISSQDELTKSQVGTVNYMAPEIIRSQQYDK-SVDIWSFG
.  |     ..    . .|.|..... |.|...||||||||||||.       ..||.|||.. |    ....|| .|||||..   .|.| ..|.||.|
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

CIAYEIITNEQLFQAQSQFEVARKIINFQYQSKHFINQDLFEIIEQCLQVDQNKRITSDAILD-----KLNNII
|| || .. . .|.   .... .||            ... ..|..|||.| .||.|   .|      |.   .
CILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 9436.AA Pkinase 13-267 28 8.3e-72 249.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-267
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

YSNIELIGQGAISQVFKATKENK--IFAVKILTSKTIGGNQNRYWKN--EIEIITQLQKNLKASPCPYITQIYDVFQENESAFIVNEYCDQG----DLYN
|  .. ||.|. ..|.|... .   |.||||.  ...  .....  .  ||.|   |.       .|.| ..||.|... .  .| |||. |    ||. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

FIQ-KCHQHL--NHFSLAIMMKQLIEGIIYLHERKIIHRDLKPENILVAYQDNVYV---LKITDFGISSQ----DELTKSQVGTVNYMAPEIIR-SQQYD
.|. . |  .      .  .|.|...|. |.|...||||||||||||.   .| ..   .||.|||.. |    .. ... .|| .|||||.|| .| |.
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYG

KSVDIWSFGCIAYEIITNEQLFQAQ------SQFEVARKIINFQYQSKHFIN---------------------QDLFEIIEQCLQVDQNKRITSDAILDK
..||.||.||| || .. . .|. .      .| .. ..|   .. .  .                       ... ..|. ||..| .||.| . ||  
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
Kinase 9436.AA AGC 13-260 18 5.1e-66 168.73 In-house 1-376 (395) Show / Hide 
Range on Protein: 13-260
Range on HMM: 1-376/395
Sequence Identity: 18% (70 aa)

YSNIELIGQGAISQVFKATKE--------NKIFAVKILT----SKTIGGNQNRYWKNE------------IEIITQLQ-----KNLKASPCPYITQ-IYD
.  . .||.|. ..|. . |         .|..|.|.|      . .  |. .. ..|             .| ....     .    | .|.|..  . 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHP-I-KSHHPFIVKILHY

VFQENES--AFIVNEYCD--------QGDLYNFIQKCHQ----HLNHFSLAIMMKQ-------LIEGIIYLHE-RKIIHRD-LKPENILVAYQDNVYVLK
 || ..    ..| ||.          |..  |......    ...     ... .       .. .. |||. ..||||| |||||||   .     .|
SFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIK

ITDFGISSQ------------------------------------------------------DELTKSQVG--TVNYMAPEIIRSQQYDKSVDIWS--F
.|||| . .                                                      ...|.. .|  | .||||||.    |.|..|.||  .
LTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGL

GCIAYEIITNEQLFQAQS----------QFEVARKII--------NFQYQSK--------HFINQDLFEIIEQCLQVDQNKRITS
||. || .|    |....          ..|.  ||.        . .. ..         .. ...  .|...|..| .||...
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGC
Kinase 9436.AA Ciliate-E2 13-265 23 1.5e-65 223.99 In-house 1-361 (365) Show / Hide 
Range on Protein: 13-265
Range on HMM: 1-361/365
Sequence Identity: 23% (87 aa)

YSNIELIGQGAISQVFKATK-ENKI-------------------FAVKILTSKTIGGNQNRYWKNEIEIIT---------QLQKNLKASPCPYITQIYDV
|  |..||||. ..|.|... ...                    ...||   |..  || ...|.|| |.          . ...|.   .|.| ..|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--ENESAFIVNEYCDQGDLYNFIQ----KCHQHLN------HFSLAIMMKQLIE---------------GIIYLHERK-IIHRDLKPENILVAYQDNV
||   ... ..| |||..|||. .|.    |......      ..  . .|||...               .. |||... |||||.||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

YVLKITDFGISS-----------------------------------QDELTKSQVGTVNYMAPEIIRSQQ---------YDKSVDIWSFGCIAYEIITN
  .||.|||.|                                    |........|| .||||||.....         ||...||||.|.| || ...
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

EQLFQAQSQFEVARKII--NFQYQSKHF----------------INQDLFEIIEQ----CLQVDQNKRIT-SDAILD
.  |         ..|.  .........                . |.   .| .    .||.|..||||  . ||.
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 9436.AA Ciliate-E2-Unclassified 13-264 24 1.7e-62 213.91 In-house 1-347 (352) Show / Hide 
Range on Protein: 13-264
Range on HMM: 1-347/352
Sequence Identity: 24% (86 aa)

YSNIELIGQGAISQVFKATKENK--------IFAVKILTSKTIGGNQNRYWKNEIEIITQ-----------LQKNLKASPCPYITQIYDVFQENESAFIV
|  |. ||||. ..|.|. ....        .  ..|  .| |  .. ... ...|.  .           .|  |. .|.|.|   ...||  .  .||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

NEYCDQGDLYNFIQKCHQ---------------HLNHFSLAI------MMKQLIEGIIYLHERK-IIHRDLKPENILVAYQDNVYVLKITDFGISS----
 |||..||| ..|.|...               .      |.      ...|...|. |||. . |||||.||||||.  . . | .||.|||||.    
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

---------------QDELTKSQVGTVNYM----APEIIRSQQYD----KSVDIWSFGCIAYEIITNEQLFQAQSQFE----------------VARKII
               .........|| |||    |||....|.||    ...||||.|.|.||.....  |..... .                . ..|.
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

NFQYQSKHFIN-----------QDLFE-IIEQCLQVDQNKRITSDAIL
. ..| ..| .           .|. . .. ..|....||||| . ||
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase 9436.AA CAMK 18-265 18 8.9e-59 187.7 In-house 1-421 (425) Show / Hide 
Range on Protein: 18-265
Range on HMM: 1-421/425
Sequence Identity: 18% (79 aa)

LIGQGAISQVFKATKENKI--------------FAVKILTSKTIGGNQ-------------------------NRY-WKNEIEIITQLQKN---LKASPC
 .|.|. ..|....  |                .|.||.  | . ..|                         .|   ..||||  .||..   |.    
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLD---H

PYITQIYDVFQE-------------------NESAFIVN---EYCDQG----DLYNFIQKCHQ--------------HLNHFSLAIMMKQLIEGIIYLHE
| | ..|.|..                    ..  ..|    |||. |    ||...|..  .              ...    . ...|..... |.|.
PNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS

RKIIHRDLKPENILVAYQD--------------NVYVLKITDFGISSQ---------------------------DELTKSQVGTVNYMA-PEIIRSQQ-
..|.||||||||||. . .              |.. .||.||| . .                           ... | ..||  ||| ||...... 
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-------------YDKSVDIWSFGCIAYEIITNEQLFQAQ-------------SQFEVARKIINFQYQ-SKHFIN-----------------------QD
             |....|.|| |.| |   . .  |..              .. |  .||.. .|.   ...                        |.
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

LFEIIEQCLQVDQNKRITSDAILD
    | ..|||| .||.| . .|.
CKDLIRKMLQVDPEKRMTIEQCLN
Kinase 9436.AA ULK 13-259 25 1.4e-57 197.63 In-house 1-314 (324) Show / Hide 
Range on Protein: 13-259
Range on HMM: 1-314/324
Sequence Identity: 25% (83 aa)

YSNIELIGQGAIS-QVFKA--TKE---NKIFAVKILTSKTIGGNQNR--------YWKNEIEIITQL----QKNLKASPCPYITQIYDVFQENES--AFI
|. .. .|.|.   .|.|.   |    |...|.|.   | .  ..|.          ||||.|. .|     .|     . .| . ||.|..  .   .|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPN-----H-HIVKLYDWFETSNHNNIYI

VNEYCDQGDLYNFIQKCHQHL-----NHFS---LAIMMKQLIEGIIYLHERKIIHRDLKPENILVAYQDNV---------YVLKITDFGISSQ-DE----
. |||..||| ..|.| . .      . .|     . .||...|  .||...|||||.||.|||.   .           .||||.||| . . |.    
IMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNME

--LTKSQV------GTVNYMAPEIIR----SQQYD-KSVDIWSFGCIAYEIITNEQLFQAQSQFEVA----------------RKIINFQYQ---SKHFI
  .....|      ||  ||||.|.      ..|. . .||||.||| ||.....  |...   .                   |  ..|..   .   |
QQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKI

NQDLFEIIEQCLQVDQNKRIT
 ... ..| ..||.|...||.
SPECKDLIRRMLQYDEKDRIS
Kinase 9436.AA ULK 13-259 26 6.8e-57 195.32 In-house 1-319 (329) Show / Hide 
Range on Protein: 13-259
Range on HMM: 1-319/329
Sequence Identity: 26% (85 aa)

YSNIELIGQGAISQVFKAT---KE---NKIFAVKILTSKTIGGNQNR--------YWKNEIEIITQL-----QKNLKASPCPYITQIYDVFQENES--AF
|. .. .|.|.  .|.|..   ..   |...|.|.. ....  ..|           ||||.|. .|      ||     .|.| . ||.|..  .   .
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKN----HHPNIVKLYDWFETSNHNNIY

IVNEYCDQGDLYNFIQKCHQHL------NHFS---LAIMMKQLIEGIIYLHERKIIHRDLKPENILVAYQDNV---------YVLKITDFGISSQ---D-
|. |||..||| ..|.| . .       ...|     . .||...|  .||...|||||.||.|||.   .           .||||.||| . .   | 
IIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN

---ELTKSQV------GTVNYMAPEIIR----SQQYD-KSVDIWSFGCIAYEIITNEQLFQAQSQFEVA-----RKIIN------------FQYQ---SK
   ......|      ||  ||||.|.      ..|. . .||||.||| ||.....  |.|.  ..       . | |            .|..   ..
MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

HFINQDLFEIIEQCLQVDQNKRIT
  | ... ..| ..||.|...||.
PQISPECKDLIRRMLQYDEKDRIS
Kinase 9436.AA CMGC 13-219 20 1.1e-53 174.34 In-house 1-347 (513) Show / Hide 
Range on Protein: 13-219
Range on HMM: 1-347/513
Sequence Identity: 20% (73 aa)

YSNIELIGQGAISQVFKATK----------------ENKIFAVKILTSKTIGGNQNR-------YWK---NEIEIITQLQKNLKASP-----------CP
| .|. ||.|. ..|.|..                  |.| |.|.. ..    .| .        ..    ||.|  .|.|| ..              .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

YITQIYDVFQENE-----------------SAFIVNEYCDQGDLYNFIQKCHQ-----HLNHFSLAI---------------MM------KQLIEGII--
.| ..||.|. ..                 . ..| ||.|. |||..|.....       ...|                  .|      .|...|.   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLK

YLHERK--IIHRDLKPENILVAYQDNV-----------------YVLKITDFGISSQDELT-------------------------KSQVGTVNYMAPEI
|.| ..  ||||||||||||.  .  .                 ..||| ||| . . .                            ..| |  | ||||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

IRSQQ----------YDKSVDIWSFGCIAYEIITN--------EQLFQAQS
. . .          |....|.||.||| .|..|.        . ||. .|
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHS
Kinase 9436.AA STE 13-261 23 3e-52 179.89 In-house 1-349 (359) Show / Hide 
Range on Protein: 13-261
Range on HMM: 1-349/359
Sequence Identity: 23% (84 aa)

YSNIELIGQGAISQVFKATKE-----------------NKIFAVKILT----SKTIGGNQNRYWKNE-----IEIITQLQKNL---KASP--CPYITQIY
. .|| ||.||  .|.|| .                  ..|.|.|..     .. .  ||    . |     .|.. |..| .   | .   .|.| . |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQ-EN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYY

DVFQEN-------ESAFIVNEYCDQGDLYNFIQ---KCHQHLN----------HFSLAIMMKQLIEG-IIYLHERKIIHRDLKPENILVAYQDNVYVLKI
. .  .       .. .|. ||.| | |  .|.   .| . ||             .|.. .|...|   |||. .|||||.|| |||.         |.
GCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKL

TDFGISSQDE--------------------LTKSQVGTVNYMAPEIIRS------QQYDKSVDIWSFGCIA-------YEIITNEQL---FQAQSQ----
.|||...| .                     ... |||  .||||.|.       ..|| ..||||.|| .       ..  .   .   |...      
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ

--FEVARKIINFQY---QS-----------------KHFINQDLFEIIEQCLQVDQNKRITSD
  ||.  .|.|..    ..                 .|   ... . |..||| | ||| |..
QQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTAS
Kinase 9436.AA TKL 19-267 18 5.3e-50 172.44 In-house 1-364 (364) Show / Hide 
Range on Protein: 19-267
Range on HMM: 1-364/364
Sequence Identity: 18% (67 aa)

IGQGAISQVFKATKEN----------KIFAVKILTSKTIGG-------------------NQNRYWKNEIEIITQLQKNLKASPCPYITQIYDVFQENES
||.|. ..|.|..  .          |  |||.. |.                       |.. ..... ... ..   .. . .| | |.. . .....
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLR-HPNIVQFMGYCCCPPC

-------------AFIVNEYCDQGDLYNFIQKCHQHLNHFSLAIMMKQLIEGIIYLHERK--------IIHRDLKPENILVAYQDN-----------VYV
              .|| |||. |.|.....       .  .  ....   |. ||| ..        |||||||..||||    .            ..
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

LKITDFGISS-----------------------QDELTKSQVGTVNYMAPEIIRSQ----------------QYDKSVDIWSFGCIAYEIITNEQLFQAQ
.||.|||.|                        ... | .|.|| ..||||..| |                .|....|..||| . .||.| .. .. .
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

SQFEVA---------RKIINFQYQSKHF--------------INQDLFEIIEQCLQVDQNKRITSDAILDKL
  ...           .... ...                  . ... .....| . | .|| . . ||..|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 9436.AA TyrKc 13-267 25 1.1e-17 63.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-267
Range on HMM: 1-280/280
Sequence Identity: 25% (74 aa)

YSNIELIGQGAISQVFKATKENKIFAVKILTSKTIGGNQNRYWKNEIEIITQL--QKNLKASPCPYITQIYDVFQEN-------ESAFIVNEYCDQGDLY
 . .. .| ||  .|.|.|      ||| | . .      .   .|..| ..|  .        | | ..| |  .        |  .|| ||.. ||| 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGH-------HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

NFIQKCHQHLNHFSLAIMMKQLIEGIIYLHERKIIHRDLKPENILVAYQDNVYVLKITDFG----ISSQ-------DELTKSQ--VGT----VNYMAPEI
....|.. .|..  |  .. |  .|  |||....|||||   |.||. .    . ||.|||    | .        |  .|..   |     .  |||| 
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

IRSQQYDKSVDIWSFGCIAYEIITNEQLFQAQ------SQFEVARKIINFQYQSKHFI---------NQDLFEIIEQCLQVDQNKRITSDAILDKL
|.   .    |.||||   .|| |. |           | .|| ... .  .  .             .....|..|| . | ..| |  .| ...
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 9436.AA Pkinase_Tyr 13-210 29 1.5e-12 43.11 Pfam 1-209 (270) Show / Hide 
Range on Protein: 13-210
Range on HMM: 1-209/270
Sequence Identity: 29% (65 aa)

YSNIELIGQGAISQVFKATKE------NKIFAVKILTSKTIGGNQ--NRYWKNEIEIITQL-QKNLKASPCPYITQIYDVFQ-ENES--AFIVNEYCDQG
 . .. .|.||  .|.|.|        .   |||.|   .    |   .   .|..| .|| .       .| | . | |   . |.   .|| ||.  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGH-------HPNIVRLYGVCTDQGEPNQIYIVMEYMPHG

DLYNFIQKC---HQHLNHFSLAIMMKQLIEGIIYLHERKIIHRDLKPENILVAYQDNVYVLKITDFGISS---QDELTKSQVGT-----VNYMAPEIIRS
||... .|     |.|..  |  |  |  .|  ||.....|||||   |.||.  .|  | ||.||| .     |.   .....     .  |||| |. 
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT--ENN-VVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINY

QQYDKSVDIWSFGCIAYEIIT
  .    |.||||   .||.|
GKFTTKSDVWSFGVLMWEIFT
Kinase 9436.AA CMGC 235-265 25 0.001357 6.65 In-house 479-509 (513) Show / Hide 
Range on Protein: 235-265
Range on HMM: 479-509/513
Sequence Identity: 25% (8 aa)

KHFINQDLFEIIEQCLQVDQNKRITSDAILD
.. ....... ....|| | .|||| . .|.
RKCCDPQAIDLLKKMLQYDPDKRITAEQALQ