Gene 9435 (Tetrahymena)
9435
Group:
Other
Family:
Ciliate-B1
Sequence
Protein domains of 9435.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 9435.AA | Ciliate-B1 | 43-225 | 46 | 2.4e-108 | 366.24 | In-house | 92-290 (290) | Show / Hide |
Range on Protein: 43-225 Range on HMM: 92-290/290 Sequence Identity: 46% (92 aa) YYIISELCEYGDLCSHLFNFYDQYTFEIKLEFLVEIISGIEALHKMGISHRDIKTDNILIALD-------KQTQHYYLKITDFGISSLKME-NLQSKVGT ||||.|.||.|||.....|.....|..|.|.|...|..||..|||..|.|||.|..||||... ||..||..||||||||....| ..||.||| YYIIMEYCEQGDLYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEYMMQSCVGT VVYMAPEILN-SANYDYKVDIWSFGIIAFEIMKNELYFP--YDGDANTINQIRKHTK--YQRGLIDN--LEIEN-ILELCLQKDPKQRPEASLIKQRLM ..|||||||| ...||.||||||||.|..||..||..|. ........||||.... ||.. ..| .||.. |...|||.||..|.... |..||| INYMAPEILNFNQQYDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIRNFQCCDYQCHFQNNIYQEIQQLIQKYCLQPDPENRITIDQIIDRLM |
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S_TKc | 9435.AA | S_TKc | 4-225 | 26 | 2.1e-39 | 138.15 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 4-225 Range on HMM: 1-231/231 Sequence Identity: 26% (68 aa) YPHLK--GQGAFARVYIGMNCNGKEFVAIKQISSERIVN---------------------NCYYIISELCEY--GDLCSHLFNFYDQ-----YTFEIKLE | |. |.|||..|| . . . .. ||||.|. |.| . ...|.. |.|. ||| ... . . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF FLVEIISGIEALHKMGISHRDIKTDNILIALDKQTQHYYLKITDFGISSLKMENLQSKVGTVVYMAPEILNSANYDY-KVDIWSFGIIAFEIMKNELYFP .. .|....| .|..|| |||.| .|||. .||.|||.. . . .|| |||||.| |.. |.|.||.|.| .| . . || YMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP YDGDANTINQIRKHTKYQRGLIDNLEIENILELCLQKDPKQRPEASLIKQ--------RLM .. ....|. | .... ||||||..|| | . | . --QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 9435.AA | TKL | 8-224 | 17 | 3.3e-39 | 136.58 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 8-224 Range on HMM: 1-364/364 Sequence Identity: 17% (65 aa) KGQGAFARVYIGMNCNG---------KEFVAIKQISSER---------------------------------------IVNNC----------------- |.|.|. || | ...| . ||.|...|. . ... IGSGGFGEVYKG-KWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC -------------YYIISELCEYGDLCSHLFNFYDQYTFEIKLEFLVEIISGIEALHKMG--------ISHRDIKTDNILIALDKQTQHYY--------- ..|. |.|. |.|...| .. .. . .| .|.. || |. | |||.|..|||. . .... GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNPNADW -LKITDFGISSLKMEN----------------------LQSKVGTVVYMAPEILNSA----------------NYDYKVDIWSFGIIAFEIMKNELYFPY .||.|||.| . .. . ...|| .||||.|. . |. |.|..||||. .||. .. || CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--PY DGDANT---------INQIRKHTKYQRGLID------------NLE---IENILELCLQKDPKQRPEASLIKQRL ... . . .. | .| .|. . . .... | . ||..|| .. |..|| YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | 9435.AA | Ciliate-E2 | 40-222 | 22 | 1.3e-38 | 130.14 | In-house | 106-361 (365) | Show / Hide |
Range on Protein: 40-222 Range on HMM: 106-361/365 Sequence Identity: 22% (61 aa) NNCYYIISELCEYGDLCSHLFNFYDQ----------YTFEIKLEFLVEIIS---------------GIEALHKMG-ISHRDIKTDNILIALDKQTQHYYL .|..|.. |.|..||| ... |.. . .| . ... .|.. ..| ||. . | ||||| .|||. . DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------I KITDFGISS----------------LKMENL-------------------QSKVGTVVYMAPEILNSAN---------YDYKVDIWSFGIIAFEIMKNEL ||.|||.| ..|. .. .|| ||||||||. . ||||.||||.|.| .| . ... KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP YFPYDGDANTINQIRK-HTKYQ----------------RGLIDNLEIENILEL----CLQKDPKQRPE-ASLIKQ | ..|| . ... . .| ... .|||||..|. .. |.. PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN |
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Kinase | 9435.AA | Pkinase | 43-224 | 26 | 1.1e-37 | 134.31 | Pfam | 75-293 (293) | Show / Hide |
Range on Protein: 43-224 Range on HMM: 75-293/293 Sequence Identity: 26% (58 aa) YYIISELCEYG----DLCSHLF-NFYDQY--TFEIKLEFLVEIISGIEALHKMGISHRDIKTDNILIALDKQTQHYYLKITDFGIS----SLKMENLQSK .|.. |.|| | ||.... . . . . .. .|..|.| .|.||| |||.| .|||| . .. .||.|||.. . . ... IYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTF VGTVVYMAPEILN-SANYDYKVDIWSFGIIAFEIMKNELYFPYDG------DANTINQIRKHTKYQRGLIDN---------------------LEIENIL .|| |||||... . |..|||.||.|.| .| . .. || . | . . . ...... . | .. CGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFI ELCLQKDPKQRPEASLIKQR--L . ||.||||.|| | |.| . KWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 9435.AA | Ciliate-E2-Unclassified | 41-222 | 24 | 1.1e-36 | 124.74 | In-house | 94-348 (352) | Show / Hide |
Range on Protein: 41-222 Range on HMM: 94-348/352 Sequence Identity: 24% (63 aa) NCYYIISELCEYGDLCSHLFNFYD----------------QYTFEIKL-----EFLVEIISGIEALHKMG-ISHRDIKTDNILIALDKQTQHYYLKITDF .. ||. |.||.||| .. .. . | . . .. .|..|.| ||. . | ||||| .|||. ... ||.||.|| QNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--NYYIKIIDF GISS------------------LKMENLQSKVGTVVYM----APEILNSANYD----YKVDIWSFGIIAFEIMKNELYFPYDGDAN-------------- |||. .| .......|| || |||.| . ||| ||.||||.|.|..|.. ... |.. . GISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYR --TINQI-RKHTKYQRGLI----DNLE------IENILELCLQKDPKQRPEASLIKQ ...| | .... ... |...| .|.|.|..|. .. |.. KQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN |
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Kinase | 9435.AA | AGC | 77-163 | 24 | 3e-36 | 89.97 | In-house | 154-297 (395) | Show / Hide |
Range on Protein: 77-163 Range on HMM: 154-297/395 Sequence Identity: 24% (37 aa) E-------IISGIEALHK-MGISHRD-IKTDNILIALDKQTQHYYLKITDFGISSL-------------------------------------------- | |....| ||. ||| ||| .| .|||. | ..|.|||| . EMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED-----GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNM ---------KMENLQSKVG--TVVYMAPEILNSANYDYKVDIWS--FGIIAFE |.. .. .| | ||||||| |.. .|.|| .|.. .| SQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYE |
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Kinase | 9435.AA | STE | 74-218 | 22 | 7.2e-32 | 109.85 | In-house | 156-349 (359) | Show / Hide |
Range on Protein: 74-218 Range on HMM: 156-349/359 Sequence Identity: 22% (47 aa) FLVEIISG-IEALHKMGISHRDIKTDNILIALDKQTQHYYLKITDFGISSLKME-------------------NLQSKVGTVVYMAPEILNS------AN ....|. | . ||...| ||||| .|||. |..|||... . . .. ||| .||||... ICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKG YDYKVDIWSFGIIAFEIMKNELYF---PYDGDANTINQI--------------RKHTKYQRGLIDN-----------------LEIENILELCLQKDPKQ ||.|.||||.|. . | . . .. |.. .. . . | .| | . ...||||||.. YDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNK RPEAS || || RPTAS |
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Kinase | 9435.AA | CAMK | 40-162 | 19 | 2.4e-30 | 94.44 | In-house | 129-325 (425) | Show / Hide |
Range on Protein: 40-162 Range on HMM: 129-325/425 Sequence Identity: 19% (39 aa) NNCYYIIS---ELCEYGDLCSHLFNFYDQYTF------------EIKL------EFLVEIISGIEALHKMGISHRDIKTDNILIALDKQTQH-------- ....|.. |.|. |.|. ||.. . . . .. . |.|... .|...| |||.| .|||. .. . DKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIF ----YYLKITDFGISSLKMEN--------------------------LQSKVGTVVYMA-PEILNSAN--------------YDYKVDIWSFGIIAF . .||.||| . .... .. .|| ||| ||.||. |..|.|.|| |.| . DWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY |
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Kinase | 9435.AA | ULK | 72-214 | 26 | 7.2e-30 | 101.5 | In-house | 133-317 (329) | Show / Hide |
Range on Protein: 72-214 Range on HMM: 133-317/329 Sequence Identity: 26% (50 aa) LEFLVEIISGIEALHKMGISHRDIKTDNILIALDKQTQ-------HYYLKITDFGISSLKMEN------LQSKV------GTVVYMAPEILN----SANY ..|. |..| .|||..| ||||| .|||| ... . .. |||.||| . ... ... | || ||||.||. .| IQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPY D-YKVDIWSFGIIAFEIMKNELYFPYDGDANTI-NQIRKHTKYQ--------RGLID----------NLEIENILELCLQKDPKQR . ||.||||.|.| .|. .. .| .. ..|.| ... .. |..... .||.|.|.| YDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDR |
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Kinase | 9435.AA | ULK | 72-214 | 28 | 2.3e-26 | 90.61 | In-house | 129-312 (324) | Show / Hide |
Range on Protein: 72-214 Range on HMM: 129-312/324 Sequence Identity: 28% (55 aa) LEFLVEIISGIEALHKMGISHRDIKTDNILIALDKQTQ-------HYYLKITDFGISSLKMEN------LQSKV------GTVVYMAPEILN----SANY ..|. |..| .|||..| ||||| .|||| ... . .. |||.||| . ..| .|. | || ||||.||. .| IQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPY D-YKVDIWSFGIIAFEIMKNELY--FPYDGDANTINQIRKHTKYQRG------LIDN---------------LEIENILELCLQKDPKQR . ||.||||.|.| .|. || |. .. .. ... . | .. .| | |..... .||.|.|.| YDYKCDIWSLGCIFYEM----LYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDR |
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Kinase | 9435.AA | LRRK | 48-171 | 32 | 1.1e-23 | 80.71 | In-house | 135-283 (351) | Show / Hide |
Range on Protein: 48-171 Range on HMM: 135-283/351 Sequence Identity: 32% (48 aa) ELCEYGDLCSHLFNFY-DQ-------YTFEIKLEFLVEIISGIEALHKMG--ISHRDIKTDNILI-ALDKQT------QHYYLKITDFGISS----LKME |. .||| ..|.|. |. . .||. ..| .|.| ||. | ||| |..|||. .. .|. || |||||. ..|. EYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMG NLQSKVGTVVYMAPEILNSA---NYDYKVDIWSFGIIAFEIMKNE-LYF . .||. ..|||||.. .|. |||. |||.| .|.. . ..| VAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPF |
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Kinase | 9435.AA | TyrKc | 9-224 | 21 | 4.3e-14 | 5.17 | SMART | 8-280 (280) | Show / Hide |
Range on Protein: 9-224 Range on HMM: 8-280/280 Sequence Identity: 21% (62 aa) GQGAFARVYIGMNCNGKEFVAIKQISSE-------------RI---------------VN-------NCYYIISELCEYGDLCSHLFNFYDQYTFEIKLE | ||| .|| |. . ||.| . .. .. ..|. |....||| ..| . .. . . .|. GEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLS FLVEIISGIEALHKMGISHRDIKTDNILIALDKQTQHYYLKITDFGISSLKMEN--------LQSK----VGT----VVYMAPEILNSANYDYKVDIWSF | . | .| | ||.... |||. . |.|.. .. ||.||| | . .| | . |||| .| . | |.||| FCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF GIIAFEIMKNELYFPYDG-------DANTINQIRKHTKYQRGLI--------DNLEIENILELCLQKDPKQRPEASLIKQRL |. .||. . || | .. |..... . |. .| . | . ||..|| | |.... GVCMWEIFTYG-QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 9435.AA | Pkinase_Tyr | 43-165 | 28 | 3.9e-08 | 28.18 | Pfam | 82-208 (270) | Show / Hide |
Range on Protein: 43-165 Range on HMM: 82-208/270 Sequence Identity: 28% (37 aa) YYIISELCEYGDLCSHLFNF---YDQYTFEIKLEFLVEIISGIEALHKMGISHRDIKTDNILIALDKQTQHYYLKITDFGISSLK--MENL-QSKVGTVV .||. |....||| ..| . .. | . .|.. ..| .| | |. ... |||. . |.|.. ||.||| . . .. ... |. . IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-----NNVVKICDFGLARDIYNDDYYYRKRGGGKL ---YMAPEILNSANYDYKVDIWSFGIIAFEIM |||| .| . | |.||||. .||. PIKWMAPECINYGKFTTKSDVWSFGVLMWEIF |
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Kinase | 9435.AA | CAMK | 7-38 | 22 | 8.2e-05 | 10.65 | In-house | 1-44 (425) | Show / Hide |
Range on Protein: 7-38 Range on HMM: 1-44/425 Sequence Identity: 22% (10 aa) LKGQGAFARVYIGMNCNGK------------EFVAIKQISSERI |.|.|. |. ... | . . |||| |. ... TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKL |
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Kinase | 9435.AA | Ciliate-B1 | 9-40 | 34 | 0.000108 | 12.49 | In-house | 8-42 (290) | Show / Hide |
Range on Protein: 9-40 Range on HMM: 8-42/290 Sequence Identity: 34% (12 aa) GQGAFARVYIGM---NCNGKEFVAIKQISSERIVN ||||. |..| | . ...||.|.|.. . | GQGAISQVFYGQFCQNQQCQQEVAVKKITKQTQDN |
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Kinase | 9435.AA | LRRK | 198-226 | 37 | 0.000111 | 12.47 | In-house | 323-351 (351) | Show / Hide |
Range on Protein: 198-226 Range on HMM: 323-351/351 Sequence Identity: 37% (11 aa) EIENILELCLQKDPKQRPEASLIKQRLMK . .. ...| | |||.|| .| | .|| MYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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Kinase | 9435.AA | ULK | 9-34 | 33 | 0.001757 | 8.29 | In-house | 8-37 (324) | Show / Hide |
Range on Protein: 9-34 Range on HMM: 8-37/324 Sequence Identity: 33% (10 aa) GQGAFA-RVYIGM-NCNG--KEFVAIKQIS |.|.|. || | . .. ...||.|.|. GKGSFGVKVYKGRNKKTNTQNQYVACKMID |
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Kinase | 9435.AA | STE | 9-34 | 31 | 0.002109 | 8.02 | In-house | 8-48 (359) | Show / Hide |
Range on Protein: 9-34 Range on HMM: 8-48/359 Sequence Identity: 31% (13 aa) GQGAFARVYIGMNCN---------------GKEFVAIKQIS |.||| || .|| . .|..||||.. GKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMN |
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Kinase | 9435.AA | Pkinase_Tyr | 198-224 | 37 | 0.008595 | 10.08 | Pfam | 244-270 (270) | Show / Hide |
Range on Protein: 198-224 Range on HMM: 244-270/270 Sequence Identity: 37% (10 aa) EIENILELCLQKDPKQRPEASLIKQRL || ... .| ..||..|| | | ..| EIYDLMKQCWHYDPEDRPTFSEIHEQL |
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Kinase | 9435.AA | ULK | 9-36 | 34 | 0.010585 | 5.36 | In-house | 8-39 (329) | Show / Hide |
Range on Protein: 9-36 Range on HMM: 8-39/329 Sequence Identity: 34% (11 aa) GQGAFARVYIGM-NCNG---KEFVAIKQISSE |.|.|..|| | . .. .| ||.|.|... GKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQ |
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Kinase | 9435.AA | Pkinase | 9-38 | 30 | 0.016532 | 9.95 | Pfam | 8-37 (293) | Show / Hide |
Range on Protein: 9-38 Range on HMM: 8-37/293 Sequence Identity: 30% (9 aa) GQGAFARVYIGMNCNGKEFVAIKQISSERI |.|.|..||.... . . ||.|.|. ... GSGSFGCVYKCHHKGTGKIVAVKIIKKRHE |
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Kinase | 9435.AA | ULK | 40-55 | 58 | 0.033052 | 3.61 | In-house | 91-107 (329) | Show / Hide |
Range on Protein: 40-55 Range on HMM: 91-107/329 Sequence Identity: 58% (10 aa) N-NCYYIISELCEYGDL | |..||| |.|. ||| NHNNIYIIMEYCNGGDL |
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Kinase | 9435.AA | ULK | 40-55 | 58 | 0.051962 | 3.0 | In-house | 88-104 (324) | Show / Hide |
Range on Protein: 40-55 Range on HMM: 88-104/324 Sequence Identity: 58% (10 aa) N-NCYYIISELCEYGDL | | .||| |.|. ||| NHNNIYIIMEYCNGGDL |