Gene 20855 (Tetrahymena)

20855

Species: Tetrahymena
Alias: 3700.m00248, 20855, PreTt20855, 520, 12.m00529, TTHERM_00151970
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-B1

Sequence

Name Sequence Type Origin Length Description Download
20855.AA Protein None 3349 None Fasta, JSON
20855.kin_dom Protein Kinase Domain None 264 None Fasta, JSON
20855.NA RNA None 10050 None Fasta, JSON

Protein domain

Protein domains of 20855.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20855.AA Ciliate-B1 17-273 38 2.4e-82 279.86 In-house 1-290 (290) Show / Hide 
Range on Protein: 17-273
Range on HMM: 1-290/290
Sequence Identity: 38% (113 aa)

YFILGKINEGAISEVYKAQ---AQSTQEFVAIKILNRFRRMDN--MPNIYFENEIEITQKLANMD---------YKSANIANIIEVFTINQGQSYMIVQE
|   ..|  ||||.|...|   .| .|..||.|..   .  ||    | | ..|.||.|.|.             .  .| ||..|.  .  |.| |. |
YQQNNVIGQGAISQVFYGQFCQNQQCQQEVAVKKITK-QTQDNDKQQNKYYQQELEIIQCLIKKMNNNKISCQSSPCDHICNIYDVIQCQ--QQYYIIME

YCQYGDLYQNMFVNQGKLDERTKLIYCILICEGLVYLHNNNIVHRDLKPENIMIA---------YQNNQYRLKITDYGLCKQGEE-LFNSFVGTITYMAP
||..||||.  . .. ..    .|. || | .|. |||...|.||||||||| |.         .|.|.| .||||.|. |...|  ..|.||||.||||
YCEQGDLYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEYMMQSCVGTINYMAP

EILL-NQQYTKKVDIWSMGCIMDEIVRETTTFD--GESFQQIQNDIINYRGYTYNNFLS----QIIQK-----CLVVDPKNRIDSTQLQQELR
|||  ||||.||||||| |||| ||      |   | . |.. | |.|.  ..|..  .    |.||      || .||.||| . |....| 
EILNFNQQYDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIRNFQCCDYQCHFQNNIYQEIQQLIQKYCLQPDPENRITIDQIIDRLM
Kinase 20855.AA S_TKc 17-276 30 7.1e-65 222.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-231/231
Sequence Identity: 30% (84 aa)

YFILGKINEGAISEVYKAQAQSTQEFVAIKILNRFRRMDNMPNIYFENEIEITQKLANMDYKSANIANIIEVFTINQGQSYMIVQEYCQY--GDLYQNMF
| || || .|| ..|||..  .|.. |||||..          . ...||.| .|      .  || ....||     ... .| |||    |||.. . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK------HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIK

VNQGK-----LDERTKLIYCILICEGLVYLHNNNIVHRDLKPENIMIAYQNNQYRLKITDYGLCKQGEELFNSFVGTITYMAPEILLNQQYTK-KVDIWS
 ....     ..| .   |.  ||..| |.|...|.|||||||||..       ..||.| ||..|     ..|.||  |||||.|   .|.| |.|.||
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWS

MGCIMDEIVRETTTFDGESFQQIQNDIINYRGYTYNNFLSQIIQKCLVVDPKNRIDSTQLQQ-----ELRQLL
 |||. | .   . |.    |.. . |          ... .|.|||..||..|.   .. |      . . .
CGCILYEMLCGYPPFP--QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20855.AA Pkinase 17-272 28 2e-56 198.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 17-272
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

YFILGKINEGAISEVYKAQAQSTQEFVAIKILNRFRRMDNMPNIYFE-NEIEITQKLANMDYKSANIANIIEVFTINQGQSYMIVQEYCQYG----DLYQ
| |..|| .|. ..|||.. ..|.. ||.||... .. .... . .  .||.| ..| |    . ||  ....|.   .... .|.|||. |    ||. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N----HPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFD

NMF-VNQGKL--DERTKLIYCILICEGLVYLHNNNIVHRDLKPENIMIAYQNNQY--RLKITDYGLCKQ---GEELFNSFVGTITYMAPEILL-NQQYTK
 .   ..|..  .|..   |.  |..|| |.|...|.|||||||||.|  .|..   ..||.| ||.||     . ...|.||. |||||... .| |..
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGP

KVDIWSMGCIMDEIVRETTTFDGE----------SFQQIQN-DIINYRGYTYN-------------------NFLSQIIQKCLVVDPKNRIDSTQLQQE-
|||.||.|||. | .   . |.|.           ...|   ..   . ....                     . ..| .|| .||| |.  .|. |  
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-L
 .
WF
Kinase 20855.AA CAMK 22-213 21 1.1e-48 154.65 In-house 1-324 (425) Show / Hide 
Range on Protein: 22-213
Range on HMM: 1-324/425
Sequence Identity: 21% (69 aa)

KINEGAISEVYKAQAQSTQ------------EFVAIKILNRFRRMDNM-------------------------PNIYFENEIEITQKLANMD--YKSANI
.. .|. ..|....  .|.            . |||||... .  |..                             ...|||| .|| . .   .  ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ANIIEVFT------------INQGQ------SYMIVQ---EYCQYGDL--Y-QNMFVNQ---------------GKLDERTKLIYCILICEGLVYLHNNN
 ...||.               . |       . .|    |||. |.|  .  .. | .               |...||    |   ||... |.|..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKPENIMIAYQN--------------NQYRLKITDYGLCKQGEE--------------------------LFNSFVGTITYMA-PEILLNQQ---
|||||||||||.. . |              |.. .||.| |. .. ..                          ... |.||  ||| ||.|. ..   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YTKKVDIWSMGCIM
           |..|.|.||.|.|.
MQNATDEEKPYYGPKCDMWSCGVIL
Kinase 20855.AA Ciliate-E2 17-270 22 1.2e-48 165.06 In-house 1-361 (365) Show / Hide 
Range on Protein: 17-270
Range on HMM: 1-361/365
Sequence Identity: 22% (85 aa)

YFILGKINEGAISEVYKAQAQSTQEFVAIKILNRFR------------------RMDNMPNIYFENEIEITQKLANMDYK------------SANIANII
| .. || .|. . |||..  ..|. .|||| . .                   .| .   .....|| | ...   .||            . || ...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMY

EVFTINQGQSYMIVQEYCQYGDLYQ------NMFVNQ----GKLDERTKLIYCILICE---------------GLVYLHNNN-IVHRDLKPENIMIAYQN
|.|  .. ... .| ||||.|||..        . ..    ....|.  . .   |..               .| |||..| |.|||.|||||..    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NQYRLKITDYGLCKQ----------------------------------GEELFNSFVGTITYMAPEILLNQQ---------YTKKVDIWSMGCIMDEIV
    .||.| ||.|.                                   ...||...||  ||||||| ...         |..|.||||.|.|. | .
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

RETTTFDGESFQQIQNDIINYRGY-----------------TYNNFLSQIIQK----CLVVDPKNRID-STQLQQ
   . |    .|||..  |... .                    .   ..|.|    .|..||..||.   |. .
FGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 20855.AA ULK 17-264 24 2.2e-46 159.97 In-house 1-319 (329) Show / Hide 
Range on Protein: 17-264
Range on HMM: 1-319/329
Sequence Identity: 24% (79 aa)

YFILGKINEGAISEVYKAQAQST----QEFVAIKILN--RFRRMDNMPN-----IYFENEIEITQKLA---NMDYKSANIANIIEVFTINQGQSYMIVQE
| .  .. .|.   |||.  . |    .| ||.|..    ...  |. .       ..|||.| .||    .  ..  ||   ...|   .   . |..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCQYGDLYQNMFVNQG---------KLDERTKLIYCILICEGLVYLHNNNIVHRDLKPENIMIAYQNNQ---------YRLKITDYGLCKQ-GEE-----
||. ||| | .  |..         .| |   ..... |..|. .|| .||.|||.||.||.|   . .         ..|||.| |..|.  ..     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LFNSFV------GTITYMAPEILL----NQQYT-KKVDIWSMGCIMDEIVRETTTFDGESFQQIQ-----NDI--------------INYR----GYTYN
.. ..|      ||  ||||.||     ...|. .|.||||.|||. |..   . | .  |.. .     . |              ....    ...  
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

NFLSQIIQKCLVVDPKNRID
. . ..|...|..|.| ||.
PECKDLIRRMLQYDEKDRIS
Kinase 20855.AA ULK 17-264 24 3.6e-44 153.05 In-house 1-314 (324) Show / Hide 
Range on Protein: 17-264
Range on HMM: 1-314/324
Sequence Identity: 24% (79 aa)

YFILGKINEGAIS-EVYKAQ-AQS--TQEFVAIKILN--RFRRMDNMPN-----IYFENEIEITQKLANMDYKSAN--IANIIEVFTINQGQSYMIVQEY
| .  .. .|.    |||.   ..  ....||.|. .   ..   |. .       ..|||.| .|| .   |. |  |   ...|   .   . |..||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKEL--KHPNHHIVKLYDWFETSNHNNIYIIMEY

CQYGDLYQNMFVNQGKLDERT----------KLIYCILICEGLVYLHNNNIVHRDLKPENIMIAYQNNQ---------YRLKITDYGLCKQ-GE-----E
|. ||| ..   ...|| | |           ..... ||.|. .||..||.|||.||.||.|   . .         ..|||.| |..|.  .      
CNGGDL-EQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ

LFNSFV------GTITYMAPEILL----NQQYT-KKVDIWSMGCIMDEIVRETTTFDGESFQQIQN---DI----------INYRGYTYN---------N
.. ..|      ||  ||||.||     ...|. .|.||||.|||. |..   . | .  |.. ..   .           |...   ..         .
MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISP

FLSQIIQKCLVVDPKNRID
 . ..|...|..|.| ||.
ECKDLIRRMLQYDEKDRIS
Kinase 20855.AA Ciliate-E2-Unclassified 17-270 22 4.8e-44 150.67 In-house 1-348 (352) Show / Hide 
Range on Protein: 17-270
Range on HMM: 1-348/352
Sequence Identity: 22% (78 aa)

YFILGKINEGAISEVYKAQAQSTQEFV-----AIKILNRFRRMDNMPNIYFENEIEITQKLANMDYKS----------ANIANIIEVFTINQGQSY---M
| |. .|..|. ..|||.|  ... ..     ..|| .. ..  .  .  . ||... ... . .  .           |. ... |  . . |..    
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

IVQEYCQYGDLYQNMFVNQG----------------KLDERTKL-----IYCILICEGLVYLHNNN-IVHRDLKPENIMIAYQNNQYRLKITDYGLCKQ-
|| |||..||| | .  . .                ...|.  .      |.  |..|| ||| .| |.|||.|||||..  ... |..||.|.|..|. 
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

-----------------GEELFNSFVGTITYM----APEILLNQQYT----KKVDIWSMGCIMDEIVRETTTFDGESFQQ----------------IQND
                  ......|.||. ||    |||.| .|.|     .|.||||.|.|. |..  .  |....  |                ....
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

IIN--YRGYTYNN-------------FLSQIIQKCLVVDPKNRIDSTQLQQ
|..  .    ...             |.....||.|...|..||.  |. .
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase 20855.AA TKL 23-272 16 5.2e-42 145.9 In-house 1-364 (364) Show / Hide 
Range on Protein: 23-272
Range on HMM: 1-364/364
Sequence Identity: 16% (61 aa)

INEGAISEVYKAQAQSTQ--------EFVAIKILNRFRRMD-------------------NMPNIYFENEIEITQKLANMDYKSANIANIIEVFTINQG-
| .|. .||||.. . .         . ||.|....   .                    |.| . .... |. . .     .  ||  .. . . ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------QS---YMIVQEYCQYGDLYQNMFVNQGKLDERTKLIYCILICEGLVYLHNNN--------IVHRDLKPENIMIAYQNN-----------QYRL
       ..   ..|| |||. |.|. ..           ..  .. |. |. |||..|        |.|||||..||..   ..           ....
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KITDYGLCK----------------------QGEELFNSFVGTITYMAPEILLNQ----------------QYTKKVDIWSMGCIMDEIVRETTTFDGES
||.|.||..                      ....  .. .||. .||||.| .|                .|..|.|..|.| .. ||.   . .... 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

FQQIQ-----NDIINYRGYTY------------------NNF---LSQIIQKCLVVDPKNRIDSTQLQQEL
. ...      ... ....                    ...   .....|.|   ||..|   ... ..|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 20855.AA CMGC 17-213 22 2.7e-40 129.49 In-house 1-325 (513) Show / Hide 
Range on Protein: 17-213
Range on HMM: 1-325/513
Sequence Identity: 22% (74 aa)

YFILGKINEGAISEVYKAQA--------------QSTQEFVAIKILNRFRRMDN-------MPNIYF--ENEIEITQKLANMD------------YKSAN
| |..|| ||. ..|||..                 |.|.||||.. .   ...        ... .    ||.| ..| . .             .  |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IANIIEVFTINQ---------------GQSYMIVQEYCQYGDLYQNMFVNQG--------KLDERT----------KLIYCIL--------ICEGLV--Y
| .....|. ..                ..  .| ||... |||| .  ||.        .|.|             .| ...        |..||   |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHNNN--IVHRDLKPENIMIAYQNNQ-----------------YRLKITDYGLCKQGEEL------------------------FNSFVGTITYMAPEIL
.| ..  |.|||||||||.|  ..                   .|||| | ||... ..                         . . | |  | |||||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNQQ----------YTKKVDIWSMGCIM
|. .          ||...|.|| |||.
LGWKHYTNHNYSMHYTTPIDMWSVGCIF
Kinase 20855.AA STE 18-268 20 1.4e-39 137.45 In-house 1-351 (359) Show / Hide 
Range on Protein: 18-268
Range on HMM: 1-351/359
Sequence Identity: 20% (73 aa)

FIL-GKINEGAISEVYKAQAQS---------------TQEFVAIKILN------------RFRRMDNMPNIYFENEIEITQKLANMDYK---SANIANII
. . .|| .||  .||||                   |.|..|||..|              . .    |.  |.. .| . .  |      . || . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-E--LENKNHEEMQQILKEIKIMKKCNHMHPNIVKYY

EVFTIN-----QGQSYMIVQEYCQYGDLY---QNMFVNQGKLD----------ERTKLIYCILICEG-LVYLHNNNIVHRDLKPENIMIAYQNNQYRLKI
  .  .     ....  |. ||. .| |    .. .  .. |.          |    ..|  |..| | |||...|.|||.|| ||..         |.
GCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKL

TDYGLCKQGEE-------------------LFNSFVGTITYMAPEILLN------QQYTKKVDIWSMGCIM-------DEIVRETTTFDGESFQQIQ---
.| |.|.| ..                     |.||||  .||||....      ..|. |.|||| || .        .   .. .     ... .   
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ

----------NDIINYRG------------------YTYNNFLSQIIQKCLVVDPKNRIDSTQL
          ...                         .   . . |.|||. ||..| ...||
QQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQL
Kinase 20855.AA CAMK-Unique 99-213 27 3.8e-36 116.66 In-house 112-283 (363) Show / Hide 
Range on Protein: 99-213
Range on HMM: 112-283/363
Sequence Identity: 27% (47 aa)

IVQEYCQYGDLYQNMFVN-------------------QGKLDE--RTKLIYCILICEGLVYLHNNNIVHRDLKPENIMIAYQNN-------------QYR
||.|||| |||.. .  .                   ||.. |  .  . ..  . . . |.|...|||||||.||||. |  .             ...
IVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWH

LKITDYGLCKQGEELFNS-----FVGTITYMAP--------------EILLNQQYTKKV----DIWSMGCIM
.|..|.|||.. ..   .     ..||. ||||              |.. .| |  ..    ||||.| ||
IKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIM
Kinase 20855.AA TyrKc 17-272 24 7.8e-16 33.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-272
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

YFILGKINEGAISEVYKAQAQSTQEFVAIKILNRFRRMDNMPNIYFENEIEITQKL--ANMDYKSANIANIIEVFTINQG-----QSYMIVQEYCQYGDL
   . |. |||  ||||...    . ||.| |.            | .|..|  ||   .      || ... | |  ..     . .||| ||. .|||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHP-----NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

YQNMFVNQGKLDERTKLIYCILICEGLVYLHNNNIVHRDLKPENIMIAYQNNQYRLKITDYGLCKQGE---------ELFNS-------FVGTITYMAPE
 .    ...||  ...| .|. |..|  ||| .|..||||   |.... ..   . ||.| ||.. ..         .   .       ..  |  ||||
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

ILLNQQYTKKVDIWSMGCIMDEIVRETTTFDGE------SFQQIQNDIINY-RGYTYNN-----------FLSQIIQKCLVVDPKNRIDSTQLQQEL
 .    .| | |.|| |  | ||     .   .      | |.. ... .  |     |            . ||...|   ||..|   ... ...
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 20855.AA Pkinase_Tyr 93-149 33 6.6e-12 40.94 Pfam 76-137 (270) Show / Hide 
Range on Protein: 93-149
Range on HMM: 76-137/270
Sequence Identity: 33% (21 aa)

QGQS--YMIVQEYCQYGDLYQNMFVN---QGKLDERTKLIYCILICEGLVYLHNNNIVHRDL
||..  ..|| ||...|||.     .   ...|.  ..| .|. |..|. ||...|..||||
QGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 20855.AA CAMK 251-270 40 0.014708 3.26 In-house 402-421 (425) Show / Hide 
Range on Protein: 251-270
Range on HMM: 402-421/425
Sequence Identity: 40% (8 aa)

IQKCLVVDPKNRIDSTQLQQ
|.|.|.|||..|.  .|  .
IRKMLQVDPEKRMTIEQCLN
Kinase 20855.AA CAMK-Unique 249-270 27 0.017181 3.81 In-house 338-359 (363) Show / Hide 
Range on Protein: 249-270
Range on HMM: 338-359/363
Sequence Identity: 27% (6 aa)

QIIQKCLVVDPKNRIDSTQLQQ
.....|..|||. |. . .| .
DFVKCCMTVDPDHRWSAKELLE
Kinase 20855.AA Pkinase_Tyr 190-208 47 0.313486 4.79 Pfam 181-199 (270) Show / Hide 
Range on Protein: 190-208
Range on HMM: 181-199/270
Sequence Identity: 47% (9 aa)

MAPEILLNQQYTKKVDIWS
|||| . .  .| | |.||
MAPECINYGKFTTKSDVWS
S_TKc 20855.AA S_TKc 787-1047 28 8.4e-71 242.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 787-1047
Range on HMM: 1-231/231
Sequence Identity: 28% (78 aa)

NYFQKVVGIGNISKVFKAVNLQTCEYVAIKVISKIRLGDQNDNLYYEREILILKKLMKNENQHQNIIKIFEIFESNNCQFVVFELLTD--GNLIEYLLSK
  . ...| |  .||.|...  | ..||||.|.             .||| ||||      .| ||.|....|.. .. ..|.|..    |.| .|. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

DMN-----IDEIQALNIMYQVTKAICHLHKLKIMHRDIKPENILLKVDSQHITVKLIDFGVSSQNENSIADSMVGSISYISKEVLLHQKMYNE-KCDVWS
  .     ..| .|  .|||. .|. ..|...|.|||.|||||||       ..|..|||.. |      ....|.  |.. |||     |.  |||.||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWS

LGCLFHELITGNQLFCGETIKQIYDQIMSFRQYDQNSKWSYIISKCLEVDIEKRISSKELLD----LLQSEYN
.||.. |...|  .|.  ........|.        .    .|.|||..| |||..  |.|       . .. 
CGCILYEMLCGYPPFP--QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20855.AA Pkinase 789-1042 25 2.4e-58 204.92 Pfam 3-293 (293) Show / Hide 
Range on Protein: 789-1042
Range on HMM: 3-293/293
Sequence Identity: 25% (75 aa)

FQKVVGIGNISKVFKAVNLQTCEYVAIKVISKIRLGDQNDNLYYE-REILILKKLMKNENQHQNIIKIFEIFESNNCQFVVFELLTDG----NLIEYLL-
. ...| |. ..|.|...  |.. ||.|.|.| .  .. |      .|| |.|.|      | ||......||...   .|.|..  |     | .|.  
IGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

SKDMNI--DEIQALNIMYQVTKAICHLHKLKIMHRDIKPENILLKVDSQHI--TVKLIDFGVSS---QNENSIADSMVGSISYISKEVLLHQKMYNEKCD
... ..  .| .. ..|||. ... ..|. .|.|||.||||||.. .  ||  .||..|||..       || ... .|.. |.. ||......|  |.|
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWSLGCLFHELITGNQLFCGE------TIKQIYDQIMS-------------------------FRQYDQNSKWSYIISKCLEVDIEKRISSKELLDL--L
.||.||...|...|. .|.|.      . .|....||.                         .. . ...    .|..||..| .||.. ...|    .
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 20855.AA CAMK 792-1040 19 2.7e-58 186.11 In-house 1-421 (425) Show / Hide 
Range on Protein: 792-1040
Range on HMM: 1-421/425
Sequence Identity: 19% (83 aa)

VVGIGNISKVFKAVNL-QTC-----------EYVAIKVISKIRLGD-------------------------QNDNLYYEREILILKKLMKNEN--QHQNI
. | |. .||.....   |.           . ||||.|.| .| |                         ..|    .||| |.||| ...|  .| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKIFEIFES-------------------NNCQFVVF---ELLTDG----NLIEYLLSK--------------DMNIDEIQALNIMYQVTKAICHLHKLKI
||..|..|.                   ... . |.   |. . |     | .|. ..              .  ..| .|  .. |.  |. ..|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

MHRDIKPENILLKVDS--------------QHITVKLIDFGVSSQ---NENSI----------------------ADSMVGSISYIS-KEVLLH------
.|||.|||||||  ..              .  ..|.|||| . .   .||.                          ..|. .|..  |||.       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------QKMYNEKCDVWSLGCLFHELITGNQLFCGE-------------TIKQIYDQIMSFR-QYDQNS--------------------------KWSY
       .. |..|||.||.|..   . .|   | |.             ...... .||. . ...                                 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

IISKCLEVDIEKRISSKELLD
 |.|.|.|| |||.. .. |.
LIRKMLQVDPEKRMTIEQCLN
Kinase 20855.AA Ciliate-B1 787-1043 30 3e-58 199.81 In-house 1-290 (290) Show / Hide 
Range on Protein: 787-1043
Range on HMM: 1-290/290
Sequence Identity: 30% (90 aa)

NYFQKVVGIGNISKVFKAV---NLQTCEYVAIKVISKIRL-GDQNDNLYYEREILILKKLMKNENQ---------HQNIIKIFEIFESNNCQFVVFELLT
.  ..| | | ||.||..    | |. . ||.|.|.|  . .| . |.||. |. |...| |..|           ..|  |..... .   ... |.  
YQQNNVIGQGAISQVFYGQFCQNQQCQQEVAVKKITKQTQDNDKQQNKYYQQELEIIQCLIKKMNNNKISCQSSPCDHICNIYDVIQCQQQYYIIMEYCE

DGNLIEYLLSKDMNIDEIQALNIMYQVTKAICHLHKLKIMHRDIKPENILLK----------VDSQHITVKLIDFGVSSQNENSIADSMVGSISYISKEV
.|.|  |.. .  |   . .|... | .|.|  ||| ||.|||.||||||.            . ..| .|  ||| |.. .. .  | || | |.. |.
QGDLYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQNHYI-FKITDFGISKMQQEYMMQSCVGTINYMAPEI

LLHQKMYNEKCDVWSLGCLFHELITGNQLFC--GETIKQIYDQIMSFRQYDQNSKWS----YIISK-----CLEVDIEKRISSKELLDLLQ
|  .. |  | | ||.||. .|.||. ||||  | |....  || .|  .|...  .    ..|.      ||..| |.||..  ..| | 
LNFNQQYDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIRNFQCCDYQCHFQNNIYQEIQQLIQKYCLQPDPENRITIDQIIDRLM
Kinase 20855.AA Ciliate-E2 787-1040 21 3.7e-55 187.78 In-house 1-361 (365) Show / Hide 
Range on Protein: 787-1040
Range on HMM: 1-361/365
Sequence Identity: 21% (81 aa)

NYFQKVVGIGNISKVFKAVNLQTCEYVAIKVISKIRLGDQN------DNLYYEREIL-----ILKKLMKNENQ-------------------HQNIIKIF
  |.|. | || ..|.|. . .. . .|||.|    .  ..      .. .|. .|.     . .| ......                   | ||||..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

EIFE--SNNCQFVVFELLTDGNLIEYLLSKDMN----------IDEIQALNIMYQVTK---------------AICHLHKLK-IMHRDIKPENILLKVDS
| |.  ..|. . |.|..  |.| .|. ... .          ..| ....||.|...               |. .||. . |.||||||||||.    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

QHITVKLIDFGVSSQNENS---------------------------------IADSMVGSISYISKEVLLH--------QKMYNEKCDVWSLGCLFHELI
    .|.|||| | .. ..                                 .... .|.  | . |.|          || |..|||.||||....|..
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

TGNQLFCGETIKQIYDQIMSFR----------------QYDQNSKW-SYIISK----CLEVDIEKRIS-SKELLD
.|.  |    ..|| ..  .|.                 ... |.    .|.|    .|..| ||||.  ...|.
FGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 20855.AA Ciliate-E2-Unclassified 789-1039 20 1.8e-46 159.19 In-house 3-347 (352) Show / Hide 
Range on Protein: 789-1039
Range on HMM: 3-347/352
Sequence Identity: 20% (71 aa)

FQKVVGIGNISKVFKAVNLQTCEYV-----AIKVISKIRLGDQNDNLYYEREILILK-----------KLMKN---ENQHQNIIKIFEIFESNNCQFVVF
..|. | |. .||.|... ..  ..     ..|.... ..  .| .  . .|.....           |.|..    ..| .|.| |..|.. .. . | 
IIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

ELLTDGNLIEYLLSKDM----------------NIDEIQAL-----NIMYQVTKAICHLHKLK-IMHRDIKPENILLKVDSQHITVKLIDFGVSS-----
|.. .|.|..|. ..                   ..| ||.     ....|. .....||. . | ||||||||||.. . .   .|.|||| |.     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

------------QNENSIADSMVGSISYI----SKEVLLHQKMYN---EKCDVWSLGCLFHELITGNQLFCGETIKQ----------------IYDQIMS
            .. . ......|...|.    . |||  |. ..   .|||.||||....|...|.  | ... .|                .|..|. 
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

FRQYDQNSKW-----------SYIIS----KCLEVDIEKRISSKELL
  .. ....|             .|.    |.|.....|||. ...|
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase 20855.AA ULK 787-1034 25 1.5e-43 149.92 In-house 1-319 (329) Show / Hide 
Range on Protein: 787-1034
Range on HMM: 1-319/329
Sequence Identity: 25% (82 aa)

NYFQKVVGIGNISKVFKAVNLQT----CEYVAIKVISKIRLGDQNDNLY-------YEREILILKKLM---KNENQHQNIIKIFEIFESN--NCQFVVFE
 .  .. | |   ||.|. | .|     |.||.|.|.|  .  .|.. .        ..|| |.|||    ...|.|.||.| ...||.   |. . ..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LLTDGNLIEYLLSKDM---------NIDEIQALNIMYQVTKAICHLHKLKIMHRDIKPENILLKVDSQH---------ITVKLIDFGVSSQNENS-----
.  .|.| .|.  .           .. | .|.....|   .  .||| .|.||||||.|||.. . ..         ...|. ||| . . .|.     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

IADSMV------GSISYISKEVLL-H--QKMYN-EKCDVWSLGCLFHELITGNQLFCGETIKQIYDQIM-SFRQY---------DQNSKWS---------
.. ..|      |.  | . ..|  .  || |.  |||.|||||.|.|...|   |..  . . |.||. . ...         .|. ..          
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

----YIISKCLEVDIEKRIS
     .|...|..| ..|||
PECKDLIRRMLQYDEKDRIS
Kinase 20855.AA CAMK-Unique 789-1040 19 6.6e-43 139.35 In-house 3-359 (363) Show / Hide 
Range on Protein: 789-1040
Range on HMM: 3-359/363
Sequence Identity: 19% (69 aa)

FQKVVGIGNISKVFKAVNLQTCEYVAIKVISKIRLGDQNDNL-----------------YYEREILILKKLMKNENQHQNIIKIFEI----FESNN----
. ...| || ..|... .  |    |.|.. | . |     .                  ..||. |.|..      |.||||....    |.  .    
MHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMV-----DHPNIIKLYDWNNPIFCDRKYPLC

-----------CQFVVFELLTDGNLIEYLLSK-------------------DMNIDE--IQALNIMYQVTKAICHLHKLKIMHRDIKPENILLKVDSQ--
             . | |....| | .....                         |   ....|| ... |. ..|...| |||.|.|||...   .  
DLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDN

-----------HITVKLIDFGVSSQNENSIAD----SMVGSISYISK--------------EVLLHQKMYNEKC----DVWSLGCLFHELITGNQLFCGE
              .||.||| . . ......    .|.|...|..               ||.  |. | ..|    | |||| . .....|.  | .|
NHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQC-YDQQCSPASDIWSLGVIMYYMLCGCPPFDCE

TIK--------QIYDQIMSFRQ-YDQNSKWSY----------IISKCLEVDIEKRISSKELLD
...         |.. |.. .  .  ...|.           .. .|..||  .|.|.||||.
CEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLE
Kinase 20855.AA ULK 787-1034 25 1.3e-41 144.56 In-house 1-314 (324) Show / Hide 
Range on Protein: 787-1034
Range on HMM: 1-314/324
Sequence Identity: 25% (81 aa)

NYFQKVVGIGNIS-KVFKAVNLQT---CEYVAIKVISKIRLGDQNDN-------LYYEREILILKKLM--KNENQHQNIIKIFEIFESN--NCQFVVFEL
 .  .. | |    ||.|. | .|    .|||.|.|.|  . ... .          ..|| |.|||   |..| | .|.| ...||.   |  . ..|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPN-H-HIVKLYDWFETSNHNNIYIIMEY

LTDGNLIEYLLSKDM--------NIDEIQALNIMYQVTKAICHLHKLKIMHRDIKPENILLKVDSQH---------ITVKLIDFGVSSQNEN-----SIA
  .|.| .|.  .          .. | .|.....|   .  .||| .|.||||||.|||.. . ..         ...|. ||| . . .|      . 
CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMC

DSMV------GSISYISKEVLL-H--QKMYN-EKCDVWSLGCLFHELITGN-----QLFCGETIK-------------QIYDQIMSFRQ--YDQN--SKW
 ..|      |.  | . ..|  .  || |.  |||.|||||.|.|...|      . |. . ..             .|..|   |.   .|..  .. 
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC

SYIISKCLEVDIEKRIS
  .|...|..| ..|||
KDLIRRMLQYDEKDRIS
Kinase 20855.AA STE 787-1039 23 7.2e-41 142.06 In-house 1-352 (359) Show / Hide 
Range on Protein: 787-1039
Range on HMM: 1-352/359
Sequence Identity: 23% (85 aa)

NYFQKVVGIGNISKVFKAVNLQTC---------------EYVAIKVISKIRLG----------DQNDNLYYEREILILKKLMKNENQ-HQNIIKIFEIFE
  .....| |.  .|.||.|  .|               |..|||.... .            ..|.|   . .||   |.||. |. |.||.| .  ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SN-------NCQFVVFELLTDGNLIEYLLSK-----DMN--------IDEIQALNIMYQVTKA-ICHLHKLKIMHRDIKPENILLKVDSQHITVKLIDFG
 .       .  ... |..  | | . . .|     ..|        ..| |   | .|. |.   .||...|.|||||| ||||        |||.|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFG

VSSQNENSIA--------------D----SMVGSISYISKEVLLH-----QKMYNEKCDVWSLGCLFHELITGNQLFCG-ETIKQIYDQIMSFRQYD---
|..| ..|.|              .    ..||.  . . ||..       | |..|||.|||||.  |..||.  ..     . ..  ..... ..   
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------------QN------------------SKWSY----IISKCLEVDIEKRISSKELL
            ..                  .|||      |.|||. | .|| ....||
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLL
Kinase 20855.AA CMGC 791-1005 20 2.2e-40 129.8 In-house 5-363 (513) Show / Hide 
Range on Protein: 791-1005
Range on HMM: 5-363/513
Sequence Identity: 20% (75 aa)

KVVGIGNISKVFKAVNLQTC--------------EYVAIKVISKIRLGDQNDNL----------YYEREILILKKLMKNE------------NQHQNIIK
|..| |  ..|.|... .|               |.|||| |..    .... .             ||| |||.| ||.            ..| ||.|
KKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF--YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVK

IFEIFESNN-----------------CQFVVFELLTDGNLIEYLLSKD--------MNIDEIQ------------ALNIM------YQVTKAIC--HLHK
...|| ..|                 . . |||.. | .| .|. ..         |. .| .              ..|      ||. ...   ..|.
LYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYM-DHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHS

LK--IMHRDIKPENILLKVDSQH-----------------ITVKLIDFGVSSQNENS-----------------------IADSMVGSISYISKEVLLHQ
 .  |.|||.||||||.  . .                   ..|..||| . . ..                           . | .  | . |.||  
HWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGW

KMYN---------EKCDVWSLGCLFHELITG--------NQLFCGETIKQI--------YDQI
| |.         ...|.||.|| | |..||          || |.. . .        .||.
KHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQL
Kinase 20855.AA TKL 793-1042 16 1.2e-33 118.16 In-house 1-364 (364) Show / Hide 
Range on Protein: 793-1042
Range on HMM: 1-364/364
Sequence Identity: 16% (61 aa)

VGIGNISKVFKAVNLQ--------TCEYVAIKVISKIRLGDQNDNL-----------------YYEREILILKKLMKNENQ--HQNIIKIFEIFESNNC-
.| |  ..|.|..  .        |.. ||.|....      ..|.                  ....   ... ..  ..  |.||...  .  ...| 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------QFVVFELLTDGNLIEYLLSKDMNIDEIQALNIMYQVTKAICHLHKLK--------IMHRDIKPENILLKVDSQ-----------HITV
             . | |.   |.| .||.         | ....... .....||  .        | |||.|..|||.. . .           ....
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLIDFGVSSQNENSIADSM---------------------VGSISYISKEVLLHQ---------------KMYNEKCDVWSLGCLFHELITGNQLFCGET
|. ||| |  ...|  ...                     .|.. . . |||  |               . |.|||||.| | .. |..|. .      
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------

IKQIYDQIMSFRQY---------DQNSK--------------------------WSYIISKCLEVDIEKRISSKELLDLL
    |...... ..          ....                          .. .. .| . | ||| | .|.|. |
---PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 20855.AA TyrKc 789-1042 20 1.1e-14 14.67 SMART 3-280 (280) Show / Hide 
Range on Protein: 789-1042
Range on HMM: 3-280/280
Sequence Identity: 20% (59 aa)

FQKVVGIGNISKVFKAVNLQTCEYVAIKVISKIRLGDQNDNLYYEREILILKKL-MKNENQHQNIIKIFEIFESN-------NCQFVVFELLTDGNLIEY
. |. | |.  .|.|..     . ||.|.. .             ||. |..||      .|.||.... .  .           ..|.|.   |.| .|
LGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGG----HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LLSKDMNIDEIQALNIMYQVTKAICHLHKLKIMHRDIKPENILLKVDSQHITVKLIDFGVSSQNENS-------IADSM----VGS----ISYISKEVLL
| ..  ..   . |....|. .   .||. .. |||.   |.|.. .    |||  ||| |   ..           ..     |     |   . |.. 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

HQKMYNEKCDVWSLGCLFHELIT-GNQLFCG-----ETIKQIYDQIMSF---RQYDQ---------NSKWSYIISKCLEVDIEKRISSKELLDLL
  .....| |||| | .  |. | | |   |      . .... ....    .| .           ..   |...| . | |.| . .|. ...
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 20855.AA Pkinase_Tyr 866-917 23 5.9e-05 17.41 Pfam 83-137 (270) Show / Hide 
Range on Protein: 866-917
Range on HMM: 83-137/270
Sequence Identity: 23% (13 aa)

FVVFELLTDGNLIEYLLSK---DMNIDEIQALNIMYQVTKAICHLHKLKIMHRDI
..|.|.   |.| .|| ..   . ...  . |.. .|. |.  .|.  .. |||.
YIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 20855.AA Pkinase_Tyr 962-988 40 0.179515 5.61 Pfam 184-209 (270) Show / Hide 
Range on Protein: 962-988
Range on HMM: 184-209/270
Sequence Identity: 40% (11 aa)

EVLLHQKMYNEKCDVWSLGCLFHELIT
|.. . | ...| |||| | |  |..|
ECINYGK-FTTKSDVWSFGVLMWEIFT
Kinase 20855.AA Ciliate-B1 1830-2093 47 2.1e-167 562.47 In-house 1-290 (290) Show / Hide 
Range on Protein: 1830-2093
Range on HMM: 1-290/290
Sequence Identity: 47% (137 aa)

NQQQNQLGQGAVSAIYYAE---NKQTGQPVAIKVVTKQKVANDKQENYYYQQELEITKAIIAKGKN----------ENIVNILELIEGSSEYFIVTEYYK
.||.|..||||.|...|..   |.|..|.||.|..|||...||||.|.||||||||....|.|..|          ..|.||...|.....|.|..||..
YQQNNVIGQGAISQVFYGQFCQNQQCQQEVAVKKITKQTQDNDKQQNKYYQQELEIIQCLIKKMNNNKISCQSSPCDHICNIYDVIQCQQQYYIIMEYCE

DGDLFNLLERFSFKFSPDIAISFCISIANGLSFLHSSKICHRDLKPENILIAK--------QADESYLIKIADFGISKMAED-MMKSTIGTITYMAPEIL
.|||.|........|..||...|||.||.|...||..||||||||||||||.|        .....|..||.|||||||... ||.|..|||.|||||||
QGDLYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEYMMQSCVGTINYMAPEIL

K-CQEYDQKVDIWSFGCLIYEIFTGEQLFG--GNSLKEVALKITGFQEDTLNKIPESKIPKSVTQ-IIKKCLKRQPAMRISLDQIIKDLL
. .|.||.|||||||||..|||.|.||||.  ||...||| .|..||...........|.....| |.|.||...|..||..||||..|.
NFNQQYDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIRNFQCCDYQCHFQNNIYQEIQQLIQKYCLQPDPENRITIDQIIDRLM
Kinase 20855.AA S_TKc 1830-2093 26 1.9e-69 237.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 1830-2093
Range on HMM: 1-231/231
Sequence Identity: 26% (74 aa)

NQQQNQLGQGAVSAIYYAENKQTGQPVAIKVVTKQKVANDKQENYYYQQELEITKAIIAKGKNENIVNILELIEGSSEYFIVTEYYKD--GDLFNLLERF
 .  ...|.|| .  | . .| ||. ||||..               ..|..| |      . .|||.... ..  .....|.||     |||| .... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

SFK-----FSPDIAISFCISIANGLSFLHSSKICHRDLKPENILIAKQADESYLIKIADFGISKMAEDMMKSTIGTITYMAPEILKCQEYDQ-KVDIWSF
  .     |..  | ...  |...| ..|| .|.||||||||||. .       |||.|||...      .. .||  |||||.|    |.  |.|.||.
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GCLIYEIFTGEQLFGGNSLKEVALKITGFQEDTLNKIPESKIPKSVTQIIKKCLKRQPAMRISLDQIIK--------DLL
||..|| ..|. .|      .. .|. |              .... ..|.|||.. |. |..  .. .          .
GCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20855.AA ULK 1830-2094 26 1.6e-64 220.7 In-house 1-329 (329) Show / Hide 
Range on Protein: 1830-2094
Range on HMM: 1-329/329
Sequence Identity: 26% (87 aa)

NQQQNQLGQGAVSAIYYAENKQT----GQPVAIKVVTKQKVANDKQENY------YYQQELEITKAIIAK--GKN--ENIVNILELIEGSSE--YFIVTE
 .  ..||.|.    | ..||.|    .. ||.|.. |||  ....|..        ..| .| | .  .  .||  .|||  ..  | | .  ..|..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YYKDGDLFNLLER---------FSFKFSPDIAISFCISIANGLSFLHSSKICHRDLKPENILIAKQ---------ADESYLIKIADFGISKMAE-D----
|  .|||......         .  ..| ..||.|.. |.||. .||. .| |||.||.|||| .          .  .. .|||||| .|. . |    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNDNMEQ

-MMKSTI------GTITYMAPEILK----CQEYD-QKVDIWSFGCLIYEIFTGEQLFGGNSLKEVA-LKITGFQEDT-----------LNKI---PESKI
 ||...       ||  ||||.||.    ...|.  |.||||.||..||. .|.  | ..   .   ..|.   ...           |.     .. .|
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

PKSVTQIIKKCLKRQPAMRISLDQIIKDLLQ
 . . ..|...|....  ||| .....  . 
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 20855.AA ULK 1830-2094 26 1e-62 214.64 In-house 1-324 (324) Show / Hide 
Range on Protein: 1830-2094
Range on HMM: 1-324/324
Sequence Identity: 26% (87 aa)

NQQQNQLGQGAVS-AIYYAENKQT---GQPVAIKVVTKQKVANDKQENY------YYQQELEITKAIIAKGK---NEN--IVNILELIEGS--SEYFIVT
 .  ..||.|.     | ..||.|   .| ||.|.. |.|  ..|.|..        ..| .| | .    |   ..|  ||  ..  | |    ..|..
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKL----KELKHPNHHIVKLYDWFETSNHNNIYIIM

EYYKDGDLFNLLER--------FSFKFSPDIAISFCISIANGLSFLHSSKICHRDLKPENILIAKQ---------ADESYLIKIADFGISKMAE------
||  .|||......        .  ..| ..||.|.. |.||. .||. .| |||.||.|||| .          .  .. .|||||| .|. .      
EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNNNMEQ

DMMKSTI------GTITYMAPEILK----CQEYD-QKVDIWSFGCLIYEIFTGEQLFGGNSLKEVALKITGFQE-----------DTLNKI---PESKIP
.|....       ||  ||||.||.    ...|.  |.||||.||..||. .|.  | ..   .  |.|   ..             ...    .. || 
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS

KSVTQIIKKCLKRQPAMRISLDQIIKDLLQ
. . ..|...|....  ||| ..|..  . 
PECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 20855.AA CAMK 1835-2091 19 3.7e-60 192.23 In-house 1-422 (425) Show / Hide 
Range on Protein: 1835-2091
Range on HMM: 1-422/425
Sequence Identity: 19% (82 aa)

QLGQGAVSAIYYAENKQTG------------QPVAIKVVTKQKVAND------------------------KQENYYYQQELEITKAIIAKGK---NENI
.||.|. .  . ...|.|.            | ||||.. |.|. ..                         .     ..|.|| | . ..|.    .||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNILELIEG-------------------SSEYFIVT---EYYKDG----DLFNLLERF--------------SFKFSPDIAISFCISIANGLSFLHSSKI
....| .|                     .....|.   ||   |    |||. . .               ...|. . |  .   |. .. ..|| .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

CHRDLKPENILIAKQADES-------------YLIKIADFGISKMAED--------------------------MMKSTIGTITYMA-PEILKC------
.||||||||||. .  |.|             . |||.||| ... ..                          .||   ||  ||| ||.|.       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QEYDQKVDIWSFGCLIYEIFTGEQLFGGN-------------SLKEVALKITGFQED-TLNKIPESK------------------IPKSVTQ
        . |..|.|.|| |.. |   .|.  | |              ...|   ||.  . |    .....                   . ... .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

IIKKCLKRQPAMRISLDQIIKD
 |.|.|.. |  |....|. ..
LIRKMLQVDPEKRMTIEQCLNH
Kinase 20855.AA Pkinase 1830-2092 27 4.7e-59 207.31 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1830-2092
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

NQQQNQLGQGAVSAIYYAENKQTGQPVAIKVVTKQKVANDKQENYYYQ-QELEITKAIIAKGKNENIVNILELIEGSSEYFIVTEYYKDG----DLFNLL
 .   ..|.|. .  | . .| ||. ||.|.. |.  ...... .    .|..| | .      .||| ...  | .... .|.||   |    ||| ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

E-RFSFKF--SPDIAISFCISIANGLSFLHSSKICHRDLKPENILIAKQADESYLIKIADFGISK---MAEDMMKSTIGTITYMAPEILK-CQEYDQKVD
. . . .|  |.. .....  |. || ..|| .|.||||||||||| .. . .  .||.|||..|      . |..  ||. |||||... .|.|..|||
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVD

IWSFGCLIYEIFTGEQLFGGN------SLKEVALKITG--FQEDTLNKIPES--------------KIPKSVTQIIKKCLKRQPAMRISLDQIIKD--L
.||.||..|| ..|. .| |       . ...  .| |  . .|  .....|              .....  ..||.||.. |. |.. .|| ..  .
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 20855.AA Ciliate-E2 1830-2090 21 3.1e-57 195.03 In-house 1-361 (365) Show / Hide 
Range on Protein: 1830-2090
Range on HMM: 1-361/365
Sequence Identity: 21% (81 aa)

NQQQNQLGQGAVSAIYYAENKQTGQPVAIKVVTKQK----------VANDKQENYYYQQELEITKAIIAKGK-------------------NENIVNILE
   ....|||. . .|......... .|||. . ||           .. .  ... ....|..| .|   .                   . ||... |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

LIE--GSSEYFIVTEYYKDGDLFNLLE--RFSF--------KFSPDIAISFCISIAN---------------GLSFLHSSK-ICHRDLKPENILIAKQAD
  .    . ...|.||.. |||| ...  . ..        .|.   .. .   |..               .| .||| . |.|||.||||||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

ESYLIKIADFGISK----------------------------------MAEDMMKSTIGTITYMAPEILKCQE---------YDQKVDIWSFGCLIYEIF
    |||.|||.||                                  . ..| ....||  |||||||. ..         || |.||||.|...||  
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

TGEQLFGGNSLKEVALKITGFQEDTLNKIPES-------------------KIPKSVTQIIKK----CLKRQPAMRIS-LDQIIK
.|.  |              .|.   .||  .                   |..... ..|||    .|...|  ||.  .||..
FGKPPF--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 20855.AA TKL 1836-2092 18 3.1e-55 189.84 In-house 1-364 (364) Show / Hide 
Range on Protein: 1836-2092
Range on HMM: 1-364/364
Sequence Identity: 18% (68 aa)

LGQGAVSAIYYAENKQ--------TGQPVAIKVVTKQKVANDKQ-----------------ENYYYQQELEITKAIIAKGK--NENIVNILE-LIEGSS-
.|.|. . .| .. ..        ||..||.|.  .. . ..                   .. . . . .. . |  . .   .||| ..   ..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------EYFIVTEYYKDGDLFNLLERFSFKFSPDIAISFCISIANGLSFLHSSK--------ICHRDLKPENILIAKQAD----------ESYLI
           ...||.||.. |.|...|        ..  ......|| |...|||..        | |||||..|||. .             . . .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIADFGISKMAEDM----------------------MKSTIGTITYMAPEILKCQ----------------EYDQKVDIWSFGCLIYEIFTGEQLFG-GN
||.|||.|.. . .                        . .||. .||||.|. |                ||..|.|..||| ...||.|... .   .
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

SLKEV---------ALKITGFQEDTLNKIPE--------SKIPKSVTQIIKKCLKRQPAMRISLDQIIKDL
.  ..         .. .  ..  ..  |..        . .|.|. .....| .  |  | | ..|.| |
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 20855.AA Ciliate-E2-Unclassified 1833-2094 24 1.3e-50 173.76 In-house 4-352 (352) Show / Hide 
Range on Protein: 1833-2094
Range on HMM: 4-352/352
Sequence Identity: 24% (85 aa)

QNQLGQGAVSAIYYAENKQTGQPVAIKVVTKQKVANDKQENY--YYQQELEITKAI----------IAKG-----KNENIVNILELIEGSSEYFIVTEYY
. |.|||. . .| ...|...|  |.|   |... ..|| ..   . .|... . .          |..      ....||. ..  .     .||.|| 
IKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYC

KDGDLFNLLERFSF----------------KFSPDIAI-----SFCISIANGLSFLHSSK-ICHRDLKPENILIAKQADESYLIKIADFGISKMAE----
..|||.. .. ...                .|.   |.      ..  | .||..||... |.|||.||||||. ..    | |||.||||||  .    
EGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQQNNN

--------------DMMKSTIGTITYM----APEILKCQEYD----QKVDIWSFGCLIYEIFTGEQLFGGNSLKE--------------VALKITGFQED
              .||....||. ||    |||.|. |.||     |.||||.|...||. .|.  |..|. ..                |.   .| .
CDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKN

TLNKIPES-----KIPKSVTQIIK----KCLKRQPAMRISLDQIIKDLLQ
. ..  .      ......  .|.    |.|| .|  ||...||..  . 
IQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 20855.AA STE 1830-2093 20 8.3e-49 168.46 In-house 1-359 (359) Show / Hide 
Range on Protein: 1830-2093
Range on HMM: 1-359/359
Sequence Identity: 20% (76 aa)

NQQQNQLGQGAVSAIYYAENK------QTGQP---------VAIKVVT----KQKVAN------DKQENYYYQQELEITKAIIAKGK--NENIVNILELI
 . . ..|.||    |.| |.      .||.          .|||..     ..|. .      ... |   .|...    |  | .   .|||. .   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EGS-------SEYFIVTEYYKDGDLFNLLE-RFSFKFS------------PDIAISFCISIANG-LSFLHSSKICHRDLKPENILIAKQADESYLIKIAD
.         .| .|. ||   | |  ... ... ...             .. . .| .|  | |..||| .| |||.|| |||.         .|..|
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCD

FGISKMAED-------------------MMKSTIGTITYMAPEILKC------QEYDQKVDIWSFGCLIYEIFTGEQLFGG-NSLKEVALKI--TGFQE-
||...  .|                   . .. .||  .||||....      ..|| |.||||.||.| |  ||.  .   . ..   ...  .. |. 
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ

--------DTLNKIPE------------------SKIPKSVTQIIKKCLKRQPAMRISLDQIIK---DLL
        ..  ..|.                  .|  ..  . |.|||.. |  | . .| .|     .
FEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 20855.AA CMGC 1830-2039 18 7.4e-43 138.07 In-house 1-347 (513) Show / Hide 
Range on Protein: 1830-2039
Range on HMM: 1-347/513
Sequence Identity: 18% (66 aa)

NQQQNQLGQGAVSAIYYAENKQTGQP--------------VAIKVVTKQKVANDKQ-------------ENYYYQQELEITKAIIA-------KGKNEN-
 .  ...|.|. .  | . .|.|.|.              |||| . ...  ....                 . ..|  .. .          .|..| 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHNN

IVNILELIEGSS-----------------EYFIVTEYYKDGDLFNLLERFSF--------KFSPDI------------AISFC------ISIANGLS--F
||.... .  .                  . ..|.||  | ||...... .|        ..|.                .|         | .||   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYM-DHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSSK--ICHRDLKPENILIAKQADE----------------SYLIKIADFGISKMAEDM------------------------MKSTIGTITYMAPEIL
.|| .  |.||||||||||| .. .                 .. .||.||| ..  ..                         . . . |  | |||||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

KCQE----------YDQKVDIWSFGCLIYEIFTG--------EQLFGGNS
   .          |....|.||.|| ..|..||        . || |.|
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHS
Kinase 20855.AA CAMK-Unique 1830-2090 20 7.6e-43 139.14 In-house 1-359 (363) Show / Hide 
Range on Protein: 1830-2090
Range on HMM: 1-359/363
Sequence Identity: 20% (74 aa)

NQQQNQLGQGAVSAIYYAENKQTGQPVAIKVVTKQKVANDKQEN----------------YYYQQELEITKAIIAKGKNENIVNILEL----IEGSS---
    . .|.|. . .| . .. ||   |.|.| ||.. |.||                    .  |..| |      . .||. ...      . .    
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMV----DHPNIIKLYDWNNPIFCDRKYPL

------------EYFIVTEYYKDGDLFNLLER-FSFK------------------FSP--DIAISFCISIANGLSFLHSSKICHRDLKPENILIAKQADE
            ...||.||  .|||| .. . . |.                  ||     ... . ...  ....|| .| |||||.|||.. .  ..
CDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKD

------------SYLIKIADFGISKMAE----D-MMKSTIGTITYMAP--------------EILKCQEYDQKV----DIWSFGCLIYEIFTGEQLFGGN
             . ||..|||...  .    . ||....||. ||||              |... | |||..    |||| | . |. ..|.  | ..
NNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCE

SLK--------EVALKITGFQEDTLNKIPESK---IPKSVTQIIKKCLKRQPAMRISLDQIIK
. .        |   .|.  .  .. .  ..    | .. ....|.|... |. |.|. ....
CEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLE
Kinase 20855.AA TyrKc 1830-2092 25 3.9e-28 100.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 1830-2092
Range on HMM: 1-280/280
Sequence Identity: 25% (76 aa)

NQQQNQLGQGAVSAIYYAENKQTGQPVAIKVVTKQKVANDKQENYYYQQELEITKAIIAKG-KNENIVNILELIEGS-------SEYFIVTEYYKDGDLF
 .   .|| ||   .| .. |   ..||.|.. . .            .|..| . .   | ...|||...  .  .         ..||.|| . ||| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKL---GGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

NLLERFSFKFSPDIAISFCISIANGLSFLHSSKICHRDLKPENILIAKQADESYLIKIADFGISKMAEDM--------MKS------TI--GTITYMAPE
. | .   |....  .|||. ||.| ..||| .. ||||   |.|....      .||.||| |.  .|         ...      .     |  ||||
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

ILKCQEYDQKVDIWSFGCLIYEIFT-GEQLFGG-----NSLKEVALKITGFQEDTLNKIPES-------KIPKSVTQIIKKCLKRQPAMRISLDQIIKDL
 ..  ..  | |.|||| ...|||| |.|   |      | .||  ..   ..    ..|..         |. . ||.|.| ...|..| .  .|....
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV---KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 20855.AA Pkinase_Tyr 1841-2047 27 1.9e-23 80.07 Pfam 16-228 (270) Show / Hide 
Range on Protein: 1841-2047
Range on HMM: 16-228/270
Sequence Identity: 27% (60 aa)

VSAIYYAENKQTGQPVAIKVVTKQKVANDKQENYYYQQELEITKAIIAKG-KNENIVNILELIE-GSSE--YFIVTEYYKDGDLFNLLERF---SFKFSP
. .... . ..|..|||.|.. |.    ....|  .....    .|  .  ...|||. .  .   .    ..||.|| . ||| . | .      ....
YKGTWKGDPDNTKIPVAVKML-KE--GAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTM

DIAISFCISIANGLSFLHSSKICHRDLKPENILIAKQADESYLIKIADFGISKMA-----E-DMMKSTIGTITYMAPEILKCQEYDQKVDIWSFGCLIYE
   ...|. ||.|...|.| .. ||||   |.|...    .  .||.||| ..          . ...   |  |||| ..  ..  | |.|||| |..|
KDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWE

IFT-GEQL-FGGNSLKEVALKI
||| |||  . | |  ||  .|
IFTYGEQPTYPGMSNEEVYEYI
Kinase 20855.AA Pkinase_Tyr 2064-2092 24 0.002877 11.69 Pfam 242-270 (270) Show / Hide 
Range on Protein: 2064-2092
Range on HMM: 242-270/270
Sequence Identity: 24% (7 aa)

PKSVTQIIKKCLKRQPAMRISLDQIIKDL
|. . ...|.| . .|..| .  .|. .|
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 20855.AA Ciliate-B1 2722-2959 34 9.1e-72 244.74 In-house 45-290 (290) Show / Hide 
Range on Protein: 2722-2959
Range on HMM: 45-290/290
Sequence Identity: 34% (88 aa)

KQNLYFEKEIQTLKYLHEKV---------EKHQHILQVEDIIYDKTSNTNNTVYLVTELCDQGDLYEFQQKFYPQFDLETKLAFSIQIAQGLQHLHNQKI
.||.| ..|. ....| .|.          . .||..  |.|      .. . | ..|.|.||||| . ......| .. .| |.||||.|.| ||..||
QQNKYYQQELEIIQCLIKKMNNNKISCQSSPCDHICNIYDVI-----QCQQQYYIIMEYCEQGDLYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKI

VHRDLKPENCLVK-SLLNSQVSSFHEKFQIKIGDFGVSQINYQLGFLKSQIGTPNYMAPEIIN-QEMYSQQVDIWSLGCIIYEIFTNQQLFS--GGNLVQ
.|||||||| |.           . .. ..||.||| | .  .   ..|..||.|||||||.| .  |...|||||.|||.|||.||.|||   | .. .
CHRDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEY-MMQSCVGTINYMAPEILNFNQQYDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQE

IVKAAIQHNNSFEYIQGNIQESKNINQLIKQ-----CLAQNPSQRLSINQVVNFLI
..   ..    |..   . ... ||.|.|.|     ||  .|..| .|.|... | 
VANQIRN----FQCCDYQCHFQNNIYQEIQQLIQKYCLQPDPENRITIDQIIDRLM
S_TKc 20855.AA S_TKc 2687-2958 22 1.8e-54 188.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 2687-2958
Range on HMM: 1-231/231
Sequence Identity: 22% (68 aa)

KRIKQVL------SVYIADWQG-GDQLCVQSQRLVQLDVCNSKQNLYFEKEIQTLKYLHEKVEKHQHILQVEDIIYDKTSNTNNTVYLVTELCDQ--GDL
 .| ...      .|| . . . | .  .   .              ...||| ||       .| .| .  |...|      . .|.|.|.||.  |||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK------HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDL

YEFQQKFYPQ-----FDLETKLAFSIQIAQGLQHLHNQKIVHRDLKPENCLVKSLLNSQVSSFHEKFQIKIGDFGVSQINYQLGFLKSQIGTPNYMAPEI
... .|  ..     |.  .   .  ||...|...|...|.|||||||| |. .             .|||.|||.. .       ....|||.|||||.
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------HIKICDFGLARQL------TTFCGTPWYMAPEV

INQEMYSQ-QVDIWSLGCIIYEIFTNQQLFSGGNLVQIVKAAIQHNNSFEYIQGNIQESKNINQLIKQCLAQNPSQRLSINQVVN---------FL
.    |.   .|.||.|||.|| .. . .|.  .. .. |                  |.   ..|..||  .|..|... .. .         ..
L---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20855.AA Pkinase 2730-2958 25 7.8e-54 189.97 Pfam 50-293 (293) Show / Hide 
Range on Protein: 2730-2958
Range on HMM: 50-293/293
Sequence Identity: 25% (68 aa)

EIQTLKYLHEKVEKHQHILQVEDIIYDKTSNTNNTVYLVTELCDQG----DLYEFQQ-KFYPQF--DLETKLAFSIQIAQGLQHLHNQKIVHRDLKPENC
||| .| |.     | .|..  |. .|     .. .|.|.|.|. |    ||... . . .  |  . ..   .  ||..||...|...|.||||||||.
EIQIMKRLN-----HPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENI

LVK--SLLNSQVSSFHEKFQIKIGDFGVSQI--NYQLGFLKSQIGTPNYMAPEIIN-QEMYSQQVDIWSLGCIIYEIFTNQQLFSGG------NLVQIVK
|..    ...          .||.|||..    .   . ...  |||.|||||.|. ...|.. ||.||.|||.|| .. . .|.|       .  |...
LIDNNGHIDA---------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMIC

AAIQHNNSFEYIQGNIQE----------------SKNINQLIKQCLAQNPSQRLSINQVVNF--L
   .  ..|.. . .                   |..  ..|| ||...|..|... |...   .
RIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 20855.AA TKL 2743-2958 18 1.3e-49 171.19 In-house 83-364 (364) Show / Hide 
Range on Protein: 2743-2958
Range on HMM: 83-364/364
Sequence Identity: 18% (54 aa)

KHQHILQVEDIIYDKTS--------NTNNTVYLVTELCDQGD-LYEFQQKFYPQFDLETKLAFSIQIAQGLQHLHNQK--------IVHRDLKPENCLVK
.|..|.|   .  . ..        .. .  ..|.|.|. |. |. ..        .. .. ....||.|...||...        |.|||||..|.||.
RHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVD

SLLN--SQVSSFHEKFQ-------IKIGDFGVSQINYQLG--------------------FLKSQIGTPNYMAPEIINQE----------------MYSQ
. ..  | . .             .||.||| |. . | |                     . .|.|||..||||.....                 ||.
ENWTNVS-NYM-----YNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSE

QVDIWSLGCIIYEIFTNQQLFSGGNLVQIVKA----AIQHNNSFEYIQGNIQ--------------ESKNINQLIKQCLAQNPSQRLSINQVVNFL
..|..| | ...||.| .. ... .  ... .    ...  .. .  .  |                 . . .|...| ...|..|.| ....  |
KCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 20855.AA Ciliate-E2 2722-2956 21 3.3e-47 160.07 In-house 58-361 (365) Show / Hide 
Range on Protein: 2722-2956
Range on HMM: 58-361/365
Sequence Identity: 21% (72 aa)

KQNLYFEKEIQTLKYLHE---KVEK---------HQHILQVEDIIYDKTSNTNNTVYLVTELCDQGDLYEFQQKFY----------PQFDLETKLAFSIQ
.|  ....||. .. ...   |  .         | .|..  .  ..|   ..|..|||.|.|..|||... ....           .|...  . .. |
NQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYECFQEK---DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQ

IAQ---------------GLQHLHNQK-IVHRDLKPENCLVKSLLNSQVSSFHEKFQIKIGDFGVSQINYQL----------------------------
|.|               .|..||... |.|||.|||| |.                ||| ||| |... .                             
ILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQ

----GFLKSQIGTPNYMAPEIIN---------QEMYSQQVDIWSLGCIIYEIFTNQQLFSGGNLVQIVKAAIQHNNSFEYIQGN----------------
       ....|||.||||||.|         |. |. ..||||||.|.||  ...  |             | ..    |. .                
IIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWK

--IQESKNINQLIKQ----CLAQNPSQRLS-INQVVN
   . |..  .|||.    .|  .|..|.. ..|. |
SWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 20855.AA CAMK 2727-2958 18 1.3e-44 141.27 In-house 78-425 (425) Show / Hide 
Range on Protein: 2727-2958
Range on HMM: 78-425/425
Sequence Identity: 18% (67 aa)

FEKEIQTLKYLHEKVE--KHQHILQVEDIIYDKTSN-------TNNT--------VYLVT---ELCDQG----DLYEFQQKFYP---------QFDLETK
...||. .| |... .  .| .|..  ... |.. .       | ..        .|.|.   |.|. |    ||... ..  .             . .
VRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGR

L------AFSIQIAQGLQHLHNQKIVHRDLKPENCLV-KSLLNSQVSSFHEK--------FQIKIGDFGVS--QINYQLGF-------------------
.       .  ||.......|...|||||||||| |. ..  .|.. .   .        ..||| ||| .   .  .  |                   
FTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDP-V-E-HDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTE

---LKSQIGTPNYMA-PEIINQ--------------EMYSQQVDIWSLGCIIYEIFTNQQLFSGG-------------NLVQIVKAAIQHNNSFE-----
   .| . ||| ||| ||..|.              . |....|.||.|.| |   .    | |              |. .. .  .. . .|.     
GQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFS

--------YIQGNIQES------KNINQLIKQCLAQNPSQRLSINQVVN--FL
         . ..| ..      .   .||...|  .|..|..| |. |  ..
PISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 20855.AA Ciliate-E2-Unclassified 2728-2956 24 6.3e-43 146.73 In-house 53-348 (352) Show / Hide 
Range on Protein: 2728-2956
Range on HMM: 53-348/352
Sequence Identity: 24% (77 aa)

EKEIQTLK------YLHEKVEK-----HQHILQVEDIIYDKTSNTNNTVYLVTELCDQGDLYEFQQKFYP----------------QFDLETKL-----A
.||.. .|      |  .|  .     |.|.. | .. ...   . ...|.|.|.|..||| .. .|.                  .|. .  .      
MKEMNNKKKYHQRKY--NKIMQQILLNHPHPFIVKMFYCFQ---DKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKF

FSIQIAQGLQHLHNQK-IVHRDLKPENCLVKSLLNSQVSSFHEKFQIKIGDFGVSQ-----INYQLGF------------LKSQIGTPNYM----APEII
.  || |||..|| .. |.|||.|||| |...  .        ...||| ||| |      .|.. ..            .....||||||    |||..
YFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--------NYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL

NQEMYSQQ----VDIWSLGCIIYEIFTNQQLFSGGNLVQ--IVKAAIQHN-----NSFEYI-QGNIQESK--------NIN--------QLIKQCLAQNP
 .. |...    .||||||.|.||. ...  |.. |  |  ....... |     . .. | |.||| .|        ...        .|....|  ||
QGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNP

SQRLSINQVVN
..|....|. |
NKRITFEQILN
Kinase 20855.AA CAMK-Unique 2740-2958 21 9.1e-40 128.82 In-house 71-363 (363) Show / Hide 
Range on Protein: 2740-2958
Range on HMM: 71-363/363
Sequence Identity: 21% (65 aa)

KVEKHQHILQVEDI---IYDKTSNTNN---------------TVYLVTELCDQGDLYEFQQK---FY---------------PQFDLE--TKLAF-SIQI
| ..|..|....|.   |.     . .                 |.|.|.|. |||..  ||   ||                . . |  .  .| . ..
KMVDHPNIIKLYDWNNPIF----CDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCL

AQGLQHLHNQKIVHRDLKPENCLVKSLLN-----SQVSSFHEKFQIKIGDFGVSQINYQLGFLK---SQIGTPNYMAP--------------EIINQEMY
.. . ..|.|.|||||||.||..|.. ..        ..      ||. ||| .    .        . .||| ||||              |.||.  |
LSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCY

SQQV----DIWSLGCIIYEIFTNQQLFSGGNLV--------QIVKAAIQHNN-SFEYIQGNIQ--ESKNINQLIKQCLAQNPSQRLSINQV--VNFL
.||.    |||||| | |. ..    | . .           | ... ...  .|.  . ..    |..  ...|.|.   |..|.|...   . ..
DQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 20855.AA ULK 2719-2956 22 1.1e-38 132.72 In-house 41-325 (329) Show / Hide 
Range on Protein: 2719-2956
Range on HMM: 41-325/329
Sequence Identity: 22% (68 aa)

CNSKQNL--------YFEKEIQTLKYLHEKVE-----KHQHILQVEDIIYDKTSNTNNTVYLVTELCDQGDLYEFQQKFYPQ---------FDLETKLAF
.| |.|.         ...||...| |.   .     .|..| .  |. .....   | .|...|.|..||| .. .|  ..         .  .  . |
MNQKNNEQEGQYMWQLLKNEIKIMKKLKS--PNRHKNHHPNIVKLYDWFETSNH---NNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQF

SIQIAQGLQHLHNQKIVHRDLKPENCLVKSLL---NSQVSSFHE---KFQIKIGDFGVSQI-NYQ---LGFLKSQI------GTPNYMAPEIIN----QE
 .||..|...|| ..|.|||.||.| |..      .|.     .   . ..||.||| ..  ..       ....       ||| ||||.|..    |.
FKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSK-----KVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQK

MYS-QQVDIWSLGCIIYEIFTNQQLFSGGNLVQIV-----KAAIQHNNS--------FEYIQ--GNIQESKNINQLIKQCLAQNPSQRLSINQVVN
 |.   .||||||||.||. ...  |..    . .     |   . ...        ... .   ..| |... .||...|  ....| |. .. |
PYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFN
Kinase 20855.AA CMGC 2730-2903 21 1.4e-38 123.78 In-house 71-345 (513) Show / Hide 
Range on Protein: 2730-2903
Range on HMM: 71-345/513
Sequence Identity: 21% (62 aa)

EIQTLKYLHEKV------------EKHQHILQVEDIIYDKTSNTN------------NTVYLVTELCDQGDLYEFQQKFYP--------QFDLET-----
||. ||.|...             ..| .|..  ||.|.| |..|            | .|||.|..|. |||.. ..  .         ..        
EIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSE-HENKHP

-------KLAFS------IQIAQGLQ--HLHNQK--IVHRDLKPENCLVKS--------------LLNSQVSSFHEKFQIKIGDFGVSQ-INYQ------
       .  |.       || .||   ..| ..  |.|||||||| |. .              . |..     .....||.||| .  ..        
HRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDW-NPC----QKNGRLKICDFGLARWYHPHSDHHFQ

---------------LGFLKSQIGTPNYMAPEIIN-QEMYS---------QQVDIWSLGCIIYEIFTN--------QQLFSG
               . .. ... |  | ||||.   . |.         ...|.||.|||..|..|.        . || |
QQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPG
Kinase 20855.AA ULK 2720-2956 23 4.7e-38 132.64 In-house 42-320 (324) Show / Hide 
Range on Protein: 2720-2956
Range on HMM: 42-320/324
Sequence Identity: 23% (70 aa)

NSKQNL--------YFEKEIQTLKYLHEKVE-KHQH--ILQVEDIIYDKTSNTNNTVYLVTELCDQGDLYEFQQKFYPQ--------FDLETKLAFSIQI
| |.|.         ...|||..| |.   | ||..  | .  |. .....   | .|...|.|..||| .. .|  ..        .  .  . | .||
NKKKNEQEGQYMWQLLKNEIQIMKKLK---ELKHPNHHIVKLYDWFETSNH---NNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQI

AQGLQHLHNQKIVHRDLKPENCLVKSLL---NSQVSSFHE---KFQIKIGDFGVSQI-NY---QLGFLKSQI------GTPNYMAPEIIN----QEMYS-
..|...||...|.|||.||.| |..      .|.     .   . ..||.||| ... ..   .   ....       ||| ||||.|..    |. |. 
CNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSK-----KVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYD

QQVDIWSLGCIIYEIFTNQQLFSGGNLVQIV-KAAIQH------------NNSFEYIQGN--IQESKNINQLIKQCLAQNPSQRLSINQVVN
  .||||||||.||. ...  |..    . . .  ...            |. ...  ..  .. |... .||...|  ....| |. .. |
YKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFN
Kinase 20855.AA STE 2727-2953 19 8.8e-38 131.02 In-house 75-350 (359) Show / Hide 
Range on Protein: 2727-2953
Range on HMM: 75-350/359
Sequence Identity: 19% (58 aa)

FEKEIQTLKYLHEKVEKHQHILQVEDIIYDKT--SNTNNTVYLVTELCDQGDLYEFQQ-KFYPQFDL-----------ETKL-AFSIQIAQG-LQHLHNQ
..|||...| ..     |..| .  .  ...   .. ....... |..| | | .. . |. ....|           |. . ..  || .| |..||..
ILKEIKIMKKCNH--M-HPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSH

KIVHRDLKPENCLVKSLLNSQVSSFHEKFQIKIGDFGVSQINYQ-----------------LGFLKSQIGTPNYMAPEIINQEM------YSQQVDIWSL
.|.|||.|| | |.                .|. ||||. .  .                  .  .. .||| .||||.|.|.       |. ..|||||
HIIHRDIKPANILL----------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSL

GCIIYEIFTNQQLFSGGNLVQIVKAAIQHN-------------NSFEYIQGNIQES-----------------KNINQLIKQCLAQNPSQRLSINQ
|| | |  | .  .. ..  .   .... .             .    .. .....                 .. .. |..||  .|..| . .|
GCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase 20855.AA Pkinase_Tyr 2765-2849 29 2.5e-16 55.94 Pfam 82-158 (270) Show / Hide 
Range on Protein: 2765-2849
Range on HMM: 82-158/270
Sequence Identity: 29% (26 aa)

VYLVTELCDQGDLYEFQQKF---YPQFDLETKLAFSIQIAQGLQHLHNQKIVHRDLKPENCLVKSLLNSQVSSFHEKFQIKIGDFGVS
.|.|.|..  |||... .|     ........| ...|||.|...|......||||   ||||..           ....||.||| .
IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-----------NNVVKICDFGLA
TyrKc 20855.AA TyrKc 2687-2958 21 2.6e-16 40.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 2687-2958
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

KRIKQVL------SVYIADWQGGDQLCVQSQRLV---QLDVCNSKQNLYFEKEIQTLKYL--HEKVEKHQHILQVEDIIYDKTSNTN---NTVYLVTELC
 . ...|       || . |           . |    |  .       | .|.. .. |  |     |..|..   .. ..  |       ...|.|..
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---REDFMREARIMCKLGGH-----HPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYM

DQGDLYEFQQKFYPQFDLETKLAFSIQIAQGLQHLHNQKIVHRDLKPENCLVKSLLNSQVSSFHEKFQIKIGDFGVSQINYQL-------GFLKSQ--IG
. ||| .. .|  |.. ....| |..|||.| ..|| ....||||   ||||.. .           ..||.||| |   |            ...   |
PHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

TP-----NYMAPEIINQEMYSQQVDIWSLGCIIYEIFTNQQLFSGG-----NLVQIVKAAIQHNNSFEYIQGNIQE------SKNINQLIKQCLAQNPSQ
.        |||| ||  ... . |.|| |  ..||||. |    |        | | . ... .  .  . .  .      .. . |..||| . .|..
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPED

RLSINQVVNFL
| . .... ..
RPTFSEIHECF
Kinase 20855.AA Pkinase_Tyr 2868-2896 48 1.9e-05 19.08 Pfam 181-209 (270) Show / Hide 
Range on Protein: 2868-2896
Range on HMM: 181-209/270
Sequence Identity: 48% (14 aa)

MAPEIINQEMYSQQVDIWSLGCIIYEIFT
|||| ||   .. . |.|| |  ..||||
MAPECINYGKFTTKSDVWSFGVLMWEIFT
Kinase 20855.AA Pkinase_Tyr 2930-2958 27 0.001458 12.69 Pfam 242-270 (270) Show / Hide 
Range on Protein: 2930-2958
Range on HMM: 242-270/270
Sequence Identity: 27% (8 aa)

SKNINQLIKQCLAQNPSQRLSINQVVNFL
.. | .|.||| ...|..| .  .....|
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL