Gene 9756 (Tetrahymena)
9756
Group:
Other
Family:
Ciliate-A8
Sequence
Protein domains of 9756.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 9756.AA | Ciliate-A8 | 30-170 | 58 | 3.9e-91 | 309.06 | In-house | 1-151 (151) | Show / Hide |
Range on Protein: 30-170 Range on HMM: 1-151/151 Sequence Identity: 58% (89 aa) YEYQKVLVKGDFSIIVMAYSYRLQQQVAIKIIQRLKQQNKAYLQEFYKEIQVIQVFENKKYALQIIETIQDKRQKFIGIVAEICQC--------NLATIL |.|||||.|||||..|.|||...|.|||||||....||||.. .||.|.||..|...|.||.|||||.||||.|.||.||.|.|.| |||.|| YKYQKVLEKGDFSYVVQAYSINHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCDCFDFYKKKENLASIL D--LNTLSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSKNQFK . ||...|||..|||||||.|||.||....||.|||...||||.|||||. ENNLNKFTFEQIVALTYQLLKCLLVFQEKGIIHCDIKPQNILYSWSKNQFI |
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| Kinase | 9756.AA | Ciliate-E1 | 36-218 | 26 | 4.6e-31 | 98.46 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 36-218
Range on HMM: 1-202/202
Sequence Identity: 26% (54 aa)
LVKGDFSIIVMAYSYRLQ-QQVAIKIIQRLKQQNKAYLQEFYKEIQ-VIQVFENKKYALQIIETIQDKRQKFIGIVAEICQCNLATILD-----------
. .|.|||.. |... . .|||.|||.. ..|. ..|. ||.. . . |....| .|||..|... ... |. | |.|.| |.
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC
---LNTLSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSKNQFKIANYGLSKIKSNPFYEKIQTFDDGKLCYRSPEVIN------GLKIQFNI
| ..|.|......||.. | .. | ||.||| . ||.... ...... |.||. | .. .| .. . .|..||..| . . |.
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQ-YKGYTHYYYPPEQYNCPEQEHNKNQKINY
SVDIY
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KSDIY
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| Kinase | 9756.AA | S_TKc | 30-291 | 17 | 6.3e-15 | 41.96 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 30-291
Range on HMM: 1-231/231
Sequence Identity: 17% (48 aa)
YEYQKVLVKGDFSIIVMAYSYRLQQQVAIKIIQRLKQQNKAYLQEFYKEIQVIQVFENKKYALQIIETIQDKRQKFIGIVAEICQC---NLATILDLNT-
|| ... || |. .. . ...|||||| . ...|||. . . .. ......|| ... .| | | .| .... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR
------LSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSKNQFKIANYGLSKIKSNPFYEKIQTFDDGKLCYRSPEVINGLKIQFNI-SVDIY
.. .. ..||.. | . || |.| | || .. . ||. ||... | | . |..|||. ... ..|..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL---------TTFCGTPWYMAPEVL-----GYGKCKCDWW
SIGLLLTEAFIQRKLTKAELDDLKEKDLLSVLQFLHNSEQIQFIQKILSKMVNPNQNQRLQPLNLIK-----NLNALY
|.| .| | . . . ... . .| . .... ...|. . . ..|. . . ..
SCGCILYEMLCGYPPFP-QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 9756.AA | Ciliate-B2 | 30-221 | 26 | 7.4e-15 | 31.28 | In-house | 1-197 (197) | Show / Hide |
Range on Protein: 30-221
Range on HMM: 1-197/197
Sequence Identity: 26% (54 aa)
YEYQKVLVKGDFSIIVMAY---SYRLQQQVAIKIIQRLKQQNKAYLQEFYKEIQVIQVFENKKYALQIIETIQDKRQKFIGIVAEICQCNLATILD---L
| | . || . .| | | | | .|.|| .. .| .|. .||.....|| . . ..|. || . . . .. |.|.| | |. .
YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDK---EEIQHEIKIMKMFEYNINVVKYIDHIQINETIDV-LIMEKCECSLKQELQKIQK
NTLSFEQ--VLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSKNQFKIANYGLSKIKSNPFYEKIQTFDDGKLCYRSPEVINGL-----KIQFNISVD
|.. . . .||. | | |. .| ||| . || ... .... ..| | ||.. || | | ||| .. . . |
QQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQN-GNYVYCDFGISSIKKDNQQIKIKGFT---KKYASPEQMECDHNQTFVTNIDFQSD
IYSIG
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IYSMG
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| Kinase | 9756.AA | Ciliate-E2 | 30-224 | 18 | 6.2e-11 | 33.75 | In-house | 1-286 (365) | Show / Hide |
Range on Protein: 30-224 Range on HMM: 1-286/365 Sequence Identity: 18% (55 aa) YEYQKVLVKGDFSIIVMAYSYRLQQQVAIKIIQRL-----------------KQQNKAYLQEFYKEIQVIQVFE---------------NKKYALQIIET |. .|.. .| |... . .. |.|.|||||... |...| .... .||.... . | .. ....|. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC IQDKRQKFIGIVAEICQC-NLATILDLNTLSF------------EQVLALTYQLLH---------------CLLLFQKYD-TIHSDIKHESILYSKSKNQ |.| .. | .| | || .| .. | ... .... ...|.| .| . || ||| | ||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ FKIANYGLSKIKSNP---------FYEKIQTF---------------------DDGKLCYRSPEVINGLKIQ-------FNISVDIYSIGLLL ||. ||||. ... ..... . | . | .||..|| |.. . ..||.|.| .| IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL |
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| Kinase | 9756.AA | Ciliate-E3 | 30-228 | 26 | 1.6e-10 | 29.33 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 30-228 Range on HMM: 1-202/202 Sequence Identity: 26% (54 aa) YEYQKVLVKGDFSIIVMAYSYRLQQQVAIKIIQRLKQQN---KAYLQEFYKEIQVIQVFENKKYALQIIETIQDKRQKFIGIVAEICQC-NLATILDLNT | |. | .| |.. |.. . |.|||| | .||| .|. .|.| | . | .. ... . . |. | | || | | .| . . YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIKQQN LSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSKNQF--KIANYGLSKIKSNPFYEK--IQTFDDGKLCYRSPEVINGLKIQFNISVDIYSIG .. . .. . |.. .. |||||| . || .|..|| ||. |.|| .. .| ..|...| . .. .| . |. |.||.| KTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRK---NKGHTHTQYQGWTPFYAAPEQN-DQQQISKESDYYSVG LLLTEAF . . AVFCQLC |
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| Kinase | 9756.AA | C8 | 27-224 | 18 | 5.1e-10 | 31.07 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 27-224 Range on HMM: 1-226/226 Sequence Identity: 18% (42 aa) KNKYEYQKVLVKGDFSIIVMAYSYRLQQQVAIKIIQRLKQQNKAYLQEFYKEIQVIQVFENKKYALQIIETIQDKRQKF----IG------------IVA |...| | .| ..... |. . ......|. . .|.. ... ||... |||. . .. ... ..| . | FNNFQY---LSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVM E--ICQCNLATILDL-----NTLSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSKNQF---KIANYGLSKI--KSNPFYEKIQTFDDGKLCY | .|. ||. . | .| |. . .. |.. .. . .| ||| . .| ..|. |.. |.. |. .. .. . | . | EMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAY RSPEVING---LKIQFNISVDIYSIGLLL ||.... |..| |..|.||.| FAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 9756.AA | Ciliate-C5 | 69-299 | 23 | 6.3e-10 | 28.6 | In-house | 31-260 (260) | Show / Hide |
Range on Protein: 69-299
Range on HMM: 31-260/260
Sequence Identity: 23% (57 aa)
KAYLQEFYKEIQVIQVFENKKYALQIIETIQDKRQKFIGIVAEICQCNLATIL-----DLNTLSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYS
|. .. | ..... . |... || . .... .. .||| |. . ||. |.. . |. |. . ||||.| | |||
KPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIGFAIQMSTVFEKIQQNNLIHSDVKPENILYD
KSKNQFKIANYGLSKIKSNPFYEKIQTFDDGKLC--YRSPEVINGLKIQFNISVDIYSIGLLLTEAFIQRKLTKAELDDLKEKDLLSVLQFLHNSEQIQF
|....|| || | . .|.| | ||... ||| ||| .|..| | . . | . ... .| .... . . |
SQEKCFNLCDYGESKS----FKDGSKTYDLKGFTRKYAAPEITDD-NGFFNIKYDIYGLGIILLELTLGKFLEDEDCTFIRNGKL---PNYISKNALYQD
IQKILSKMVNPNQNQRLQPLNLIKNLNALYNINEDCLR
| .|. ||.. ..|.. ..| |.|| | |. .
INQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI
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| Kinase | 9756.AA | TKL | 151-226 | 20 | 7.4e-10 | 31.68 | In-house | 162-281 (364) | Show / Hide |
Range on Protein: 151-226 Range on HMM: 162-281/364 Sequence Identity: 20% (24 aa) IHSDIKHESILYSKSKN-------------QFKIANYGLSKIKSNPF-----------------YEKIQTFDDGKLCYRSPEVINGL------------- || |.| . || . . ||. .|||. .|. . ..| | ... .|||..| IHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFC -KIQFNISVDIYSIGLLLTE . ... ..|.|| |..| | KGFEYSEKCDVYSFGIVLWE |
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| Kinase | 9756.AA | DYRK2 | 104-221 | 27 | 1.7e-09 | 26.74 | In-house | 74-189 (318) | Show / Hide |
Range on Protein: 104-221 Range on HMM: 74-189/318 Sequence Identity: 27% (34 aa) KFIGIVAEICQCNLATILDLNTL---SFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESI-LYSKSKNQFKIANYGLSKIKSN-PFYEKIQTFDDGKLCY ... |. | . ||. . | | . | . ....|.|| . .| . || | | | | |... .. |.. |.| ..| ||. . | NHHCITFELLSMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQS-----RFY RSPEVINGLKIQFNISVDIYSIG |.|||| | .... ..|. | | RAPEVI--LGGKYGMAIDMWSFG |
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| Kinase | 9756.AA | ULK | 30-224 | 20 | 5.7e-09 | 28.02 | In-house | 1-242 (324) | Show / Hide |
Range on Protein: 30-224 Range on HMM: 1-242/324 Sequence Identity: 20% (50 aa) YEYQKVLVKGDFS-IIVMAYSYRL---QQQVAIKIIQRLKQQNKAYLQE-------FYKEIQVIQVFE--NKKY--ALQIIETIQDKRQKFIGIVAEICQ |. ..| || | .. . .|.||.|.|.. |...| ..|| . .|||... . . .. . .. ... ..| |. | |. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN C-NLATILDLN----------TLSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSK-----------NQFKIANYGLSKIKSNP-FYEKI-QT . .| ... | .|| .... .|.. . .| || ||| . || .. . ...||| |..|. |. . . . || GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT FDD-----GKLCYRSPEVINGL--KIQFN-ISVDIYSIGLLL . | | .|....|. ..... . .||.|.| .. CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF |
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| Kinase | 9756.AA | DYRK2 | 30-67 | 39 | 5e-06 | 15.26 | In-house | 1-41 (318) | Show / Hide |
Range on Protein: 30-67 Range on HMM: 1-41/318 Sequence Identity: 39% (16 aa) YEYQKVLVKGDFSIIVMAYSYRLQQQVAIKII---QRLKQQ || .|. || | | .| . ..| ||||.| .|. .| YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQ |
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| Kinase | 9756.AA | TyrKc | 30-287 | 14 | 8e-06 | -128.79 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 30-287 Range on HMM: 1-280/280 Sequence Identity: 14% (44 aa) YEYQKVLVKGDFSIIVMAYSYRLQQQVAIKIIQRLKQQNKAYLQEFYKEIQVIQVF-ENKKYALQIIETIQDKR------QKFIGIVAEICQCNLATILD . |.| | | ... . . .|||.| .. . ...|..|... . . . .... . .. . .. . .| | ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR LNT--LSFEQVLALTYQL------LHCLLLFQKYDTIHSDIKHESILYSKSKNQFKIANYGLSKIKSNP-------FYEKIQTFDDGK--LCYR--SPEV . |. .. | .| || || |. .|... . . ||. |||. . | . .. ..|| | .| .||. KHRPKLCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC INGLKIQFNISVDIYSIGLLLTEAFIQRKLTKAELDDLKE----KDLLSVLQFLHNSEQIQFIQK---------------ILSKMVNPNQNQRLQPLNLI | . |.. |..| | .. | | | . . .. |.... . . . | .. . . ..| ... I--NYGKFTTKSDVWSFGVCMWEIF-----TYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH KNL . . ECF |
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