Gene 22398 (Tetrahymena)
22398
Group:
Other
Family:
Ciliate-A8
Sequence
Protein domains of 22398.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
---|---|---|---|---|---|---|---|---|---|
Kinase | 22398.AA | Ciliate-A8 | 29-177 | 58 | 6.1e-94 | 318.39 | In-house | 1-151 (151) | Show / Hide |
Range on Protein: 29-177 Range on HMM: 1-151/151 Sequence Identity: 58% (89 aa) YIFEKILQKGDFSEVVLAHSENLNKKVAIKILKNTDEQNKINFEEFKKEIRAFEMLKGEKYILPFIEQIQDDKLNLFAVVTEFCDNFDFYKKKGNLASIF |...|.|.|||||.||.|.|.|....|||||.|....|||||..||.|.|.|....|.|||||..||.|||......|.||||||.|||||||.|||||. YKYQKVLEKGDFSYVVQAYSINHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCDCFDFYKKKENLASIL K--LNKLDLKQILALTYQLLRGLVLLENKGIIIGHIKSDNILYSRSKNQFI . |||....||.|||||||..|.....||||...||..|||||.|||||| ENNLNKFTFEQIVALTYQLLKCLLVFQEKGIIHCDIKPQNILYSWSKNQFI |
|||||||||
Kinase | 22398.AA | Ciliate-E1 | 35-219 | 23 | 1.9e-30 | 96.43 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 35-219 Range on HMM: 1-202/202 Sequence Identity: 23% (48 aa) LQKGDFSEVVLAHSENLN-KKVAIKILKNTDEQNKINFEEFKKEIRAFEMLKGEKYILPFIEQIQDDKLNLFAVVTEFCDNFDFYKKKGN--LASIF--- . .|.|| |. | ..| | ..||.|| . . .|...|.. .||. ....|.|.||. .|..|..|...... ..|.|. .. . ... | .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRL-EYWQQC --KLNKLDLKQILALTYQLLRGLVLLENKGIIIGHIKSDNILYSRSKNQFIIA--NPSH--YKNDQYNENQQGTNQKSKSQEDS-------DKQNQKNIL . |... .|......||. || |....||...|| .|||.... ...... |. .|.... .. | .. ...| .|... |. QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK VDIY .||| SDIY |
|||||||||
Kinase | 22398.AA | S_TKc | 29-291 | 16 | 9.8e-13 | 9.83 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 29-291 Range on HMM: 1-231/231 Sequence Identity: 16% (50 aa) YIFEKILQKGDFSEVVLAHSENLNKKVAIKILKNTDEQNKINFEEFKKEIRAFEMLKGEKYILPFIEQIQDDKLNLFAVVTEFCDNFDFYKKK--GNLAS | . ... || |..| ... . ...|||||.| | ...||. .. . ..| ... .|| . . .|.|.|| |.| . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCD-------GDLGDLFD IFKLNK-------LDLKQILALTYQLLRGLVLLENKGIIIGHIKSDNILYSRSKNQFI------------------------IANPSHYKNDQYNENQQG . | .. .. .. ..||....| . ..||| .| .||| .. | . YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQLTTFCGTPWYMAPEVL---------------- TNQKSKSQEDSDKQNQKNI-LVDIYSIGLLVIEALLQRPLENEEQLNLNDQDLMKVLPSLQTSEHYEFIHNFVCKMVNKDISQRLQPEDLIN------NL . . .|..|.| ...| | .|. ..| ..|.. |... |..|. .|| ..|. .. . . ---------------GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCH EQF . | PWF |
|||||||||
Kinase | 22398.AA | Ciliate-E3 | 29-178 | 27 | 5.7e-12 | 33.9 | In-house | 1-145 (202) | Show / Hide |
Range on Protein: 29-178 Range on HMM: 1-145/202 Sequence Identity: 27% (42 aa) YIFEKILQKGDFSEVVLAHSENLNKKVAIKILKNTDEQN---KINFEEFKKEIRAFEMLKGEKYILPFIEQIQDDKLNLFAVVTEFCDNFDFYKKKGNLA | .|| .| |. | |.. ..|..|||| . ...|| .| . .|. . .. .... .|. |... . .| |.| | |.| YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQIN-SQNVVKCHDQYYDQQNKMIFIVQEYCSN-------GDLY SIFKLNKLDLKQ--ILALTYQLLRGLVLLENKGIIIGHIKSDNILYSRSKNQFII | .. . | |. . |...|. . | || . || |||| . ..|| || HYIK--QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLII |
|||||||||
Kinase | 22398.AA | Pkinase | 29-149 | 19 | 1e-09 | 35.44 | Pfam | 1-121 (293) | Show / Hide |
Range on Protein: 29-149 Range on HMM: 1-121/293 Sequence Identity: 19% (26 aa) YIFEKILQKGDFSEVVLAHSENLNKKVAIKILKNTDEQNKINFEEFKK--EIRAFEMLKGEKYILPFIEQIQDDKLNLFAVVTEFCDNF----DFY---- | ..... .| |..| ..| . .|.||.||.| .... .. . ||. .|. . |. ... .|.. .|.|.|.. | . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIY--MVMEYCEGGLYVMDLFDYIS KKKGNLASIFKLNKL--DLKQILALTYQLLRGL . ... . ... ||.|||| T--------WRHGCFYFSEWECKFYMYQILRGL |
|||||||||
Kinase | 22398.AA | Ciliate-E2a | 29-78 | 35 | 4.3e-09 | 22.94 | In-house | 1-50 (275) | Show / Hide |
Range on Protein: 29-78 Range on HMM: 1-50/275 Sequence Identity: 35% (18 aa) YIFEKILQKGDFSEVVLAHSENLNKK-VAIKILKNTDEQNKINFEEFKKEI | |.|.. || | |.|| . .|. ...|. | ..|.|.. |.|..|| YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEI |
|||||||||
Kinase | 22398.AA | CK2 | 29-117 | 28 | 2.4e-08 | 20.25 | In-house | 1-85 (288) | Show / Hide |
Range on Protein: 29-117 Range on HMM: 1-85/288 Sequence Identity: 28% (26 aa) YIFEKILQKGDFSEVVLAHSENLNKKV--AIKILKNTDEQNKINFEEFKKEIRAFEMLKGEKYILPFIEQIQDDKLNLFAVVTEFCDNFDF | .. . .| .||| . . |.|. ||||| . . | ||. | |.| . | ... ..| . |.| |. .| || YEVIRKIGRGKYSEVFEGINIKNNEKCKIVIKILKP------VKKKKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYVNNTDF |
|||||||||
Kinase | 22398.AA | CAMK | 34-123 | 16 | 6.4e-08 | 20.85 | In-house | 1-160 (425) | Show / Hide |
Range on Protein: 34-123 Range on HMM: 1-160/425 Sequence Identity: 16% (26 aa) ILQKGDFSEVVLAHSENLN------------KKVAIKILKNTDEQNKI-------------------------NFEEFKKEIRAFEMLKG------EKYI .| .| |..| |. | . .||||||.. . ..| . .....||. .|.| . | TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI LPFIEQIQDDK-----------------LNLFAVVT---EFCDN-------FDFYKKKGN . ..| ..|.. . . |. |.|.. ||. ...|. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGC |
|||||||||
Kinase | 22398.AA | PDK1 | 29-60 | 38 | 7.1e-08 | 19.65 | In-house | 1-36 (307) | Show / Hide |
Range on Protein: 29-60 Range on HMM: 1-36/307 Sequence Identity: 38% (14 aa) YIFEKILQKGDFSEVVLAHSENL----NKKVAIKIL .||.|.. .| .|.|.|| . ||..||||. FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIKIC |
|||||||||
Kinase | 22398.AA | CAMK1 | 29-78 | 28 | 1.1e-07 | 18.3 | In-house | 1-41 (276) | Show / Hide |
Range on Protein: 29-78 Range on HMM: 1-41/276 Sequence Identity: 28% (15 aa) YIFEKILQKGDFSEVVLAHSENL---NKKVAIKILKNTDEQNKINFEEFKKEI |.| |.. .| ||||.|. . .|..|||.... || . YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK------------KKFM |
|||||||||
Kinase | 22398.AA | MARK | 29-79 | 27 | 1.5e-07 | 20.94 | In-house | 1-51 (262) | Show / Hide |
Range on Protein: 29-79 Range on HMM: 1-51/262 Sequence Identity: 27% (14 aa) YIFEKILQKGDFSEVVLAHSENLNKKVAIKILKNTDEQNKINFEEFKKEIR | . | . .| ...| ||.. . ..||||||..... . ...... ||. YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIE |
|||||||||
Kinase | 22398.AA | Ciliate-F2 | 132-178 | 40 | 5.2e-07 | 21.73 | In-house | 91-137 (200) | Show / Hide |
Range on Protein: 132-178 Range on HMM: 91-137/200 Sequence Identity: 40% (19 aa) KLDLKQILALTYQLLRGLVLLENKGIIIGHIKSDNILYSRSKNQFII || .|. . |.. || ||| |.| | || .|..| | |..|.. KLTDNQQYEEIQQFINGLAELENLGLIHGDIKIENMIYNRPKQRFMF |
|||||||||
Kinase | 22398.AA | TyrKc | 29-288 | 14 | 6.2e-07 | -110.48 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 29-288 Range on HMM: 1-280/280 Sequence Identity: 14% (46 aa) YIFEKILQKGDFSEVVLAHSENLNKKVAIKILKNTDEQNKINFEEFKKEIRAFEML-KGEKYILPFIEQIQDD-----KLNLFAVVTEFCDNFDFYKKKG ..|.| | | ||.... .||.| ||. |.| .|.| .| . . |. .. . .. .|.|.. ..| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM-------PHG NLASIFKLNK--LDLKQILALTYQLLRGLVLLENKGIIIGH--IKSDNILYSRSKNQFIIANPSHYK-------NDQYNE-----NQQGTNQKSKSQED- .| . . .. | .|. | .| .| |. |..| | . |.|... . . | | |.. ... .|...... DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCI--HRDLAARNCLVGENH---------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT ----------SDKQNQKNILVDIYSIGLLV--IEALLQRPLENEEQLNLNDQDLMKVLPSL--QTSEHY----------EFIHNFVCKMVNKDISQRLQP . . . .. |..| | . | . | | ....| ...|.... . . .. . ... . . | ..| MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF EDLINNL .... . SEIHECF |
|||||||||
Kinase | 22398.AA | Ciliate-F2 | 29-60 | 43 | 0.067343 | 3.0 | In-house | 1-31 (200) | Show / Hide |
Range on Protein: 29-60 Range on HMM: 1-31/200 Sequence Identity: 43% (14 aa) YIFEKILQKGDFSEVVLAHSENLNKKVAIKIL | . || | | . | ||| . |||||. YQYVGILGNGLFGQQIQAYSENY-QSVAIKII |
|||||||||
Kinase | 22398.AA | Pkinase | 216-288 | 15 | 2.656211 | 2.15 | Pfam | 193-293 (293) | Show / Hide |
Range on Protein: 216-288 Range on HMM: 193-293/293 Sequence Identity: 15% (16 aa) VDIYSIGLLVIEALLQRPLENEE-------QLNLNDQDLMKVLPSLQTSEHY-------------------EFIHNFVCKMVNKDISQRLQPEDLINN-- ||..|.|....| |. ||. .. |. . ...... |.. .. | |.... .|| ..|. .|.. . VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW L . F |