Gene 6891 (Tetrahymena)

6891

Species: Tetrahymena
Alias: PreTt06891, 6891, 3715.m00036, 400, TTHERM_00497250, 62.m00175
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A7

Sequence

Name Sequence Type Origin Length Description Download
6891.AA Protein None 336 None Fasta, JSON
6891.kin_dom Protein Kinase Domain None 309 None Fasta, JSON
6891.NA RNA None 1011 None Fasta, JSON

Protein domain

Protein domains of 6891.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6891.AA Ciliate-A7 28-334 41 1.1e-173 583.29 In-house 1-360 (360) Show / Hide 
Range on Protein: 28-334
Range on HMM: 1-360/360
Sequence Identity: 41% (150 aa)

KLEQIGESSNSCIFSITNKNKQSQILKVIKHNSQNSYKLEGREQCSGHSRECAHLQNEYNMLRKLNHPNIIELKHDQLIQNTSIVDTNINGCCILLEKGN
...||.||||||||.|.|...|.||.||.||.....|.|||||||..|..||..|.||||.|.|..||.||.|.......|........|.||||.|...
RMKQIFESSNSCIFEIKNSSNQYQIVKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAE

CDLLQMLSQVYPN-VLEMS------------YLKYCFKKIAFAIQYLHEEKKIAHNDIKLENIILFNSEP-------KISDFGFAQKHELDPIV------
|||.|..||.||. .|...            ....||..||.|..|||.||.|||||||.|||..|....       |..|||||.|.. ....      
CDLFQYFSQHYPHKNLHHNEKIENQCEYCVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLRQ

-----QIKNWLHRSKKNVAPEIINNMKK------LKAK-----QIDDIKAFDERKTDIFALGIALFNALIHQNPFEIMADSNDSLY-SKFYEQDGASKFW
     |.||| .|.|...||||||...|      .|.|     |||....|||.|.|.||.|...|..|..||||...|..... | .|.|.|...||||
QIIEDQYKNWKYRCKQYFAPEIINCLNKCCDKNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHYFQKTYSKFW

SDPQISRMLDFIS----------SFEHSKVPQLKNLLEGMLHPNPKQRYCIKQVLSHEWF
...||..|.....          ........|.|.||..||.|||.|||||||.|.|.||
QWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQHPWF
S_TKc 6891.AA S_TKc 26-334 17 7.5e-28 99.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-334
Range on HMM: 1-231/231
Sequence Identity: 17% (57 aa)

SYKLEQIGESSNSCIFSITNKN-KQSQILKVIKHNSQNSYKLEGREQCSGHSRECAHLQNEYNMLRKLNHPNIIELKHDQLIQNTSIVDTNINGCCILLE
  .|..||. . .. .  ..|. ..   .|.||                       |...| ..|.| .||||. |.               .  .. .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------------EHIRREIQILKK-HHPNIVKLYDVFQD----------DHLYMVME

KGNC---DLLQMLSQVYPNV----LEMSYLKYCFKKIAFAIQYLHEEKKIAHNDIKLENIILFNSEPKISDFGFAQKHELDPIVQIKNWLHRSKKNVAPE
  .    ||.... .  ..     .     .. .. |. |..|.|.  .| | |.| ||| | . . ||.|||.| .   . ..   ..       .|||
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL--TTFCGTPWY-------MAPE

IINNMKKLKAKQIDDIKAFDERKTDIFALGIALFNALIHQNPFEIMADSNDSLYSKFYEQDGASKFWSDPQISRMLDFISSFEHSKVPQLKNLLEGMLHP
..                .. .| |. ..|. |.  |  . ||.         . . ... |                         |..|......|. 
VL---------------GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG------------------------SPEAKDFIRKCLQK

NPKQRYCIKQVLS-------HEWF
.|..|. . ..|        |.||
DPEKRPTA-EALQDEWDIKCHPWF
Kinase 6891.AA Ciliate-E2 129-334 19 2.7e-26 87.23 In-house 120-365 (365) Show / Hide 
Range on Protein: 129-334
Range on HMM: 120-365/365
Sequence Identity: 19% (55 aa)

DLLQMLSQV----------YPNVLEMSYLKYCFKKIAF---------------AIQYLHEEKKIAHNDIKLENIILFNSEPKISDFGFAQKHELDPIVQI
||.. . .           . . . .   || .|.|.                |..|||....| | |||.|||..    .||.|||...|   | . ..
DLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRT

-----KNWLHRS-------------------------KKNVAPEIINNMKKLKAKQIDDIKAFDERKTDIFALGIALFNALIHQNPFEIMADSNDSLYSK
     |...  .                            .||||.|. |  .       .     | ||..||. |.  |  . ||             
HKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ----QKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------

FYEQDGASKFWSDPQISRMLDFISSFE-----------------HSKVPQL-KNLLEG----MLHPNPKQRYC-IKQVLSHEWF
               .   ..   .|                  . |..|  |.|.      ||  .|..|.  ..|.| |.||
---------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 6891.AA Pkinase 84-334 20 1.5e-24 87.84 Pfam 49-293 (293) Show / Hide 
Range on Protein: 84-334
Range on HMM: 49-293/293
Sequence Identity: 20% (57 aa)

NEYNMLRKLNHPNIIELKHDQLIQNTSIVDTNINGCCILLEKGNC-----DLLQMLSQVYPNVL--EMSYLKYCFKKIAFAIQYLHEEKKIAHNDIKLEN
.|  ....||||||..|..          ...|    . .|  ..     ||  ..|  . ...  ..  .| ... |. ...|.|. ..| | |.|.||
SEIQIMKRLNHPNIVRLYDWFED------KDHIY---MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPEN

IILF-NSEP----KISDFGFAQKHELDPIVQIKNWLHRSKKNVAPEIINNMKKLKAKQIDDIKAFDERKTDIFALGIALFNALIHQNPFEIMA---DSND
| .  | ..    ||.|||.| ...     .  ...  .   .|||.|.                . .| |....|. |.  |  . ||   .   |. .
ILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR------------GGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-H

SLYSKFYEQDGASKFWSDPQISRML--------DFISSFEHSKVPQLKNLLEGMLHPNPKQRYCIKQVLSHEWF
. . ....  |.   .. |. ...         .  . | |   . .| .....|...||.|. ..|.| |.||
DQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 6891.AA Ciliate-E2-Unclassified 26-334 17 6.3e-17 55.26 In-house 1-352 (352) Show / Hide 
Range on Protein: 26-334
Range on HMM: 1-352/352
Sequence Identity: 17% (69 aa)

SYKLEQIGESSNSCIFSITNKNKQSQI-----LKVIKHNSQNSYKL-EGREQCSGHSRECAHLQNEYN--------MLRKLNHPNIIELKHDQLIQNTSI
  ...|||. ......   .|... |.     .|.|....|....  . ..  . .  ..    .  .         |. ..||.|. . .         
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFY---------

VDTNINGCCILLEKGNCDLLQMLSQVYPN----------------VLEMSYLK-----YCFKKIAFAIQYLHEEKKIAHNDIKLENIILFNS----EPKI
.... . ..| .|. .   |.   . ...                 ..    |     . |. |  ...|||....| | |||.|||.. |.    ..||
CFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKI

SDFGFAQKHELDPIVQIKN--------WLHRSKKNV----------APEIINNMK--KLKAKQIDDIKAFDERKTDIFALGIALFNALIHQNPFE-IMAD
.|||.. | . ..  . .|        . .... ..          |||.. . .  . ||            | ||..||. |.  |  . ||.    .
IDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-----------YKCDIWSLGVILYEMLFGYYPFYDNNCE

SND-------------SLYSKFYEQDGASKFWSDP-----QIS-RMLDFISSFEHSKVPQLKNLLEGMLHPNPKQRYCIKQVLSHEWF
...              ||.......  .......     ..|    |||.           .||  ||  ||..|. ..|.| | ||
QHQQLITQWINNAYRKQLYQNIKQKN-IQFPKFPWQQIPKHWSPEAKDFIN-----------DLLQKMLKKNPNKRITFEQILNHPWF
Kinase 6891.AA CAMK 31-194 17 2.8e-15 44.99 In-house 1-245 (425) Show / Hide 
Range on Protein: 31-194
Range on HMM: 1-245/425
Sequence Identity: 17% (44 aa)

QIGESSNSCIFSITNK-NK------------QSQILKVIKHNSQN----------SYKLEGREQCSGHSR----ECAHLQNEYNMLRK-------LNHPN
..|. | .  .  ..| ..            |    |.|. .             . |.. .........     .. ...|.....|       |.|||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCY-KIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

IIELKH-------DQLIQNTSIVDTNING------------CCILL---EKGNC-----DLLQMLSQVYP---------NVLEMSYL-----KYCFKKIA
|| | .          .       ||. .            ... .   |         ||.... .  .          | |  ..     ...|. |.
IIKLYEVYEDPHYFK-N-------TND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQIC

FAIQYLHEEKKIAHNDIKLENIILFNSE------------------PKISDFGFAQK
 |..|.|. . |.| |.|.||| | ...                   ||.|||||.|
SAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANK
Kinase 6891.AA CAMKL 157-192 46 6.3e-13 37.44 In-house 139-176 (297) Show / Hide 
Range on Protein: 157-192
Range on HMM: 139-176/297
Sequence Identity: 46% (18 aa)

AIQYLHEEKKIAHNDIKLENIILFNSE---PKISDFGFA
|..|.|. . |.| |||.||| | ..     ||.||||.
AVNYCHSHG-IVHRDIKPENILLDENGNNNIKIIDFGFS
Kinase 6891.AA CAMK 214-334 20 7.6e-13 37.0 In-house 286-425 (425) Show / Hide 
Range on Protein: 214-334
Range on HMM: 286-425/425
Sequence Identity: 20% (32 aa)

VA-PEIIN-----NMKKLKAKQIDDIKAFDERKTDIFALGIALFNALIHQNPFEIMADSNDS-------LYSKFYEQDGASKFW-SDPQ-----------
.| ||..|     ||        |. |  . .|.|. ..|. |.  |    ||.   |...         ... .|.  . |..  .|.           
MAAPEVLNGKGHCNMQ--N-A-TDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPE

----ISRMLDFISSFEHSKVPQ------LKNLLEGMLHPNPKQRYCIKQVLSHEWF
    ||               .       |.|. .|| ..|..|. |.|.|.|.|.
WWDDISDE-----------F-HHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 6891.AA CAMK1 308-334 40 8.8e-12 30.46 In-house 250-276 (276) Show / Hide 
Range on Protein: 308-334
Range on HMM: 250-276/276
Sequence Identity: 40% (11 aa)

KNLLEGMLHPNPKQRYCIKQVLSHEWF
|... .|| ..||.||...|.| | |.
KDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 6891.AA Ciliate-E2a 157-194 34 1.3e-11 30.48 In-house 114-158 (275) Show / Hide 
Range on Protein: 157-194
Range on HMM: 114-158/275
Sequence Identity: 34% (16 aa)

AIQYLHEEKKIAHNDIKLENIILF-----N---SEPKISDFGFAQK
...|.|  ..| | |.|.|||..      .   |. ||.|||.|..
GLHYMH-QRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATF
Kinase 6891.AA Ciliate-E2a 308-334 44 4.5e-11 28.86 In-house 249-275 (275) Show / Hide 
Range on Protein: 308-334
Range on HMM: 249-275/275
Sequence Identity: 44% (12 aa)

KNLLEGMLHPNPKQRYCIKQVLSHEWF
|.|. .|| ..||.|....| | | ||
KDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 6891.AA AMPK 305-334 36 5e-11 29.04 In-house 225-254 (254) Show / Hide 
Range on Protein: 305-334
Range on HMM: 225-254/254
Sequence Identity: 36% (11 aa)

PQLKNLLEGMLHPNPKQRYCIKQVLSHEWF
|. |.|...|| ..| .|. |...  |.||
PEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase 6891.AA CAMKL 306-334 34 1.9e-10 29.42 In-house 269-297 (297) Show / Hide 
Range on Protein: 306-334
Range on HMM: 269-297/297
Sequence Identity: 34% (10 aa)

QLKNLLEGMLHPNPKQRYCIKQVLSHEWF
....|. .|| .||..|. |.|...|.|.
DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 6891.AA MARK 157-192 43 7.1e-10 28.64 In-house 116-153 (262) Show / Hide 
Range on Protein: 157-192
Range on HMM: 116-153/262
Sequence Identity: 43% (17 aa)

AIQYLHEEKKIAHNDIKLENIILFNS---EPKISDFGFA
|..|.|.   |.| |||.||| .        ||.||||.
AVNYCHSKN-IVHRDIKPENILIDENGNHNIKIIDFGFS
Kinase 6891.AA TSSK 157-192 43 2.7e-08 23.3 In-house 135-170 (289) Show / Hide 
Range on Protein: 157-192
Range on HMM: 135-170/289
Sequence Identity: 43% (16 aa)

AIQYLHEEKKIAHNDIKLENIILFNS-EPKISDFGFA
|..|.|  . ..| |.|.|||.|.     |..|||||
AVKYCH-SHNVVHRDLKCENILLDKHWNIKLTDFGFA
Kinase 6891.AA MARK 305-334 30 3.5e-08 23.03 In-house 233-262 (262) Show / Hide 
Range on Protein: 305-334
Range on HMM: 233-262/262
Sequence Identity: 30% (9 aa)

PQLKNLLEGMLHPNPKQRYCIKQVLSHEWF
....||.  .| .||..|  |.....|.|.
KECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 6891.AA TSSK 308-334 37 7.8e-08 21.77 In-house 263-289 (289) Show / Hide 
Range on Protein: 308-334
Range on HMM: 263-289/289
Sequence Identity: 37% (10 aa)

KNLLEGMLHPNPKQRYCIKQVLSHEWF
|.|.. || |.|..|. |.....|.| 
KDLIRHMLQPHPCNRPHINEICHHCWM
Kinase 6891.AA TyrKc 28-334 16 1.5e-05 -132.71 SMART 3-280 (280) Show / Hide 
Range on Protein: 28-334
Range on HMM: 3-280/280
Sequence Identity: 16% (57 aa)

KLEQIGESSNSCIFSITNKNKQSQIL---KVIKHNSQNSYKLEGREQCSGHSRECAHLQNEYNMLRKL--NHPNIIELKHDQLI--------QNTSIVDT
.....||     ..  | |     |    |..|...                   . . .| ....||  .||||. |    .         .   ||  
LGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVM-

NINGCCILLEKGNC-DLLQMLSQVYPNVLEMSYLKYCFKKIAFAIQYLHEEKKIAHNDIKLENIILFNSE-PKISDFGFAQKHELD-------PIVQI--
       . ..|.. | |.         | |. | .    ||   .|||.  .. | |.   |. . .    |||||| . ... |              
------EYMPHGDLKDYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKE

---KN------WLHRSKKNVAPEIINNMKKLKAKQIDDIKAFDERKTDIFALGIALFNALIHQNPFEIMADSNDSLYSKFYEQ-----DGASKFWSDPQI
   ..      |.       ||| |            . . | . |.|... |. .         .||.     ..  . |.        ..    . . 
HKGGKTMLPIRWM-------APECI------------NYGKFTT-KSDVWSFGVCM---------WEIF-----TYGQQPYPGMIQQMMSNQEVIEYVKQ

SRMLDFISS-----FEHSKVPQLKNLLEGMLHPNPKQRYCIKQVLSHEWF
 ....   .     |     . . .. .   | .|..| . ...  || |
GYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 6891.AA CAMK1 152-194 32 2.5e-05 11.38 In-house 115-162 (276) Show / Hide 
Range on Protein: 152-194
Range on HMM: 115-162/276
Sequence Identity: 32% (16 aa)

KKIAFAIQYLHEEKKIAHNDIKLENIILFNSEPK------ISDFGFAQK
|.|. |..|.| .| |.| |.| ||. . . ..       |.||| ...
KQILSAVEYMH-SKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKI
Kinase 6891.AA AMPK 151-190 41 9.7e-05 10.06 In-house 106-145 (254) Show / Hide 
Range on Protein: 151-190
Range on HMM: 106-145/254
Sequence Identity: 41% (17 aa)

FKKIAFAIQYLHEEKKIAHNDIKLENIIL-FNSEPKISDFG
|. |  .. |.| . .|.| | |.||. |  | . || |||
FQQIISGVEYCH-RHMIVHRDLKPENLLLDHNKNIKIVDFG
Kinase 6891.AA CAMK1 53-101 20 0.000299 8.19 In-house 32-74 (276) Show / Hide 
Range on Protein: 53-101
Range on HMM: 32-74/276
Sequence Identity: 20% (11 aa)

LKVIKHNSQNSYKLEGREQCSGHSR-ECAHLQNEYNMLRK---LNHPNIIELK
.|.|.           ... ..... . . |.|| ....|   ..||||| ..
IKCIDK----------KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFY
Kinase 6891.AA Ciliate-E2a 82-100 57 0.001177 6.66 In-house 46-64 (275) Show / Hide 
Range on Protein: 82-100
Range on HMM: 46-64/275
Sequence Identity: 57% (11 aa)

LQNEYNMLRKLNHPNIIEL
..|| | .|.|.||||| |
FMNEINIMRQLDHPNIIKL
Kinase 6891.AA AMPK 82-100 42 0.004283 5.1 In-house 46-64 (254) Show / Hide 
Range on Protein: 82-100
Range on HMM: 46-64/254
Sequence Identity: 42% (8 aa)

LQNEYNMLRKLNHPNIIEL
.|.|  .|....||.|| |
IQREIHILKLFRHPHIIQL
Kinase 6891.AA MARK 82-100 47 0.005147 5.89 In-house 46-64 (262) Show / Hide 
Range on Protein: 82-100
Range on HMM: 46-64/262
Sequence Identity: 47% (9 aa)

LQNEYNMLRKLNHPNIIEL
.. | . ..||.|||||.|
VMREIEIMKKLDHPNIIKL
Kinase 6891.AA CAMKL 81-100 39 0.008918 4.52 In-house 58-80 (297) Show / Hide 
Range on Protein: 81-100
Range on HMM: 58-80/297
Sequence Identity: 39% (9 aa)

HLQNEYNMLRKLN---HPNIIEL
... |.. ...||   ||||| |
RIRREIQIMKMLNIGKHPNIIKL
Kinase 6891.AA TSSK 89-100 61 0.190301 0.49 In-house 69-81 (289) Show / Hide 
Range on Protein: 89-100
Range on HMM: 69-81/289
Sequence Identity: 61% (8 aa)

LRK-LNHPNIIEL
.|| |.|||||..
MRKTLKHPNIIQF
Kinase 6891.AA Ciliate-E2 26-101 20 0.209912 0.56 In-house 1-98 (365) Show / Hide 
Range on Protein: 26-101
Range on HMM: 1-98/365
Sequence Identity: 20% (21 aa)

SYKLEQIGESSNSCIFSITNKNKQSQI------------------------LKVIKHNSQNSYKLEGREQ----CSGHSRECAHLQNEYNMLRKLNHPNI
  ....||. . ....  .....| |.                        .|..|.|  .. | | ..     | .       . || |.|..||||||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FY----KKI-NEKNILEQLNHPNI

IELK
|...
IKMY