Gene 3172 (Tetrahymena)
3172
Group:
Other
Family:
Ciliate-A7
Sequence
Protein domains of 3172.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 3172.AA | Ciliate-A7 | 56-413 | 29 | 6.30000000001e-140 | 471.15 | In-house | 21-360 (360) | Show / Hide |
Range on Protein: 56-413
Range on HMM: 21-360/360
Sequence Identity: 29% (122 aa)
SNKIVVKEIKHKVEG-----------QHCEQCYDLKNEVEKLKEMKHPHIIALQE-------NKIYEFRMSCAIFLPKALEDLFDYMIKYNVEDNLKSL-
.....||..||.... .||..||.||||...||.|.|||||.|.| ......|..|.|....| .|||.|........||...
NQYQIVKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAECDLFQYFSQHYPHKNLHHNE
-------------KICFYQIGQAIKYLHQVKNMVHGDVKPENIFVFSEEE------FKLADFGFCKKYQKFASREE---------FIRQYTSRSLKYHPP
..||.||.||..|||..||..|.|.||||||.|.... ||||||||.||||.....|. .......|...|..|
KIENQCEYCVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLRQQIIEDQYKNWKYRCKQYFAP
EFVDCLEQ---------------PNFNLNLIDEYSSDVFGLGVALFQLVFKQCPYYEEAEFQYSTSTEKKQPVQQIQQSNKDLIDISQVNITGMISKSLK
|...||.. ...|....||...|||..||..||..|.|.|...||..|.....
EIINCLNKCCDKNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYK---------------------------------
QINIHRKLQLSPESTNNTNKTPVNSPSNSTSPPQMSAVKKKKQNKRKYYHRQDKLYGILYQPNNIEEFWNHFKDEIQDMIKNTDLSQEDIDILKDLILKC
|.|...| |....|...|...||||..|||||||||| .|.|||..|||. |.
-----------------------------------------------YKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKM
ITPFHYLRVGIDDFLAHPFF
..|... |..|...|.||.|
LCPNPSQRYCIKQILQHPWF
|
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| Kinase | 3172.AA | Ciliate-E2-Unclassified | 140-413 | 17 | 5.6e-20 | 66.0 | In-house | 149-352 (352) | Show / Hide |
Range on Protein: 140-413
Range on HMM: 149-352/352
Sequence Identity: 17% (52 aa)
FYQIGQAIKYLHQVKNMVHGDVKPENIFVFSEE---EFKLADFGFCKKYQK-------------FASREEFIRQYTSRSLK--YHPPEFVDCLEQPNFNL
|.|| |...|||. .| .| | |||||.. .. . |..|||..||||. . ..... . . . . | .|| .|.. | .
FAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE---VLQGQNYDH
NLIDEYSSDVFGLGVALFQLVFKQCPYYEEAEFQYSTSTEKKQPV-----QQIQQSNKDLIDISQVNITGMISKSLKQINIHRKLQLSPESTNNTNKTPV
|..|...||| |....| ..|.| . . |. ....... |..|. .. |... .
SKA--YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQ------------------------------
NSPSNSTSPPQMSAVKKKKQNKRKYYHRQDKLYGILYQPNNIEEFWNHFKDEIQDMIKNTDLSQEDIDILKDLILKCITPFHYLRVGIDDFLAHPFF
..|.| .|...||. |.. | .... | ||.|
---------------------------------------------------------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
|
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| Kinase | 3172.AA | Ciliate-E2 | 79-413 | 14 | 1.6e-18 | 60.22 | In-house | 63-365 (365) | Show / Hide |
Range on Protein: 79-413
Range on HMM: 63-365/365
Sequence Identity: 14% (64 aa)
LKNEVEKLKEMK----------------HPHIIALQENKIYEFRMSCAIFLPKALE-DLFDYM----IKYNVE----DNLKSLKIC--FYQIGQ------
.|.| ..|.. ||.|| . | . . . .. . . . |||||. .| | | ... .|. ..|| |
IKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKA
---------AIKYLHQVKNMVHGDVKPENIFVFSEEEFKLADFGFCKKYQKF-------ASREEFIRQY-----TSR----------------SLKYHPP
|..|||. .| .| | |||||.. |..|||..|||... ..... |.. .. | .|
EFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAP
EFVDCLE---QPNFNLNLIDEYSSDVFGLGVALFQLVFKQCPYYEEAEFQYSTSTEKKQPVQQIQQSNKDLIDISQVNITGMISKSLKQINIHRKLQLSP
| . . | .. |..|.. ||| |....|.. |.
EILNGKKYDNQ---QKQKGYDYKCDIWSLGVILYEMLFGKPPF---------------------------------------------------------
ESTNNTNKTPVNSPSNSTSPPQMSAVKKKKQNKRKYYHRQDKLYGILYQPNNIEEFWNHFKDEIQDMIKNTDLSQED-----------------IDIL-K
..| . .. |..... .. |
--------------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECK
DLILK----CITPFHYLRVG-IDDFLAHPFF
||| | .. | . ... | ||.|
DLIKKFGKRMLQKDPEKRITGWEQILNHPWF
|
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| S_TKc | 3172.AA | S_TKc | 22-413 | 13 | 5.7e-16 | 57.24 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 22-413
Range on HMM: 1-231/231
Sequence Identity: 13% (53 aa)
NCFTKHIESSNNSVVSAIIKVPLKKRRNMNSCSVSNKIVVKEIKHKVEGQHCEQCYDLKNEVEKLKEMKHPHIIALQENKIYEFRMSCAIFLPKALE---
. ..| . ..| ... . .|.|| ....|.. ||. .||.|. | . ... . ... .
YEILRKIGKGAFGKVYKCRHKK-----------TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYD--VFQD-DHLYMVMEYCDGDLG
DLFDYMIKYNVE-----DNLKSLKICFYQIGQAIKYLHQVKNMVHGDVKPENIFVFSEEEFKLADFGFCKKYQKFASREEFIRQYTSRSLKYHPPEFVDC
|||||. |.. . . . .||| .|..|.|. . .| |.|||||.. . . |..|||..... .. | .|| .
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL--
LEQPNFNLNLIDEYSSDVFGLGVALFQLVFKQCPYYEEAEFQYSTSTEKKQPVQQIQQSNKDLIDISQVNITGMISKSLKQINIHRKLQLSPESTNNTNK
. ..|. .|. |. .. . |.. . .. ..|
---------GYGKCKCDWWSCGCILYEMLCGYPPFP-----------QMQMMFKKIG-------------------------------------------
TPVNSPSNSTSPPQMSAVKKKKQNKRKYYHRQDKLYGILYQPNNIEEFWNHFKDEIQDMIKNTDLSQEDIDILKDLILKCITPFHYLRVGIDDFLA----
. .||.| || . | .. . |.
---------------------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD
---HPFF
||.|
IKCHPWF
|
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| Kinase | 3172.AA | WEE | 136-184 | 24 | 2.5e-14 | 44.51 | In-house | 113-181 (297) | Show / Hide |
Range on Protein: 136-184 Range on HMM: 113-181/297 Sequence Identity: 24% (17 aa) LKICFYQIGQAIKYLHQVKNMVHGDVKPENIFVFSEE--------------------EFKLADFGFCKK .. . .| |.....|. .||| |.||||||. .. .|..||| ... IWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTD |
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| Kinase | 3172.AA | Pkinase | 67-201 | 21 | 3.7e-14 | 51.15 | Pfam | 33-171 (293) | Show / Hide |
Range on Protein: 67-201 Range on HMM: 33-171/293 Sequence Identity: 21% (32 aa) KVEGQHCEQCYDLKN--EVEKLKEMKHPHIIALQENKIYEFRMSCAIFLPKALE-----DLFDYMI-KYNVED--NLKSLKICFYQIGQAIKYLHQVKNM |.......... . . |.. .|...||.|. | . ..| . .. . .. . |||||. ... . .| ..||| ....|.|. .. KKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYD--WFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGI VHGDVKPENIFVFSEEEF----KLADFGFCKKYQKFASREEFIRQYTSR .| |.|||||.. .. . |..|||..|... . . .|.. IHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTF |
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| Kinase | 3172.AA | CMGC | 119-201 | 18 | 2.6e-13 | 39.2 | In-house | 140-285 (513) | Show / Hide |
Range on Protein: 119-201
Range on HMM: 140-285/513
Sequence Identity: 18% (27 aa)
DLFDYMIKYN----------VEDNL----------KSLKICF------YQIGQAIK--YLHQVK-NMVHGDVKPENIFVFSEEEF---------------
||..|. ... .. . | . ||| ...| |.|. . | .| | ||||| . .. |
DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQ
-----KLADFGFCKKYQKF----------------ASREEFIRQYTSR
|..|||....| . .. . |.||..
KNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHY
|
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| Kinase | 3172.AA | Ciliate-E2c | 140-188 | 51 | 4.3e-13 | 42.33 | In-house | 120-167 (310) | Show / Hide |
Range on Protein: 140-188 Range on HMM: 120-167/310 Sequence Identity: 51% (25 aa) FYQIGQAIKYLHQVKNMVHGDVKPENIFVFSEEEFKLADFGFCKKYQKF | || .| ||||. ||. |.|.|||||. . . |.||||| |. | . FSQIISAFKYLHKEKNIFHRDIKPENILI-HNGMIKIADFGFSKICQDD |
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| Kinase | 3172.AA | DCAMKL | 141-180 | 45 | 5.7e-12 | 32.97 | In-house | 122-164 (279) | Show / Hide |
Range on Protein: 141-180 Range on HMM: 122-164/279 Sequence Identity: 45% (20 aa) YQIGQAIKYLHQVKNMVHGDVKPENIFVFS----EEEFKLADFG .....|.|||| .| || |.|||| | | . ||.||| TCLCKALKYLHE-MNIVHRDIKPENLLVCKHEDGEKSLKLCDFG |
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| Kinase | 3172.AA | AGC | 146-184 | 45 | 1.9e-11 | 24.36 | In-house | 165-204 (395) | Show / Hide |
Range on Protein: 146-184 Range on HMM: 165-204/395 Sequence Identity: 45% (18 aa) AIKYLHQVKNMVHGD-VKPENIFVFSEEEFKLADFGFCKK |. |||. .. .| | .||||| .. ||.|||.||. ALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKE |
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| Kinase | 3172.AA | Ciliate-E2b | 146-183 | 42 | 6e-11 | 29.68 | In-house | 114-150 (272) | Show / Hide |
Range on Protein: 146-183 Range on HMM: 114-150/272 Sequence Identity: 42% (16 aa) AIKYLHQVKNMVHGDVKPENIFVFSEEEFKLADFGFCK ...||| .| ...|.||||| | .. ||.|.| | CLEYLH-NQNIIYRDIKPENIMVDHKGYMKLIDMGTAK |
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| Kinase | 3172.AA | ULK | 140-184 | 35 | 1.9e-07 | 22.12 | In-house | 136-191 (329) | Show / Hide |
Range on Protein: 140-184 Range on HMM: 136-191/329 Sequence Identity: 35% (20 aa) FYQIGQAIKYLHQVKNMVHGDVKPENIFVFSEE------------EFKLADFGFCKK |.|| .. |.||. .| .| | ||.|| . .|.|||||.|. FKQILNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH |
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| Kinase | 3172.AA | AGC | 386-413 | 26 | 2e-06 | 10.93 | In-house | 358-395 (395) | Show / Hide |
Range on Protein: 386-413 Range on HMM: 358-395/395 Sequence Identity: 26% (10 aa) LKDLILKCITPFHYLRVG----------IDDFLAHPFF .|||| |.... | | ... .||.| AKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| TyrKc | 3172.AA | TyrKc | 34-252 | 14 | 2e-05 | -134.92 | SMART | 14-280 (280) | Show / Hide |
Range on Protein: 34-252 Range on HMM: 14-280/280 Sequence Identity: 14% (42 aa) SVVSAIIKVPLKKRRNMNSCSVSNKIVVKEIKHKVEGQHCEQCYDLKNEVEKLKEM--KHPHIIAL-----QE--NKIYEF---RMSCAIFLPKALEDLF |. .. | . || .|. |. .| . ... .||.|..| |. | | . .. .. || EVYKGTWK---------------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLK DYMIKYNVEDNLKSLKICFYQIGQAIKYLHQVKNMVHGDVKPENIFVFSEEEFKLADFGFCKKY-----------QKFAS---REE-------------F || |. . ..| | .|| . |||. | .| | |. | .. | .||| ... . .. . . DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN IRQYTSRS----------------LKYHPP---------EFVDCLEQPNFNLNLID-------EYSSDVFGLGVALFQL------VFKQCPYYEEA . .|. | . .| | . ...| . . . ..... . . |... .|. YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | 3172.AA | ULK | 348-413 | 18 | 2.6e-05 | 14.57 | In-house | 250-329 (329) | Show / Hide |
Range on Protein: 348-413 Range on HMM: 250-329/329 Sequence Identity: 18% (15 aa) LYGILY--QPNNIEEFWNHFKDEIQD------MIKNTDLSQED-------IDILKDLILKCITPFHYLRVGIDDFLAHPFF ||| . . . ...... ...|.. .||.. | .. . .|||| .... | ......||.| LYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | 3172.AA | Ciliate-E2b | 227-256 | 23 | 3.5e-05 | 11.87 | In-house | 189-218 (272) | Show / Hide |
Range on Protein: 227-256 Range on HMM: 189-218/272 Sequence Identity: 23% (7 aa) YSSDVFGLGVALFQLVFKQCPYYEEAEFQY |..|.. .|. |. . ... |. |... .| YKVDIWSVGICLYEFMCGYVPWAEDVQDPY |
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| Kinase | 3172.AA | DCAMKL | 81-99 | 57 | 0.000911 | 6.99 | In-house | 64-82 (279) | Show / Hide |
Range on Protein: 81-99 Range on HMM: 64-82/279 Sequence Identity: 57% (11 aa) NEVEKLKEMKHPHIIALQE |||. .. .|||||| | | NEVSIMQKIKHPHIIQLYE |
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| Kinase | 3172.AA | Pkinase | 386-413 | 32 | 0.00413 | 12.08 | Pfam | 266-293 (293) | Show / Hide |
Range on Protein: 386-413 Range on HMM: 266-293/293 Sequence Identity: 32% (9 aa) LKDLILKCITPFHYLRVGIDDFLAHPFF .||.| .|... . | .... | ||.| CKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 3172.AA | Ciliate-E2c | 79-95 | 47 | 0.008655 | 5.71 | In-house | 61-77 (310) | Show / Hide |
Range on Protein: 79-95 Range on HMM: 61-77/310 Sequence Identity: 47% (8 aa) LKNEVEKLKEMKHPHII ...|.. .|.|.||||| IIREINMMKHMNHPHII |
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| Kinase | 3172.AA | ULK | 226-250 | 21 | 0.028274 | 3.85 | In-house | 231-258 (329) | Show / Hide |
Range on Protein: 226-250 Range on HMM: 231-258/329 Sequence Identity: 21% (6 aa) EYS---SDVFGLGVALFQLVFKQCPYYE .|. .|.. ||. ...... ..|.|. PYYDYKCDIWSLGCIFYEMLYGKPPFYA |
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| Kinase | 3172.AA | ULK | 79-101 | 32 | 0.088287 | 2.1 | In-house | 57-87 (329) | Show / Hide |
Range on Protein: 79-101 Range on HMM: 57-87/329 Sequence Identity: 32% (10 aa) LKNEVEKLKEMK--------HPHIIALQENK ||||.. .|..| ||.|. | . . LKNEIKIMKKLKSPNRHKNHHPNIVKLYDWF |
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| Kinase | 3172.AA | CMGC | 388-413 | 30 | 0.123731 | 0.09 | In-house | 488-513 (513) | Show / Hide |
Range on Protein: 388-413 Range on HMM: 488-513/513 Sequence Identity: 30% (8 aa) DLILKCITPFHYLRVGIDDFLAHPFF ||. |. . . | ... |.||.| DLLKKMLQYDPDKRITAEQALQHPYF |
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