Gene 21201 (Tetrahymena)
21201
Group:
Other
Family:
Ciliate-A7
Sequence
Protein domains of 21201.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 21201.AA | Ciliate-A7 | 71-352 | 35 | 3.7e-125 | 422.1 | In-house | 26-360 (360) | Show / Hide |
Range on Protein: 71-352
Range on HMM: 26-360/360
Sequence Identity: 35% (119 aa)
LKEM-VHKQLD----------CHTKQCYLLENEYYFLSQISHPHIIKLTS--------ELKSESKSCYFTLEKGLCDMYDRTFRQDHTQLKNYDLN----
.|. .| ... | .|| | |||.||.. .|||||.| . |.. .. .| ...|.. || . . | . ||...|
VKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAECDLFQ--YFSQHYPHKNLHHNEKIE
--------EVRNCAKQVALALHYLHTELHVSHNDIKPENIIMFDKNL------FKLADFGYAKQIEKTLIYSS--------DLYNKWKYRCREYMAPELI
..|.|..|.| ||||||.|....|||||||||..|..| |||||||.||..... ...| |.|..|||||..|.|||.|
NQCEYCVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLRQQIIEDQYKNWKYRCKQYFAPEII
QIVNN----NVAINNKKILTNILNNCYIDEVKTDVFAFGMSIFVMIFSVLPYKTQEGAFFEDE-IFQYLDNKSSYVSFWMNFKDILNEFEKEEK-----E
...|. |.|.|.|.|...| |.|..||.|.||||||.|.|...|...|............ ...|.....|....||......|.|.||.. .
NCLNKCCDKNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMIKNT
RQQNYGIEHLKDLLENMLCHNPSERFNTLQIITHPWL
.||...|...||||..|||.|||.|....||..|||.
DQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQHPWF
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| Kinase | 21201.AA | Ciliate-E2 | 89-352 | 19 | 2.4e-23 | 77.01 | In-house | 80-365 (365) | Show / Hide |
Range on Protein: 89-352
Range on HMM: 80-365/365
Sequence Identity: 19% (65 aa)
LENEYYFLSQISHPHIIKLTSELKS-ESKSCYFTLEKGLC-DMYD--------RTFRQDHTQLKNYDLNEVRNCAKQVAL---------------ALHYL
. || |.|..||.|||. .. ...|. .| |..| |.. .. . |.....|... ||.. ||.||
I-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYL
HTELHVSHNDIKPENIIMFDKNLFKLADFGYAKQIEKTLIYSS-----DLYNKWK----------------------YRCREYMAPELIQIVN--NNVAI
| . .. | |||||||.. |..|||..|.. . .. . .| | . .||||| .. . |.
HSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ---
NNKKILTNILNNCYIDEVKTDVFAFGMSIFVMIFSVLPYKTQEGAFFEDEIFQYLDNKSSYVSFWMNFKDILNEFEKEEKERQQNYGIEHL---------
.. | |....|. .. |.| .|. .. | ....|.... | . .
----------QKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQ
--KDLLEN----MLCHNPSERFN-TLQIITHPWL
|||. . ||. .|..|.. ||. |||.
ECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 21201.AA | Ciliate-E2-Unclassified | 96-352 | 19 | 4.2e-22 | 73.48 | In-house | 75-352 (352) | Show / Hide |
Range on Protein: 96-352 Range on HMM: 75-352/352 Sequence Identity: 19% (61 aa) LSQISHPHIIKLTSELKSESKSCYFTLEKGLCDMYDRTFRQDH------------TQLKN---YDLNEVR-----NCAKQVALALHYLHTELHVSHNDIK |... ||.|.|. . ... . .|. .| .|. | . . ..|. . .... . ..|. ..| ||| .... | ||| LLNHPHPFIVKMFYCFQDKQN-IYIVME--YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIK PENIIMFDKN---LFKLADFGYAKQIE-----------KTLIYSSDLYNKWKYRC--REYM----APELIQIVNNN--VAINNKKILTNILNNCYIDEVK ||||.. ... |..||| .|... |. |....... .| .|| |||..| |.. | | PENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWT---FCGTPNYMPQYTAPEVLQGQNYDHSKA------------------YK TDVFAFGMSIFVMIFSVLPYK--TQEGAFFEDEIFQYLDNKSSYVSFWMNFKDILNEFEKEEKERQQN-----YGIE-HLKDLLE----NMLCHNPSERF |....|. .. |.| .|.. ..| ... .... . | . .. . | ..|. . . .. ... . ||... || ||..| CDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-N-N------A-YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI NTLQIITHPWL . ||. |||. TFEQILNHPWF |
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| Kinase | 21201.AA | Pkinase | 84-352 | 17 | 1e-21 | 77.88 | Pfam | 40-293 (293) | Show / Hide |
Range on Protein: 84-352
Range on HMM: 40-293/293
Sequence Identity: 17% (53 aa)
KQCYLLEN--EYYFLSQISHPHIIKLTSELKSESKSCYFTLEKGLC-----DMYDRTFRQDHTQLKNYDLNEVRNCAKQVALALHYLHTELHVSHNDIKP
.... . . | . . ..||.|..| . ....|. .| . | .|. ...|. . . .|......|.. .| |.| . | |.||
WKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS-MGIIHRDLKP
ENIIMFDKNLF----KLADFGYAKQIEKTLIYSSDLYNKWKYRCREYMAPELIQIVNNNVAINNKKILTNILNNCYIDEVKTDVFAFGMSIFVMIFSVLP
||| . ... |..||| |||.. | .. ... ..|||||.|. . . | |....| .. |..
ENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIR-------------------GGQYYGPKVDMWSCGCILYEMLCGR--
YKTQEGAFFEDEIFQYLDNK----SSYVSFWMNFKDILNEFEKEEKERQQNYGI---------------EHLKDLLENMLCHNPSERFNTLQIITHPWL
... . . .| ... ... .. . .. | .||.....|| .|..| . || |||.
--------------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| S_TKc | 21201.AA | S_TKc | 61-352 | 16 | 2.1e-15 | 48.88 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 61-352
Range on HMM: 1-231/231
Sequence Identity: 16% (53 aa)
LQNAEQI------TCFLKEMVH-------KQLDCHTKQCYLLENEYYFLSQISHPHIIKLTSELKSESKSCYFTLEKGLC---DMYDRTFRQDHTQL-KN
. ..| .... .. |... ...| |.. ||.|.|| . .. |. .| |..|. .. . | .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP
YDLNEVRNCAKQVALALHYLHTELHVSHNDIKPENIIMFDKNLFKLADFGYAKQIEKTLIYSSDLYNKWKYRC--REYMAPELIQIVNNNVAINNKKILT
.. ..| ..|...|| |.| .. | |.||||| . . |..||| |.|. . | ..|||||..
FPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL----------------
NILNNCYIDEVKTDVFAFGMSIFVMIFSVLPYKTQEGAFFEDEIFQYLDNKSSYVSFWMNFKDILNEFEKEEKERQQNYGIEHLKDLLENMLCHNPSERF
. | |. ..| .. |. |. ....|. . . .||.....|. .|..|
------GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRP
NTLQIIT-------HPWL
.. . |||.
TA-EALQDEWDIKCHPWF
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| Kinase | 21201.AA | Aur | 154-195 | 39 | 1.7e-12 | 28.79 | In-house | 108-149 (257) | Show / Hide |
Range on Protein: 154-195 Range on HMM: 108-149/257 Sequence Identity: 39% (17 aa) KQVALALHYLHTELHVSHNDIKPENIIMFD-KNLFKLADFGYA .|...||.|.| . .. | |||||||.. . .. |..|||.. YQICNALDYCH-SKNIIHRDIKPENILLDQCNGNIKICDFGWS |
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| Kinase | 21201.AA | CMGC | 137-200 | 18 | 8e-11 | 30.84 | In-house | 161-256 (513) | Show / Hide |
Range on Protein: 137-200 Range on HMM: 161-256/513 Sequence Identity: 18% (18 aa) DHTQ------------LKNYDLNEVRNCAKQVALALH--YLHTE-LHVSHNDIKPENIIMFDKNLF--------------------KLADFGYAKQIEK .. . |.. . .| ..|. .|. |.| . . | |.||||| . ... |..||| |..... SE-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP |
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| Kinase | 21201.AA | CAMKL | 303-352 | 27 | 1e-10 | 30.31 | In-house | 246-297 (297) | Show / Hide |
Range on Protein: 303-352 Range on HMM: 246-297/297 Sequence Identity: 27% (15 aa) KDILNEFEKEEKERQQNYGIE----HLKDLLENMLCHNPSERFNTLQIITHPWL || ........ .. | ..||. || .||..|.. || |||. KDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 21201.AA | DCAMKL | 155-204 | 35 | 2.2e-10 | 27.93 | In-house | 123-177 (279) | Show / Hide |
Range on Protein: 155-204 Range on HMM: 123-177/279 Sequence Identity: 35% (20 aa) QVALALHYLHTELHVSHNDIKPENIIMFD----KNLFKLADFGYAKQIEK--TLIY ... || ||| |. . | |||||| . . ||.||| |. ... ..| CLCKALKYLH-EMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGPLY |
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| Kinase | 21201.AA | CAMK | 323-352 | 36 | 4.7e-10 | 27.84 | In-house | 396-425 (425) | Show / Hide |
Range on Protein: 323-352 Range on HMM: 396-425/425 Sequence Identity: 36% (11 aa) EHLKDLLENMLCHNPSERFNTLQIITHPWL . |||. .||. .|..|.. |. |||. QECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | 21201.AA | STE | 147-226 | 26 | 5.4e-10 | 31.6 | In-house | 151-235 (359) | Show / Hide |
Range on Protein: 147-226 Range on HMM: 151-235/359 Sequence Identity: 26% (24 aa) NEVRNCAKQVALA-LHYLHTELHVSHNDIKPENIIMFDKNLFKLADFGYAKQIEKTLI-----------YSSDLYNKWKYRCREYMAPELIQ .... ..|. . |.||| . | |||| || . ||.||| ..|..... .... .. . .|||| || SQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQ |
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| Kinase | 21201.AA | CAMKL | 154-200 | 32 | 2.1e-09 | 26.0 | In-house | 134-181 (297) | Show / Hide |
Range on Protein: 154-200 Range on HMM: 134-181/297 Sequence Identity: 32% (16 aa) KQVALALHYLHTELHVSHNDIKPENIIMFDKN--LFKLADFGYAKQIEK .|. |..|.| . | ||||||| ... |..||| . .... RQIVSAVNYCHSHG-IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRP |
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| Kinase | 21201.AA | CAMK | 84-200 | 19 | 2.8e-09 | 25.3 | In-house | 73-248 (425) | Show / Hide |
Range on Protein: 84-200
Range on HMM: 73-248/425
Sequence Identity: 19% (35 aa)
KQCYLLENEYYFLSQ-------ISHPHIIKLTSELK------------SESK-------SCYFTL---EKGLC-----DMYDRTFRQDHTQLKN------
| . ...|. ... ..||.|||| . || .|. . | |..|. .. . ..
KDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV
----YDLNEVRNCAKQVALALHYLHTELHVSHNDIKPENIIMFDK-----------------NLFKLADFGYAKQIEK
.. |.| . .|.. |.||.| . | |.||||| . |. | |..||| |.....
ERGRFTEREARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDP
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| Kinase | 21201.AA | LKB | 325-352 | 39 | 3.9e-09 | 23.33 | In-house | 238-265 (265) | Show / Hide |
Range on Protein: 325-352 Range on HMM: 238-265/265 Sequence Identity: 39% (11 aa) LKDLLENMLCHNPSERFNTLQIITHPWL | .|.. || ...||. .|| |||. LQNLIKGMLQYDHNKRFSCHQIMHHPWF |
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| Kinase | 21201.AA | LKB | 159-200 | 40 | 5.7e-09 | 22.83 | In-house | 116-156 (265) | Show / Hide |
Range on Protein: 159-200 Range on HMM: 116-156/265 Sequence Identity: 40% (17 aa) ALHYLHTELHVSHNDIKPENIIMFDKNLFKLADFGYAKQIEK .. ||| .|.| |||| |. . | |. ||| | |... GCEYLHSQ-RVVHKDIKPGNLLLTHDNTLKICDFGVAEQLHH |
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| Kinase | 21201.AA | DCAMKL | 326-352 | 44 | 3.5e-08 | 20.98 | In-house | 253-279 (279) | Show / Hide |
Range on Protein: 326-352 Range on HMM: 253-279/279 Sequence Identity: 44% (12 aa) KDLLENMLCHNPSERFNTLQIITHPWL ||| .|| .| |. || ||| KDLISHMLQVDPEKRYTAEQIMQHPWV |
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| Kinase | 21201.AA | CMGC | 327-352 | 38 | 2.6e-07 | 19.11 | In-house | 488-513 (513) | Show / Hide |
Range on Protein: 327-352 Range on HMM: 488-513/513 Sequence Identity: 38% (10 aa) DLLENMLCHNPSERFNTLQIITHPWL |||..||. .|..| |. ||.. DLLKKMLQYDPDKRITAEQALQHPYF |
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| Kinase | 21201.AA | Aur | 325-352 | 42 | 4.6e-07 | 14.13 | In-house | 230-257 (257) | Show / Hide |
Range on Protein: 325-352 Range on HMM: 230-257/257 Sequence Identity: 42% (12 aa) LKDLLENMLCHNPSERFNTLQIITHPWL .||| . | |.|..| . || ||| AKDLISKILQHDPKQRMTLDQIMNHPWI |
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| Kinase | 21201.AA | STE | 323-352 | 25 | 1.2e-05 | 16.02 | In-house | 328-359 (359) | Show / Hide |
Range on Protein: 323-352 Range on HMM: 328-359/359 Sequence Identity: 25% (8 aa) EHLKDLLENMLCHNPSERFNTLQIIT--HPWL ...|| ... | .|..| .. | . ||.. PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| TyrKc | 21201.AA | TyrKc | 46-352 | 13 | 0.000106 | -146.63 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 46-352 Range on HMM: 1-280/280 Sequence Identity: 13% (48 aa) LQETQQIQT-----------SFQNNQLQNAEQITCFLKEMVHKQLDCHTKQCYLLENEYYFLSQI--SHPHIIKLTSELKSES------KSCYFTLEKGL .. ... . |.. | . . . .| .... .||.|..| ... . . .| . ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME--Y CDMYD-RTFRQDHTQLKNYDLNEVRNCAKQVALALHYLHTELHVSHNDIKPENIIMFDKNLFKLADFGYAKQIEKT---LIYSSDLYNKWKYRCRE---- .. | . . ..| . . . . |.| ||| .. | |. |. ... | .||| .. |. |.| | | . ... MPHGDLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLP --YMAPELIQIVNNNVAINNKKILTNILNNCYIDEVKTDVFAFGMSIFVMIFSVLPYKTQEGAFFEDEIFQYLDNKSSYVSFWMNFKDILNEFEKEEKER |||| | |... | |.||..|| .. . | . ...|.| |. ..... .. . . IRWMAPECI----------NYGKFTT----------KSDVWSFGVCMWEIF-------TYGQQPYPGMIQQ-----------MMSNQEVIEYVKQGYRMP QQNY--------GIEHLKDLLENMLCHNPSERFNTLQIITHPWL | . . . .. . ..|..| . .| | . QPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | 21201.AA | DCAMKL | 86-107 | 40 | 0.000738 | 7.28 | In-house | 59-80 (279) | Show / Hide |
Range on Protein: 86-107 Range on HMM: 59-80/279 Sequence Identity: 40% (9 aa) CYLLENEYYFLSQISHPHIIKL . . .|| ...|.|||||.| EHMIDNEVSIMQKIKHPHIIQL |
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| Kinase | 21201.AA | CAMKL | 83-107 | 19 | 0.033166 | 2.67 | In-house | 39-80 (297) | Show / Hide |
Range on Protein: 83-107 Range on HMM: 39-80/297 Sequence Identity: 19% (8 aa) TKQCYLLEN--------------EYYFLSQIS---HPHIIKL .. .. . | |. ..... ||.|||| WNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKL |
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