Gene 14731 (Tetrahymena)

14731

Species: Tetrahymena
Alias: PreTt14731, 721, 14731, 345.m00013, TTHERM_01358400
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A7

Sequence

Name Sequence Type Origin Length Description Download
14731.AA Protein None 300 None Fasta, JSON
14731.kin_dom Protein Kinase Domain None 238 None Fasta, JSON
14731.NA RNA None 903 None Fasta, JSON

Protein domain

Protein domains of 14731.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 14731.AA Ciliate-A7 58-298 27 1.9e-115 389.81 In-house 51-360 (360) Show / Hide 
Range on Protein: 58-298
Range on HMM: 51-360/360
Sequence Identity: 27% (86 aa)

ACSQLHNEFKIASQLDHPNITR--------PIDIQQYYKGGCMILFPQANCDGFDLFTKSVPQIDIIKN----------------YLRSMASALAYLHK-
.| .|.||.......|||.|..        ..|........|.||..||.||.|..|....|......|                ..|..|.||.|||. 
ECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAECDLFQYFSQHYPHKNLHHNEKIENQCEYCVNQMRHCFRQIAQALHYLHNE

MDIAHNDFKLENVLCFKNEN--GEIEFQLSDFGFSYSTQNKQEQNS--------NRIKEWDFRATQYFSPSIYSQISK-----------------KEFTE
..|||||.|.||...|.|.|  ....|.|.||||....|......|        ...|.|..|..|||.|.|.....|                 ....|
KNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLRQQIIEDQYKNWKYRCKQYFAPEIINCLNKCCDKNSAKNKKFISQQIDNQCE

NCEKQGDIFSLGYSFFIVLFQRRLSLKHEFTSDSPI-YKNIIKFGKS--FIQQKLKTSVQITQ--------------EDYDLCLDLLIKMLKKEDSERIT
..||..|.|..|.|||..|||.... ........|. ||.......|  .............|              .|.|...|||.|||....|.|..
FDEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYC

ALEILEHPFL
...||.||..
IKQILQHPWF
Kinase 14731.AA Ciliate-E2 61-298 18 8.2e-17 54.23 In-house 79-365 (365) Show / Hide 
Range on Protein: 61-298
Range on HMM: 79-365/365
Sequence Identity: 18% (61 aa)

QLHNEFKIASQLDHPNITRPIDIQQY-YKGGCMILFPQANCDGFDLFT-------KSVPQ--------IDIIKNYLRSMAS---------------ALAY
.. || .| .||.|||| . ..  |   .  . . .    |.| |||        |.  .        .  ||.. .  ..               || |
KI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVME--YCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEY

LHKMD-IAHNDFKLENVLCFKNENGEIEFQLSDFGFSYSTQNKQEQNS--NRIKEWDFRA---------------------TQYFSPSIYSQISKKEFTE
||.   | | | |.||.|            ..|||.|   ........  .. |.. |                       . .  .    .| ...  .
LHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYD

N------CEKQGDIFSLGYSFFIVLFQRRLSLKHEFTSDSPIYKNIIKFGKSFIQQKLKTSVQ------------------ITQEDYDLCLDLLIK----
|        .. ||.|||  ... || ..                        .||...  ..                  ....  . | ||. |    
NQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKR

MLKKEDSERIT-ALEILEHPFL
||.|. ..||| . .||.||..
MLQKDPEKRITGWEQILNHPWF
S_TKc 14731.AA S_TKc 11-298 18 1.4e-14 37.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-298
Range on HMM: 1-231/231
Sequence Identity: 18% (58 aa)

YEIINQISNDARTILSVVKCIDESEKLSENIVLKECVHSIVDNKCFSACSQLHNEFKIASQLDHPNITRPIDIQQYYKGGCMILFPQANC---DGFDLFT
|||...|   |    .| ||.. .    .   .|.               .. .| .| .. .|||| . .|. |   .   . .  ..    | ||.  
YEILRKIGKGA--FGKVYKCRHKK--TGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIK

KSVP-------QIDIIKNYLRSMASALAYLHKMDIAHNDFKLENVLCFKNENGEIEFQLSDFGFSYSTQNKQEQNSNRIKEWDFRAT-QYFSPSIYSQIS
|  .           .. |.. ...||.|.|.. | | | | ||.|. .      .  ..|||..                  |  |  | .| .     
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----

KKEFTENCEK-QGDIFSLGYSFFIVLFQRRLSLKHEFTSDSPIYKNIIKFGKSFIQQKLKTSVQITQEDYDLCLDLLIKMLKKEDSERITALEILE----
         |   |. |.|  ... |  . .        .  ..|.|                       . ..|.. |.|.|. ..|.|| |.|.    
------GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPFL
   ||..
IKCHPWF
Kinase 14731.AA DCAMKL 120-163 47 6.4e-13 35.98 In-house 121-164 (279) Show / Hide 
Range on Protein: 120-163
Range on HMM: 121-164/279
Sequence Identity: 47% (21 aa)

LRSMASALAYLHKMDIAHNDFKLENVLCFKNENGEIEFQLSDFG
.. ...|| ||| | | | | |.|| |  |.| ||..  | |||
MTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFG
Kinase 14731.AA MAPKAPK 121-164 43 9.6e-12 32.18 In-house 110-152 (292) Show / Hide 
Range on Protein: 121-164
Range on HMM: 110-152/292
Sequence Identity: 43% (19 aa)

RSMASALAYLHKMDIAHNDFKLENVLCFKNENGEIEFQLSDFGF
.  .||...||.|.||| | |.||.|| ...   .   |.||||
KDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCP-VKLCDFGF
Kinase 14731.AA MAPKAPK 121-173 32 1.2e-11 35.43 In-house 111-162 (268) Show / Hide 
Range on Protein: 121-173
Range on HMM: 111-162/268
Sequence Identity: 32% (17 aa)

RSMASALAYLHKMDIAHNDFKLENVLCFKNENGEIEFQLSDFGFSYSTQNKQE
.. ..|....|.|.||| | |.|| |.  ... .    |.||||   |.....
KQICQAVQHCHSMNIAHRDLKPENLLYKDTQP-NCVLKLTDFGFAKETTRHNT
Kinase 14731.AA CMGC 239-298 18 2.5e-11 32.56 In-house 419-513 (513) Show / Hide 
Range on Protein: 239-298
Range on HMM: 419-513/513
Sequence Identity: 18% (18 aa)

SPIYKNIIKFGKSFIQQKLKTSVQITQE-----------------------------------DYDLCLDLLIKMLKKEDSERITALEILEHPFL
|. ..| |. ...| ... |.  ..                                      . ....||| |||. . ..|||| ..|.||..
SEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 14731.AA CAMK 64-165 18 3.2e-11 31.69 In-house 80-243 (425) Show / Hide 
Range on Protein: 64-165
Range on HMM: 80-243/425
Sequence Identity: 18% (30 aa)

NEFKIASQ-------LDHPNITRPIDIQQ----------------YYKG----GCMIL----FPQAN---CDGFDLFTKSVP----------------QI
.| .| ..       |||||| . ... .                ..       .|..    . .     .| ||  ..  .                . 
REIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTE

DIIKNYLRSMASALAYLHKMDIAHNDFKLENVLCFKNENGEI-------------EFQLSDFGFS
.  . | | ..||..|.|...|.| | |.||.|. .|....                 ..||||.
REARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA
Kinase 14731.AA PHK 121-165 40 5.8e-10 29.79 In-house 116-156 (273) Show / Hide 
Range on Protein: 121-165
Range on HMM: 116-156/273
Sequence Identity: 40% (18 aa)

RSMASALAYLHKMDIAHNDFKLENVLCFKNENGEIEFQLSDFGFS
|.  .. .|.|. .| | | |.||.||  |.|      .|||||.
RQLFEGVCYMHAHNIVHRDLKPENILCDDNMN----IKISDFGFA
Kinase 14731.AA CAMK 241-298 22 7e-10 27.29 In-house 355-425 (425) Show / Hide 
Range on Protein: 241-298
Range on HMM: 355-425/425
Sequence Identity: 22% (16 aa)

IYKNIIKFGKSFIQQKLKT---------SVQITQE----DYDLCLDLLIKMLKKEDSERITALEILEHPFL
....|.|   .|.  ....            |..|      . | ||. |||... ..|.|. ..|.||..
LFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 14731.AA Pkinase 64-165 28 6.5e-09 32.6 Pfam 49-159 (293) Show / Hide 
Range on Protein: 64-165
Range on HMM: 49-159/293
Sequence Identity: 28% (32 aa)

NEFKIASQLDHPNITRPIDIQQYYKGGCMILFPQANCD--GFDLF------TKSVP--QIDIIKNYLRSMASALAYLHKMDIAHNDFKLENVLCFKNENG
.| .|   |.|||| | .|. .. |. . . .. ....   .|||       . .   . . .|.|.. ....|.|.|.| | | | |.||.|.  ..||
SEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI--DNNG

EI--EFQLSDFGFS
.|   . ..|||..
HIDACVKICDFGLA
Kinase 14731.AA Pkinase 212-298 16 5e-08 29.46 Pfam 194-293 (293) Show / Hide 
Range on Protein: 212-298
Range on HMM: 194-293/293
Sequence Identity: 16% (18 aa)

DIFSLGYSFFIVLFQRRLSLKHEFTSDSPIYKNI----IKFGKSFIQQKLKTSVQITQEDY---------------------DLCLDLLIKMLKKEDSER
|..|.|  ....|. |            |....         .  |...... .    .                       . |.|.. ..|.|  ..|
DMWSCGCILYEMLCGR------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

ITALEILEHPFL
.|| .||.||..
PTAEQILQHPWF
Kinase 14731.AA CAMKL 271-298 39 9e-08 20.73 In-house 270-297 (297) Show / Hide 
Range on Protein: 271-298
Range on HMM: 270-297/297
Sequence Identity: 39% (11 aa)

CLDLLIKMLKKEDSERITALEILEHPFL
| ||. |||..  ..|.|. .|..||..
CRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 14731.AA RSK 117-165 34 1.4e-07 24.19 In-house 107-154 (278) Show / Hide 
Range on Protein: 117-165
Range on HMM: 107-154/278
Sequence Identity: 34% (17 aa)

KNYLRSMASALAYLHKMDIAHNDFKLENVLCFKNENGEIEFQLSDFGFS
. |..  ..|. .||. .| | | |.||.|    . .| .  |.||||.
CFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFC
Kinase 14731.AA CAMKL 119-165 42 1.7e-07 19.84 In-house 132-176 (297) Show / Hide 
Range on Protein: 119-165
Range on HMM: 132-176/297
Sequence Identity: 42% (20 aa)

YLRSMASALAYLHKMDIAHNDFKLENVLCFKNENGEIEFQLSDFGFS
| | . ||..|.|...|.| | |.||.|  .| |      ..|||||
YFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFS
Kinase 14731.AA RSK 273-298 35 8e-07 21.37 In-house 248-278 (278) Show / Hide 
Range on Protein: 273-298
Range on HMM: 248-278/278
Sequence Identity: 35% (11 aa)

DLLIKMLKKEDSERIT-----ALEILEHPFL
||. |||... . |..     | ||..||..
DLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 14731.AA MAPKAPK 273-298 30 2e-06 15.67 In-house 267-292 (292) Show / Hide 
Range on Protein: 273-298
Range on HMM: 267-292/292
Sequence Identity: 30% (8 aa)

DLLIKMLKKEDSERITALEILEHPFL
||  |.|... ..|.|. ....||..
DLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase 14731.AA DCAMKL 273-298 38 2.1e-05 12.15 In-house 254-279 (279) Show / Hide 
Range on Protein: 273-298
Range on HMM: 254-279/279
Sequence Identity: 38% (10 aa)

DLLIKMLKKEDSERITALEILEHPFL
||  .||...   | || .|..||  
DLISHMLQVDPEKRYTAEQIMQHPWV
Kinase 14731.AA PHK 273-298 50 6.2e-05 12.47 In-house 248-273 (273) Show / Hide 
Range on Protein: 273-298
Range on HMM: 248-273/273
Sequence Identity: 50% (13 aa)

DLLIKMLKKEDSERITALEILEHPFL
||  |.|    ..|||| | |.||| 
DLISKCLQVDPQQRITAEECLQHPFF
Kinase 14731.AA CMGC 113-155 24 0.000682 7.65 In-house 181-243 (513) Show / Hide 
Range on Protein: 113-155
Range on HMM: 181-243/513
Sequence Identity: 24% (16 aa)

IDIIKNYLRSMASALA--YLHKMD--IAHNDFKLENVLCFKN------------------ENGEI
|  |. | . .  .|.  |.|...  | | | | ||.|  .|                  .||..
I-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRL
Kinase 14731.AA MAPKAPK 273-298 38 0.000883 8.48 In-house 243-268 (268) Show / Hide 
Range on Protein: 273-298
Range on HMM: 243-268/268
Sequence Identity: 38% (10 aa)

DLLIKMLKKEDSERITALEILEHPFL
||  |.|. . .||.|  |...||..
DLIRKLLRTDPTERLTIEEFMNHPWI
Kinase 14731.AA CAMKL 50-79 22 0.084662 1.35 In-house 32-79 (297) Show / Hide 
Range on Protein: 50-79
Range on HMM: 32-79/297
Sequence Identity: 22% (11 aa)

IVD-NKCFSACSQLHN--------------EFKIASQLD---HPNITR
|.| .|.   .  . |              | .| ..|.   |||| .
IIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIK