Gene 8254 (Tetrahymena)
8254
Group:
Other
Family:
Ciliate-A5
Sequence
Protein domains of 8254.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 8254.AA | Ciliate-A5 | 52-289 | 40 | 3.4e-131 | 442.17 | In-house | 31-275 (275) | Show / Hide |
Range on Protein: 52-289 Range on HMM: 31-275/275 Sequence Identity: 40% (98 aa) ELFQQATNKQQQMQIPSIVNIIDIKTEINEHFCSNFYKVIIVYEYFDNTLEKLITMNKNQQ--TPFNEQDIYFLIDCILSALMCMHYSTFNHCDIRPKTI ..||| ... .| | |.||..||..|...|.|||.||||...|||.||.||....|.|..| ...|||......||..|..|........|.||||..| KHFQQYFEQRMQLQHPNIVKLIDFHTHKKEEFCSQFYKVNCYYEYHDNNLEQEMQMRKQCQKDIFYNEQELWYIMDCLISVCMYLQQNNICHGDIRPQNI LVSPDGSYKITDMN----FLYNQQPTPYKQTVLGAATYHKMYLSPEKLIAIKNRDLQKIQEYIDDWQRGDVFSLGLVALEMATLRDITQEVIDYETLEIR ....||..|..||| |.|......|||......|..|.||||........||.|.||.....|...|||.||...|||.|.||.||...||||..|. CLTQDGQVKLMDMNESKDFFYQINWSSYKQYQHHMSTENKQYLSPMQWYQMMHRDEQNIQRPEHNWYKSDVFCLGMICLEMCTMRDCTQFYYDYETFQIQ KNALDELLEIVKS-RYSFNLYSLISQMLELDYTKRNDFYKLAEFL .|.|...|...|. .||......|.|||.....||.||......| NNQLIKQLIQMKEKKYSEQFINFIKQMLQFEENKRPDFHQIYQYL |
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| Kinase | 8254.AA | Ciliate-E4 | 45-161 | 23 | 8.7e-10 | 29.26 | In-house | 35-150 (150) | Show / Hide |
Range on Protein: 45-161 Range on HMM: 35-150/150 Sequence Identity: 23% (27 aa) SNKGEFKELFQQATNKQQQMQIPSIVNIIDIKTEINEHFCSNFYKVIIVYEYFDNTLEKLITMNKNQQTPFNEQDIYFLIDCILSALMCMHYSTFNHCDI .| . .. || . | . . |. . . . ||| .|......|| |. | | |. .| |. |. . | .|. | |. QNETKARQQQQQFR-RRQDLNHENIIMVYEYFHKKEDQFCSSIYRLYWFMEYLQKDLQQHIKQHKQQGQHFDESEIWQIAFCCINAMYYLQQVNITHGDL RPKTILVSPDGSYKITD .| |... || | KPSNIFFDQYFMVKIAD |
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| Kinase | 8254.AA | Ciliate-A9 | 89-135 | 41 | 5.1e-09 | 16.72 | In-house | 95-142 (392) | Show / Hide |
Range on Protein: 89-135 Range on HMM: 95-142/392 Sequence Identity: 41% (20 aa) KVIIVYEYFD-NTLEKLITMNKNQQTPFNEQDIYFLIDCILSALMCMH .. || ||.. .|| |. | .|||| | . ||.||.|.|| NIHIVMEYMKCGTLQQLMKERKKNNQWFNEQEISQIMKCIMSAVMYMH |
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| S_TKc | 8254.AA | S_TKc | 24-289 | 15 | 2.5e-07 | -69.43 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 24-289
Range on HMM: 1-231/231
Sequence Identity: 15% (47 aa)
LQFVQQI--------NNVRYGE------AKVTFVLSNKGEFKELFQQATNKQQQMQIPSIVNIIDIKTEINEHFCSNFYKVIIVYEYFDN---TLEKLIT
.....| .| . |. | ... . .. . | ||...|. . .. .| || |. .| ..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIK
MNKNQQTP--FNEQDIYFLIDCILSALMCMHYSTFNHCDIRPKTILVSPDGSYKITDM---NFLYNQQPTPYKQTVLGAATYHKMYLSPEKLIAIKNRDL
.. . .. |.| .. |.. |..|| .| . |.|. | ||.. ||.| .| |. | |..|| |
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTP----WYMAPEVL--------
QKIQEYIDDWQ--RGDVFSLGLVALEMAT---LRDITQEVIDYETLEIRKNALDELLEIVKSRYSFNLYSLISQMLELDYTKRNDFYKLAE---------
. . |. |.| . ||.. . . ......... | . ..|...|. | .|| .. .
--------GYGKCKCDWWSCGCILYEMLCGYPPFP----------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP
FL
..
WF
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| Kinase | 8254.AA | Ciliate-E2-Unclassified | 59-161 | 20 | 8e-06 | 16.27 | In-house | 39-190 (352) | Show / Hide |
Range on Protein: 59-161 Range on HMM: 39-190/352 Sequence Identity: 20% (31 aa) NKQQQMQ-IPSIVNIIDIKTE-------------------------INEHFCS-NFYKVIIVYEYF-DNTLEKLIT-------------MNKNQQTPFNE ...|.|. . |.|.... . .....| . ...||.||. ...|.. |. .|..|. | | KQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTE QDIY-----FLIDCILSALMCMHYST-FNHCDIRPKTILVSPDG---SYKITD | . |.. .||..| .|.. . | || | ||.. .| ||.| QQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIID |
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| Kinase | 8254.AA | Ciliate-B2 | 185-220 | 33 | 2.9e-05 | 8.21 | In-house | 167-197 (197) | Show / Hide |
Range on Protein: 185-220 Range on HMM: 167-197/197 Sequence Identity: 33% (12 aa) KMYLSPEKLIAIKNRDLQKIQEYIDDWQRGDVFSLG | | ||| .....| | . ||. . |..|.| KKYASPEQMECDHN---QTFVTNIDF--QSDIYSMG |
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| Kinase | 8254.AA | Ciliate-B2 | 91-161 | 26 | 3e-05 | 8.19 | In-house | 77-147 (197) | Show / Hide |
Range on Protein: 91-161 Range on HMM: 77-147/197 Sequence Identity: 26% (19 aa) IIVYEYFDNTLEKLITMNKNQQTPFNEQDIYFLIDCILSALMCMHYSTFNHCDIRPKTILVSPDGSYKITD ... | . |.. . . ||. ||.| .| .| . .| .. | ||.|. ||.. | |. .| VLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCD |
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| Kinase | 8254.AA | BIKE | 258-288 | 41 | 4.2e-05 | 14.18 | In-house | 237-267 (267) | Show / Hide |
Range on Protein: 258-288 Range on HMM: 237-267/267 Sequence Identity: 41% (13 aa) SRYSFNLYSLISQMLELDYTKRNDFYKLAEF |.|| .. || ||| | || | | ... SKYSREMHCLIRYMLEPDMEKRPDIYQVSHV |
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| Kinase | 8254.AA | PKD | 122-156 | 45 | 0.000157 | 11.19 | In-house | 105-139 (260) | Show / Hide |
Range on Protein: 122-156 Range on HMM: 105-139/260 Sequence Identity: 45% (16 aa) FLIDCILSALMCMHYSTFNHCDIRPKTILVSPDGS ||| || || .| ||| .| .| | .|| FLITQILCALKYLHHQNIVHCDLKPENVLLSSMGS |
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| Kinase | 8254.AA | Ciliate-C6 | 215-234 | 60 | 0.000166 | 11.89 | In-house | 235-254 (306) | Show / Hide |
Range on Protein: 215-234 Range on HMM: 235-254/306 Sequence Identity: 60% (12 aa) DVFSLGLVALEMATLRDITQ |.||||.. | | || || | DIFSLGMILLYMLTLSDISQ |
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| Kinase | 8254.AA | Ciliate-E6 | 179-220 | 21 | 0.000745 | 8.56 | In-house | 115-154 (154) | Show / Hide |
Range on Protein: 179-220 Range on HMM: 115-154/154 Sequence Identity: 21% (9 aa) GAATYHKMYLSPEKLIAIKNRDLQKIQEYIDDWQRGDVFSLG ... . |..|| .. |. | ..... | || .|.. QKNQNKYHYCPPEQFDYSKDQ--QSKHYKVNWTQEGDIWSVC |
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| Kinase | 8254.AA | Ciliate-E5 | 215-227 | 53 | 0.000785 | 8.12 | In-house | 259-271 (271) | Show / Hide |
Range on Protein: 215-227 Range on HMM: 259-271/271 Sequence Identity: 53% (7 aa) DVFSLGLVALEMA |..|||.| ||. DIYSLGIVFLELT |
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