Gene 4613 (Tetrahymena)

4613

Species: Tetrahymena
Alias: 1219, 524.m00005, PreTt04613, 3827.m00988, TTHERM_01639960, 4613
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A3

Sequence

Name Sequence Type Origin Length Description Download
4613.AA Protein None 164 None Fasta, JSON
4613.kin_dom Protein Kinase Domain None 137 None Fasta, JSON
4613.NA RNA None 492 None Fasta, JSON

Protein domain

Protein domains of 4613.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 4613.AA Ciliate-A3 1-162 96 2.3e-126 426.09 In-house 46-207 (237) Show / Hide 
Range on Protein: 1-162
Range on HMM: 46-207/237
Sequence Identity: 96% (156 aa)

MKFIVIEYCNEGDLYTYHIKKQQEVQTLEQALEVIDIAIQITKGMMILKELNLAHRDLKPENILIHNDGEKIIAKISDYGLTKEVQRDLKSIVGTPSYMA
|||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||.||||||.||.|||
MKFIVIEYCNEGDLYTYHIKKQQEVQTLEQALEVIDIAIQITKGMMILKELNLEHRDLKPENILIHNDGEKIIAKISDYGLTKEVQCDLKSIVRTPNYMA

PEILSAYKKGSVYDDKIDVWSFGLILYEMFTCKQIFKGDQKQIFNQLIHYNNKIDQLLFQDR
||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||.|
PEILSAKKKGSVYDDKIDVWSFGLILYEMFTCKQIFKGDQKQIFNQLIHYNNKIDQLLFQER
Kinase 4613.AA Ciliate-B1 2-161 39 2.4e-40 138.96 In-house 92-257 (290) Show / Hide 
Range on Protein: 2-161
Range on HMM: 92-257/290
Sequence Identity: 39% (68 aa)

KFIVIEYCNEGDLYTYHIKKQQEVQTLEQALEVIDIAIQITKGMMILKELNLAHRDLKPENILIHND---------GEKIIAKISDYGLTKEVQR-DLKS
..|. |||. ||||.|  ...|. ..     .|.|..|||.||   | . ...|||||||||||| .          .. | || |.|. |  |  ...|
YYIIMEYCEQGDLYNYIYNCHQNFTH----DIVLDFCIQIAKGIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEYMMQS

IVGTPSYMAPEILSAYKKGSVYDDKIDVWSFGLILYEMFTCKQIFK---GDQKQIFNQLIHYNNKIDQLLFQD
.|||. |||||||.  .    || |.| ||||.|.|| .| .| |     .|... || . ..   .|  ||.
CVGTINYMAPEILNFNQQ---YDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIRNFQCCDYQCHFQN
Kinase 4613.AA TKL 3-137 25 7e-36 125.53 In-house 114-290 (364) Show / Hide 
Range on Protein: 3-137
Range on HMM: 114-290/364
Sequence Identity: 25% (48 aa)

FIVIEYCNEGDLYTYHIKKQQEVQTLEQALEVIDIAIQITKGMMILKELN--------LAHRDLKPENILIHNDGE-----------KIIAKISDYGLTK
.|| |||  |.|. |..               ...|..| .||  |   |        ..|||||..|||......            . .||.|.|| .
CIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSR

EVQRD----------------------LKSIVGTPSYMAPEILS---AYK---------KGSVYDDKIDVWSFGLILYEMFTCKQIFK
.....                      . ...||| .||||.|     |.         ||. |. |.||.|||..|.|..|... ..
FMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY
Kinase 4613.AA ULK 3-131 36 1e-33 115.11 In-house 96-251 (329) Show / Hide 
Range on Protein: 3-131
Range on HMM: 96-251/329
Sequence Identity: 36% (58 aa)

FIVIEYCNEGDLYTYHIKKQQ------EVQTLEQALEVIDIAIQITKGMMILKELNLAHRDLKPENILIHNDGEK---------IIAKISDYGLTKEVQR
.|. |||| ||| .|  |..       | ..|..  |.| . .||  |.. | . |  |||.||.||||||. .|         ...||.| |. | |. 
YIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQ-EAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDN

D------LKSIV------GTPSYMAPEILSAYKKGSVYDDK-IDVWSFGLILYEMFT
|      ... |      ||| ||||.||.   ..  |.|.  |.||.| |.||| .
DNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase 4613.AA ULK 3-131 36 2.2e-33 115.85 In-house 93-247 (324) Show / Hide 
Range on Protein: 3-131
Range on HMM: 93-247/324
Sequence Identity: 36% (57 aa)

FIVIEYCNEGDLYTYHIKKQQ-----EVQTLEQALEVIDIAIQITKGMMILKELNLAHRDLKPENILIHNDGEK---------IIAKISDYGLTKEVQ--
.|. |||| ||| .|  |..      | ..|..  |.| . .||  |.. | . |  |||.||.||||||. .|         ...||.| |. | |.  
YIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQ-EAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNN

----RDLKSIV------GTPSYMAPEILSAYKKGSVYDDK-IDVWSFGLILYEMFT
     .....|      ||| ||||.||.   ..  |.|.  |.||.| |.||| .
NMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase 4613.AA Ciliate-E2 3-153 29 1.7e-32 108.81 In-house 110-310 (365) Show / Hide 
Range on Protein: 3-153
Range on HMM: 110-310/365
Sequence Identity: 29% (62 aa)

FIVIEYCNEGDLYTYHIKK-QQEVQTLE-----QALEVIDIAIQITK---------------GMMILKELN-LAHRDLKPENILIHNDGEKIIAKISDYG
..| |||. |||. | ... ... . .|        |...|  ||..               ..  |.. |   |||.||||||.         ||.| |
YLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFG

LTKEVQRD----------------------------------LKSIVGTPSYMAPEILS--AYK---KGSVYDDKIDVWSFGLILYEMFTCKQIFKGDQK
| |... |                                   ..|.||| |||||||.   |    |.  || |.|.||.| ||||| . |  |   |.
LSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---QQ

QIFNQLIHYNNK
|| .. | ....
QIKQCKIDFPCP
Kinase 4613.AA Ciliate-E2-Unclassified 3-131 32 3.9e-32 108.78 In-house 97-265 (352) Show / Hide 
Range on Protein: 3-131
Range on HMM: 97-265/352
Sequence Identity: 32% (57 aa)

FIVIEYCNEGDLYTYHIK---------------KQQEVQTLEQAL--EVIDIAIQITKGM-MILKELNLAHRDLKPENILIHNDGEKIIAKISDYGLTKE
.|| |||. |||  |. |               ||..  | .||.  .  ... || .|   . ...|  |||.||||||..|.|..   ||.|.|. |.
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

VQRD------------------LKSIVGTPSYM----APEILSAYKKGSVYDDK----IDVWSFGLILYEMFT
 | .                  .....|||.||    |||.|    .|  ||..    .|.||.| ||||| .
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL----QGQNYDHSKAYKCDIWSLGVILYEMLF
Kinase 4613.AA Ciliate-E2c 3-129 35 5.4e-29 98.81 In-house 90-212 (310) Show / Hide 
Range on Protein: 3-129
Range on HMM: 90-212/310
Sequence Identity: 35% (49 aa)

FIVIEYCNEGDLYTYHIKK-QQEVQTLEQALEVIDIAIQITKGMMILKEL-NLAHRDLKPENILIHNDGEKIIAKISDYGLTKEVQRDLKS-------IV
... ||||.|.|  |  .| . ...      ....  .||  ..  |..  | .|||.|||||||||.    . || | |. |..| | ..       ..
YLIMEYCNGGTLEQYIYHKPKPNEK------QCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNG----MIKIADFGFSKICQDDNIQNTQGFNTCC

GTPSYMAPEILSAYKKGSVYDD-KIDVWSFGLILYEM
||| ||||.||.     . |.  | |.|| |  ||.|
GTPMYMAPQILEG----KNYYTEKSDIWSLGVTLYYM
Kinase 4613.AA Pkinase 4-155 31 7.6e-28 99.53 Pfam 77-238 (293) Show / Hide 
Range on Protein: 4-155
Range on HMM: 77-238/293
Sequence Identity: 31% (55 aa)

IVIEYCNEG----DLYTYHIK--KQQEVQTLEQALEVIDIAIQITKGMMILKELNLAHRDLKPENILIHNDGEK---IIAKISDYGLT----KEVQRDLK
.| |||. |    ||.  .|.  ..  .  . .  |..... || .|.  . . .  |||||||||||.|.|.    .  ||.| ||        .. ..
MVMEYCEGGLYVMDLF-DYISTWRHGCFY-F-SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV--KICDFGLAKQFDY-NNS-MT

SIVGTPSYMAPEILSAYKKGSVYDDKIDVWSFGLILYEMFTCKQIFKGD-------QKQIFNQLIHYNNKID
...||| |||||..    .|. |. |.|.||.|.|||||.. . .|.|.       |.|....  .  .. |
TFCGTPWYMAPEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFD
Kinase 4613.AA STE 37-133 31 2.7e-26 89.91 In-house 156-265 (359) Show / Hide 
Range on Protein: 37-133
Range on HMM: 156-265/359
Sequence Identity: 31% (37 aa)

IAIQITKG-MMILKELNLAHRDLKPENILIHNDGEKIIAKISDYGLTKEVQR-------------------DLKSIVGTPSYMAPEILSAYKKG--SVYD
|. || || .  | ...  |||.|| |||.        .|..| |. . ..                      ...|||| .||||...  ..|  . ||
ICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD

DKIDVWSFGLILYEMFTCK
 | |.||.|. . || | |
TKCDIWSLGCTIIEMATGK
Kinase 4613.AA LRRK 4-136 31 7.2e-26 88.48 In-house 132-283 (351) Show / Hide 
Range on Protein: 4-136
Range on HMM: 132-283/351
Sequence Identity: 31% (50 aa)

IVIEYCNEGDLYTYHIKKQQEVQ------TLEQALEVIDIAIQITKGMMILKELN--LAHRDLKPENILI--HNDG-------EKIIAKISDYGLTK--E
.| ||   ||||.. ... .. .       .   | .. ||.|| |||  |   |  . |||||..|||.  ....       . ..|||.|.|..    
MVMEYAPHGDLYHF-LHNKKQDGFHFMKAHISWML-KLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQ

VQRD--LKSIVGTPSYMAPEILSAYKKG--SVYDDKIDVWSFGLILYEMFTCK-QIF
. .   .|  ||.| .|||||.   ...  ..|..|.|. |||.||.|  | . ..|
CFHMGVAKGCVGNPGWMAPEIM---RYNGEEEYTEKVDCYSFGMILWELLTRQHHPF
Kinase 4613.AA S_TKc 1-164 20 2.2e-12 4.69 SMART 1-220 (231) Show / Hide 
Range on Protein: 1-164
Range on HMM: 1-220/231
Sequence Identity: 20% (50 aa)

MK------------------------------------------------------------FIVIEYCNE--GDLYTYHIKKQQE-VQTLEQALEVIDI
 .                                                            ..| |||.   |||..|  |.. .  .      ..  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

AIQITKGMMILKELNLAHRDLKPENILIHNDGEKIIAKISDYGLTKEVQRDLKSIVGTPSYMAPEILSAYKKGSVYDD-KIDVWSFGLILYEMFTCKQIF
. || ...  . ...  ||||||||||. .       ||.| || ...    ....||| |||||.|        |.  |.|.||.| |||||.. .  |
MYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCILYEMLCGYPPF

KGDQKQIFNQLIHYNNKI---DQLLFQDRN--------K
  .....|...      .   ...|  | .        .
P-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTAEALQ
Kinase 4613.AA Pkinase_Tyr 3-131 32 2.9e-09 32.0 Pfam 83-209 (270) Show / Hide 
Range on Protein: 3-131
Range on HMM: 83-209/270
Sequence Identity: 32% (44 aa)

FIVIEYCNEGDLYTYHIKKQQEVQTLEQALEVIDIAIQITKGMMILKELNLAHRDLKPENILIHNDGEKIIAKISDYGLTKEVQRDLKS-IVGT-----P
.|| ||.  |||..|  |.  | .      . .....|| |||  | . |. ||||   |.|...   . ..||.| ||.. .. |     ...      
YIVMEYMPHGDLLDYLRKHR-EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPI

SYMAPEILSAYKKGSVYDDKIDVWSFGLILYEMFT
  |||| .. .|    .  | ||||||  ..|.||
KWMAPECINYGK----FTTKSDVWSFGVLMWEIFT
Kinase 4613.AA TyrKc 1-158 16 2.4e-07 -103.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-158
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)

M--------------------------------------------KF----------------------------IVIEYCNEGDLYTYHIKKQQEVQTL
                                             |.                            || ||.  |||  |  |.. .    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----

EQALEVIDIAIQITKGMMILKELNLAHRDLKPENILIHNDGEKIIAKISDYGLTKEVQRD--------LKSI---VGTPS-----YMAPEILSAYKKGSV
 .  . .....|| .||  | . |. ||||   |.|.....   ..|||| ||....  |         ..     |. .      |||| .    . ..
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGK

YDDKIDVWSFGLILYEMFT-CKQIFKG------DQKQIFNQLIHY-------N-------------------------------NKIDQLL
.  | ||||||  ..|.|| ..|   |      . ....... .        |                               . | ...
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF