Gene 10908 (Tetrahymena)

10908

Species: Tetrahymena
Alias: 145, 3827.m00984, PreTt10908, TTHERM_00720110, 114.m00143, 10908
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A3

Sequence

Name Sequence Type Origin Length Description Download
10908.AA Protein None 520 None Fasta, JSON
10908.kin_dom Protein Kinase Domain None 237 None Fasta, JSON
10908.NA RNA None 1563 None Fasta, JSON

Protein domain

Protein domains of 10908.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 10908.AA Ciliate-A3 16-252 97 3.7e-184 618.1 In-house 1-237 (237) Show / Hide 
Range on Protein: 16-252
Range on HMM: 1-237/237
Sequence Identity: 97% (230 aa)

NKNTIIQGGQAFQVDYEVLKKIQDKYSENLENLVKIYDQSSETEKMKFIVIEYCNEGDLYTYHIKKQQEVQTLEQALEVIDIAIQITKGMMILKELNLEH
||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
NKNTIIQGGQAFQVDYEVLKKIQDKYSENLENLVKIYDQSSEKEKMKFIVIEYCNEGDLYTYHIKKQQEVQTLEQALEVIDIAIQITKGMMILKELNLEH

RDLKPENILIHNDGEKIIAKISDYGLTKEVQRDLKSIVRTPNFMAPEILFANNKGSVYDDKIDVWSFGLILYEMFTCKQIFKGDQKQIFNQLIHYNNKID
|||||||||||||||||||||||||||||||.||||||||||.||||||.|..|||||||||||||||||||||||||||||||||||||||||||||||
RDLKPENILIHNDGEKIIAKISDYGLTKEVQCDLKSIVRTPNYMAPEILSAKKKGSVYDDKIDVWSFGLILYEMFTCKQIFKGDQKQIFNQLIHYNNKID

QLLFQERFQDVSKLVIRCLLKDPKKRPDFKQIQTELI
|||||||||||||||||||.|||||||||||||||||
QLLFQERFQDVSKLVIRCLQKDPKKRPDFKQIQTELI
Kinase 10908.AA Ciliate-B1 32-252 32 1.8e-44 153.63 In-house 55-290 (290) Show / Hide 
Range on Protein: 32-252
Range on HMM: 55-290/290
Sequence Identity: 32% (81 aa)

EVLKKIQDKYSEN--------LENLVKIYDQSSETEKMKFIVIEYCNEGDLYTYHIKKQQEVQTLEQALEVIDIAIQITKGMMILKELNLEHRDLKPENI
|.......|  .|         .. . |||   ..   ..|. |||. ||||.|  ...|. ..     .|.|..|||.||   | . .. |||||||||
EIIQCLIKKMNNNKISCQSSPCDHICNIYDV-IQCQQQYYIIMEYCEQGDLYNYIYNCHQNFTH----DIVLDFCIQIAKGIQYLHKHKICHRDLKPENI

LIHND---------GEKIIAKISDYGLTKEVQR-DLKSIVRTPNFMAPEILF-ANNKGSVYDDKIDVWSFGLILYEMFTCKQIFK---GDQKQIFNQLIH
||| .          .. | || |.|. |  |  ...|.| |.| ||||||   ..    || |.| ||||.|.|| .| .| |     .|... || . 
LIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEYMMQSCVGTINYMAPEILNFNQQ----YDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIRN

YNNKIDQLLFQERFQ-DVSKLVIR-----CLLKDPKKRPDFKQIQTELI
..     .. |  || .  .....     || .||..|.   ||...| 
FQ----CCDYQCHFQNNIYQEIQQLIQKYCLQPDPENRITIDQIIDRLM
Kinase 10908.AA TKL 63-251 21 6.7e-40 138.87 In-house 114-364 (364) Show / Hide 
Range on Protein: 63-251
Range on HMM: 114-364/364
Sequence Identity: 21% (57 aa)

FIVIEYCNEGDLYTYHIKKQQEVQTLEQALEVIDIAIQITKGMMILKELN--------LEHRDLKPENILIHNDGE-----------KIIAKISDYGLTK
.|| |||  |.|. |..               ...|..| .||  |   |        . |||||..|||......            . .||.|.|| .
CIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSR

EVQRD----------------------LKSIVRTPNFMAPEILFANN------------KGSVYDDKIDVWSFGLILYEMFTCKQIFK---GDQKQIFNQ
.....                      . ... ||..||||.|  ..            ||. |. |.||.|||..|.|..|... ..    .. ... .
FMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDP

LIHYNNKIDQLLFQERFQD------------------VSKLVIRCLLKDPKKRPDFKQIQTEL
 ..   ... . ..    .                  ..||  .|   ||.||| |..|  .|
-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 10908.AA Ciliate-E2 47-247 26 2.5e-33 111.76 In-house 93-359 (365) Show / Hide 
Range on Protein: 47-247
Range on HMM: 93-359/365
Sequence Identity: 26% (74 aa)

NLVKIYDQSSE-TEKMKFIVIEYCNEGDLYTYHIKK-QQEVQTLE-----QALEVIDIAIQITK---------------GMMILKELN-LEHRDLKPENI
|..|.|.   | ...  ..| |||. |||. | ... ... . .|        |...|  ||..               ..  |.. |   |||.|||||
NIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENI

LIHNDGEKIIAKISDYGLTKEVQRD-----------LKSIVR------------------------TPNFMAPEILFANN-----KGSVYDDKIDVWSFG
|.         ||.| || |... |           ..   .                        ||..||||||   .     |.  || |.|.||.|
LF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG

LILYEMFTCKQIFKGDQKQIFNQLIHYNNK--------IDQLL----FQERFQDVSKLVIR----CLLKDPKKRPD-FKQI
 ||||| . |  |   |.|| .. | ....        | | .    ...  |..  |  .    .| |||.||.. ..||
VILYEMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase 10908.AA Pkinase 64-251 28 4.1e-30 107.57 Pfam 77-293 (293) Show / Hide 
Range on Protein: 64-251
Range on HMM: 77-293/293
Sequence Identity: 28% (64 aa)

IVIEYCNEG----DLYTYHIK--KQQEVQTLEQALEVIDIAIQITKGMMILKELNLEHRDLKPENILIHNDGEK---IIAKISDYGLT----KEVQRDLK
.| |||. |    ||.  .|.  ..  .  . .  |..... || .|.  . . .  |||||||||||.|.|.    .  ||.| ||        .. ..
MVMEYCEGGLYVMDLF-DYISTWRHGCFY-F-SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV--KICDFGLAKQFDY-NNS-MT

SIVRTPNFMAPEILFANNKGSVYDDKIDVWSFGLILYEMFTCKQIFKGD-------QKQIFNQLIHYNNKIDQLLFQERF-----------------QDV
... ||..||||..    .|. |. |.|.||.|.|||||.. . .|.|.       |.|....  .  .. |     ..                  .. 
TFCGTPWYMAPEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

SKLVIRCLLKDPKKRPDFKQIQTE--L
 ... .|| ||||||| ..||     .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 10908.AA ULK 32-247 29 2.4e-29 99.63 In-house 62-323 (329) Show / Hide 
Range on Protein: 32-247
Range on HMM: 62-323/329
Sequence Identity: 29% (78 aa)

EVLKKIQDK-YSEN-LENLVKIYDQSSETE-KMKFIVIEYCNEGDLYTYHIKKQQ------EVQTLEQALEVIDIAIQITKGMMILKELNLEHRDLKPEN
...||. ..  ..|  .| || || . ..  .  .|. |||| ||| .|  |..       | ..|..  |.| . .||  |.. | . |  |||.||.|
KIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQ-EAIQFFKQILNGFKELHKHNIIHRDIKPQN

ILIHNDGEK---------IIAKISDYGLTKEVQRD------LKSIV------RTPNFMAPEILFANNKGSVYDDK-IDVWSFGLILYEMFTCK-----QI
|||||. .|         ...||.| |. | |. |      ... |       || .|||.||  . ..  |.|.  |.||.| |.||| . |     . 
ILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-

FKGDQKQIFNQLIHYNNKI-----DQLLFQE-------RFQDVSKLVIRCLLKDPKKRPDFKQI
|  ...|| ..|| . ...     .| |  .       . ...  |  |.| .|.|.| .. ..
FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEEL
Kinase 10908.AA Ciliate-E2-Unclassified 34-247 23 9.3e-29 96.89 In-house 56-346 (352) Show / Hide 
Range on Protein: 34-247
Range on HMM: 56-346/352
Sequence Identity: 23% (70 aa)

LKKIQDKYSEN------------LENLVKIYDQSSE-TEKMKFIVIEYCNEGDLYTYHIK---------------KQQEVQTLEQAL--EVIDIAIQITK
.....  |. .            . .......   . ...  .|| |||. |||  |. |               ||..  | .||.  .  ... || .
MNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQ

GM-MILKELNLEHRDLKPENILIHNDGEKIIAKISDYGLTKEVQRD------------------LKSIVRTPNFM----APEILFANNKGSVYDDK----
|   . ...|  |||.||||||..|.|..   ||.|.|. |. | .                  ..... |||.|    |||.|    .|  ||..    
GLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL----QGQNYDHSKAYK

IDVWSFGLILYEMFTCKQIFKGDQKQI---------------FNQLIHYNNKIDQLLFQE-----RFQDVSKLVIR-----CLLKDPKKRPDFKQI
.|.||.| ||||| . .  |.. .. .                 . . ....|..  | .     . ..  |  |.     .| |.|.||..|.||
CDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI
S_TKc 10908.AA S_TKc 1-252 24 2.1e-28 101.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-252
Range on HMM: 1-231/231
Sequence Identity: 24% (66 aa)

MQNRIFVGQ------KSTYQKNKNT-----IIQGGQAFQVDYEVLKKIQDKYSENLENLVKIYDQSSETEKMKFIVIEYCNE--GDLYTYHIKKQQE-VQ
 .    .|.      .  . |. .      ||   . ..   ..|||       . .|.||.||   .  .  ..| |||.   |||..|  |.. .  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-------HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

TLEQALEVIDIAIQITKGMMILKELNLEHRDLKPENILIHNDGEKIIAKISDYGLTKEVQRDLKSIVRTPNFMAPEILFANNKGSVYDD-KIDVWSFGLI
      ..  .. || ...  . ...  ||||||||||. .       ||.| || ...    .... ||..||||.|        |.  |.|.||.| |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCI

LYEMFTCKQIFKGDQKQIFNQLIHYNNKIDQLLFQERFQDVSKLVIRCLLKDPKKRPDFKQIQT--------ELI
||||.. .  |  .....|...                ...  .. .|| |||.|||   .. .        . .
LYEMLCGYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 10908.AA ULK 46-247 29 6.3e-28 96.22 In-house 73-318 (324) Show / Hide 
Range on Protein: 46-247
Range on HMM: 73-318/324
Sequence Identity: 29% (73 aa)

EN--LVKIYDQSSETE-KMKFIVIEYCNEGDLYTYHIKKQQ-----EVQTLEQALEVIDIAIQITKGMMILKELNLEHRDLKPENILIHNDGEK------
.|   || || . ..  .  .|. |||| ||| .|  |..      | ..|..  |.| . .||  |.. | . |  |||.||.||||||. .|      
PNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQ-EAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKV

---IIAKISDYGLTKEVQ------RDLKSIV------RTPNFMAPEILFANNKGSVYDDK-IDVWSFGLILYEMFTCKQIFKGDQKQIFN----QLIHY-
   ...||.| |. | |.       .....|       || .|||.||  . ..  |.|.  |.||.| |.||| . |  |... ..  .    .||.  
HPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNG

-----NNKIDQLLFQ------ERFQDVSKLVIRCLLKDPKKRPDFKQI
       |  .. |.       . ...  |  |.| .|.|.| .. .|
KEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEI
Kinase 10908.AA MLK 63-251 28 6e-27 90.59 In-house 86-291 (291) Show / Hide 
Range on Protein: 63-251
Range on HMM: 86-291/291
Sequence Identity: 28% (61 aa)

FIVIEYCNEGDLYTYH--IKKQQE----------VQTLEQALEVIDIAIQITKGMMILKELN---LEHRDLKPENILIHN---DGEKIIAKISDYGLTKE
.|| ||| .| ||..   .... .          |.....|   ...| |. .||  | ..    . |||||. ||||..   | .. ..||.| |. ..
CIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHA---MNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRD

VQRD---LKSIVRTPNFMAPEIL--FANNKGSVYDDKIDVWSFGLILYEMFTCKQIFKGDQKQIFNQLIHYNNKIDQLLFQERFQDVSKLVIRCLLKDPK
...      |   |. .||||..  |   ... |. | ||||.|..|.||.|..  .|.......      .|..   . ..     .||  .|   ||.
WHQMCTNMMSNAGTYAWMAPEVIQQF---RCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPH

KRPDFKQIQTEL
|||.|.||...|
KRPSFRQIVQHL
Kinase 10908.AA TKL-Unique 94-251 29 3.2e-26 89.57 In-house 112-290 (290) Show / Hide 
Range on Protein: 94-251
Range on HMM: 112-290/290
Sequence Identity: 29% (53 aa)

VIDIAIQITKGMMILKELN--LEHRDLKPENILIHND--GEKIIAKISDYGLTKEVQRDLKSIVR------------TPNFMAPEILFANNKGSVYDDKI
....||.| .||  |  ..    |||||. |.|. |.    .. .||.| || |   ...|....            ... ||||.|  |.  . |. |.
RVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF--CQYSEKS

DVWSFGLILYEMFTCKQ------IFKG-DQKQIFNQLIHYNNKIDQLLF-QERFQDVSKLVIRCLLKDPKKRPDFKQIQTEL
||.||| .|.|..| |.       ..| ||.|.. ...||  .  ..   ..  .. ..|  .|   || .|| | .| ..|
DVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWC-EMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 10908.AA LRRK 64-253 29 9.3e-26 88.09 In-house 132-351 (351) Show / Hide 
Range on Protein: 64-253
Range on HMM: 132-351/351
Sequence Identity: 29% (65 aa)

IVIEYCNEGDLYTYHIKKQQEVQ------TLEQALEVIDIAIQITKGMMILKELN--LEHRDLKPENILI--HNDG-------EKIIAKISDYGLTK--E
.| ||   ||||.. ... .. .       .   | .. ||.|| |||  |   |  . |||||..|||.  ....       . ..|||.|.|..    
MVMEYAPHGDLYHF-LHNKKQDGFHFMKAHISWML-KLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQ

VQRD--LKSIVRTPNFMAPEILFAN-NKGSVYDDKIDVWSFGLILYEMFTCK-QIFKG-D-QKQI-FNQLIHY---NNKIDQLL--FQER---FQDVSKL
. .   .|  | .| .|||||. .| ..  .|..|.|. |||.||.|  | . ..| . |  ... .. .|     .   . .   .. .   . ....|
CFHMGVAKGCVGNPGWMAPEIMRYNGEE--EYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDL

VIRCLLKDPKKRPDFKQIQTELIQ
   |   |||||| | ||   | |
IQHCWQHDPKKRPHFSQIVKRLSQ
TyrKc 10908.AA TyrKc 15-251 21 2.7e-13 -7.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-251
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

KNKNTIIQGGQ----------------AFQVDYEVLKKIQDKYSE-----NL----ENLVKIYDQSSETE------KMKFIVIEYCNEGDLYTYHIKKQQ
  .. ..  |.                  . |      ..| ..|     .|    .|.|..|   .. .      .  .|| ||.  |||  |  |.. 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

EVQTLEQALEVIDIAIQITKGMMILKELNLEHRDLKPENILIHNDGEKIIAKISDYGLTKEVQRD-----LKSIVRT-----PNF------MAPEILFAN
.     .  . .....|| .||  | . |. ||||   |.|.....   ..|||| ||....  |      |.  |.      ..      |||| .   
K----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

NKGSVYDDKIDVWSFGLILYEMFTCKQIFKGD---QKQIFNQLIHYNNKIDQLLFQER---------FQDVSKLVIRCLLKDPKKRPDFKQIQTEL
 . ...  | ||||||  ..|.||  |    .   |.    ..|.|  . . .   .           ... ..  .|   ||..|| |..|  ..
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 10908.AA Pkinase_Tyr 63-191 32 1.9e-07 25.83 Pfam 83-209 (270) Show / Hide 
Range on Protein: 63-191
Range on HMM: 83-209/270
Sequence Identity: 32% (44 aa)

FIVIEYCNEGDLYTYHIKKQQEVQTLEQALEVIDIAIQITKGMMILKELNLEHRDLKPENILIHNDGEKIIAKISDYGLTKEVQRDLKS-IVRT-----P
.|| ||.  |||..|  |.  | .      . .....|| |||  | . |. ||||   |.|...   . ..||.| ||.. .. |     .|.      
YIVMEYMPHGDLLDYLRKHR-EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPI

NFMAPEILFANNKGSVYDDKIDVWSFGLILYEMFT
  |||| .. .     .  | ||||||  ..|.||
KWMAPECINYGK----FTTKSDVWSFGVLMWEIFT
Kinase 10908.AA Pkinase_Tyr 232-251 40 0.001045 13.18 Pfam 251-270 (270) Show / Hide 
Range on Protein: 232-251
Range on HMM: 251-270/270
Sequence Identity: 40% (8 aa)

RCLLKDPKKRPDFKQIQTEL
.|  .||..|| |..|. .|
QCWHYDPEDRPTFSEIHEQL