Gene 4601 (Tetrahymena)
4601
Sequence
Protein domains of 4601.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 4601.AA | Bud32 | 2-177 | 49 | 2.7e-126 | 406.2 | In-house | 1-213 (269) | Show / Hide |
Range on Protein: 2-177 Range on HMM: 1-213/269 Sequence Identity: 49% (105 aa) EGLELIS--------QGAEARFFYSCYLTVSKQKVYKVKNFLGE------PAIMKEKLVKAYRHPDLDQRLSKERITFEVRNMIRARKAGINTPYVMQTD ..|||.. ||||||.||.|||||||||||...||.|. ..|.||...||||||.|||.|.|.|...|||.|.|.|||||..|||...| MSLELYKDVDIAPISQGAEARVFYTCYLTVSKQKVYTTCNFQGRAKDSHQQCIIKERFPKAYRHPQLDQQLTKHRTKQEVRAMNRCRKAGICVPYVYFCD FVQRKIYIRYIYEI------YQILKDMT----------------ELLKEVGRILAKLHDSHILHGDLTTSNIMVTHPVAETTKLYGQIYLIDFGLSYIKD .....||..||.|. |....... |..|.|||...|.|..||.||||||||.|..||.|..||||||..|||||||||.. NYNHCIYMEYIEESPGGHGFYTVKNYIWQHQETQKEDQHDQCLREFCKKVGRQIGKMHWNHIIHGDLTTSNMMLRHPYADWTKLYGQMHLIDFGLSYISN SI-EEKAVDLYVL |. |.|.|||||| SVPEDKGVDLYVL |
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| Kinase | 4601.AA | Ciliate-E2 | 122-165 | 33 | 3.4e-07 | 20.74 | In-house | 176-207 (365) | Show / Hide |
Range on Protein: 122-165 Range on HMM: 176-207/365 Sequence Identity: 33% (15 aa) LHDSH-ILHGDLTTSNIMVTHPVAETTKLYGQIYLIDFGLSYIKD || . |.| |. .||.. | .|||||| . | LHSKNNIIHRDIKPENILF-------------IKIIDFGLSKKYD |
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| Kinase | 4601.AA | Trio | 122-159 | 41 | 5.2e-07 | 13.33 | In-house | 111-144 (258) | Show / Hide |
Range on Protein: 122-159 Range on HMM: 111-144/258 Sequence Identity: 41% (16 aa) LHDSHILHGDLTTSNIMVTHPVA-ETTKLYGQIYLIDFG || .|||| |. .|.|..|. | . || ..||| LHNCHILHLDIKPENMMMWHYNAGRP-----QIKICDFG |
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| Kinase | 4601.AA | STE | 118-161 | 29 | 4e-06 | 17.58 | In-house | 164-194 (359) | Show / Hide |
Range on Protein: 118-161 Range on HMM: 164-194/359 Sequence Identity: 29% (13 aa) ILAKLHDSHILHGDLTTSNIMVTHPVAETTKLYGQIYLIDFGLS .|. ||. || | |. .||.. . |.|||.. LLYYLHSHHIIHRDIKPANILL-------------VKLCDFGVC |
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| Kinase | 4601.AA | CMGC | 119-161 | 25 | 5e-06 | 14.9 | In-house | 193-251 (513) | Show / Hide |
Range on Protein: 119-161 Range on HMM: 193-251/513 Sequence Identity: 25% (15 aa) LA--KLHDSH--ILHGDLTTSNIMVTHPVAETTKLY------------GQIYLIDFGLS |. .| |.| || .||...| |... |.. ..||||. LKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA |
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| Kinase | 4601.AA | Dicty3 | 110-138 | 30 | 1.7e-05 | 13.86 | In-house | 115-144 (351) | Show / Hide |
Range on Protein: 110-138 Range on HMM: 115-144/351 Sequence Identity: 30% (9 aa) ELLKEVGRILAKLHDS-HILHGDLTTSNIM ..... .|...|.. ||.|.|... ||| KIICDLVKTLNYIHKNCHIIHRDIKCDNIM |
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| Kinase | 4601.AA | CK1 | 122-161 | 24 | 2.5e-05 | 14.66 | In-house | 148-195 (339) | Show / Hide |
Range on Protein: 122-161 Range on HMM: 148-195/339 Sequence Identity: 24% (12 aa) LHDSHILHGDLTTSNIMVTHPVA-ETTKLYG--------QIYLIDFGLS .|| ...| |. .|... .. | |.|.||||.. MHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMA |
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| Kinase | 4601.AA | Ciliate-E2b | 122-161 | 35 | 3.3e-05 | 11.95 | In-house | 118-149 (272) | Show / Hide |
Range on Protein: 122-161 Range on HMM: 118-149/272 Sequence Identity: 35% (14 aa) LHDSHILHGDLTTSNIMVTHPVAETTKLYGQIYLIDFGLS || |...|. .||||.| |...|||.|.. LHNQNIIYRDIKPENIMVDH--------KGYMKLIDMGTA |
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| Kinase | 4601.AA | S_TKc | 21-237 | 13 | 7.9e-05 | -106.12 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 21-237 Range on HMM: 1-231/231 Sequence Identity: 13% (38 aa) LTVSKQ-------KVYKVKNFL-GEPAIMKEKLVKAYRHPDLDQRLSKERITFEVRNMIRARKAGINTPYVMQTDFVQRKIYIRYIYEIYQILK----DM .. .. ||||... |. .|. |.| |.. . . . |.. . | . ..| . . |. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK------HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDL TELLKEVGRI--------------------LAKLHDSHILHGDLTTSNIMVTHPVAETTKLYGQIYLIDFGLSYIKDSIEE---------------K-AV ...|. || |. .|. .|.| || .||.... .| ..||||. . | .. FDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL--TTFCGTPWYMAPEVLGYGKCKC DLYVLGI------QQSRMLRSERMGCYQVIVSRELAWEMINMLGELGDDMVEFIDS--NKDQN---SANRLFS--------RFI | . .|. . . . ...|. ... .||. .|| . .| .. .. DWWSCGCILYEMLCGYPPFP-QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 4601.AA | VRK | 122-162 | 33 | 8.1e-05 | 11.85 | In-house | 146-181 (284) | Show / Hide |
Range on Protein: 122-162 Range on HMM: 146-181/284 Sequence Identity: 33% (14 aa) LHDSHILHGDLTTSNIMVTH-PVAETTKLYGQIYLIDFGLSY ||.. |||.. .||.. . ... | ||.|.||.| LHENEYVHGDIKAANILLGFEKNPD------QVYLVDYGLAY |
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| Kinase | 4601.AA | NKF4 | 119-161 | 37 | 0.000174 | 9.74 | In-house | 149-191 (336) | Show / Hide |
Range on Protein: 119-161 Range on HMM: 149-191/336 Sequence Identity: 37% (16 aa) LAKLHDSHILHGDLTTSNIMVTHPVAETTKLYGQIYLIDFGLS .| || || | ||. ||... . ... | . ||||| MAHLHKNHIIHRDLKPYNIIIVEGRKGQSDLEPVVKVADFGLS |
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| V_ATPase_I | 4601.AA | V_ATPase_I | 532-879 | 31 | 6.3e-82 | 283.29 | Pfam | 399-757 (833) | Show / Hide |
Range on Protein: 532-879 Range on HMM: 399-757/833 Sequence Identity: 31% (122 aa) PFQFGIMFGDIGHGGFLFLFGLYLCINHKKNPFDTRRDLNVL---------YSVRYVVLLLGFFALYSGLIYNDFFSLPIYLFHKSCYVN---------Q || ||.||||.||| .||..|.. ..|| . . ||..|..| | | |.||||.|. ....| . ... PFFFGMMFGDMGHGLIMFLIALWMVKWEKK-------LGWMKIRDEIFQMFFYGRYIMLYMGVFSIYTGFIYNDCFGKFMNIFGSGWHWPMMASQIHWYD RDENGELEYVKKPNCT------YPFGFDPKWYIAQNELTFFNSFKMKLAVIIGVIQMTFGIILKGFNNKYFGQWIDFFFEFIPQLVFMVTTFGYMIFMIV |.. .... . |. . |||| |. | .|.|.||| ||.|||...|.|||.||||... ||. .|.. || ...||||...| |||....|. RTWWSHEMITLAPHVGGVFGGPYPFGIDWIWHGAENKLTFLNSYKMKMSIIMGVIHMTFGFCFGFFNHWHFKKMIDIYDAFIPQMIWMWCIFGYLCWCII IKWNINYQQDTSQAPSIINLMINLPLKLGMIPDGKSLWNQEN------------QEYLQQNLLYISVCMVPLMLFPKPFLLYLKNRKNNKRTYDDFIQEL ||.. . . .||.| .. || |. . |...| |. . . .||.||| ||..|. .. | ... . . YKWCVDWFKTMHCAPFILIMLINMFLMP-------------GTIDCYDDQWYPGQAHWQVFLVVLALICVPWMLFWKPMFLMWEHKKRSHKGMHNY---V RKSQIEKEETIKKQFLKENSIQESMDFDQFESITKDKHEFD-FSEVFVHQVIETIEF-VLGSISSTASYLRLWALSLAHSQLSKVF .. | | .| . . . . .... .. .. . ||.. . .|..||||.|||| .|| .| ||||||||||.|||.|.| |. SNQQQEEREDLQNH---DDEHVHMWMDHEEHHVH-GEHEEFEMGDVMIHQVIHTIEFPCLGCVSHTASYLRLWALCLAHAQISMVL |
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