Gene 22429 (Tetrahymena)

22429

Species: Tetrahymena
Alias: 18.m00455, TTHERM_00221010, 22429, 3701.m01496, PreTt22429, 501
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
22429.AA Protein None 615 None Fasta, JSON
22429.NA RNA None 1851 None Fasta, JSON
22429.kin_dom Protein Kinase Domain None 264 None Fasta, JSON

Protein domain

Protein domains of 22429.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22429.AA Aur 30-293 50 2.1e-207 553.73 In-house 1-257 (257) Show / Hide 
Range on Protein: 30-293
Range on HMM: 1-257/257
Sequence Identity: 50% (134 aa)

FDGQKVLGKGAFGKVIRVLHRKSQLIYAIKEINKKNLKLNNMVEQVTNEVKIMYSLNHPYILKLYNHFEDDTNIYLVLEYAQGGQLYVQLWKQPNHQFEE
|. .| ||||.||.|  . |.|.. |.|.| ..|...| ..|..|. .|.||...||||.|||.|..|.||..|||.||||.||.|| .|.||||. | |
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

KKVAKYIFQLCKALELCHSKGIIHRDIKPENILLD-KDGNVKLADFGWSNFKQRESDIRTTFCGTLDYLAPEMLQSNHQHDFGVDIWSVGVLAYELLSGA
.. |||. |.| ||. ||||.|||||||||||||| ..||.|..|||||..... ...|.||||||||..||| .... ||. ||||..|||.|||..|.
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPN-NNRRMTFCGTLDYMPPEMVEGQM-HDHKVDIWCLGVLCYELCHGC

SPFAPKNNQNNADYVEN--TTKQNIK-NLRYEYPKNFPIMAKDLITKILVVDPKSRLSLKEILAHPWI
.||...         ||  .| ..|| ......|......||||| |||..|||.|..|..|..||||
PPFESN---------ENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 22429.AA AGC 30-293 28 8.70000000001e-120 310.97 In-house 1-395 (395) Show / Hide 
Range on Protein: 30-293
Range on HMM: 1-395/395
Sequence Identity: 28% (114 aa)

FDGQKVLGKGAFGKVIRVLHR------KSQLIYAIKEINKKN-LKLNN--MVEQVTNE------------VKIMYSLN----------HPYILK-LYNHF
|.  ||.|||.||||. | ..       .. .||.| ..||   ....  |||.. .|             .|.  .|          ||.| | |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDDTN--IYLVLEYAQ---------GG-QLYVQLWKQ-PNHQFEEKKVAKYIFQ-------LCKALELCHS-KGIIHRD-IKPENILLDKDGNVKLADFG
.|...  .|.|.||..         ||  |. .| ..  .  |.|. .  |. .       .. |||  || .|||||| .||||||||.||..||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

WS--------------------------------------NFKQRES------------DIRTTFCG--TLDYLAPEMLQSNHQHDFGVDIWS--VGVLA
 .                                      |..||.             |  .||||  | .|.|||.|     ... .|.||  .|.| 
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

YELLSGASPFAPKNNQ---NNADYVENTTKQNIK------NLRYEYP----------KNFPIMAKDLITKILVVDPKSRLS----------LKEILAHPW
||.|.| .||  .|.|       . .. . |.|.      | . ..|          ..|   |||||.| |..||. ||            .|| .|||
YEMLTGYPPFYGDNPQENRH-PFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

I
 
F
Kinase 22429.AA CAMK 35-293 24 1.3e-102 331.46 In-house 1-425 (425) Show / Hide 
Range on Protein: 35-293
Range on HMM: 1-425/425
Sequence Identity: 24% (103 aa)

VLGKGAFGKVIRVLHRKSQ------------LIYAIKEINKKNLKLNN-------------------------MVEQVTNEVKIMYS-------LNHPYI
.||.|.|||| .. |....              .||| |.|| || ..                         . ..| .|..|| .       |.|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKLYNHFED-------------------DTNIYLVL---EYAQGG----QLYVQLWKQPN-------------HQFEEKKVAKYIFQLCKALELCHSKGI
.||| ..||                   |...|.|.   ||..||     |.  . ....             . |.|. ...|. |.| |.. |||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENILLDKD-----------------GNVKLADFGWSNFKQR-----------------------ESDIRTTFCGTLDYLA-PEMLQS------
.|||.||||||||..                 .|.|..||| .|....                       | .  .|||||. | | ||.|..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------NHQHDFGVDIWSVGVLAYELLSGASPFAPKNNQNNAD-----YVENTTKQNIKNLRYE-YPKNFPI-----------------------MAKD
       .  ... .|.||.||. | .|.| .||  .....  .     . .. ....|.. .|. .|. |..                        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LITKILVVDPKSRLSLKEILAHPWI
|| |.|.|||. |......|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 22429.AA S_TKc 30-293 35 2e-99 337.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 30-293
Range on HMM: 1-231/231
Sequence Identity: 35% (99 aa)

FDGQKVLGKGAFGKVIRVLHRKSQLIYAIKEINKKNLKLNNMVEQVTNEVKIMYSLNHPYILKLYNHFEDDTNIYLVLEYAQG--GQLYVQLWKQPN---
..  ...|||||||| .. |.|.. |.|||.|.          |.. .|..|. . .||.| ||| .|.| ...|.|.||. |  | |.  . |..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-HQFEEKKVAKYIFQLCKALELCHSKGIIHRDIKPENILLDKDGNVKLADFGWSNFKQRESDIRTTFCGTLDYLAPEMLQSNHQHDF-GVDIWSVGVLAY
 ..| |  ...|. |.|.||| |||.||||||.||||||||.  ..|..||| . .        ||||||..|.|||.|    ....  .|.||.|.. |
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY

ELLSGASPFAPKNNQNNADYVENTTKQNIKNLRYEYPKNFPIMAKDLITKILVVDPKSRLSLKEILA-------HPWI
|.|.|  ||            .... ..|.          .  |||.| |.|..||. |..  |.|.       |||.
EMLCGYPPFP----------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22429.AA CAMKL 30-293 35 2.2e-91 291.87 In-house 1-297 (297) Show / Hide 
Range on Protein: 30-293
Range on HMM: 1-297/297
Sequence Identity: 35% (106 aa)

FDGQKVLGKGAFGKVIRVLH-RKSQLIYAIKEINKKNLKLNNMVEQ------------VTNEVKIMYSLN---HPYILKLYNHFEDDTN------IYLVL
..  |.||||.||||   .| |  .  .||| |.|| ....  ...            .. |..|| .||   || | ||| ..|....      ||||.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYAQGGQ--LYVQLWKQPNHQ--FEEKKVAKYIFQLCKALELCHSKGIIHRDIKPENILLDKDG--NVKLADFGWSNF---K-QRESDIRTTFCGTLDYL
||..||   |.  . |....   ..|.   .|  |.. |.. |||.||.||||||||||||..|  |.|..||| ||.   .   . .  .||||.. | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEMLQS-NHQHD-FGVDIWSVGVLAYELLSGASPF-APKNNQNNADYVENTTKQNIKNLRYEYPKNFPI-MAKDLITKILVVDPKSRLSLKEILAHPWI
|||..|. | ..| . ||||| ||. | .. |. || .. .|  . .    . .  |. . |..|. . .  ..||| |.|.|.|. | ....|. ||| 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN-KQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 22429.AA Pkinase 30-293 31 3.4e-88 304.12 Pfam 1-293 (293) Show / Hide 
Range on Protein: 30-293
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

FDGQKVLGKGAFGKVIRVLHRKSQLIYAIKEINKKNLKLNNMVEQVTN--EVKIMYSLNHPYILKLYNHFEDDTNIYLVLEYAQGG----QLY----VQL
.   ...|.|.||.| .  |.... |.|.|.|.|.  .  .. .. ..  |..|| .||||.|..||  |||...||.|.||..||     |.    .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

WKQPNHQF--EEKKVAKYIFQLCKALELCHSKGIIHRDIKPENILLDKDGNV----KLADFGWSNFK-QRESDIRTTFCGTLDYLAPEMLQSNHQHDFGV
  . .  |  .|. . .|. |....|| |||.||||||.||||||.|..|..    |..||| . ..    .   ||||||..|.||| ....  ..  |
--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSVGVLAYELLSGASPFAPK---NNQNNADYVENTTKQNIKNLRYEYPKNFP-----------------IMAKDLITKILVVDPKSRLSLKEILAHPW
|.||.|.. ||.|.|  ||  .    | .. ... . ... .    .... . .                   .||.|...| .|||.|.. ..|| |||
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

I
.
F
Kinase 22429.AA Ciliate-E2 30-293 27 3.4e-88 299.32 In-house 1-365 (365) Show / Hide 
Range on Protein: 30-293
Range on HMM: 1-365/365
Sequence Identity: 27% (108 aa)

FDGQKVLGKGAFGKVIRVLHRKSQ-----------------------LIYAIKEINKKNLKLNNMVEQVT----------NEVKIMYSLNHPYILKLYNH
.. .|..|.|.||.| .. ..| |                        |||.| ..|....  ......           || .|. .||||.|.|.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--DDTNIYLVLEYAQGGQLY---VQLWKQPNHQFE------EKKVAKYIFQLCK---------------ALELCHSKG-IIHRDIKPENILLDKDGNV
|.  ||.|||||.||.||| |.    . .|. ||..|      ||...... |...               ||| .|||. ||||||||||||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLADFG-------------------WSNFKQRESDIRTT-------------FCGTLDYLAPEMLQSNH--------QHDFGVDIWSVGVLAYELLSGAS
|..|||                   |  | . . .. ..             .|||. |.|||.|..          ..|. .||||.||. ||.|.|  
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFAPKNNQNNADYVENTTKQNIKNLRYEYP------------------KNFPIMAKDLITK----ILVVDPKSRLS-LKEILAHPWI
||                 |.||.  ...|                  |. .  .|||| |    .|..||. |..  ..|| |||.
PF----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 22429.AA Ciliate-E2-Unclassified 30-293 30 5.4e-87 295.33 In-house 1-352 (352) Show / Hide 
Range on Protein: 30-293
Range on HMM: 1-352/352
Sequence Identity: 30% (106 aa)

FDGQKVLGKGAFGKVIRVLHRKSQLIYAIKEINKKNLKLNNMVEQV---------TNEVK-------------IMYSLNHPYILKLYNHFEDDTNIYLVL
.  .|..|.|.|||| .. |.| ...||.|...|.. .  . ....          |. |             |.....||.|.|.. .|.|. |||.|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYAQGGQLYVQLWKQPN---------------HQFEEKKVA-----KYIFQLCKALELCHSKG-IIHRDIKPENILLDKDG---NVKLADFGWSNFKQRE
||..|| |   . |...               ..|.|....     .|. |....|| .|.|. ||||||||||||.|..|   ..|..||| | . |  
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---------------SDIRTTFCGTLDYL----APEMLQS-NHQHD--FGVDIWSVGVLAYELLSGASPFAPKNNQN----NADYVEN-----TTKQNIK
               ... .|||||. |.    |||.||. |. |   . .||||.||..||.| |  ||  .|       ..  . |       .||||
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIK

NLRYEYPK--------NFPIMAKDLIT----KILVVDPKSRLSLKEILAHPWI
.  ...||        . .  |||.|.    |.|...|..|.....|| |||.
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 22429.AA CAMK1 30-293 36 8.4e-85 246.44 In-house 1-276 (276) Show / Hide 
Range on Protein: 30-293
Range on HMM: 1-276/276
Sequence Identity: 36% (105 aa)

FDGQKVLGKGAFGKVIRVLHRKS---QLIYAIKEIN-KKNLKLNNMV--EQVTNEVKIMYS---LNHPYILKLYNHFEDDTNIYLVLEYAQGGQLYVQLW
.  .|..|.|||..| .. |...   .  |||| |. ||..| ..|   |.. ||. || .   ..|| | |.| ..|.|. .|||.|. .|| |  .  
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

KQPNHQFEEKKVAKYIFQLCKALELCHSKGIIHRDIKPENILL-DKDGN--VK--LADFGWSNFKQRESDIRTTFCGTLDYLAPEMLQS--NHQHDFGVD
.  .... ||. .. . |...|.| .||||| |||.||||.|. ||| .  .|  .|||| | .   .... .| |||..| |||.|       .|  .|
E--KGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD

IWSVGVLAYELLSGASPFAPKNNQNNADYVENTTKQNIKNLRYEYPKN--FP--IM-AKDLITKILVVDPKSRLSLKEILAHPWI
.||.||  | || | .||       ... |.|.  . ||.  ||.|..         |||.|.. |.|||| |.. ...|.||||
MWSIGVITYILLCGYPPF-------YDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 22429.AA MARK 30-293 34 5.8e-83 271.02 In-house 1-262 (262) Show / Hide 
Range on Protein: 30-293
Range on HMM: 1-262/262
Sequence Identity: 34% (94 aa)

FDGQKVLGKGAFGKVIRVLHRKSQLIYAIKEINKKNLKLNNMVEQVTNEVKIMYSLNHPYILKLYNHFE--DDTN-IYLVLEYAQGGQLYVQLWKQPNHQ
.   |..|.|...||  ..|....  .||| ..|..|  ..  . |  |..|| .|.||.| ||.  .|  . .. |||..||| || ||  . ..||. 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FEEKKVAKYIFQLCKALELCHSKGIIHRDIKPENILLDKDG--NVKLADFGWSNFKQRESDIRTTFCGTLDYLAPEMLQSNHQHDFGVDIWSVGVLAYEL
 .|.   ..  |.. |.. ||||.|.||||||||||.|..|  |.|..|||.|. .  .    .|||||. | |||....     . ||||| ||. | .
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSI-CIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFM

LSGASPFAPKNNQNNADYVENTTKQNIKNLRYEYPKNFPIMAKDLITKILVVDPKSRLSLKEILAHPWI
..|  ||       ........ ...| . .|..| . .  ...|| ..|.|.|. | ...||. |||.
VCGYFPFD------GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 22429.AA AktR 30-293 38 1.7e-80 273.7 In-house 1-268 (268) Show / Hide 
Range on Protein: 30-293
Range on HMM: 1-268/268
Sequence Identity: 38% (106 aa)

FDGQKVLGKGAFGKVIRVLHR-KSQLIYAIKEINKKNLKLNNMVEQVTNEVKIMY-SLNHPYILKLYNHFEDDTNIYLVLEYAQGGQLYVQLWKQPNHQF
|.  |.|||||||||. | .. ..| .||.| | ||... .|. ... .| .||    ||| | ||.  |..........|| .|| |.  |  . ...|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHL--KKKKKF

EEKKVAKYIFQLCKALELCHSK-GIIHRDIKPENILLDKDGNVKLADFGWSN--FKQRESDIRTTFCGTLDYLAPEMLQSNHQHDFGVDIWSVGVLAYEL
.|... .|. | . |||  |..  || ||.||||||||.||.||..||| |.  |.  .... ..||||  |.||||..    |.. ||.|..|.. ||.
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LSGASPFAPKNNQNNADYVENTTKQNIKN-LRYEYPKNFPIMAKDLIT-KILVVDPKSRLS-----LKEILAHPWI
..|  ||  ||..      ..  |..||. .. .||..|   .||||. |.|  .|. ||       .||  ||| 
VTGCPPFYHKNQN------QMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 22429.AA RSK 33-293 35 2.3e-79 270.0 In-house 1-278 (278) Show / Hide 
Range on Protein: 33-293
Range on HMM: 1-278/278
Sequence Identity: 35% (99 aa)

QKVLGKGAFGKVI---RVLHRKSQLIYAIKEINKKNLKLNNM-VEQVTNEVKIMYSLN-HPYILKLYNHFEDDTNIYLVLEYAQGGQLYVQLWKQPN-HQ
 ||||.|..|||    .. |.... ||| | ..|. .. ..  .. .  |..|.   . || | .|.  |.... .||..||  || |.  | |.     
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FEEKKVAKYIFQLCKALELCHSKGIIHRDIKPENILLDK---DGNVKLADFGWSNF-KQRESDIRTTFCGTLDYLAPEMLQ---SNHQHDFGVDIWSVGV
| |. .. |. .. .|.|  |..||||||.||||||.|    .| .|| ||| .   . ...    |||.|..|.|||||     .  ||  .|.|| ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LAYELLSGASPFAPKNNQNNADYVENTTKQNIKNLRYEYPKNFPIMAKDLITKILVVDPKSRLS-----LKEILAHPWI
| ||.|.|..||.   |.||.. . .  ...  .|. . ...    |||||.| | .||. ||.     ..||..|||.
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 22429.AA TyrKc 30-293 23 4e-17 54.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 30-293
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

FDGQKVLGKGAFGKVIRVLHRKSQLIYAIKEINKKNLKLNNMVEQVTNEVKIMYSL--NHPYILKLYNHFEDD-------TNIYLVLEYAQGGQLYVQLW
    |.|| ||||.| .   .   .  |.| ...        .|   .| .|| .|  .|| |..||    ..         ...|.||. .| |   | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KQPNHQFEEKKVAKYIFQLCKALELCHSKGIIHRDIKPENILLDKDGNVKLADFGWSNFKQRE-------SDIRTTF--CGT----LDYLAPEMLQSNHQ
|  .. .  |.  .. .| ..  |  |||..||||.   |.|..... || .||| | .   .       . .|..   .|     .  .||| .   . 
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGK

HDFGVDIWSVGVLAYELLSGASPFAPKNNQ--NNADYVENTTKQNIKNLRYEY------PKNFPIMAKDLITKILVVDPKSRLSLKEILAHPWI
  .  |.|| ||. .|...   .  |   |   ... | .  ||     . ..      .   . | . ....    ||..| . .||  |  .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase 22429.AA Pkinase_Tyr 30-175 30 4e-16 55.25 Pfam 1-156 (270) Show / Hide 
Range on Protein: 30-175
Range on HMM: 1-156/270
Sequence Identity: 30% (48 aa)

FDGQKVLGKGAFGKVIRVLHR----KSQLIYAIKEINKKNLKLNN-MVEQVTNEVKIMYSL-NHPYILKLYNHFE-DDTN--IYLVLEYAQGGQLYVQLW
    |.||.||||.| .   .    . ..  |.| . | .    . . |   .|.||| .| .|| |..||     ..    ||.|.||...| |.  | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KQ--PNHQFEEKKVAKYIFQLCKALELCHSKGIIHRDIKPENILLDKDGNVKLADFG
|.  .....  |   .. .| .|..|  .||..||||.   |.|..... || .|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 22429.AA Pkinase_Tyr 213-245 33 1.912495 2.13 Pfam 196-231 (270) Show / Hide 
Range on Protein: 213-245
Range on HMM: 196-231/270
Sequence Identity: 33% (12 aa)

DIWSVGVLAYELLS-GASP-FAPKNNQNNADYV-EN
|.|| ||| .|... |..| ..   |.   .|. |.
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED