Gene 19498 (Tetrahymena)

19498

Species: Tetrahymena
Alias: 19498, 752, TTHERM_01266090, 301.m00012, PreTt19498
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
19498.AA Protein None 791 None Fasta, JSON
19498.kin_dom Protein Kinase Domain None 252 None Fasta, JSON
19498.NA RNA None 2376 None Fasta, JSON

Protein domain

Protein domains of 19498.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19498.AA Aur 74-325 43 2e-178 475.67 In-house 7-257 (257) Show / Hide 
Range on Protein: 74-325
Range on HMM: 7-257/257
Sequence Identity: 43% (111 aa)

LGEGSFGFVLLIKNIQTNQLYALKLIPMSSIETLTHKRIIEREVKVHPELSHPYIIKMHDAFINKDAIYIILDYAVNKNVSETFLQD--FKYNEARAFKY
||.|.||.| |... .|....|||.. .. |..  ... ..||.|.. .|.||.|.||.. |.... ||.||.||..... . . .   ....| ||.||
LGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDEQRAAKY

FYQTCLAIDYLHKKGIMHRDIKPENLLLD-ENDNIKLCDFGWCAEIT-KNRRNTLCGTFEYMAPETITERDYDYKIDIWQLGILLYELLHGRTPFKPNFE
.||.|.|.||.|.|.|.||||||||.||| .|.|||.|||||... . .|||.|.|||..||.|| . ....|.|.|||.||.|.|||.||. ||..|  
MYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPPFESN--

LGEDERMEYYKNTINQGHIVFDSHISPSAIDLISQILIYVPEKRISIQGILAHVWI
   ....|.|.. .|...|.|.||||. | ||||.|| . |..|.... |..| ||
---ENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 19498.AA AGC 74-325 25 3.8e-85 219.32 In-house 7-395 (395) Show / Hide 
Range on Protein: 74-325
Range on HMM: 7-395/395
Sequence Identity: 25% (101 aa)

LGEGSFGFVLLIKNI------QTNQLYALKLIPMSS-IET----LTHKRIIE------------REVKVHPELS--------HPYIIK-MHDAFINKDA-
.|.|||| | | .        .|...||.| .  .  |        .. ..|            |.. ..   .        ||.|.| .| .| .||  
IGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHT

-IYIILDY---AVN----KNVSETFLQDF------KYNEARAFKYFYQ-------TCLAIDYLHK-KGIMHRD-IKPENLLLDENDNIKLCDFGWCAEIT
 .|....|    ||        |.||. .      . .| ||  |. .       ..||..|||. .|| ||| .||||.||||. .|||.||| | |. 
YLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGM

K----------------------------------------------------NRRNTLCG--TFEYMAPETITERDYDYKIDIWQ--LGILLYELLHGR
.                                                    .| .|.||  | |||||| .    |..  |.|   ||.|.||.| |.
NDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGY

TPFKPNFELGED---------ERMEYYKNTIN-----QGHIVFD----------SHISPSAIDLISQILIYVPEKRIS----------IQGILAHVWI
.||      |..          .|| ... .|     .  . |.          ...|| | |||.. |   ||||.           .. | .| | 
PPFY-----GDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
S_TKc 19498.AA S_TKc 63-325 30 1.2e-80 275.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 63-325
Range on HMM: 1-231/231
Sequence Identity: 30% (85 aa)

FIIDQQGNKINLGEGSFGFVLLIKNIQTNQLYALKLIPMSSIETLTHKRIIEREVKVHPELSHPYIIKMHDAFINKDAIYIILDYAVN--KNVSETFLQD
. | ..     .|.|.|| | . ... |....|.| |.          . |.||.... .  ||.|.|..|.| . | .|....|. .   .. .   . 
YEILRK-----IGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

FK------YNEARAFKYFYQTCLAIDYLHKKGIMHRDIKPENLLLDENDNIKLCDFGWCAEITKNRRNTLCGTFEYMAPETITERDYDY-KIDIWQLGIL
 .      ..| .| .|.||.|.|..|.|..||.|||.||||.||||  .||.|||| ....     .|.||| .||||| .    |.. |.|.| .|..
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LYELLHGRTPFKPNFELGEDERMEYYKNTINQGHIVFDSHISPSAIDLISQILIYVPEKRISIQGILA-------HVWI
|||.| |..||         . .. .|.             ||.|.|.|...| . ||||...  .|.       | |.
LYEMLCGYPPFP--------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19498.AA Pkinase 74-325 27 7.3e-79 273.11 Pfam 7-293 (293) Show / Hide 
Range on Protein: 74-325
Range on HMM: 7-293/293
Sequence Identity: 27% (81 aa)

LGEGSFGFVLLIKNIQTNQLYALKLIPMSSIETLTHKRIIE-REVKVHPELSHPYIIKMHDAFINKDAIYIILDYAVNK----NVSETFLQ---DFKY--
.|.|||| | . ... |....|.| |. ....   ... .  .|.... .|.||.|....|.| .|| ||....|. .       . ....   . ..  
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYISTWRHGCFYF

NEARAFKYFYQTCLAIDYLHKKGIMHRDIKPENLLLDENDNI----KLCDFGWCA---EITKNRRNTLCGTFEYMAPETIT-ERDYDYKIDIWQLGILLY
 |  . .|.||.. ...|.|..||.|||.||||.|.|.|..|    |.|||| ..   .  .   .|.||| .||||| |   ..|..|.|.| .|..||
SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILY

ELLHGRTPFKPN----FELGEDERMEYYKNTINQGHIVFDSHIS-----------------PSAIDLISQILIYVPEKRISIQGILAHVWI
|.| ||.||.        . ......  . ...  ..  .. ||                 ....|.|. .| . |.||.... || | |.
EMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 19498.AA CAMK 73-325 20 2.1e-74 238.97 In-house 1-425 (425) Show / Hide 
Range on Protein: 73-325
Range on HMM: 1-425/425
Sequence Identity: 20% (89 aa)

NLGEGSFGFVLLIKNIQTN------------QLYALKLIPMSSIE-------------------------TLTHKRIIEREVKVHPELS-------HPYI
 ||.|||| | | ....|.            | .| | |. . .                          .   .. ..||....  |.       || |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKMHDAFI------------NKDA--------IYIIL---DYAVNK----NVSETFLQD---------------FKYNEARAFKYFYQTCLAIDYLHKKG
||.....             . .         .|...   .|. .      . .   .                ....|. | .|| | | |..|.|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IMHRDIKPENLLLDEND-----------------NIKLCDFGWCAEITKNR-------------------------RNTLCGTFEYMA-PETIT------
|.|||.||||.|||.|.                 |||..|||  ......                           .| ||| |||| || .       
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------ERDYDYKIDIWQLGILLYELLHGRTPFKPNFELGEDE------RMEYYKNTINQGHIVFDSH----------------ISPS--------AI
        .. |..|.|.| .|..|| .| |. ||    .  . |       ..  .  | .|   |...                || .        ..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLISQILIYVPEKRISIQGILAHVWI
|||...| . ||||..|. .|.| |.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 19498.AA MARK 74-325 33 1.7e-73 239.6 In-house 7-262 (262) Show / Hide 
Range on Protein: 74-325
Range on HMM: 7-262/262
Sequence Identity: 33% (88 aa)

LGEGSFGFVLLIKNIQTNQLYALKLIPMSSIETLTHKRIIEREVKVHPELSHPYIIKMHDAFI--NKDA-IYIILDYAVNKNVSETFLQD----FKYNEA
.|.||.. | |  .. |.. .|.| ..  ..     .. ..||....  |.||.|||.....   ..   ||.|..|| .... .   .      . .||
IGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEA

RAFKYFYQTCLAIDYLHKKGIMHRDIKPENLLLDEND--NIKLCDFGWCAEITKNR-RNTLCGTFEYMAPETITERDYD-YKIDIWQLGILLYELLHGRT
|  ..| | . |. |.|.|.| ||||||||.|.|||   |||..|||....|. ..  || ||| .||||| .  ..|| .|.||| ||..|| ...|. 
R--RIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYF

PFKPNFELGEDERMEYYKNTINQGHIVFDSHISPSAIDLISQILIYVPEKRISIQGILAHVWI
||.     | .  ..  .  |. |.  . .|.|... .||...|   ||.|..|. |. | |.
PFD-----GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 19498.AA CAMKL 74-325 30 2.6e-70 223.54 In-house 7-297 (297) Show / Hide 
Range on Protein: 74-325
Range on HMM: 7-297/297
Sequence Identity: 30% (91 aa)

LGEGSFGFVLLIKN-IQTNQLYALKLIPMSSIETLTHKRI------------IEREVKVHPELS---HPYIIKMHDAFINKDA------IYIILDYAVNK
||.|||| | | .. . |.. .| | |  . |   ....             |.||.. .  |.   || |||... . ...       ||... |. . 
LGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGG

N------VSETFLQD--FKYNEARAFKYFYQTCLAIDYLHKKGIMHRDIKPENLLLDEND--NIKLCDFGWCAEIT------KNRRNTLCGTFEYMAPET
.      . .       .. .|||  .|| | . |..|.|..|| ||||||||.|||||.  |||..||| .....       .  .| ||. .||||| 
EMDLFDYIVKHGHRRGRMPEHEAR--RYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEI

ITE--RDYD-YKIDIWQLGILLYELLHGRTPFK-PNFE--LGEDERMEYYKNTINQGHIVFDSHISPSAIDLISQILIYVPEKRISIQGILAHVWI
.    ..|| .|.||| .|..|| .. |. ||. .. .    ..   .| |. .  ...   .|.| ...|||...|   ||||..|. |. | | 
FQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 19498.AA Ciliate-E2 74-325 23 4.5e-67 229.16 In-house 7-365 (365) Show / Hide 
Range on Protein: 74-325
Range on HMM: 7-365/365
Sequence Identity: 23% (90 aa)

LGEGSFGFVLLIKNIQT-----------------------NQLYALKLIPMSSIETLTHKRIIEREVKVHP-----------ELSHPYIIKMHDAFI--N
.|.|.|| | . |....                       ...||.| .  . || .  .  | ||..              .|.||.||||...|.  .
IGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYECFQEKD

KDAIYIILDYAVNKNVSE-----TFLQDFK------YNEARAFKYFYQTCL---------------AIDYLHKKG-IMHRDIKPENLLLDENDNIKLCDF
.. ||....|.  ..  .        ....      ..|  . ....| .                |. |||.|. |.||||||||.|.     ||..||
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDF

GWCAEITKNRRNTL---------------------------------CGTFEYMAPETITERD---------YDYKIDIWQLGILLYELLHGRTPFKPNF
| . ...... |..                                 ||| .||||| .   .         ||||.||| ||..|||.| |..||    
GLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----

ELGEDERMEYYKNTINQGHIVFD------------------SHISPSAIDLISQ----ILIYVPEKRIS-IQGILAHVWI
            . | |. | |.                   ..|....|||..    .| . |||||. .. || | |.
-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 19498.AA Ciliate-E2-Unclassified 63-325 26 5.7e-61 208.88 In-house 1-352 (352) Show / Hide 
Range on Protein: 63-325
Range on HMM: 1-352/352
Sequence Identity: 26% (96 aa)

FIIDQQGNKINLGEGSFGFVLLIKNIQTNQLYALKLIP------MSSIET-----LTHKRIIEREVKVHPE------------LSHPYIIKMHDAFINKD
..| .|     .|.|.|| | . ......|.||.| .       . .|..     .  |.. ...   | .            . ||.|.||...| .|.
YKIIKQ-----IGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQ

AIYIILDYAVNKNVSETFL-------------------QDFKYNEAR---AFKYFYQTCLAIDYLHKKG-IMHRDIKPENLLLDEND---NIKLCDFGWC
 |||...|. ... ..                      . |  ..|.   | .||.| .....|||.|. | ||||||||.|.|.|    .||..||| .
NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS

AEIT-----------------KNRRNTLCGTFEYM----APETITERDYD----YKIDIWQLGILLYELLHGRTPFKPNFELGED----------ERMEY
 ..                  ... .| ||| .||    ||| . .  ||    ||.||| ||..|||.| |. ||. | .  ..           |...
KKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL

YKNTINQGHIVFD-------SHISPSAIDLIS----QILIYVPEKRISIQGILAHVWI
|.| ...   ..         |.||.|.|.|.    ..| . |.|||... || | |.
YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 19498.AA ULK 74-325 26 6.4e-59 202.07 In-house 7-329 (329) Show / Hide 
Range on Protein: 74-325
Range on HMM: 7-329/329
Sequence Identity: 26% (85 aa)

LGEGSFGFVLLIKNIQT----NQLYALKLIPMSSIETLTHKRI-------IEREVKVHPELS--------HPYIIKMHDAFINKDA--IYIILDYAVNKN
||.|||| |   .|..|    |...| | |. ...    . .        ...|.|.  .|         ||.|.|..| | ...   ||||..|    .
LGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGD

VSETFLQDFKYNEAR----------AFKYFYQTCLAIDYLHKKGIMHRDIKPENLLLDENDN------------IKLCDFGWCAEITKN------RRNTL
 ..   .. | .|            | ..|.| . .  .|||..|.||||||.| |.....             .|..||| .  ....         ..
LEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCV

-----CGTFEYMAPETITER----DYD-YKIDIWQLGILLYELLHGRTPFKPN-FELGEDERMEYYKN------TINQGHIVFD-----SHISPSAIDLI
     |||  ||||. . ..    .|. || ||| ||...||.| |..||. . ... .   .. ..|      .|..  . |.      .|||  .|||
NEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLI

SQILIYVPEKRISIQGILAHVWI
.. |.| ...|||.. ...| |.
RRMLQYDEKDRISWEELFNHPWF
Kinase 19498.AA ULK 74-325 27 6e-57 195.51 In-house 7-324 (324) Show / Hide 
Range on Protein: 74-325
Range on HMM: 7-324/324
Sequence Identity: 27% (89 aa)

LGEGSFG-FVLLIKNIQT---NQLYALKLIPMSSIETLTHKR-------IIEREVKVHPELS---HPY--IIKMHDAFINKDA--IYIILDYAVNKNVSE
||.||||  |   .|..|   ||..| | |.....    ...        ...|...  .|    ||.  |.|..| | ...   ||||..|    . ..
LGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQ

TFLQDFK---------YNEARAFKYFYQTCLAIDYLHKKGIMHRDIKPENLLLDENDN------------IKLCDFGWCAEITKN-RRNTLC--------
   .. |          .|  | ..|.| | .  .|||..|.||||||.|.|. ...             .|..||| .  . .|    ..|        
YIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKR

--GTFEYMAPETITER----DYD-YKIDIWQLGILLYELLHGRTPFKPN-FELGEDERMEYYKN------TINQGHIVFD-----SHISPSAIDLISQIL
  ||  ||||. . ..    .|. || ||| ||...||.| |..||. .  .. .   ..  .|      .|..  | |.      .|||  .|||.. |
IKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRML

IYVPEKRISIQGILAHVWI
.| ...|||.. |..| |.
QYDEKDRISWEEIFNHPWF
Kinase 19498.AA STE 70-325 20 4.1e-54 186.08 In-house 1-359 (359) Show / Hide 
Range on Protein: 70-325
Range on HMM: 1-359/359
Sequence Identity: 20% (75 aa)

NKI--NLGEGSFG---FVLLIKNI---QTNQL---------YALKLIPMSSIET--------------LTHKRIIEREVKVHPELS--HPYIIKMHDAFI
 ..   .|.|.||     . .||.   .|...         .| | ..... ..               . .  |..|.|.. ...  ||.|.| .....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NK-------DAIYIILDYAVNKNVSETFLQDFKYN--------------EARAFKYFYQTCLA-IDYLHKKGIMHRDIKPENLLLDENDNIKLCDFGWCA
..       | ..|.. |  .  ...   . .. .              |    .. .|.. .  .|||...|.|||||| | ||     .|||||| |.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

EITKN------------------RRNTLCGTFEYMAPETITE------RDYDYKIDIWQLGILLYELLHGRTPFKPNFELGEDERMEYYKNTIN------
 .|..                  .|||..||  .|||| |.        .||.| ||| ||... |.. |. |.     .    ..   .   .      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---QGHIVFDSHIS-------------------PSAIDLISQILIYVPEKRISIQGILA--HVWI
   ...  . .|.|                   |. .| |.. |.. |.|| . .  |   | .|
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 19498.AA TyrKc 70-323 19 1.9e-12 -21.44 SMART 3-280 (280) Show / Hide 
Range on Protein: 70-323
Range on HMM: 3-280/280
Sequence Identity: 19% (59 aa)

NKINLGEGSFGFVLLIKNIQTNQLYALKLIPMSSIETLTHKRIIEREVKVHPEL--SHPYIIKMHDAFINK-------DAIYIILDYAVNKNVSETFLQD
 .  |||| || | . . .   .  | | .  ..      .. . || ..  .|  .|| |.... . . .       . ..|.. |. . .  . .|..
LGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD-YLRK

FK--YNEARAFKYFYQTCLAIDYLHKKGIMHRDIKPENLLLDENDNIKLCDFGWCAEITKN-------RRNTL----CGT----FEYMAPETITERDYDY
 .   . .   .. .| .   .|||.|.. |||.   | |..||  .| .||| . .|.            .     .|        ||||.| .. .  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KIDIWQLGILLYELL-HGRTPF-------KPNFE----LGEDERMEYYKN----TINQGHIVFDSHISPSAIDLISQILIYVPEKRISIQGILAHV
| |.|  |....|..  | .|        ..|.|    . . .||.  .|            |  . ..   ....|   . ||.| . . |    
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 19498.AA Pkinase_Tyr 173-265 30 7e-06 20.64 Pfam 118-217 (270) Show / Hide 
Range on Protein: 173-265
Range on HMM: 118-217/270
Sequence Identity: 30% (31 aa)

YQTCLAIDYLHKKGIMHRDIKPENLLLDENDNIKLCDFGWCAEI-----T-KNRRNTLCGTFEYMAPETITERDYDYKIDIWQLGILLYELLH-GRTP-F
.| . . .||. |.. |||.   | |..||  .| |||| .  |       . | ..       |||| | .. .  | |.|  |.|..|..  |..| .
WQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY

K
.
P