Gene 9821 (Tetrahymena)

9821

Species: Tetrahymena
Alias: 603, 3690.m00066, PreTt09821, 9821, TTHERM_00267860, 24.m00252
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: RCK

Sequence

Name Sequence Type Origin Length Description Download
9821.AA Protein None 701 None Fasta, JSON
9821.kin_dom Protein Kinase Domain None 285 None Fasta, JSON
9821.NA RNA None 2106 None Fasta, JSON

Protein domain

Protein domains of 9821.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 9821.AA RCK 4-288 59 2.2e-225 722.59 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-298/298
Sequence Identity: 59% (179 aa)

YNIISEIGRGAFGIVKKAQNKETKEIVAIKQMLQEYETWDECINLRELKSLRKLT-HVNIIKLKEVFRVKK--QLSFVFEYVEKNIYKLYENAKQDGATS
|.||...|.|..| | |||||||.||||||.| |....|.||.||||.||||||. | ||||||||.|...  ||.|||||...|.|......|. . . 
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKE-RRKY

LPENT--IKSIVYQIASALSYMHKHGFFHRDLKPENLLISS---------DGIVKLIDFGLAREVRSRPPYTDYVSTRWYRAPEILLRSTHYNSPVDIFA
||||.  ||.|.|||. .|..|||||||||||||||.....         ....|..||||.||.||.||||||||||||||||.|||.|.||||.||.|
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWA

LGCIMAELYLMKPLFNGSSEIDQIQKITSVLGTPQKQDWPDGFILASTKYYTFPQYPAIPLSQVIPNCPPDALNLISEMLKWDPQKRITAAKILQHPYF
.||||.||| ..|||.||||||||.||..|.|||.|.|||||. |||.....|||....||.|.||||..|...|. .||.|||||||||...||||||
VGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 9821.AA MAK 4-288 45 2.8e-161 517.54 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-352/352
Sequence Identity: 45% (161 aa)

YNIISEIGRGAFGIVKKAQN------------------------------KETKEIVAIKQMLQEYETWDECINLRELKSLRKLT-HVNIIKLKEVFR--
| .|  .| |..| | .|.                               ..| |.||||.| . . .|.||.|||| |||.||  | ||.|||||.|  
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

VKKQLSFVFEYVEKNIYKLYENAKQDGATSLPENTIKSIVYQIASALSYMHKHGFFHRDLKPENLLISSD-----------------GIVKLIDFGLARE
   .| ||||| . |   ||.  |      .|| .|..|.|||  .| .||||||||||.||||....                    ..|. |||||||
ENDHLYFVFEYMKEN---LYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLARE

VRSRPPYTDYVSTRWYRAPEILLRSTHYNSPVDIFALGCIMAELYLMKPLFNGSSEIDQIQKITSVLGTPQKQD----------------WPDGFILAST
.||.||||||||||||||||.||||| |.||.|. |.|||||||| ..||| |||||||| ||..|||||.|.|                ||||. ||. 
IRSKPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHM

KYYTFPQYPA---IPLSQVIPNCPP-DALNLISEMLKWDPQKRITAAKILQHPYF
  ..|||  .   .||...|||| . ||. |. .||.|||.|| ||.  ...|||
MNFRFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase 9821.AA CMGC 4-288 26 3.3e-136 450.52 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-513/513
Sequence Identity: 26% (137 aa)

YNIISEIGRGAFGIVKKAQN--------------KETKEIVAIKQMLQEYETWDEC----------INLRELKSLRKLT-----------------HVNI
| ||. ||.|..|.| |...              .||.|||||| . .. ......          . |||.| |..|                  | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IKLKEVFRVKK-----------------QLSFVFEYVEKNIYKLYENAKQD----GATSLPENT------------IKSIV------YQIASALS--YMH
.||...|. |.                 .| .||||.... |.. .| ..|    .   |.|              ||...      |||  .|   |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KHG--FFHRDLKPENLLISSD--------------------GIVKLIDFGLAR--EVRSRP--------------------PYTDYVSTRWYRAPEILLR
.|.  ..||||||||.||...                    |..|..||||||  ...|..                    |||.||.|||||||||||.
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

S---------THYNSPVDIFALGCIMAELYLM--------KPLFNGSSE-----------IDQIQKITSVLGTPQ---------------KQDWPD----
.         .||..|.|. ..|||.||.|.         |||| |.||           |||..||  |||||                ...||.    
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

---------------------GFILASTKYYTFPQYPAIPLSQVIPN-----------------------------------CPPDALNLISEMLKWDPQ
                     .  ..  .  .||..| .|.....|.                                   |.|.|..|.. ||..||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRITAAKILQHPYF
|||||. .||||||
KRITAEQALQHPYF
Kinase 9821.AA CDK 4-288 34 1.3e-112 361.62 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-284/284
Sequence Identity: 34% (112 aa)

YNIISEIGRGAFGIVKKAQNKETK-----EIVAIKQMLQEY---ETWDECIN---LRELKSLRKLTHVNIIKLKEVFRVK-----------KQLSFVFEY
| .. .||.|..|.| ||..|.|.     .|||.|.   |    |  .| ..   .|| . |..| | ||.||..|.  |           . |..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VEKNIYKLYENAKQDGATSLPENTIKSIVYQIASALSYMHKHGFFHRDLKPENLLISSDGI-----VKLIDFGLAREVRS-------RPPYTDYVSTRWY
..   .|. .              ||.. .|. ..|.|.|.... |||||| |.||...|.     .|. ||||||.  .       . .||  | |.||
MDHDLKKYMD--------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPEILLRSTHYN--SPVDIFALGCIMAELYL---MKPLFNGSSEIDQIQKITSVLGTPQKQDWPDGFILASTKYYTFPQYPAIPLSQVIPNCPPDALNL
||||.|| |.||.   |.|. ..|||.||...    |||| |.|||||. ||  ..|||  ..||.   |                            .|
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DL

ISEMLKWDPQKRITAAKILQHPYF
.. ||  ||.|||.|   ||||||
LNKMLCYDPKKRISAEQALQHPYF
Kinase 9821.AA CDC2 4-288 39 2.6e-108 334.03 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-301/301
Sequence Identity: 39% (121 aa)

YNIISEIGRGAFGIVKKAQNKETKEIVAIKQMLQEYETWD----ECINLRELKSLRKLT-HVNIIKLKEVFRVKKQLSFVFEYVEKNIYKLYE-NAKQDG
|  |  || | .|.| |.....|..|||.|.   |.|. .    . . .||.  | .|  | ||.||..|.   . |  ||||.. .  |. .   ... 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTA-IREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKN-

ATSLPENTIKSIVYQIASALSYMHKHGFFHRDLKPENLLISSDGIVKLIDFGLAREVRS-RPPYT--DYVSTRWYRAPEILLRSTHYNSPVDIFALGCIM
 ...|....||. ||| ..... | .. .|||||| |.||...| .|. |||||| .     .||    | |.|||||||||.. .|. |||. ..|||.
-KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIF

AELYLM---KPLFNGSSEIDQIQKITSVLGTPQKQDWPDGFILASTKYY--TFPQYPAIPLSQVIPN---------CPPDALNLISEMLKWDPQKRITAA
||...    |||| | |||||. ||  .||||  |.||.   . . ..|  |||..... ||...||         ..|... |...||  ||||||.| 
AEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPG---VTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAK

KILQHPYF
..||||||
EALQHPYF
Kinase 9821.AA Pkinase 4-288 31 7.2e-101 346.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-293/293
Sequence Identity: 31% (97 aa)

YNIISEIGRGAFGIVKKAQNKETKEIVAIKQMLQEYETWDECINLR---ELKSLRKLTHVNIIKLKEVFRVKKQLSFVFEYVEKNIYKLYENA------K
| |.. ||.|.|| |.|...| | .|||.|..  . | .......|   |.. ...| | ||..|...|. |. . .|.||.|.  | . . .      .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

QDGATSLPENTIKSIVYQIASALSYMHKHGFFHRDLKPENLLISSDGIV----KLIDFGLARE--VRSRPPYTDYVSTRWYRAPEILLRSTHYNSPVDIF
. . . ..|...|...|||...| |.|..|. ||||||||.||...| .    |..|||||.     . . .|... |.||.|||... ...| ..||..
HGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

ALGCIMAELYLMKPLFNGS----SEIDQIQKITSVLGTPQKQDWPDGFILASTKYYTFPQYPAIPLSQVIPNCPPDALNLISEMLKWDPQKRITAAKILQ
..|||..|... .|.| |.    . .||.|.|  ..|.| . |||        .  .. . . . .. . .| ..... .|. .|..||.||.||. |||
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPYF
||.|
HPWF
Kinase 9821.AA S_TKc 4-288 30 2.1e-97 330.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-231/231
Sequence Identity: 30% (92 aa)

YNIISEIGRGAFGIVKKAQNKETKEIVAIKQMLQEYETWDECINLRELKSLRKLTHVNIIKLKEVFRVKKQLSFVFEYVEK---NIYKLYENAKQDGA-T
| |. .||.|||| |.|...|.|..|||||..         .  .||.. |.|  | ||.||..||.  . | .|.||..    . ... .. .  |   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

SLPENTIKSIVYQIASALSYMHKHGFFHRDLKPENLLISSDGIVKLIDFGLAREVRSRPPYTDYVSTRWYRAPEILLRSTHYNS-PVDIFALGCIMAELY
 .|| ......|||..|| |.|.||. ||||||||.|...   .|..||||||..      | .. |.||.|||.|    .|.  ..|. ..|||..|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

LMKPLFNGSSEIDQIQKITSVLGTPQKQDWPDGFILASTKYYTFPQYPAIPLSQVIPNCPPDALNLISEMLKWDPQKRITAAKILQ-------HPYF
  .|.|    ..... |.                                         .|.|...|. .|..||.||.|| ..||       ||.|
CGYPPFP---QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 9821.AA MAPK 4-288 33 2.3e-91 309.87 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-328/328
Sequence Identity: 33% (113 aa)

YNIISEIGRGAFGIVKKAQNKE------TKEIVAIKQMLQEYETWDECIN-LRELKSLRKL-THVNIIKLKEVFRVK-----KQLS------FVFEYVEK
|.|.. || ||.|.| .|  |.      ....|||| . .  ..   |   .||.| || .  | |||||...|. .     . |.      .|.|. | 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NIYKLYENAKQDGATSLPENTIKSIVYQIASA--LSYMHKHGFFHRDLKPENLLISSDGIVKLIDFGLAREVRSRPPY---------------TDYVSTR
. ... .  .      | .  |....|||  .  | |.|  .  ||||||.|.|. ... .|. |||||| . .   .               |.||.||
DLHQIIKSQQ-----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

WYRAPEILLR--STHYNSPVDIFALGCIMAELYL-MKPLFNGSSEIDQIQKITSVLGTPQKQDW---P-DGFILASTKYYT-FPQYPAIPLSQVIPN---
|||||||.|   ..||.  ||. ..|||.||..   |||| |.. |||...|..||||| ....   . .       . .  .|.||..|.....||   
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF

-CPPDALNLISEMLKWDPQKRITAAKILQHPYF
 . |.|..|.. || .||.||||..  ||||||
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 9821.AA CDK5 4-288 38 2.6e-87 275.91 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-287/287
Sequence Identity: 38% (113 aa)

YNIISEIGRGAFGIVKKAQNKETKEIVAIKQMLQEYETWDE---CINLRELKSLRKLTHVNIIKLKEVFRVKKQLSFVFEYVEKNIYKLYENAKQDGATS
|. .  || | .|.| ||.||||.||||.|.   . |  ||   .  .||   |. | | ||. |  |    | |  |||.. . . |  .. .      
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSE--DEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG----E

LPENTIKSIVYQIASALSYMHKHGFFHRDLKPENLLISSDGIVKLIDFGLARE----VRSRPPYTDYVSTRWYRAPEILLRSTHYNSPVDIFALGCIMAE
.  ..|||. ||    |.. |.|   |||||| ||||.  |. || ||||||     ||    |.  | | |||.| .|. | ||. ..|.   |||.||
MDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC---YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAE

LY-LMKPLFNGSSEIDQIQKITSVLGTPQKQDWPDGFILASTK--YYTFPQYPAIP-LSQVIPNCPPDALNLISEMLKWDPQKRITAAKILQHPYF
.    .||| |... ||  .|  ..|||    ||    |   |     .| ||| . ..|..|.     ..| ..||. .|..||.|.. |.||||
MANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 9821.AA CDKL 4-222 44 4.3e-82 279.03 In-house 1-218 (286) Show / Hide 
Range on Protein: 4-222
Range on HMM: 1-218/286
Sequence Identity: 44% (100 aa)

YNIISEIGRGAFGIVKKAQNKETKEIVAIKQMLQ-EYETWDECINLRELKSLRKLTHVNIIKLKEVFRVKKQLSFVFEYVEKNIYKLYENAKQDGATSLP
| ... .| |. | | |  |||| .|||||  .  |..     | .||.| |. | | ||  |.|||| |. |  ||||.....  . |  .. |   ..
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEE-YPNG---VD

ENTIKSIVYQIASALSYMHKHGFFHRDLKPENLLIS-SDGIVKLIDFGLAREVRSRPP--YTDYVSTRWYRAPEILLRSTHYNSPVDIFALGCIMAELYL
|. ......|| .|... |||   ||| ||||.||. ..|.||| |||.||   . |   ||||| |||||||| |.  | | .|||| |.||.|||.  
EHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMID

MKPLFNGSSEIDQIQKITSVLGT
  ||. |.|.|||  .|  .||.
GQPLWPGQSDIDQLYHIQKCLGP
Kinase 9821.AA CDK4 4-288 38 2.6e-79 269.82 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-290/290
Sequence Identity: 38% (113 aa)

YNIISEIGRGAFGIVKKAQNKETKEIVAIKQ-MLQEYET--WDECINLRE---LKSLRKLTHVNIIKLKEVFRVKKQLS------FVFEYVEKNIYKLYE
|  . ||| ||.|.| .|   .|  .|| || . .  |         .||   .. | .. | ||.||..|. |            ||| ..     . .
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

NAKQDGATSLPENTIKSIVYQIASALSYMHKHGFFHRDLKPENLLISSDGIVKLIDFGLAREVRSRPPYTDYVSTRWYRAPEILLRSTHYNSPVDIFALG
.. . |   .|. ||| .  |. ... . | |   ||||||.|.|..||| ||| ||||||.  .    |  | | ||||||.|| |. ||.|||. ..|
KCPPPG---MPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQSY-YNTPVDMWSVG

CIMAELYLMKPLFNGSSEIDQIQKITSVLGTPQKQDWPDGFILASTKYYTFPQYPAIPLSQVIPNCPPDALNLISEMLKWDPQKRITAAKILQHPYF
||.||.|  .||| |.|| || .||  | |.|  .|||    |.      |||. . |.  . |     .. |. .|| ....||..| . ||||||
CIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP---WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase 9821.AA ERK 106-227 41 2e-46 160.59 In-house 110-241 (307) Show / Hide 
Range on Protein: 106-227
Range on HMM: 110-241/307
Sequence Identity: 41% (55 aa)

IKSIVYQIASALSYMHKHGFFHRDLKPENLLISSDGIVKLIDFGLAR----EVRSR-----PPYTDYVSTRWYRAPEILLRSTHYNSPVDIFALGCIMAE
... .||| ..| |.|  . .|||||| |.|. |..  |  ||||||    .. ..     . .|.||.|||||||||.|  . |....|| . |||.||
CQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAE

LYLMKPLFNGSSEIDQIQKITSVLGTP-QKQD
..  |||| | . ..||. |....|||  ..|
MLGRKPLFPGKDYVHQINRIFQIIGTPHSEED
Kinase 9821.AA ERK 242-288 43 7.5e-17 59.43 In-house 257-307 (307) Show / Hide 
Range on Protein: 242-288
Range on HMM: 257-307/307
Sequence Identity: 43% (22 aa)

FPQ--YPAIPLSQVIPN--CPPDALNLISEMLKWDPQKRITAAKILQHPYF
.|   .|..|.. ..||  | |.|..|.. || .||.||||..  |.||||
LPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase 9821.AA Pkinase_Tyr 4-154 27 4.6e-16 55.04 Pfam 1-161 (270) Show / Hide 
Range on Protein: 4-154
Range on HMM: 1-161/270
Sequence Identity: 27% (44 aa)

YNIISEIGRGAFGIVKKAQNK----ETKEIVAIKQMLQEYETWD--ECINLRELKSLRKL-THVNIIKLKEVFR-VKKQ--LSFVFEYVEK-NIYKLYEN
  .. ..|.|||| |.|.  |    .||  ||.| . . .   .      .||.| ...|  | ||..|  |    ...  .  |.||... . ..   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

AKQDGATSLPENTIKSIVYQIASALSYMHKHGFFHRDLKPENLLISSDGIVKLIDFGLAREV
 . ..  .|.  .. .. .|||....| . ... ||||   | |......||  |||||| .
HR-EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase 9821.AA TyrKc 4-288 21 1.7e-15 27.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

YNIISEIGRGAFGIVKKAQNKETKEIVAIKQMLQEYETWDECIN--LRELKSLRKL--THVNIIKLKEVFRVK-------KQLSFVFEYVE----KNIYK
   . ..|.||||.| |.. |   . ||.| .  .       .   .||.. ..||   | ||..|  | . .       ..|  |.||..    |.  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

LYENAKQDGATSLPENTIKSIVYQIASALSYMHKHGFFHRDLKPENLLISSDGIVKLIDFGLAREVRSR-------PPYT------DY--VSTRWYRAPE
 ...        |.  .  |. .|||.  .| |.... ||||   | |......||  ||||.|.. .          |.          .  ||. |||
KHRPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APE

ILLRSTHYNSPVDIFALGCIMAELY-LMKPLFNG-----SSEIDQIQKITSVLGTPQKQD----WPDGFILASTKYYTFPQYPAIPLSQVIPNCPPDALN
 . .   ...  |... |  | |.. . ..   |      | .. |... .    || ..                           .   . ||..  .
CI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F---VCCPDEMYQ

LISEMLKWDPQKRITAAKILQHPYF
....  . || .| | . |  | .|
IMKQCWHEDPEDRPTFSEI--HECF
Kinase 9821.AA ERK 4-72 38 1.7e-14 50.59 In-house 1-76 (307) Show / Hide 
Range on Protein: 4-72
Range on HMM: 1-76/307
Sequence Identity: 38% (29 aa)

YNIISEIGRGAFGIVKKAQNKE-----TKEIVAIKQMLQEYETWDECI-NLRELKSLRKLT-HVNIIKLKEVFRVK
|.||..||.||.|.| .|..||     | ..||||   .....  .|.  |||.| || .. | |||.|. .....
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPN
Kinase 9821.AA CDKL 249-288 36 3e-10 31.23 In-house 246-286 (286) Show / Hide 
Range on Protein: 249-288
Range on HMM: 246-286/286
Sequence Identity: 36% (15 aa)

PLSQVIPNCP-PDALNLISEMLKWDPQKRITAAKILQHPYF
|| .  ||   . ||...  .|. || .|.|... ..||||
PLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF