Gene 23757 (Tetrahymena)

23757

Species: Tetrahymena
Alias: 1208, 3736.m00001, TTHERM_00660130, PreTt23757, 98.m00100, 23757
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK

Sequence

Name Sequence Type Origin Length Description Download
23757.AA Protein None 462 None Fasta, JSON
23757.kin_dom Protein Kinase Domain None 370 None Fasta, JSON
23757.NA RNA None 1386 None Fasta, JSON

Protein domain

Protein domains of 23757.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23757.AA MAPK 17-386 38 4e-173 581.43 In-house 1-328 (328) Show / Hide 
Range on Protein: 17-386
Range on HMM: 1-328/328
Sequence Identity: 38% (150 aa)

YEVDKLLGSGAYGQVVRAKDKK-----NQNQYVAIKKL-HKIEDVIDAKRVLREIRILRYL-VHENILQLSDILYD----DEDENQEFGTIYLVTNYMEI
|. .| .|.||||.|. |.||.     .....|||||. .  ......||..|||..||..  ||||  | ||..     |.....|| .||.|. .|| 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLYQVIKSDQKLSDQHIQYIIYQILKG--LKYLHSANIIHRDLKPSNLLATEKCAIRMCDFGLSRSIEDEQKQEQQLVRNLILFFSFIILMHNLHKQTNK
||.|.|||.|.|||.||||..||||.|  |||.||||.|||||||||.| .| |  ..|||||.|||..|.....| ... .. | .             
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HC-F-Q-------------

QINKKTNKPNQYLFQTLLSYSLKQFIHNCNQFSLYEFYTVNKKQASKQINTCQLTEYVVTRYYRAPEIMLS--SHVYSKAVDIWSLGCTFAELIS-HQIL
                                                  ....||||.||.||||||||.  .. |.||||.||.|| |||... ...|
--------------------------------------------------KMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPL

FKADNYIKQIKLIFDKLGMPPEEDLQFIG-NSNAKQFVNTL---AKKNSVKVSSFINY----ENPLALDLIDKMLAINPSKRITADEALEHPYF
|. ..|| |..||.. ||.|.||..|.|. ...|....  |    |.. .  .. .       ||.|.||..|||...|.||||..|||.||||
FPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 23757.AA MAPK-Unclassified 176-386 40 9.20000000001e-132 444.03 In-house 288-575 (575) Show / Hide 
Range on Protein: 176-386
Range on HMM: 288-575/575
Sequence Identity: 40% (118 aa)

QEQQLVRNLILFFSFIILMHNLHKQTNKQINKKTNKPNQ--------------------------------YLFQTLLSYSLKQFIHNCNQFSLYEFYTV
|.||..||.|.||.|...||..|||.|||||...|||.|                                |.||...||...||||.||||..|||.|.
QDQQQIRNAIEFFKFRKNMHRYHKQQNKQINFYNNKPQQNLNNYQQASNQLLQKADRQIDQKFLCIEGAHIYDFQNSNSYQKQQFIHQCNQFPAYEFCTK

NKKQASKQINTCQ----LTEYVVTRYYRAPEIMLSSHVYSKAVDIWSLGCTFAELIS-----------HQILFKADN--------------------YIK
||||..||||.|.    .|.|||||.|||||||||.|.|...|||||.||.|||...           |..||....                    ...
NKKQKHKQINDCHHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQD

QIKLIFDKLGMPPEEDLQFIGNSNAKQFVNTLAKKNSVKVSSFINYENP----------LALDLIDKMLAINPSKRITADEALEHPYF
|||.|||.||||||||..||....|.........|..|..........|          ...|...|||..||.||||||.|||||||
QIKMIFDYLGMPPEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 23757.AA CMGC 17-386 24 3.3e-131 433.8 In-house 1-513 (513) Show / Hide 
Range on Protein: 17-386
Range on HMM: 1-513/513
Sequence Identity: 24% (138 aa)

YEVDKLLGSGAYGQVVRAKDKKNQ-------------NQYVAIKKLHKIEDVIDAK----------RVLREIRILRYL----------------VHEN-I
||..| .|.|.||.|....||...             |..|||||. . .. ..||          | ||||.||..|                 |.| |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

LQLSDILYDDEDENQE----------FGTIYLVTNYMEIDLYQVIKSDQ---------KLSDQH------------IQYII------YQILKGLK--YLH
..| ||.|.......|          |  .|||. ||. ||||.||. |         .||. |            |.|..      ||||.|||  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SAN--IIHRDLKPSNLLATEKCA--------------------IRMCDFGLSRSIEDEQKQEQQLVRNLILFFSFIILMHNLHKQTNKQINKKTNKPNQY
|..  ||||||||.|.| ...|                     .. |||||.|..........| ....  |               |..||        
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQS--F---------------KNVNK--------

LFQTLLSYSLKQFIHNCNQFSLYEFYTVNKKQASKQINTCQLTEYVVTRYYRAPEIMLSS---------HVYSKAVDIWSLGCTFAELIS--------HQ
                                 ..  .. ..|.|||||.||||||.|..         . |....|.||.|| |||..         ..
---------------------------------DD-KPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGK

ILFK-----------ADNYIKQIKLIFDKLGMP----------------PEEDLQFIG--------------------NSNAKQFVNT---LAKKNSVKV
.||.            ...| |...||. ||.|                .||. ..|.                    .. |.....    . ...  . 
PLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPW

SSFINY-----------------------------------ENPLALDLIDKMLAINPSKRITADEALEHPYF
....                                     ..|.|.||..||| ..|.|||||..||.||||
KNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 23757.AA MAPK-Unclassified 17-175 64 5.5e-117 394.95 In-house 1-164 (575) Show / Hide 
Range on Protein: 17-175
Range on HMM: 1-164/575
Sequence Identity: 64% (105 aa)

YEVDKLLGSGAYGQVVRAKDKKNQNQYVAIKKLH-KIEDVIDAKRVLREIRILRYLVHENILQLSDILYDDEDENQEFGTIYLVTNYMEI---DLYQVIK
||..|..||||||||.||.|||||||.|||||.. ......|.|||||||||||||.|.||.|..||.|..|..||||..||.|..||..   ||.|.||
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SDQ-KLSDQHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCAIRMCDFGLSRSIEDEQK
|.| ....|||||..||||.||||||||.||||||||||||....|..|.||||.||||||.|.
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIEDNQN
Kinase 23757.AA S_TKc 17-386 24 3.4e-90 306.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-386
Range on HMM: 1-231/231
Sequence Identity: 24% (93 aa)

YEVDKLLGSGAYGQVVRAKDKKNQNQYVAIKKLHKIEDVIDAKRVLREIRILRYLVHENILQLSDILYDDEDENQEFGTIYLVTNYMEI---DLYQVIKS
||. ...|.||.|.| ....||  ...||||...        ....|||.||.   |.|| .| |. .|        . .|.|. |..    ||...||.
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKK

DQK------LSDQHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCAIRMCDFGLSRSIEDEQKQEQQLVRNLILFFSFIILMHNLHKQTNKQINK
 ..      ..  |.....|||...|.|.|| .||||||||.|.| .|   |  |||||.| .                                     
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------

KTNKPNQYLFQTLLSYSLKQFIHNCNQFSLYEFYTVNKKQASKQINTCQLTEYVVTRYYRAPEIMLSSHVYSK-AVDIWSLGCTFAELISHQILFKADNY
                                                  | ...|..|.|||..     |.| ..|.||.||...|... . .|     
--------------------------------------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP----

IKQIKLIFDKLGMPPEEDLQFIGNSNAKQFVNTLAKKNSVKVSSFINYENPLALDLIDKMLAINPSKRITADEALE-------HPYF
  |....|.|.|                                      | |.|.|.|.|  .|.||.|| |||.       ||.|
--QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 23757.AA ERK 17-179 47 6.6e-64 218.63 In-house 1-170 (307) Show / Hide 
Range on Protein: 17-179
Range on HMM: 1-170/307
Sequence Identity: 47% (82 aa)

YEVDKLLGSGAYGQVVRAKDKK----NQNQYVAIKKLHKI-EDVIDAKRVLREIRILRYLV-HENILQLSDILYDDEDENQEFGTIYLVTNYMEIDLYQV
|.  |..| |||| |. |.||.    . .| |||||  .. .. |..|| ||||..||..  ||||  | ||.  .  |  ..  ||.|. .||.|| |.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE--QYNDIYCVEELMETDLHQI

IKSDQKLSDQHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCAIRMCDFGLSR----SIEDEQKQEQQ
|.|.| |||.|.|| .|||| ||||.||||.|||||||||.| .. |    |||||.|    |...  . ..|
INSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHE-CNQ
Kinase 23757.AA p38 17-173 48 2.3e-63 215.39 In-house 1-159 (289) Show / Hide 
Range on Protein: 17-173
Range on HMM: 1-159/289
Sequence Identity: 48% (77 aa)

YEVDKLLGSGAYGQVVRAKDKKNQNQ--YVAIKKLHK-IEDVIDAKRVLREIRILRYLVHENILQLSDILYDDEDENQEFGTIYLVTNYMEIDLYQVIKS
|.  . .||||||||  | |.. ...  ||||||| .  ...|.|||  ||.| |. . |||...| |.    ... ..|  .|.||  |. ||....|.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

DQKLSDQHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCAIRMCDFGLSRSIEDE
 |.|||.|||...||||.|||| |||.||||||||||.  .| | .|  ||||.|. .||
-QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE
Kinase 23757.AA ERK 256-386 47 7.4e-56 191.89 In-house 172-307 (307) Show / Hide 
Range on Protein: 256-386
Range on HMM: 172-307/307
Sequence Identity: 47% (65 aa)

QLTEYVVTRYYRAPEIMLSSHVYSKAVDIWSLGCTFAELISHQILFKADNYIKQIKLIFDKLGMP-PEEDLQFIGNSNAKQFVNTLAK--KNSVKVSSFI
..||||.||.|||||||||   |.||.|||| || |||..  . ||.  .|. || .||. .| | .||||| |.. ||....  | .  .  .  .. .
FMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIF

NYEN--PLALDLIDKMLAINPSKRITADEALEHPYF
   |  |.|.||..|||...|.||||..|.||||||
PNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase 23757.AA ERK7 17-181 43 1.5e-50 170.95 In-house 1-163 (292) Show / Hide 
Range on Protein: 17-181
Range on HMM: 1-163/292
Sequence Identity: 43% (74 aa)

YEVDKLLGSGAYGQVVRAKDKKNQNQYVAIKKLHK-IEDVIDAKRVLREIRILRYLV-HENILQLSDILYDDEDENQEFGTIYLVTNYMEIDLYQVIKSD
||. | || |||| | .| ||. . | ||.||      . .|| |  ||| .|. .  |.||..| ...  | |       |||| ..|| ||  ||.  
YEIRKRLGKGAYGIVWKAYDKRTK-QVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRD-----IYLVFEFMETDLHAVIRKG

QKLSDQHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCAIRMCDFGLSRSIEDEQ--KQEQQLV
. | | | |||.||.|. .||.||.|.|||||||||.|   .| ...||||| ||| . .  ..... .
NILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPML
Kinase 23757.AA p38 257-386 44 2.2e-49 166.84 In-house 160-289 (289) Show / Hide 
Range on Protein: 257-386
Range on HMM: 160-289/289
Sequence Identity: 44% (58 aa)

LTEYVVTRYYRAPEIMLSSHVYSKAVDIWSLGCTFAELISHQILFKADNYIKQIKLIFDKLGMPPEEDLQFIGNSNAKQFVNTLAKKNSVKVSSFINYEN
.|.||.|| ||||||||.   | ..|||||.||  ||||. ..||. |..| |.. |   .| |.|| .| | . .|. ..  ...      ..     |
MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGAN

PLALDLIDKMLAINPSKRITADEALEHPYF
|.|.||..||| . | ||||| ||..||||
PQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 23757.AA ERK5 17-168 48 2.5e-49 170.22 In-house 1-151 (295) Show / Hide 
Range on Protein: 17-168
Range on HMM: 1-151/295
Sequence Identity: 48% (74 aa)

YEVDKLLGSGAYGQVVRAKDKKNQNQYVAIKKLHKIEDVI-DAKRVLREIRILRYLVHENILQLSDILYDDEDENQEFGTIYLVTNYMEIDLYQVIKSDQ
|..   .| |||| |  |. .|| .| |||||.    ||.  ||| .||..|||   |.||. . |||   .    |.  .| |   || || |.| |.|
YKIIEKIGNGAYGVVCSARRRKNGQQ-VAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKV-PYSEMKDVYVVFDLMESDLHQIIHSNQ

KLSDQHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCAIRMCDFGLSR
 ..  || | .||||.||||.|||..|||||||||||  | | ... |||. |
PFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMAR
Kinase 23757.AA nmo 18-177 42 7.2e-49 148.07 In-house 2-159 (292) Show / Hide 
Range on Protein: 18-177
Range on HMM: 2-159/292
Sequence Identity: 42% (68 aa)

EVDKLLGSGAYGQVVRAKDKKNQNQYVAIKKLHKI-EDVIDAKRVLREIRILRYLVHENILQLSDILYDDEDENQEFGTIYLVTNYMEIDLYQVIKSDQK
. |. .| ||.| |    | . . . ||.||. ..  ... .||| ||...| .  |.|.| . |||  .  . . |  || ||  |  || ..| | |.
QPDRPIGYGAFGVVWSVTDPR-DGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDIL--QPPHKDFFQEIYVVTELMQSDLHKIIVSPQH

LSDQHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCAIRMCDFGLSRSIEDEQKQE
||  |..  .||||.||||||||||.|||.|| |||    | ...||||| |  | .|...
LSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKH
Kinase 23757.AA CDK 17-168 31 3.8e-46 145.53 In-house 1-161 (284) Show / Hide 
Range on Protein: 17-168
Range on HMM: 1-161/284
Sequence Identity: 31% (55 aa)

YEVDKLLGSGAYGQVVRAKDKKNQ----NQYVAIKKLH------KIEDVIDAKRVLREIRILRYLVHENILQLSDILYDDEDE--NQEF---GTIYLVTN
||  . .| |.||.| .|.||...    .|.||.||.       ..|.       .||| .|. | |.|| .| |. ......  |  .    ..|.|  
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

YMEIDLYQVIKSDQKLSDQHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCA-----IRMCDFGLSR
||. ||.....         |. ...|.|.|| |.|| .|.||||||.|.| ...       .   ||||.|
YMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLAR
Kinase 23757.AA ERK1 17-168 48 2.3e-45 157.04 In-house 1-148 (289) Show / Hide 
Range on Protein: 17-168
Range on HMM: 1-148/289
Sequence Identity: 48% (73 aa)

YEVDKLLGSGAYGQVVRAKDKKNQNQYVAIKKLHKIEDVIDAKRVLREIRILRYLVHENILQLSDILYDDEDENQEFGTIYLVTNYMEIDLYQVIKSDQK
|   . .| |||| |. | |. .... |||||.   |     .| ||||.||    ||||... ||.  |  |  ..  .|.|   || |||...|. |.
YTNLQYIGEGAYGMVCSAYDTVHKQR-VAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIE--QMRDVYIVQCLMETDLYKLLKT-QH

LSDQHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCAIRMCDFGLSR
||  || | .||||.||||.||||..||||||||||    | ...||||| |
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR
Kinase 23757.AA Pkinase 17-177 31 6.5e-45 159.88 Pfam 1-167 (293) Show / Hide 
Range on Protein: 17-177
Range on HMM: 1-167/293
Sequence Identity: 31% (56 aa)

YEVDKLLGSGAYGQVVRAKDKKNQNQYVAIKKLHKIEDVIDAKRVLR---EIRILRYLVHENILQLSDILYDDEDENQEFGTIYLVTNYMEI-----DLY
|.. . .|||..|.| ....|...   ||.|.. | ..  . .. .|   ||.|.. | |.||..| |. .|        . ||.|. |.|      ||.
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-------KDHIYMVMEYCEGGLYVMDLF

QVIK--SDQKL--SDQHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCAI----RMCDFGLSRSIEDEQKQE
 .|.  .. ..  |..... ..||||.||.|.|| .||||||||.|.|  ... |    . |||||.. .. . ...
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS
Kinase 23757.AA ERK7 257-386 38 1.4e-44 150.25 In-house 163-292 (292) Show / Hide 
Range on Protein: 257-386
Range on HMM: 163-292/292
Sequence Identity: 38% (50 aa)

LTEYVVTRYYRAPEIMLSSHVYSKAVDIWSLGCTFAELISHQILFKADNYIKQIKLIFDKLGMPPEEDLQFIGNSNAKQFVNTLAKKNSVKVSSFINYEN
||||| || ||||||.|.|| | |.|| ||.||  .|..  . .|     . || .| . .. | .||.. || . | . .. . ...  . . ..    
LTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCC

PLALDLIDKMLAINPSKRITADEALEHPYF
. |.||. ..|. || ||.||..||.||| 
DDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 23757.AA ERK1 254-386 47 2.4e-44 153.66 In-house 157-289 (289) Show / Hide 
Range on Protein: 254-386
Range on HMM: 157-289/289
Sequence Identity: 47% (63 aa)

TCQLTEYVVTRYYRAPEIMLSSHVYSKAVDIWSLGCTFAELISHQILFKADNYIKQIKLIFDKLGMPPEEDLQFIGNSNAKQFVNTLAKKNSVKVSSFIN
|  ||||| ||.|||||||| |  | |..|||| ||  ||..|   .|    |. |. .|   || | ..||. | |  |....  |  |. |   .   
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFP

YENPLALDLIDKMLAINPSKRITADEALEHPYF
   . ||||.||||. || |||| .||| ||| 
KADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 23757.AA CDK 261-386 34 1.6e-42 133.78 In-house 180-284 (284) Show / Hide 
Range on Protein: 261-386
Range on HMM: 180-284/284
Sequence Identity: 34% (46 aa)

VVTRYYRAPEIMLSSHVYS--KAVDIWSLGCTFAELIS---HQILFKADNYIKQIKLIFDKLGMPPEEDLQ-FIGNSNAKQFVNTLAKKNSVKVSSFINY
|||. |||||. | |  ||   ..|.||.|| |||..     . ||  |. | |...||. .| | |..   .    .                      
VVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------

ENPLALDLIDKMLAINPSKRITADEALEHPYF
      ||..|||. .|.|||.|..||.||||
------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 23757.AA nmo 256-386 38 1.7e-42 128.14 In-house 159-292 (292) Show / Hide 
Range on Protein: 256-386
Range on HMM: 159-292/292
Sequence Identity: 38% (52 aa)

QLTEYVVTRYYRAPEIMLSSHVYSKAVDIWSLGCTFAELISHQILFKADNYIKQIKLIFDKLGMPPEEDLQFIGNSNAKQFVNTLAKKNSVKVSSFINY-
..|. ||| |||||||.. .. |. |||||| || ||||.  .|||.| . |.|...| | || |  ||...  .      .    |. ...|   .   
HMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSP

--ENPLALDLIDKMLAINPSKRITADEALEHPYF
   .  | .|. .||  .|.||| . .||.||| 
DHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase 23757.AA ERK5 257-386 40 9.7e-42 144.99 In-house 165-295 (295) Show / Hide 
Range on Protein: 257-386
Range on HMM: 165-295/295
Sequence Identity: 40% (53 aa)

LTEYVVTRYYRAPEIMLSSHVYSKAVDIWSLGCTFAELISHQILFKADNYIKQIKLIFDKLGMPPEEDLQFIGNSNAKQFVNT-LAKKNSVKVSSFINYE
.|||| ||.|||||.|.||| | .|.|.|| || | |.|. . .|   |||.|..|| . |||||   .| ..    . ..   .. .  .  .      
MTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKA

NPLALDLIDKMLAINPSKRITADEALEHPYF
 . ||||. .||   ||.|||. .|| ||. 
DRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 23757.AA Pkinase 257-386 25 2.7e-31 111.75 Pfam 168-293 (293) Show / Hide 
Range on Protein: 257-386
Range on HMM: 168-293/293
Sequence Identity: 25% (34 aa)

LTEYVVTRYYRAPEIMLSSHVYSKAVDIWSLGCTFAELISHQILFKAD----NYIKQIKLIFDKLGMPPEEDLQFIGNSNAKQFVNTLAKKNSVKVSSFI
.| ...|..|.|||. ...  |...||.||.||...|... . .|. .    | . |...|. ..| |...| .   .      ...   .     . | 
MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-

NYENPLALDLIDKMLAINPSKRITADEALEHPYF
 . .. ..|.|...|. .|.||.||...|.||.|
HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 23757.AA Pkinase_Tyr 17-174 33 2.3e-18 62.82 Pfam 1-166 (270) Show / Hide 
Range on Protein: 17-174
Range on HMM: 1-166/270
Sequence Identity: 33% (58 aa)

YEVDKLLGSGAYGQVVRAKDK---KNQNQYVAIKKLHKIEDVIDA---KRVLREIRILRYL-VHENILQLSDILYDDEDENQEFGTIYLVTNYMEI-DLY
 . .| ||.||.|.|.... |   .|... ||.|.| |     ..   .  .||..|.. |  |.||..|  . .|... |     ||.|. ||.  ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN----QIYIVMEYMPHGDLL

QVIKS----DQKLSDQHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCAIRMCDFGLSRSI-EDEQ
   ..    .|.|. ...  . .|| ||. ||.| |.|||||   | | ||.  .. |||||.| | .|..
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDY
Kinase 23757.AA TyrKc 17-300 19 2.9e-14 8.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-300
Range on HMM: 1-280/280
Sequence Identity: 19% (65 aa)

YEVDKLLGSGAYGQVVRAKDKKNQNQYVAIKKLHKIEDVIDAKRVLREIRILRYL--VHENILQLSDILYDDEDENQEF---GTIYLVTNYME-IDLYQV
 . .| ||.||.|.|.... |    . ||.|.|..       .  .||.||.. |   |.||..|  .  ...     |   . ...|. ||.  || . 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---FMYIEPLMIVMEYMPHGDLKDY

IKSDQK-LSDQHIQYIIYQILKGLKYLHSANIIHRDLKPSNLLATEKCAIRMCDFGLSRSIEDE--------QKQEQQ--LVR-----------NLILF-
... .. |. ..  .. .|| .|  |||| |.|||||   | | .|.  .. .|||||| |.|.         .  ..    .            .    
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

-------FSFIILMH---NLHKQTNKQINKKTNKPNQYLFQTLLSYSLKQFIHN----CNQFSLYEFYTVNKKQASKQINTCQLTEYVVTRYYRAPEIML
       .|| ..|     . .|    . ..  ..|| ... . .       .|                                      .       
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------------F----VCC

SSHVYSKAVDIWSL----GCTFAELISHQIL
.. .|.   . |       .||.|.  |...
PDEMYQIMKQCWHEDPEDRPTFSEI--HECF