11145

Species: Tetrahymena
Alias: 11145, 3.m01860, TTHERM_00046660, 182, PreTt11145, 3824.m02906
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: MAPK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
11145.AA Protein None 643 None Fasta, JSON
11145.kin_dom Protein Kinase Domain None 329 None Fasta, JSON
11145.NA RNA None 1932 None Fasta, JSON

Protein domain

Protein domains of 11145.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 11145.AA MAPK 227-555 31 8.49999999999e-123 414.25 In-house 1-328 (328) Show / Hide
Range on Protein: 227-555
Range on HMM: 1-328/328
Sequence Identity: 31% (111 aa)

YTYSGYIGQGGYSQVYKFIDNQTNQP------VAIKFVN-LFHNEQDTKRVLRELYIQRHL-SHPNVMKIQNIYYN------KELHNFDRIYIVMEYYPF
|..  .|||| | .| ..||. |||       |||| .   |.|....||..||. ..||.  |.|..|...|..       ..|..|. ||||||.   
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

SLFDILYQYQQNLTWSHELVRIIFTQIVNG--LAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSRQNTTANFQNNQSKKRSTKPAFQEQKSLNSGSR
 |  |... |   ..|.. .. .. || .|  | |||| |.|||||||||||...|  .||.|| |.|.  .  ....|.... .. ..... . .   |
DLHQIIKSQQ---PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HC-FQKMHMTEYVATR

YYRAPEIILL--NSNYGFQSDIWSLGCLYAELLQNYDRHNSLQGILFPGQTCNPITPPSKNDSDFLKQDQLFLIIDKLGRPKKEDCSFIE-KASAVKFVR
.||||||.|     .|  . |.||.||  ||.|.       .. .|||                   .||..||.. || |..|....|.   .| ....
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLT-------DRKPLFP---------------GKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQ

GF---KCKPLYHFTQLYYS----TVYQEQFILQSTLQFSPNRRITAEQLLSTEYF
..   ...| .......      .  |    |.  |.|.|..|||.|. |. .||
SLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF

Kinase 11145.AA MAPK-Unclassified 379-555 32 2.3e-106 359.66 In-house 313-575 (575) Show / Hide
Range on Protein: 379-555
Range on HMM: 313-575/575
Sequence Identity: 32% (86 aa)

QNTTANFQNNQSKK---------------------------------------------------------RSTKPAFQEQKSLNSGS-----------R
||...||.||....                                                         ..||...|..|..|...           |
QNKQINFYNNKPQQNLNNYQQASNQLLQKADRQIDQKFLCIEGAHIYDFQNSNSYQKQQFIHQCNQFPAYEFCTKNKKQKHKQINDCHHCYHMTQYVVTR

YYRAPEIILLNSNYGFQSDIWSLGCLYAELLQNYDRHN---SLQGILFPGQTCNPITPPSKNDSD-----FLKQDQLFLIIDKLGRPKKEDCSFIEKASA
.||||||.|....|..|.||||.||..||..|.|||||   |....|||||.|.||||...||.|     ...|||...|.|.||.|..|||.||...||
WYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNFITCDSA

VKFVRGFKCKPLYHFTQLYYSTVY----------QEQFILQSTLQFSPNRRITAEQLLSTEYF
.|....||||...|||.|......          ......|..|||.|..||||.|.|...||
RKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF

Kinase 11145.AA MAPK-Unclassified 227-378 54 1.4e-105 357.05 In-house 1-157 (575) Show / Hide
Range on Protein: 227-378
Range on HMM: 1-157/575
Sequence Identity: 54% (85 aa)

YTYSGYIGQGGYSQVYKFIDNQT-NQPVAIKFVN-LFHNEQDTKRVLRELYIQRHLSHPNVMKIQNIYYNKELHN--FDRIYIVMEYYPFSLFDILYQYQ
|.|...||.|.|.||....|... ||.||||.|| .|||..|.||||||..|.|.|.|||...||.|.|||||||  ||.|||||.|...||||......
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

QNL-TWSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSR
.|. .|.|......|.||..||.|.||..||||||||||.||.|...|.|.||..||
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR

Kinase 11145.AA CMGC 227-555 22 4.4e-94 309.54 In-house 1-513 (513) Show / Hide
Range on Protein: 227-555
Range on HMM: 1-513/513
Sequence Identity: 22% (120 aa)

YTYSGYIGQGGYSQVYKFIDNQTNQP--------------VAIKFVNLFHNEQDTK----------RVLRELYIQRHLS-----------------HPNV
|.  ..||.| |..||| .|..|||.              |||| . . ..| . |          | |||. | .||.                 |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

MKIQNIYYNKE-------------LHNFDRIYIVMEYYPFSLFDILYQYQ------QNLTWSHEL------------VRIIF------TQIVNGLA--YI
 |...|.| |.             . .|. .|.|.|| . .|.......|      ...  |.              .. ..       || .||.  |.
VKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSRN--IIHRDLKPSNILIDQN--------------------LNVKIADFTLSRQNTTANFQNNQSKKRSTKPAF---------QEQKSLNSGSRYYRAP
||..  ||||||||.||||..|                     ..||.|| |.|.  .   ...|....|    |         ... . .  .|.||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQS----FKNVNKDDKPNRPYTHYVVTRWYRAP

EIILLN---------SNYGFQSDIWSLGCLYAELLQNYDRHNSL---QGILFPGQTCNPITPPSKNDSDFLK-------QDQLFLIIDKLGRP-------
||.|            .|. . |.||.||  ||....|.   ||     .||||....|.                   .||||.|.. || |       
EILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQ---SLIFRGKPLFPGHSEYPN-----------DDKNGKSHIDQLFKIFKVLGTPTWMIQKG

---------KKEDCSFIE--------------------KASAVKFVRG---FKCKPLYHFTQLYYS----------------------------------
         ..|. ..|.                    . .| ....    |. .|  ....|.                                    
KRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRK

-TVYQEQFILQSTLQFSPNRRITAEQLLSTEYF
    |    |.  ||. |..|||||| |. .||
CCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF

Kinase 11145.AA S_TKc 227-555 23 5e-69 236.54 SMART 1-231 (231) Show / Hide
Range on Protein: 227-555
Range on HMM: 1-231/231
Sequence Identity: 23% (82 aa)

YTYSGYIGQGGYSQVYKFIDNQTNQPVAIKFVNLFHNEQDTKRVLRELYIQRHLSHPNVMKIQNIYYNKELHNFDRIYIVMEYYPF---SLFDILYQYQQ
|.    ||.|....||| ... |.. |||| ..        ....||. | ..  |||. |.  ....      |..|.|||| .    .|||.. ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR

NLT---WSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSRQNTTANFQNNQSKKRSTKPAFQEQKSLNSGSRYYRAPEIILL
. .    .   .| .. ||...|.|.||..||||||||.|||.|.  ..||.|| |.||                        .   |...|.|||..  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------------TTFCGTPWYMAPEVL--

NSNYGF-QSDIWSLGCLYAELLQNYDRHNSLQGILFPGQTCNPITPPSKNDSDFLKQDQLFLIIDKLGRPKKEDCSFIEKASAVKFVRGFKCKPLYHFTQ
   ||.  .|.||.||. .|.|  |         .||                     |......|.|                                
--GYGKCKCDWWSCGCILYEMLCGY--------PPFP---------------------QMQMMFKKIG--------------------------------

LYYSTVYQEQFILQSTLQFSPNRRITAEQLLS-------TEYF
       .   ...  ||. |..|.|| ..|         ..|
-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 11145.AA Pkinase 227-555 26 1.3e-66 232.43 Pfam 1-293 (293) Show / Hide
Range on Protein: 227-555
Range on HMM: 1-293/293
Sequence Identity: 26% (91 aa)

YTYSGYIGQGGYSQVYKFIDNQTNQPVAIKFVNLFHNEQDTKRVLR---ELYIQRHLSHPNVMKIQNIYYNKELHNFDRIYIVMEYYPF-----SLFDIL
|.  . ||.|....||| ..  |.. ||.| ... |.. . .. .|   |..| ..|.|||. ..  ....      |.||.|||| .      .|||..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

Y-QYQQNLTWSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLNV----KIADFTLSRQNTTANFQNNQSKKRSTKPAFQEQKSLNSGSRYYR
  ... ... | . .. ...||. ||.|.||..||||||||.|||||.| ..    ||.|| |..|                    ..  .   |...|.
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------------Y-NNS-MTTFCGTPWYM

APEIILLNSNYGFQSDIWSLGCLYAELLQNYDRHNSLQGILFPGQTCNPITPPSKND-SDFLKQDQLFLIIDKLGRPKKEDCSFIEKASAVKFVRGFKCK
|||.|. .. ||  .|.||.||. .|.|  .                    || ...  .    ||...|  ..|.| ..|..     |  . .|  . .
APEVIRGGQYYGPKVDMWSCGCILYEMLCGR--------------------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H

PLYHFTQLYYSTVYQEQFILQSTLQFSPNRRITAEQLLSTEYF
    .. . . .    . .. . |.. |..|.||||.|  ..|
--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 11145.AA CAMKL 227-434 28 6.6e-52 163.86 In-house 1-223 (297) Show / Hide
Range on Protein: 227-434
Range on HMM: 1-223/297
Sequence Identity: 28% (70 aa)

YTYSGYIGQGGYSQVYKFID-NQTNQPVAIKFVN--LFHN-------------EQDTKRVLRELYIQRHLS---HPNVMKIQNIYYNKEL--HNFDRIYI
|.    .|.|....|   ..   |.. ||||...     |             |.|  |. ||  |...|.   |||..|.  .....|    . . ||.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYL

VMEYYPFS---LFDILYQYQQNL-TWSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNL--NVKIADFTLSRQ---NTTANFQNNQSKKRSTK
|||| .     ||| . .        . .  | .|.||| ...|.||..|.|||.|| |||.|.|   |.||.|| .| .   .                
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC----------------

PAFQEQK--SLNSGSRYYRAPEIILL--NSNYGFQSDIWSLG
  |.. .  .   ||  | ||||..    . .|.. ||||.|
-IFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCG

Kinase 11145.AA CAMK 232-436 21 6.9e-51 161.81 In-house 1-323 (425) Show / Hide
Range on Protein: 232-436
Range on HMM: 1-323/425
Sequence Identity: 21% (69 aa)

YIGQGGYSQVYKFIDNQTN------------QPVAIKFVNLF---------------------------HNEQDTKRVLRELYIQRHLS-------HPNV
 .|.|....|.. |. .|.            | ||||...                             ....| |.|.||. | ..|.       |||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

MKIQNIYYNKELH-------NFDR--------IYIVM---EYYPFS-LFDILYQYQQNL----------------TWSHELVRIIFTQIVNGLAYIHSRN
 |.  .| ...         . ..        .|.||   || .   ||| |..| .                    . . .| .| ||. ...|.||.|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDLKPSNILIDQN-----------------LNVKIADFTLSRQNTTANFQNNQSKKRSTKPAFQE---------QKSLNSGSRYYRA-PEIILL---
|.|||||| |||.|.|                  |.||.|| .... .  . ... |.. .      .           .   |. .| | ||...    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

----------NSNYGFQSDIWSLGCL
          .  ||...|.||.|..
CNMQNATDEEKPYYGPKCDMWSCGVI

Kinase 11145.AA STE 227-436 25 1.1e-43 151.47 In-house 1-257 (359) Show / Hide
Range on Protein: 227-436
Range on HMM: 1-257/359
Sequence Identity: 25% (70 aa)

YTYSGYIGQGGYSQVYKFIDN------QTNQP---------VAIKFVNLFHNE----------------QDTKRVLRELYIQRHLS--HPNVMKIQNIYY
..  . ||.|.. .||| ...      .|..          .||| .|| ...                .. ...|.|. | ....  |||. |    |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NKE--LHNFDRIYIVMEYYPF-SLFDILY---QYQQNLTWSH--------ELVRIIFTQIVNG-LAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSR
..    .| | ..|.||| .  || ||.      ...|. .         .....|  ||. | |.|.|| .|||||.||.|||.     ||..|| .. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QNTTANFQNNQSKKRSTKPA--------FQEQKSLNSGSRYYRAPEIILL-----NSNYGFQSDIWSLGCL
| |  .  . | .      .         |..     |.  . |||.|.      .. |....|||||||.
QLTDSMANI-Q-S------NNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCT

Kinase 11145.AA Ciliate-E2 227-444 23 2.7e-43 146.45 In-house 1-293 (365) Show / Hide
Range on Protein: 227-444
Range on HMM: 1-293/365
Sequence Identity: 23% (71 aa)

YTYSGYIGQGGYSQVYKFIDNQTNQ------------------PVAIKFVNLFHN-EQDTKRVLRELYIQR----------------HLSHPNVMKIQNI
|     ||||....|||  . ....                   |.||....  . ... . ...|..| |                .|.|||..|.   
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YYNKELHNFDRIYIVMEYYPF-SLFDILY----QYQQNLT----WSHELVRIIFTQIVN---------------GLAYIHSRN-IIHRDLKPSNILIDQN
...|   . . ||.||||.   .|||...    . .....     ... .. |..||..               .| |.||.| |||||.||.|||.   
FQEK---DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

LNVKIADFTLSRQNTTANFQNNQSKKRS-TKPAFQEQKSLNSG----------------SRYYRAPEIILLNSN--------YGFQSDIWSLGCLYAELL
  .||.|| ||..... | .. . |...  ..  . ..|  .|                . .| ||||.   ..        |....||||||..  |.|
--IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

QNY
 ..
FGK

Kinase 11145.AA CDK 227-374 30 1.4e-33 104.69 In-house 1-157 (284) Show / Hide
Range on Protein: 227-374
Range on HMM: 1-157/284
Sequence Identity: 30% (52 aa)

YTYSGYIGQGGYSQVYKFIDNQTN-----QPVAIKFVNLFHN--EQDTKRVL----RELYIQRHLSHPNVMKIQNIYYNKELHNF------DRIYIVMEY
|     ||.| | .||| .| ||.     | ||.| . . ..  |..   .     ||  . ..| |||. |.  ... |.. .        ..|.|.||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

YPFSLFDILYQYQQNLTWSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLN-----VKIADF
 .  |  ..             .. .. |. .||.|.||..|.||||||.||||. | .     .|||||
MDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADF

Kinase 11145.AA p38 227-379 34 2.9e-32 107.38 In-house 1-155 (289) Show / Hide
Range on Protein: 227-379
Range on HMM: 1-155/289
Sequence Identity: 34% (55 aa)

YTYSGYIGQGGYSQVYKFIDNQTNQP---VAIK-FVNLFHNEQDTKRVLRELYIQRHLSHPNVMKIQNIYYN--KELHNFDRIYIVMEYYPFSLFDILYQ
|    ..|.| | || | .| .|.|    |||| .   |  | . ||  |||   .|. | ||... ...    ... .|  .|.|..    .|  |. .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

YQQNLTWSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSRQ
 .     | . ....  ||  || |||| .||||||||||| .  .  ..| || |.|.
QR----LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARH

Kinase 11145.AA ERK 338-441 43 4.8e-22 78.98 In-house 116-211 (307) Show / Hide
Range on Protein: 338-441
Range on HMM: 116-211/307
Sequence Identity: 43% (47 aa)

QIVNGLAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSR-QNTTANFQNNQSKKRSTKPAFQEQKSLNSG---SRYYRAPEIILLNSNYGFQSDIWSL
|| .|| |||| |.|||||||||||.  |   ||.|| |.| ....  .|.| .          ....  ..   .|.||||||.| ...|    |||| 
QILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDAS--YQENHE----------CNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSC

GCLYAELL
||  ||.|
GCIFAEML

Kinase 11145.AA ERK 227-309 33 3e-18 64.67 In-house 1-90 (307) Show / Hide
Range on Protein: 227-309
Range on HMM: 1-90/307
Sequence Identity: 33% (30 aa)

YTYSGYIGQGGYSQVYKFIDNQ-----TNQPVAIKFV-NLFHNEQDTKRVLRELYIQRHLS-HPNVMKIQNIYYNKELHNFDRIYIVMEY
| .   ||.|.|  | . ||.      |.|.|||| . | | .....|| |||. ..||.  |.|. ....|   .   ... ||.| |.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEEL

Kinase 11145.AA Pkinase_Tyr 241-378 34 2.8e-16 55.76 Pfam 19-159 (270) Show / Hide
Range on Protein: 241-378
Range on HMM: 19-159/270
Sequence Identity: 34% (50 aa)

VYKFIDNQTNQPVAIKFVNLFHNEQD--TKRVLRELYIQRHL-SHPNVMKIQNIYYNKELHNFDRIYIVMEYYPF-SLFDILYQY---QQNLTWSHELVR
..|  . .|..|||.| ..  . ...   .  .||. | ..| .|||. .   . . .. .|  .||||||| |  .| | | .    .|.|| .. |. 
TWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKD-LLQ

IIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSR
. . || .|..| .|.|.|||||   |.|.. |. |||.|| |.|
MCW-QIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR

Kinase 11145.AA p38 410-555 30 3.9e-16 51.39 In-house 167-289 (289) Show / Hide
Range on Protein: 410-555
Range on HMM: 167-289/289
Sequence Identity: 30% (45 aa)

RYYRAPEIILLNSNYGFQSDIWSLGCLYAELLQNYDRHNSLQGILFPGQTCNPITPPSKNDSDFLKQDQLFLIIDKLGRPKKEDCSFIEKASAVKFVRGF
| ||||||.|.   |    ||||.||  |||..        . .||||  ...|             |||  |.  .| |..|  . |.. .|  .... 
RWYRAPEIMLNWMHYTQTVDIWSVGCIMAELIT--------GRTLFPG--DDHI-------------DQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSY

KCKPLYHFTQLYYSTVYQEQFILQSTLQFSPNRRITAEQLLSTEYF
   |   |....     |.   |   |.  | .|||||. .. .||
PQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF

Kinase 11145.AA CDK 410-555 24 4.1e-16 47.9 In-house 183-284 (284) Show / Hide
Range on Protein: 410-555
Range on HMM: 183-284/284
Sequence Identity: 24% (37 aa)

RYYRAPEIILLNSNYG--FQSDIWSLGCLYAELLQNYDRHNSLQGI-LFPGQTCNPITPPSKNDSDFLKQDQLFLIIDKLGRPKKEDCSFIEKASAVKFV
. |||||. |  ..|.   . |.||.||  ||....      ...  ||||..                .||||.|.. .| |  ..   ..|       
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTD------VTRKPLFPGDSE---------------IDQLFKIFRICGTPTEDNWPGVTKLPDY---

RGFKCKPLYHFTQLYYSTVYQEQFILQSTLQFSPNRRITAEQLLSTEYF
                         |.. |.. |..||.||| |. .||
-----------------------DLLNKMLCYDPKKRISAEQALQHPYF

Kinase 11145.AA TyrKc 227-500 22 3.2e-12 -25.06 SMART 1-280 (280) Show / Hide
Range on Protein: 227-500
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

YTYSGYIGQGGYSQVYKFIDNQTNQPVAIKFVNLFHNEQDTKRVLRELYIQRHL--SHPNVMKIQNIYYNKELHNF---DRIYIVMEYYPF-SLFDILYQ
 |    .| | . .||| . .   ..||.| ..  .     .  .||. | ..|  .|||. ..  .   ..   |   . ..||||| |  .| | |  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRK

YQQNLTWSHELVRIIFTQIVNGLAYIHSRNIIHRDLKPSNILIDQNLNVKIADFTLSRQNTTA-NFQNNQSKKRSTKPAFQEQKSLNS--GSR-----YY
.. .|... .|. . . || .| .|.||.|.|||||   |.|.. |. |||.|| |||  .   .             . .. ..  .  |..       
HRPKLCMK-DLLSFCW-QIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-----------ESKDYYRKKEHKGGKTMLPIRW

RAPEIILLNSNYGFQSDIWSLGCL-----------YAEL----LQNYDRHNSLQGILFPGQTCNPITPPSKN--------DSDFLKQDQLFLIIDK--LG
 ||| |   . . ..||.|| | .           | .     . |.. .. ..    .        |. .|         .| . |       .     
MAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM--------PQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPED

RPKKEDCSFIEKA
||  ...  .|. 
RPTFSEI--HECF

Kinase 11145.AA Ciliate-E2 531-555 33 5.6e-05 13.01 In-house 336-365 (365) Show / Hide
Range on Protein: 531-555
Range on HMM: 336-365/365
Sequence Identity: 33% (10 aa)

ILQS----TLQFSPNRRIT-AEQLLSTEYF
...      ||  |. ||| .||.|  ..|
LIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 11145.AA CAMK 532-555 33 0.000875 7.28 In-house 402-425 (425) Show / Hide
Range on Protein: 532-555
Range on HMM: 402-425/425
Sequence Identity: 33% (8 aa)

LQSTLQFSPNRRITAEQLLSTEYF
... ||  |..|.|.|| |. . .
IRKMLQVDPEKRMTIEQCLNHPWM

Kinase 11145.AA STE 532-555 38 0.000993 9.19 In-house 334-359 (359) Show / Hide
Range on Protein: 532-555
Range on HMM: 334-359/359
Sequence Identity: 38% (10 aa)

LQSTLQFSPNRRITAEQLLS--TEYF
..  ||  || | ||.|||.   . .
INKCLQKDPNKRPTASQLLKSEHPFI

Kinase 11145.AA CAMKL 531-555 24 0.001378 7.15 In-house 273-297 (297) Show / Hide
Range on Protein: 531-555
Range on HMM: 273-297/297
Sequence Identity: 24% (6 aa)

ILQSTLQFSPNRRITAEQLLSTEYF
.... ||  |..|.|..|... . .
LIRKMLQVNPEKRPTIHQIMNHPWM

Kinase 11145.AA ERK 536-555 50 0.003231 8.06 In-house 288-307 (307) Show / Hide
Range on Protein: 536-555
Range on HMM: 288-307/307
Sequence Identity: 50% (10 aa)

LQFSPNRRITAEQLLSTEYF
|.| |. |||.|. |. .||
LVFDPDKRITVEECLEHPYF

Kinase 11145.AA ERK 477-507 28 0.246175 0.97 In-house 224-255 (307) Show / Hide
Range on Protein: 477-507
Range on HMM: 224-255/307
Sequence Identity: 28% (9 aa)

DQLFLIIDKLGRP-KKEDCSFIEKASAVKFVR
.|...|.. .| |  .|| . |.   | |...
HQINRIFQIIGTPHSEEDLQYICSENAWKYIK