Gene 28942 (Tetrahymena)

28942

Species: Tetrahymena
Alias: PreTt28942, 28942, 3812.m02636, 77.m00154, 226, TTHERM_00575520
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK7

Sequence

Name Sequence Type Origin Length Description Download
28942.AA Protein None 944 None Fasta, JSON
28942.kin_dom Protein Kinase Domain None 289 None Fasta, JSON
28942.NA RNA None 2835 None Fasta, JSON

Protein domain

Protein domains of 28942.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 28942.AA ERK7 175-463 67 1.5e-217 729.01 In-house 1-292 (292) Show / Hide 
Range on Protein: 175-463
Range on HMM: 1-292/292
Sequence Identity: 67% (197 aa)

FEIIQKLGKGAYGIVWKAFCKKSKQIVALKKVFDAFHNATDAQRTFREVMFLQELNGHENIIRLINIIKAENNKDLYMVFDFMETDLHAVIR-ANILEEI
.||...||||||||||||..|..||.|||||.||||.|.|||||||||.|||||...|.|||||||.|.|.|..|.|.||.||||||||||| .|||..|
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDI

HKQYVVYQILKAMKYIHSGELIHRDLKPSNILLNSECLVKLADFGLARSVAVTD--DDDNPVRTEYVATRWYRAPEILLGSTKYAKAVDMWSIGCIVGEL
||||..||.|.|.||.|||..||||||||||||.|||.||..|||||||.| ..  |..||..||||||||||||||||||..|.|.|||||||||.||.
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEM

ITNRAIFPGNSTLNQIEKVLELTGKPTQEDIESLESQLAWNIISSINVQKKKTFHQMFPGASEEAIDLIKKLLCFNPKNRLTVEQALEHPYV
......|||.||.|||||.||...||||||||...|..|||.....|.||.||..||.|.....||||.|.||.||||.|||.||||.||||
LRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 28942.AA MAPK 175-463 42 1.5e-176 592.78 In-house 1-328 (328) Show / Hide 
Range on Protein: 175-463
Range on HMM: 1-328/328
Sequence Identity: 42% (141 aa)

FEIIQKLGKGAYGIVWKAFCKK------SKQIVALKKVFDAFHNATDAQRTFREVMFLQELNGHENIIRLINIIKAE-----NN----KDLYMVFDFMET
..|....|.||||.|..|..|.      ....||.||....|.|.|...||.||...|.....|||||.|..|...|     |.    .|.|.|...|||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHAVIR-ANILEEIHKQYVVYQILKA--MKYIHSGELIHRDLKPSNILLNSECLVKLADFGLARSVAVTD----DDDNP------VRTEYVATRWYRAP
|||..|.  ..|...|.|| .||||..  .|||||.  |||||||||||.|..|..|..|||||||.. ..    ..|.|        ||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EILLG--STKYAKAVDMWSIGCIVGELIT-NRAIFPGNSTLNQIEKVLELTGKPTQEDIESLE-SQLAWNIISSI---NVQKKKTFHQMFPG----ASEE
||.|.  ...| |||||||.||| .|..| .. .|||.....|.....|..|.|..|.|. .. |. |.| |.|      ..||....|||.    |. .
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AIDLIKKLLCFNPKNRLTVEQALEHPYV
||||..|.| |.|. |.|||.||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 28942.AA CMGC 175-463 25 2.3e-139 461.1 In-house 1-513 (513) Show / Hide 
Range on Protein: 175-463
Range on HMM: 1-513/513
Sequence Identity: 25% (130 aa)

FEIIQKLGKGAYGIVWKAFC--------------KKSKQIVALKKVFDAFHNATDAQ----------RTFREVMFLQELN----------------GHEN
.|||.|.|.|.||.|.|...              .....|||.||.. .| . ..|.          |..||...|..||                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIRLINIIKAEN---------------NKDLYMVFDFMETDLHAVIRAN----------ILEEIH------------KQYVV------YQILKAMK--YI
|..|..|.. .|               ...||.||..|..||. .|. |           |.| |            ..| .      ||||...|  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSGE--LIHRDLKPSNILLNSECLV--------------------KLADFGLARSVAVT------------------DDDDNPVRTEYVATRWYRAPEIL
||     |||||||.|||.|..| .                    |..||||||.. .                   | . |   |.||.||||||||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVVTRWYRAPEIL

LGSTKYA---------KAVDMWSIGCIVGELITN--------RAIFP-----------GNSTLNQIEKVLELTGKP----------------TQEDIESL
||...|          ...||||.||| .|..|.        . .||           |.|...|..|  .. |.|                ..|... .
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

E--------------------SQLAWNIISS---INVQKKKTFHQMFPG-----------------------------------ASEEAIDLIKKLLCFN
.                    |  |.| |.|      ...|.....||.                                   ....||||.||.|...
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PKNRLTVEQALEHPYV
|..|.|.||||.||| 
PDKRITAEQALQHPYF
Kinase 28942.AA ERK 175-463 43 1.1e-134 453.7 In-house 1-307 (307) Show / Hide 
Range on Protein: 175-463
Range on HMM: 1-307/307
Sequence Identity: 43% (135 aa)

FEIIQKLGKGAYGIVWKAFCKK-----SKQIVALKKVFDAFHNATDAQRTFREVMFLQELNGHENIIRLINIIKAE---NNKDLYMVFDFMETDLHAVIR
..||...|.||||.| .|. |.     . |.|| ||...|| .. .. || ||  .|  ..|||||| |..|.. .   . .|.|.|...|||||| .|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

AN-ILEEIHKQYVVYQILKAMKYIHSGELIHRDLKPSNILLNSECLVKLADFGLAR----SVAVTDDDDNPVRTEYVATRWYRAPEILLGSTKYAKAVDM
    |.. | || .|||| ..|||||   |||||||||||.|| |  | .||||||    |..      ..  ||||||||||||||.|  .|| ||.|.
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSIGCIVGELITNRAIFPGNSTLNQIEKVLELTGKP-TQEDIESLESQLAWNIISSINV--QKKKTFHQMFPGAS--EEAIDLIKKLLCFNPKNRLTVEQ
||.|||  |..  . .|||.....||. .....|.| ..||..  .|. ||. |.. .   ...| .  .|| |.   .||||..|.| |.|. |.|||.
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALEHPYV
.||||| 
CLEHPYF
Kinase 28942.AA p38 175-463 42 1.3e-110 373.73 In-house 1-289 (289) Show / Hide 
Range on Protein: 175-463
Range on HMM: 1-289/289
Sequence Identity: 42% (125 aa)

FEIIQKLGKGAYGIVWKAFCKKSKQI---VALKKVFDAFHNATDAQRTFREVMFLQELNGHENIIRLINIIKA-----ENNKDLYMVFDFMETDLHAVIR
.. .| .|.|||| | ||......|    || || .  |  . .| ||.||.  |. .. |||.| |...        .. .| |||  ||..||. ...
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMR-HENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMK

ANILEEIHKQYVVYQILKAMKYIHSGELIHRDLKPSNILLNSECLVKLADFGLARSVAVTDDDDNPVRTEYVATRWYRAPEILLGSTKYAKAVDMWSIGC
   | . | |. |||||.. ||||| . |||||||||| .| .| ..  ||||||    .||.     |.||||||||||||.|   .| ..||.||.||
CQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR---HCDDE----MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGC

IVGELITNRAIFPGNSTLNQIEKVLELTGKPTQEDIESLESQLAWNIISSINVQKKKTFHQMFPGASEEAIDLIKKLLCFNPKNRLTVEQALEHPYV
|  |||| |. |||.  ..|........|.|..| .. ..|. | | | |.   ... ||..|.||.  ||||. |.|   |  |.|.|.|..||| 
IMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 28942.AA CDK 175-463 33 1.3e-106 342.16 In-house 1-284 (284) Show / Hide 
Range on Protein: 175-463
Range on HMM: 1-284/284
Sequence Identity: 33% (106 aa)

FEIIQKLGKGAYGIVWKAFCKKSK-----QIVALKKVFDAF---HNATDAQR--TFREVMFLQELNGHENIIRLINIIKAEN---------NKDLYMVFD
.|...|.| |.||.| || .|...     |||||||.        .. .     . ||.  |.||  |.||..|. ..  .|         .. |||||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

FMETDLHAVIRANILEEIHKQYVVYQILKAMKYIHSGELIHRDLKPSNILLNSECL-----VKLADFGLARSVAV---TDDDDNPVRTEYVATRWYRAPE
.|..||  ...         .   .|.|... |.||   .||||||.|||.|.        .|.|||||||   .   .. . | . |  | |.||||||
YMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAPE

ILLGSTKYA--KAVDMWSIGCIVGELIT---NRAIFPGNSTLNQIEKVLELTGKPTQEDIESLESQLAWNIISSINVQKKKTFHQMFPGASEEAIDLIKK
.||||..|    ..||||.||| .|..|   ....|||.| ..|..|. .. | || ..  ....   .                          ||. |
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNK

LLCFNPKNRLTVEQALEHPYV
.||..||.|.. ||||.||| 
MLCYDPKKRISAEQALQHPYF
Kinase 28942.AA S_TKc 175-463 29 1.8e-100 340.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 175-463
Range on HMM: 1-231/231
Sequence Identity: 29% (91 aa)

FEIIQKLGKGAYGIVWKAFCKKSKQIVALKKVFDAFHNATDAQRTFREVMFLQELNGHENIIRLINIIKAENNKDLYMVFDFMET---DLHAVIRANI--
.||..|.||||.| |.|.  ||...|||.|..          ... ||.  |..  .|.||..|. ..     ..||||......   ||. .|. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LEEIHKQYVVYQILKAMKYIHSGELIHRDLKPSNILLNSECLVKLADFGLARSVAVTDDDDNPVRTEYVATRWYRAPEILLGSTKYAK-AVDMWS
     . | | ....|||..|..|.||   |||||||.||||..   .|..|||||| .           | .. |.||.|||.|    .| | ..|.||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL----GYGKCKCDWWS

IGCIVGELITNRAIFPGNSTLNQIEKVLELTGKPTQEDIESLESQLAWNIISSINVQKKKTFHQMFPGASEEAIDLIKKLLCFNPKNRLTVEQALE----
.|||. |... .  ||   ..... |..                                         |.||.|.|.|.|...|..|.|. .||.    
CGCILYEMLCGYPPFP---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPYV
   ||..
IKCHPWF
Kinase 28942.AA ERK1 175-463 45 1.4e-99 337.18 In-house 1-289 (289) Show / Hide 
Range on Protein: 175-463
Range on HMM: 1-289/289
Sequence Identity: 45% (134 aa)

FEIIQKLGKGAYGIVWKAFCKKSKQIVALKKVFDAFHNATDAQRTFREVMFLQELNGHENIIRLINIIKA---ENNKDLYMVFDFMETDLHAVIRANILE
.  .| .|.||||.|  |  .  || ||.||.   |   |  ||| ||.  |.  . ||||| . .||.|   |. .|.|.| . |||||  ....  | 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFK-HENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLS

EIHKQYVVYQILKAMKYIHSGELIHRDLKPSNILLNSECLVKLADFGLARSVAVTDDDDNPVRTEYVATRWYRAPEILLGSTKYAKAVDMWSIGCIVGEL
  |  | .||||. .|||||   .||||||||.|||  | .|. |||||| .|  . |     ||||||||||||||.| |  | |..|.||.|||. |.
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM

ITNRAIFPGNSTLNQIEKVLELTGKPTQEDIESLESQLAWNIISSINVQKKKTFHQMFPGASEEAIDLIKKLLCFNPKNRLTVEQALEHPYV
. || ||||   | |. ..| . | | |.|.. .  . | | . |.  ..|  ....||.| . |.||. |.| |||..|.|||.|| |||.
LSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 28942.AA ERK5 175-463 41 3e-95 322.72 In-house 1-295 (295) Show / Hide 
Range on Protein: 175-463
Range on HMM: 1-295/295
Sequence Identity: 41% (123 aa)

FEIIQKLGKGAYGIVWKAFCKKSKQIVALKKVFDAFHNATDAQRTFREVMFLQELNGHENIIRLINIIKAENN----KDLYMVFDFMETDLHAVIRANI-
..|| |.| ||||.|  |  .|  | ||.||.  ||   | |.|||||.  |.    |.||| . .|.. .      || |.||| || ||| .| .|  
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFR-HDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQP

LEEIHKQYVVYQILKAMKYIHSGELIHRDLKPSNILLNSECLVKLADFGLARSVAV-TDDDDNPVRTEYVATRWYRAPEILLGSTKYAKAVDMWSIGCIV
.   |  | .||||. .||.|| . |||||||||.| |  | .|. |||.|| ..    |.     |||||||||||||... |  | .|.|.||.|||.
FTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIF

GELITNRAIFPGNSTLNQIEKVLELTGKPTQEDIESLESQLAWNIISS-INVQKKKTFHQMFPGASEEAIDLIKKLLCFNPKNRLTVEQALEHPYV
||.|. | .|||   ..|.. ...  | |    |..  ..   | . . .  .. | . ...|.|   |.||. ..| | | .|.|| .|| ||..
GEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 28942.AA CDC2 175-463 32 6.5e-93 285.87 In-house 1-301 (301) Show / Hide 
Range on Protein: 175-463
Range on HMM: 1-301/301
Sequence Identity: 32% (103 aa)

FEIIQKLGKGAYGIVWKAFCKKSKQIVALKKVFDAFHNATDA----QRTFREVMFLQELNGHENIIRLINIIKAENNKDLYMVFDFMETDLHAVIR----
.. |.|.|.| ||.| |.  ....|||||||.     . ..     . . ||   |.||. |.||..|  .|.    . |||||.... ||    .    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKI--RLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIP

--ANILEEIHKQYVVYQILKAMKYIHSGELIHRDLKPSNILLNSECLVKLADFGLARSVAVTDDDDNPVRTEY----VATRWYRAPEILLGSTKYAKAVD
   .. ... |.|  ||||... . |.   .||||||.|||....  .|.||||||| . .      |.||.     | |.||||||||||. .|  .||
KNKHMPPQLVKSY-MYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGI------PIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVD

MWSIGCIVGEL---ITNRAIFPGNSTLNQIEKVLELTGKPTQEDIESLESQL-------AWNIISSINVQKKKTFHQMFPGASEEAIDLIKKLLCFNPKN
|||||||  |.   .|....|.| |   |. |. .  | |. .. .....          |. .   .. ... ... .  . .|.|||....|. .| .
MWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQK

RLTVEQALEHPYV
|.....||.||| 
RISAKEALQHPYF
Kinase 28942.AA Pkinase 175-463 31 2.3e-91 314.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 175-463
Range on HMM: 1-293/293
Sequence Identity: 31% (100 aa)

FEIIQKLGKGAYGIVWKAFCKKSKQIVALKKVFDAFHNATDAQRTFR--EVMFLQELNGHENIIRLINIIKAENNKDLYMVFDFMET-----DLHAVIR-
..|..|.|.|..| |.|.  |.. .|||.|..     .    |. .|  |.  ...| .|.||.||. .     ....|||....|      ||...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

--ANIL--EEIHKQYVVYQILKAMKYIHSGELIHRDLKPSNILLNSECLV----KLADFGLARSVAVTDDDDNPVRTEYVATRWYRAPEILLGSTKYAKA
   . .  .| . . ..||||....|.||   |||||||.|||..... .    |..|||||. .       |.  | .. |.||.|||...|...| ..
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

VDMWSIGCIVGELITNRAIFPGN----STLNQIEKVLELTGKPTQEDIESLES------QLAWNIISSINVQKKKTFHQMFPGASEEAIDLIKKLLCFNP
|||||.|||. |... | .|||     . ..|.... .  |.|. .|.. . |      .  |            . |. |. .|||..|.||..||..|
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H----------F-HWTFHNWSEECKDFIKWCLCKDP

KNRLTVEQALEHPYV
| |.| ||.|.||..
KKRPTAEQILQHPWF
Kinase 28942.AA MAPK-Unclassified 175-323 45 1.5e-61 210.84 In-house 1-159 (575) Show / Hide 
Range on Protein: 175-323
Range on HMM: 1-159/575
Sequence Identity: 45% (73 aa)

FEIIQKLGKGAYGIVWKAFCKKS-KQIVALKKVFDAFHNATDAQRTFREVMFLQELNGHENIIRLINIIKAE--NN---KDLYMVFDFMET---DLHAVI
 | .. .| ||||.| .|  ||. .| || |||  .||| ||. |. ||.  | .|| |.|||.. .|. ..   |   .|.| | |.|.|   ||| .|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLN-HPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQII

RANI--LEEIHKQYVVYQILKAMKYIHSGELIHRDLKPSNILLNSECLVKLADFGLARSV
. |.  ....| ||  ||||. .||.|| . |||||||||.|.|  |.|. .|||..||.
KSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSI
Kinase 28942.AA MAPK-Unclassified 335-463 33 4.9e-44 152.62 In-house 406-575 (575) Show / Hide 
Range on Protein: 335-463
Range on HMM: 406-575/575
Sequence Identity: 33% (57 aa)

TEYVATRWYRAPEILLGSTKYAKAVDMWSIGCIVGELITN-----------RAIFPGNS--------------------TLNQIEKVLELTGKPTQEDIE
|.||.|||||||||.| .  | ..||.|||||| .|.. .           | .||| .                       ||   ..  | | .||. 
TQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCN

SLESQLAWNIISSINVQKKKTFH-QMFPGAS---------EEAIDLIKKLLCFNPKNRLTVEQALEHPYV
  ..  |   |.|    .   |   ||. |.          |.||...|.| |||. | | .|||||||.
FITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 28942.AA Pkinase_Tyr 175-363 29 3.8e-21 72.26 Pfam 1-199 (270) Show / Hide 
Range on Protein: 175-363
Range on HMM: 1-199/270
Sequence Identity: 29% (61 aa)

FEIIQKLGKGAYGIVWKAFCK----KSKQIVALKKVFDAFHNATD--AQRTFREVMFLQELNGHENIIRLINIIK--AENNKDLYMVFDFMET-DLHAVI
 ....|||.||.| |.|. .|    . |. || |..    .   .   .  .||.  . .|  |.||.||. ..    | |  .|.|. .|.  ||.   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYL

RAN-----ILEEIHKQYVVYQILKAMKYIHSGELIHRDLKPSNILLNSECLVKLADFGLARSVAVTDDDDN-PVRT-EYVATRWYRAPEILLGSTKYAKA
|..      |   ..    .|| |.| | .|  .|||||   |.|....  || .|||||| .  ..||    .|.   .  .|. ||| .  .  .  .
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWM-APECINYGK-FTTK

VDMWS
 | ||
SDVWS
Kinase 28942.AA TyrKc 175-466 22 1.1e-16 46.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 175-466
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

FEIIQKLGKGAYGIVWKAFCKKSKQIVALKKVF-DAFHNATDAQRTFREVMFLQEL-NGHENIIRLINIIKAE-----NNKDLYMVFDFMET-DLHAVIR
 . ..||| ||.|.|.|.  |   . || |..  ||       .   ||   . .|   |.||.||. ..  .       . |..|. .|.  ||.  .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

ANI--LEEIHKQYVVYQILKAMKYIHSGELIHRDLKPSNILLNSECLVKLADFGLARSVAVTD-----DDDNPV----RTEY-VATRWYRAPEILLGSTK
..   |   .. .  .|| . | |.||  .|||||   |.|....  || .||||.| .   |     .|   .     . . .  ||. ||| .    |
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK

YAKAVDMWSIGCIVGELITNRAIFPGN-----STLNQIEKVLELTGKPTQEDI----ESLESQLAWNIISSINVQKKKTFHQMFPGASEEAIDLIKKLLC
.  . | || |    |. |. .  . .      .  .. . ..  . . | .                               |.....|  ...|.   
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMKQCWH

FNPKNRLTVEQALEHPYVKDF
..|..| | ..      ...|
EDPEDRPTFSEI-----HECF