Gene 27541 (Tetrahymena)

27541

Species: Tetrahymena
Alias: TTHERM_00355550, 3836.m02347, 27541, PreTt27541, 90, 37.m00258
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK7

Sequence

Name Sequence Type Origin Length Description Download
27541.AA Protein None 702 None Fasta, JSON
27541.kin_dom Protein Kinase Domain None 289 None Fasta, JSON
27541.NA RNA None 2106 None Fasta, JSON

Protein domain

Protein domains of 27541.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 27541.AA ERK7 13-301 67 1.5e-214 719.03 In-house 1-292 (292) Show / Hide 
Range on Protein: 13-301
Range on HMM: 1-292/292
Sequence Identity: 67% (196 aa)

FEIIQKIGKGAYGIVWKAIDRKLRQVVAVKKVFDAFHNPTDAQRTFREVMFLQELNGHENIVKLLNIIKAENNKDLYLVFDFMETDLHAVIR-ADILEEI
.||....|||||||||||.|.. .||||.||.||||.|.|||||||||.|||||...|.||..|.|.|.|.|..|.||||.||||||||||| ..||..|
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDI

HKKYVMYQILKALKYMHSGDLIHRDLKPSNILLNSECHVKLADFGLARSVAQKE--DDAPPVLTEYVATRWYRAPEILLGSTKYTKAVDMWSVGCILGEL
||.|.|||.|.|.||||||..||||||||||||.|||.||..|||||||.||.|  |.. |.|||||||||||||||||||..|||.|||||.||||||.
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEM

IIGKSIFPGVSTLNQIERVLELTGKPKNEDIEAIESSLAWNILNSINITKQKKFEQFFQGASPDALDLLKKLLVFNPKLRLDAEQALQHRYV
..||..|||.||.||||..||...||..||||||.|..|||.|...| .|.|...|.......||.||||.||||||| ||.|||||||.||
LRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 27541.AA MAPK 13-301 43 2.2e-175 588.96 In-house 1-328 (328) Show / Hide 
Range on Protein: 13-301
Range on HMM: 1-328/328
Sequence Identity: 43% (144 aa)

FEIIQKIGKGAYGIVWKAIDRK------LRQVVAVKKVFDAFHNPTDAQRTFREVMFLQELNGHENIVKLLNIIKAE-----NN----KDLYLVFDFMET
..|...||.||||.|..|||..        . ||.||....|.|||...||.||...|.....||||.|||.|...|     |.    .|.|.|...|||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHAVIR-ADILEEIHKKYVMYQILKA--LKYMHSGDLIHRDLKPSNILLNSECHVKLADFGLARSVAQKE----DDAPP------VLTEYVATRWYRAP
|||..|.  ..|...|..| |||||..  |||.||.. |||||||||||.|..| .|..|||||||.....    ... |       .||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EILLG--STKYTKAVDMWSVGCILGELII-GKSIFPGVSTLNQIERVLELTGKPKNEDIEAIE-SSLAWNILNSI---NITKQKKFEQFFQG----ASPD
||.|.  ...|||||||||||||..|..  .| .||| ....|.....|..|.|. |.|. |. |. |.| . |      ...| .|. | .    |.|.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALDLLKKLLVFNPKLRLDAEQALQHRYV
|.|||.|.|||.|. |...|.|||| |.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 27541.AA CMGC 13-301 26 5.6e-138 456.46 In-house 1-513 (513) Show / Hide 
Range on Protein: 13-301
Range on HMM: 1-513/513
Sequence Identity: 26% (139 aa)

FEIIQKIGKGAYGIVWKAIDRKLR--------------QVVAVKKVFDAFHNPTDAQ----------RTFREVMFLQELN----------------GHEN
.|||.|||.|.||.|.|..|..                ..||.||.. .| ....|.          |..||...|..||                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKLLNIIKAEN---------------NKDLYLVFDFMETDLHAVIRAD----------ILEEIH------------KKYVM------YQILKALK--YM
||||..|.. .|               ...|||||..|..||. .|.             |.| |            .|| |      ||||..||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSGD--LIHRDLKPSNILLNSECHV--------------------KLADFGLARSVAQKE----------------DDAPPV--LTEYVATRWYRAPEIL
|| .   |||||||.|||.|..| .                    |..||||||.. . .                || .|.  .|.||.||||||||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVVTRWYRAPEIL

LGS---------TKYTKAVDMWSVGCILGELIIG--------KSIFP-----------GVSTLNQIERVLELTGKP----------------KNEDIEAI
||.         ..||...||||||||..|.. |        | .||           | |...|...  .. |.|                ..|... |
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

E--------------------SSLAWNILNS---INITKQKKFEQFFQG-----------------------------------ASPDALDLLKKLLVFN
.                    |. |.| ..|       . |.....| .                                   ..|.|.|||||.|...
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PKLRLDAEQALQHRYV
|. |. ||||||| | 
PDKRITAEQALQHPYF
Kinase 27541.AA ERK 13-301 44 8.9e-135 454.05 In-house 1-307 (307) Show / Hide 
Range on Protein: 13-301
Range on HMM: 1-307/307
Sequence Identity: 44% (138 aa)

FEIIQKIGKGAYGIVWKAIDRK-----LRQVVAVKKVFDAFHNPTDAQRTFREVMFLQELNGHENIVKLLNIIKAE---NNKDLYLVFDFMETDLHAVIR
..||..||.||||.| .||| .      .| ||.||...|| .| .. || ||  .|  ..|||||..|..|.. .   . .|.|.|...|||||| .|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

AD-ILEEIHKKYVMYQILKALKYMHSGDLIHRDLKPSNILLNSECHVKLADFGLAR----SVAQKEDDAPPVLTEYVATRWYRAPEILLGSTKYTKAVDM
 .  |.. | .| ||||| .|||.|| . |||||||||||.|| |  | .||||||    |..  .    . .||||||||||||||.|  .|||||.|.
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCILGELIIGKSIFPGVSTLNQIERVLELTGKP-KNEDIEAIESSLAWNILNSINI--TKQKKFEQFFQGAS--PDALDLLKKLLVFNPKLRLDAEQ
||.|||. |.. .| .||| ....||.|.....|.|   ||.. |.|  ||. . . .    . | .|  |  |.  |.|.|||.|.|||.|. |. .|.
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALQHRYV
.|.| | 
CLEHPYF
Kinase 27541.AA p38 13-301 42 1.5e-110 373.61 In-house 1-289 (289) Show / Hide 
Range on Protein: 13-301
Range on HMM: 1-289/289
Sequence Identity: 42% (126 aa)

FEIIQKIGKGAYGIVWKAIDRKLRQV---VAVKKVFDAFHNPTDAQRTFREVMFLQELNGHENIVKLLNIIKA-----ENNKDLYLVFDFMETDLHAVIR
.. .| .|.|||| | ||.||. .|    ||.|| .  |  . .| ||.||.  |. .. |||...||..        .. .| |.|  ||..||. ...
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMR-HENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMK

ADILEEIHKKYVMYQILKALKYMHSGDLIHRDLKPSNILLNSECHVKLADFGLARSVAQKEDDAPPVLTEYVATRWYRAPEILLGSTKYTKAVDMWSVGC
   | . | ..  ||||..||| || . |||||||||| .| .| ..  ||||||    . ||    .|.||||||||||||.|   .||..||.|||||
CQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR----HCDDE---MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGC

ILGELIIGKSIFPGVSTLNQIERVLELTGKPKNEDIEAIESSLAWNILNSINITKQKKFEQFFQGASPDALDLLKKLLVFNPKLRLDAEQALQHRYV
|. ||| |.  |||   ..|..|.....|.|. | .. |.|  | | . |.  .... |.. |.||.| |.||| |.|.  |  |. ||.|.|| | 
IMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 27541.AA CDK 13-301 33 1.7e-104 335.25 In-house 1-284 (284) Show / Hide 
Range on Protein: 13-301
Range on HMM: 1-284/284
Sequence Identity: 33% (110 aa)

FEIIQKIGKGAYGIVWKAIDRK-----LRQVVAVKKVF----------DAFHNPTDAQRTFREVMFLQELNGHENIVKLLNIIKAEN---------NKDL
.|...||| |.||.| ||.|..       |.|| ||.           . |      . . ||.  |.||  |.|||||. ..  .|         .. |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGF-----PITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKL

YLVFDFMETDLHAVIRADILEEIHKKYVMYQILKALKYMHSGDLIHRDLKPSNILLNSECH-----VKLADFGLARSVAQKED-DAPPV--LTEYVATRW
|.||..|..||  ...         |  |.|.|..| |.||   .||||||.|||.|.  .     .|.|||||||     .. . .|.  .|  | |.|
YMVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLW

YRAPEILLGSTKYT--KAVDMWSVGCILGELII---GKSIFPGVSTLNQIERVLELTGKPKNEDIEAIESSLAWNILNSINITKQKKFEQFFQGASPDAL
|||||.||||..|.   ..||||||||..|..    .| .||| | ..|.... .. | |  ..   ...   .                          
YRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------

DLLKKLLVFNPKLRLDAEQALQHRYV
||| |.|...|| |. ||||||| | 
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 27541.AA S_TKc 13-301 30 7.4e-103 348.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-301
Range on HMM: 1-231/231
Sequence Identity: 30% (94 aa)

FEIIQKIGKGAYGIVWKAIDRKLRQVVAVKKVFDAFHNPTDAQRTFREVMFLQELNGHENIVKLLNIIKAENNKDLYLVFDFMET---DLHAVIRADI--
.||..||||||.| |.|....|  ..||.|..          ... ||.  |..  .|.|||||. ..     ..||.|......   ||. .|.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LEEIHKKYVMYQILKALKYMHSGDLIHRDLKPSNILLNSECHVKLADFGLARSVAQKEDDAPPVLTEYVATRWYRAPEILLGSTKYTK-AVDMWS
     . | | ...||||..||.|.||   |||||||.||||..  |.|..|||||| .           | .. |.||.|||.|    .|.| ..|.||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL----GYGKCKCDWWS

VGCILGELIIGKSIFPGVSTLNQIERVLELTGKPKNEDIEAIESSLAWNILNSINITKQKKFEQFFQGASPDALDLLKKLLVFNPKLRLDAEQALQ----
.|||| |.. |.  ||   ..... ...                                         ||.|.|...|.|...|. |. | .|||    
CGCILYEMLCGYPPFP---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HRYV
   | ..
IKCHPWF
Kinase 27541.AA ERK1 13-301 46 4.2e-98 332.23 In-house 1-289 (289) Show / Hide 
Range on Protein: 13-301
Range on HMM: 1-289/289
Sequence Identity: 46% (135 aa)

FEIIQKIGKGAYGIVWKAIDRKLRQVVAVKKVFDAFHNPTDAQRTFREVMFLQELNGHENIVKLLNIIKA---ENNKDLYLVFDFMETDLHAVIRADILE
.  .| ||.||||.|  |.|.  .| ||.||.   |   |  ||| ||.  |.  . ||||... .||.|   |. .|.|.| . |||||  ....  | 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFK-HENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLS

EIHKKYVMYQILKALKYMHSGDLIHRDLKPSNILLNSECHVKLADFGLARSVAQKEDDAPPVLTEYVATRWYRAPEILLGSTKYTKAVDMWSVGCILGEL
  |  | .||||. |||.||   .||||||||.|||  | .|. |||||| .|  | |    |||||||||||||||.| |  |||..|.||||||| |.
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM

IIGKSIFPGVSTLNQIERVLELTGKPKNEDIEAIESSLAWNILNSINITKQKKFEQFFQGASPDALDLLKKLLVFNPKLRLDAEQALQHRYV
.  . ||||   | |.  .| . | | ..|.. |    | | | |.   ..  ... | .| . ||||| |.| |||. |.. |.|| | |.
LSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 27541.AA ERK5 13-301 42 5.1e-96 325.29 In-house 1-295 (295) Show / Hide 
Range on Protein: 13-301
Range on HMM: 1-295/295
Sequence Identity: 42% (127 aa)

FEIIQKIGKGAYGIVWKAIDRKLRQVVAVKKVFDAFHNPTDAQRTFREVMFLQELNGHENIVKLLNIIKAENN----KDLYLVFDFMETDLHAVIRADI-
..|| ||| ||||.|  |. ||  | ||.||.  ||   | |.|||||.  |.    |.||. . .|.. .      || | ||| || ||| .| ..  
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFR-HDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQP

LEEIHKKYVMYQILKALKYMHSGDLIHRDLKPSNILLNSECHVKLADFGLARSVAQ-KEDDAPPVLTEYVATRWYRAPEILLGSTKYTKAVDMWSVGCIL
.   | .| .||||. |||||| . |||||||||.| |  | .|. |||.|| ..    |.    .|||||||||||||... |  ||.|.|.||||||.
FTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIF

GELIIGKSIFPGVSTLNQIERVLELTGKPKNEDIEAIESSLAWNILNS-INITKQKKFEQFFQGASPDALDLLKKLLVFNPKLRLDAEQALQHRYV
||.|  . .|||   ..|.. ...  | |    |.|. .    | . . .   . | .|. . .| . ||||| ..|.| |  |. . .|||| ..
GEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 27541.AA Pkinase 13-301 31 5.1e-94 323.45 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-301
Range on HMM: 1-293/293
Sequence Identity: 31% (97 aa)

FEIIQKIGKGAYGIVWKAIDRKLRQVVAVKKVFDAFHNPTDAQRTFR--EVMFLQELNGHENIVKLLNIIKAENNKDLYLVFDFMET-----DLHAVIR-
..|..|||.|..| |.|..... ...||||..     ..   |. .|  |.  ...| .|.|||.|. .     ....|.|....|      ||...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

--ADIL--EEIHKKYVMYQILKALKYMHSGDLIHRDLKPSNILLNSECHV----KLADFGLARSVAQKEDDAPPVLTEYVATRWYRAPEILLGSTKYTKA
     .  .| . | .|||||..|.|.||   |||||||.|||.....|.    |..|||||. .        . .| .. |.||.|||...|...|...
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

VDMWSVGCILGELIIGKSIFPGV----STLNQIERVLELTGKPKNEDIEAIESSLAWNILNSINITKQKKFEQFFQGASPDALDLLKKLLVFNPKLRLDA
|||||.|||| |.. |. .|||     . ..|.... .  |.|  .|..   |    . ..    .  . .. |   .|....|..|..| ..|| |. |
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

EQALQHRYV
||.||| ..
EQILQHPWF
Kinase 27541.AA CDC2 13-301 32 3.9e-90 277.16 In-house 1-301 (301) Show / Hide 
Range on Protein: 13-301
Range on HMM: 1-301/301
Sequence Identity: 32% (102 aa)

FEIIQKIGKGAYGIVWKAIDRKLRQVVAVKKVFDAFHNPTDA----QRTFREVMFLQELNGHENIVKLLNIIKAENNKDLYLVFDFMETDLHAVIR----
.. |.|||.| ||.| |..|..  |.||.||.     . ..     . . ||   |.||. |.|||||  .|.    . ||.||.... ||    .    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKI--RLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIP

-ADILEEIHKKYVMYQILKALKYMHSGDLIHRDLKPSNILLNSECHVKLADFGLARSVAQKEDDAPPVLT--EYVATRWYRAPEILLGSTKYTKAVDMWS
  . ....  |  |||||... . |.   .||||||.|||....  .|.||||||| .    .    ..|    | |.||||||||||. .|. .|||||
KNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIR----TYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWS

VGCILGEL---IIGKSIFPGVSTLNQIERVLELTGKPKNEDIEAIESSL-------AWNILNSINITKQKKFEQFFQGASPDALDLLKKLLVFNPKLRLD
.|||. |.   .  | .|.| |   |. .. .  | |.... . ...          |.  .  .| ....... .  . |...|||...|. .|  |. 
IGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRIS

AEQALQHRYV
|..||||.| 
AKEALQHPYF
Kinase 27541.AA MAPK-Unclassified 13-161 45 2.7e-63 216.57 In-house 1-159 (575) Show / Hide 
Range on Protein: 13-161
Range on HMM: 1-159/575
Sequence Identity: 45% (72 aa)

FEIIQKIGKGAYGIVWKAIDRKL-RQVVAVKKVFDAFHNPTDAQRTFREVMFLQELNGHENIVKLLNIIKAE--NN---KDLYLVFDFMET---DLHAVI
 | .. || ||||.| .|.| |.  | || |||  .|||.||. |. ||.  | .|| |.||... .|. ..   |   .|.|.| |.|.|   ||| .|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLN-HPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQII

RADI--LEEIHKKYVMYQILKALKYMHSGDLIHRDLKPSNILLNSECHVKLADFGLARSV
. ..  ....| .| .||||. |||.||   |||||||||.|.|  | |. .|||..||.
KSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSI
Kinase 27541.AA MAPK-Unclassified 172-301 28 7.9e-44 151.93 In-house 405-575 (575) Show / Hide 
Range on Protein: 172-301
Range on HMM: 405-575/575
Sequence Identity: 28% (49 aa)

LTEYVATRWYRAPEILLGSTKYTKAVDMWSVGCILGELIIG-----------KSIFPGVS--------------------TLNQIERVLELTGKPKNEDI
.|.||.|||||||||.| .  |...||.||.|||..|...            . .||| .                       ||   ..  | |. ||.
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

EAIESSLAWNILNSINITKQKKFEQFFQGASP----------DALDLLKKLLVFNPKLRLDAEQALQHRYV
  |... |   ..|    .. .| ...  . |          ...|...|.|.|||. |  |.|||.| |.
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 27541.AA Pkinase_Tyr 13-201 27 4.3e-20 68.67 Pfam 1-199 (270) Show / Hide 
Range on Protein: 13-201
Range on HMM: 1-199/270
Sequence Identity: 27% (57 aa)

FEIIQKIGKGAYGIVWKAIDR----KLRQVVAVKKVFDAFHNPTD--AQRTFREVMFLQELNGHENIVKLLNIIK--AENNKDLYLVFDFMET-DLHAVI
 ....|.|.||.| |.|.. .    . .. ||||..    . . .   .  .||.  . .|  |.|||.|. ..    | |  .|.|. .|.  ||.   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYL

RAD-----ILEEIHKKYVMYQILKALKYMHSGDLIHRDLKPSNILLNSECHVKLADFGLARSVAQKEDDAPPVLTE--YVATRWYRAPEILLGSTKYTKA
|.       |   ..    .|| |.. | .|  .|||||   |.|.... .|| .|||||| . ...|    . ..   .  .|. ||| .  .  .| .
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTK

VDMWS
 | ||
SDVWS
Kinase 27541.AA TyrKc 13-301 23 1.9e-15 27.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-301
Range on HMM: 1-280/280
Sequence Identity: 23% (74 aa)

FEIIQKIGKGAYGIVWKAIDRKLRQVVAVKKVF-DAFHNPTDAQRTFREVMFLQEL-NGHENIVKLLNIIKAE-----NNKDLYLVFDFMET-DLHAVIR
 . ..|.| ||.|.|.|.. .   . ||||..  ||       .   ||   . .|   |.|||.|. ..  .       . |..|. .|.  ||.  .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

ADI--LEEIHKKYVMYQILKALKYMHSGDLIHRDLKPSNILLNSECHVKLADFGLARSVAQK------EDDAPP---VLTEY-VATRWYRAPEILLGSTK
.    |   .. . ..|| .   | ||  .|||||   |.|.... .|| .||||.| .  .      .|   .     . . .  ||. ||| .    |
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK

YTKAVDMWSVGCILGELI-IGKSIFPG-----VSTLNQIERVLEL--TGKPKN--EDIEAIESSLAWNILNSINITKQKKFEQFFQGASPDALDLLKKLL
.| . | || |  . |.   |..  ||     .|    ||.| .     .|.|  . .                         |  .....  .. |.  
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS------------------------F-VCCPDEMYQIMKQCW

VFNPKLRLDAEQALQHRYV
 ..|. |   ..   |.. 
HEDPEDRPTFSEI--HECF