Gene 4173 (Tetrahymena)

4173

Species: Tetrahymena
Alias: PreTt04173, 4173, TTHERM_00492370, 3711.m00008, 418, 61.m00160
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK

Sequence

Name Sequence Type Origin Length Description Download
4173.AA Protein None 3043 None Fasta, JSON
4173.kin_dom Protein Kinase Domain None 300 None Fasta, JSON
4173.NA RNA None 9132 None Fasta, JSON

Protein domain

Protein domains of 4173.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 4173.AA ERK 2360-2659 50 1.8e-199 668.99 In-house 1-307 (307) Show / Hide 
Range on Protein: 2360-2659
Range on HMM: 1-307/307
Sequence Identity: 50% (158 aa)

YQIVKRIGDGAYGVVFKAIDKS----KNNEIVAIKKVSDAFLDPRDAKRILREIKLLKFCN-HPNIIKLKDIIKPEMPTGYKDIYLVLEYMEIDLDKTIN
|||.|.||.||||||..||||.    .....|||||...||..|...||.|||||||.... |.|||.|.||..|..|..|.|||.| |.||.||...||
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SEQALSPKIIKNLMWQLLNGIFYMHSADIIHRDIKPSNILLNKNCTLKLADMNLARKFDVEQSSITEQQISLNLYFTTYVVTRPYRAPEILLSTENYSKP
|.|.||.......|.|.|.|..|.|||..||||.||||||.|.||.|| .|..|||.||.......|   ... ..|.||.||.||||||.||...|.|.
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHE---CNQNFMTEYVATRWYRAPEIMLSWQKYTKA

IDIWSAGCIFAEMMGRKTIFKGNSYVNQLDRIIAIMGKP-DFDKLSYKVDENLKEYIKQLQE--KQPENFYEIYKSHD--PLAIDLLYKMLAFDPKERWT
.||||.|||||||.|||..|.|..||.|..||..|.|.| ....|.|. .||...|||.|..  ..|.....|.....  |.|||||.|||.|||..|.|
MDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRIT

VEQCLYHEYF
||.||.|.||
VEECLEHPYF
Kinase 4173.AA MAPK 2360-2659 44 1.1e-169 569.99 In-house 1-328 (328) Show / Hide 
Range on Protein: 2360-2659
Range on HMM: 1-328/328
Sequence Identity: 44% (147 aa)

YQIVKRIGDGAYGVVFKAIDKS-----KNNEIVAIKKVSDAFLDPRDAKRILREIKLLKFC-NHPNIIKLKDIIKPEM----PTG--YKDIYLVLEYMEI
|||.|.|| ||||||..||||.     |....|||||.|..| .| ..||..||||||... .|.|||||.||..|||    ..   ..|||.| |.|| 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLDKTINSEQALSPKIIKNLMWQLLNG--IFYMHSADIIHRDIKPSNILLNKNCTLKLADMNLARKFDVEQSSITEQQISLNLYF-----TTYVVTRPYR
|| . |.|.| || . |. .|.|.|.|  ..|.|||..||||.||||||.|.||.||..|. |||..| |.. ...|.   .. |     | ||.|| ||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HC-FQKMHMTEYVATRWYR

APEILLS--TENYSKPIDIWSAGCIFAEMMG-RKTIFKGNSYVNQLDRIIAIMGKPDFDKLSYKV-DENLKEYIKQL---QEKQPENFYEIYKS----HD
||||.|.  . .|.| .|.||.|||||||.. ||..|.|..|..|. .|....|.|. . ...   .|. ..||..|   . ... .......     ..
APEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

PLAIDLLYKMLAFDPKERWTVEQCLYHEYF
|.||||| |||.|||..|.|||..| |.||
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 4173.AA CMGC 2360-2659 27 4e-135 446.9 In-house 1-513 (513) Show / Hide 
Range on Protein: 2360-2659
Range on HMM: 1-513/513
Sequence Identity: 27% (143 aa)

YQIVKRIGDGAYGVVFKAIDKS-------------KNNEIVAIKKVSDAFLDPRDAK----------RILREIKLLKFCN-----------------HPN
|.|.|.|| |.||||.|..||              ..||||||||.. .| ....||          |.|||||.||  |                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIKLKDIIKPEM--PTGYK----------DIYLVLEYMEIDLDKTINSEQ---------ALSPKI------------IKNLM------WQLLNG--IFYM
|.||.||....   ...|.          ..||| |||. || . | . |          ||.              ||..|      .|.|.|  ..|.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAD--IIHRDIKPSNILLNKNCTL--------------------KLADMNLARKFDVEQSSITEQQISLNLY------------FTTYVVTRPYRAPEI
||..  |||||.||.|||.|.||.|                    |..|  |||....... ...|| ..               .|.||||| ||||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQS--FKNVNKDDKPNRPYTHYVVTRWYRAPEI

LLSTENYS---------KPIDIWSAGCIFAEMMGR--------KTIFK-----------GNSYVNQLDRIIAIMGKP----------------DFDKLSY
||. ..|.         .|||.||.|||||||. .        |..|.           |.|...||..|. ..|.|                . .  ..
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNM

KV--------------------DENLKEYIKQ---LQEKQPENFYEIYKSHD-----------------------------------PLAIDLLYKMLAF
.                     .|  . ||..   .....| .. .... |.                                   |.||||| ||| .
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DPKERWTVEQCLYHEYF
||..|.|.||.| |.||
DPDKRITAEQALQHPYF
Kinase 4173.AA ERK7 2360-2659 41 1.2e-101 343.94 In-house 1-292 (292) Show / Hide 
Range on Protein: 2360-2659
Range on HMM: 1-292/292
Sequence Identity: 41% (126 aa)

YQIVKRIGDGAYGVVFKAIDKSKNNEIVAIKKVSDAFLDPRDAKRILREIKLLKFCN-HPNIIKLKDIIKPEMPTGYKDIYLVLEYMEIDLDKTINSEQA
|.| ||.| ||||.| ||.|| .  ..||.||. ||| .. || |  ||| .|.  . |||||.| ..|. .     .||||| |.|| ||   |   . 
YEIRKRLGKGAYGIVWKAYDK-RTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADN---DRDIYLVFEFMETDLHAVIRKGNI

LSPKIIKNLMWQLLNGIFYMHSADIIHRDIKPSNILLNKNCTLKLADMNLARKFDVEQSSITEQQ--ISLNLYFTTYVVTRPYRAPEILLSTENYSKPID
|     .  |.|||. | ||||...||||.|||||||. .|..|..|  |||       ||..|.     |   | || || ||||||||. ..| | .|
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLAR-------SIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVD

IWSAGCIFAEMMGRKTIFKGNSYVNQLDRIIAIMGKPDFDKLSYKVDENLKEYIKQLQEKQPENFYEIYKSHDPLAIDLLYKMLAFDPKERWTVEQCLYH
 || ||| .||.  | .| |.| .||...|. ...||    .     .     ..|....... . .....  . ||||| ..|.| ||.| |.||.| |
MWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQH

EYF
 | 
PYV
Kinase 4173.AA CDK 2360-2659 38 1.6e-99 319.07 In-house 1-284 (284) Show / Hide 
Range on Protein: 2360-2659
Range on HMM: 1-284/284
Sequence Identity: 38% (126 aa)

YQIVKRIGDGAYGVVFKAIDKSKN----NEIVAIKKVSDAFL----D----PRDAKRILREIKLLKFCNHPNIIKLKDIIKPEMPTGY------KDIYLV
|.....|| |.||||.||.||  .    ..|||.||.         .    |  |   .|||.||| . ||||.||.|..  . .  .      . .|.|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITA---IREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMV

LEYMEIDLDKTINSEQALSPKIIKNLMWQLLNGIFYMHSADIIHRDIKPSNILLNKNCT-----LKLADMNLARKFDVEQSSITEQQISLNLYFTTYVVT
 |||. || | .          ||..|||||.|. |.||  |.|||.||.|||.|.| .     ||.||. |||.| ..     ..   .. | |  |||
FEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQ---MS-EPNRTY-THEVVT

RPYRAPEILLSTENYS--KPIDIWSAGCIFAEMMG---RKTIFKGNSYVNQLDRIIAIMGKPDFDKLSYKVDENLKEYIKQLQEKQPENFYEIYKSHDPL
. |||||.|| ...||   |||.||.|||||||.    || .| |.|  .||..|. |.| |. |       . | .|                      
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPG--VTKLPDY----------------------

AIDLLYKMLAFDPKERWTVEQCLYHEYF
  ||| |||..||| |.. ||.| |.||
--DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 4173.AA ERK5 2360-2659 41 4.4e-99 335.49 In-house 1-295 (295) Show / Hide 
Range on Protein: 2360-2659
Range on HMM: 1-295/295
Sequence Identity: 41% (124 aa)

YQIVKRIGDGAYGVVFKAIDKSKNNEIVAIKKVSDAFLDPRDAKRILREIKLLKFCNHPNIIKLKDIIKPEMPTG-YKDIYLVLEYMEIDLDKTINSEQA
|.|. .|| ||||||  |. . || . |||||.  ||     ||| .||.|.|.   | ||| ..||..|. | . .||.| |.. || || . | |.| 
YKIIEKIGNGAYGVVCSARRR-KNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQP

LSPKIIKNLMWQLLNGIFYMHSADIIHRDIKPSNILLNKNCTLKLADMNLARKFDVEQSSITEQQISLNLYFTTYVVTRPYRAPEILLSTENYSKPIDIW
..   |.  ..|.| |. |||||..||||.||||.| | || ||. |  .||       |  ..|.    . | || || |||||...| ..| . ||.|
FTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCT--FSPDKHQM----FMTEYVATRWYRAPELMFSSHDYTQAIDVW

SAGCIFAEMMGRKTIFKGNSYVNQLDRIIAIMGKPDFDKLSYKVDENLKEYIKQ-LQEKQPENFYEIYKSHDPLAIDLLYKMLAFDPKERWTVEQCLYHE
| |||| ||..|. .| |  |..||. |. ..| |    .     . .. |... . ..|| .. ..|   |. |.||| .|| |.| || || . | | 
SVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHP

YF
. 
FL
Kinase 4173.AA p38 2360-2659 38 2.2e-98 333.18 In-house 1-289 (289) Show / Hide 
Range on Protein: 2360-2659
Range on HMM: 1-289/289
Sequence Identity: 38% (118 aa)

YQIVKRIGDGAYGVVFKAIDKSKNNE--IVAIKKVSDAFLDPRDAKRILREIKLLKFCNHPNIIKLKDIIKP--EMPTGYKDIYLVLEYMEIDLDKTINS
|| .. .| |||| | ||.|.  ..    ||||| .  | .. .|||. ||..|||  .| |.|.| |.  |  .     .|.|.| . |. || . . .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

EQALSPKIIKNLMWQLLNGIFYMHSADIIHRDIKPSNILLNKNCTLKLADMNLARKFDVEQSSITEQQISLNLYFTTYVVTRPYRAPEILLSTENYSKPI
.. ||   |. |  |.| |  | |||.||||| ||||| .| .| |.  |  |||              .     | ||.|| ||||||.|.   | . .
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR--------------HCDDEMTGYVATRWYRAPEIMLNWMHYTQTV

DIWSAGCIFAEMMGRKTIFKGNSYVNQLDRIIAIMGKPDFDKLSYKVDENLKEYIKQLQEKQPENFYEIYKSHDPLAIDLLYKMLAFDPKERWTVEQCLY
|||| ||| ||.. ..| |.|. ...|| ||....|.||   ..   .|. . ||. . . .  .| .... ..|.||||| |||  ||  | |.|. . 
DIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQ

HEYF
|.||
HPYF
Kinase 4173.AA S_TKc 2360-2659 28 3.6e-96 326.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 2360-2659
Range on HMM: 1-231/231
Sequence Identity: 28% (89 aa)

YQIVKRIGDGAYGVVFKAIDKSKNNEIVAIKKVSDAFLDPRDAKRILREIKLLKFCNHPNIIKLKDIIKPEMPTGYKDIYLVLEYMEI---DLDKTINSE
|.|.. || ||.|.|.|...|.  ..|||||...         ..|.|||..||  .||||.||.|..        ...|.|.||..    || . | . 
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKR

QA------LSPKIIKNLMWQLLNGIFYMHSADIIHRDIKPSNILLNKNCTLKLADMNLARKFDVEQSSITEQQISLNLYFTTYVVTRPYRAPEILLSTEN
.       ...  .. .|.|..... |.||  |||||.||.||||..  ..|..|  |||..                  ||...|. |.|||.|     
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------TTFCGTPWYMAPEVL----G

YSK-PIDIWSAGCIFAEMMGRKTIFKGNSYVNQLDRIIAIMGKPDFDKLSYKVDENLKEYIKQLQEKQPENFYEIYKSHDPLAIDLLYKMLAFDPKERWT
|.| ..|.|| |||..||. ... |       |..... ..|                                     .| |.|.. |.| .||..|.|
YGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPT

VEQCLY-------HEYF
. ..|        |..|
A-EALQDEWDIKCHPWF
Kinase 4173.AA CDC2 2360-2659 36 1.8e-88 271.96 In-house 1-301 (301) Show / Hide 
Range on Protein: 2360-2659
Range on HMM: 1-301/301
Sequence Identity: 36% (119 aa)

YQIVKRIGDGAYGVVFKAIDKSKNNEIVAIKKVSDAFLDPRDAK-----RILREIKLLKFCN-HPNIIKLKDIIKPEMPTGYKDIYLVLEYMEIDLDKTI
|| ...|| | ||||.|..|.  |  |||.||.    |.  |.       ..||| .||  . ||||.||.|.|.       . .|.| ||.. || |  
YQKIEKIGEGTYGVVYKCKDMQTNQ-IVALKKIR---LEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ------NKLYMVFEYLDMDLKKYM

N-SEQ---ALSPKIIKNLMWQLLNGIFYMHSADIIHRDIKPSNILLNKNCTLKLADMNLARKFDVEQSSIT-EQQISLNLYFTTYVVTRPYRAPEILLST
  |..    ..| ..|..|.|.|.|. . |.  |.|||.||.|||..|. ..|.||. ||| | .    .| |            |||. ||||||||  
DMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTE----------HEVVTLWYRAPEILLGC

ENYSKPIDIWSAGCIFAEM---MGRKTIFKGNSYVNQLDRIIAIMGKPDFDKLSYKVDENLKEYIKQLQEKQPENFYEIYKS---------HDPLAIDLL
. || |.|.|| |||||||   . .| .| | |   || .|  |.| |  .  ..   ..|..|     . .| .. .| ..          || .||||
KRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTP--NEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLL

YKMLAFDPKERWTVEQCLYHEYF
 .||. ||  | .... | | ||
MQMLQYDPQKRISAKEALQHPYF
Kinase 4173.AA Pkinase 2360-2659 30 3.2e-87 300.85 Pfam 1-293 (293) Show / Hide 
Range on Protein: 2360-2659
Range on HMM: 1-293/293
Sequence Identity: 30% (96 aa)

YQIVKRIGDGAYGVVFKAIDKSKNNEIVAIKKVSDAFLDPRDAKRILR--EIKLLKFCNHPNIIKLKDIIKPEMPTGYKDIYLVLEYMEI-----DLDKT
|.|...|| |..|.|.|...|. .  |||.|...    ..   .. .|  ||...| .|||||..|.|.         ..||.|.||.|      ||   
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDY

IN--SEQAL--SPKIIKNLMWQLLNGIFYMHSADIIHRDIKPSNILLNKNCTL----KLADMNLARKFDVEQSSITEQQISLNLYFTTYVVTRPYRAPEI
|   .. ..  |.. .|. |.|.| |. |.||  |||||.||.|||...|...    |..|  ||..||          .  |  .||...|..|.|||.
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPEV

LLSTENYSKPIDIWSAGCIFAEMMGRKTIFKGN----SYVNQLDRIIAIMGKPDFDKLSYKVDENLKEYIKQLQEKQPENFYEIYKSHDPLAIDLLYKML
... . |....|.||.|||..||. ....|.|     . ..|. .|  |||.|     ... .. . . ... . .  . . .  .  .. ..|.....|
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCL

AFDPKERWTVEQCLYHEYF
..|||.|.| ||.| |..|
CKDPKKRPTAEQILQHPWF
Kinase 4173.AA ERK1 2360-2659 41 2.6e-82 279.78 In-house 1-289 (289) Show / Hide 
Range on Protein: 2360-2659
Range on HMM: 1-289/289
Sequence Identity: 41% (125 aa)

YQIVKRIGDGAYGVVFKAIDKSKNNEIVAIKKVSDAFLDPRDAKRILREIKLLKFCNHPNIIKLKDIIKPEMPTGYKDIYLVLEYMEIDLDKTINSEQAL
|  .. ||.||||.|  |.|. ...  |||||.|  |      .| |||||.|.  .| |||...|||. .     .|.|.| . || || | . . | |
YTNLQYIGEGAYGMVCSAYDTVHKQR-VAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHL

SPKIIKNLMWQLLNGIFYMHSADIIHRDIKPSNILLNKNCTLKLADMNLARKFDVEQSSITEQQISLNLYFTTYVVTRPYRAPEILLSTENYSKPIDIWS
|   |   ..|.| |. |.||| ..|||.||||.|||. | ||. |  |||        |.. .     . | || || ||||||.|    | | |||||
SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR--------IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWS

AGCIFAEMMGRKTIFKGNSYVNQLDRIIAIMGKPDFDKLSYKVDENLKEYIKQLQEKQPENFYEIYKSHDPLAIDLLYKMLAFDPKERWTVEQCLYHEYF
 ||| |||.  . || |  |. ||  |....| |  | |   . |  ..|.. |  |.   . ...   |. |.||| |||.| |..| |||. | | | 
VGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 4173.AA MAPK-Unclassified 2360-2510 43 1.4e-66 227.51 In-house 1-157 (575) Show / Hide 
Range on Protein: 2360-2510
Range on HMM: 1-157/575
Sequence Identity: 43% (69 aa)

YQIVKRIGDGAYGVVFKAIDKSKNNEIVAIKKVSDAFLDPRDAKRILREIKLLKFCNHPNIIKLKDIIKPEMPTG--YKDIYLVLEYMEI---DLDKTIN
|   | || ||||.| .|.||.  |  ||||||  .| .. |.||.|||| .|   ||||||...||. .. . .  ..|||.| .||..   || . | 
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SEQ-ALSPKIIKNLMWQLLNGIFYMHSADIIHRDIKPSNILLNKNCTLKLADMNLAR
| |  .. . |. .. |.|.|. |.||| ||||| ||||.|.| .|... .|  ..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase 4173.AA MAPK-Unclassified 2529-2659 30 4.8e-44 152.66 In-house 404-575 (575) Show / Hide 
Range on Protein: 2529-2659
Range on HMM: 404-575/575
Sequence Identity: 30% (53 aa)

YFTTYVVTRPYRAPEILLSTENYSKPIDIWSAGCIFAEMMGR-----------KTIFKGNS--------------------YVNQLDRIIAIMGKPDFDK
. | |||||.||||||.||  .|.. .||||.|||||||| .           . .|.| .                    .. |.  |.   | |.   
HMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEED

LSYKVDENLKEYIKQLQEKQPENFYEIYKSHDP----------LAIDLLYKMLAFDPKERWTVEQCLYHEYF
..   . . ..||. .  | |  | ... .  |          ..||.. |||.|.|. | | .| | |.||
CNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 4173.AA Pkinase_Tyr 2360-2505 29 3.6e-15 52.0 Pfam 1-154 (270) Show / Hide 
Range on Protein: 2360-2505
Range on HMM: 1-154/270
Sequence Identity: 29% (46 aa)

YQIVKRIGDGAYGVVFKAIDK---SKNNEIVAIKKVSDAFLDPRD--AKRILREIKLLKFC-NHPNIIKLKDIIK-PEMPTGYKDIYLVLEYMEI-DLDK
 .. | .| ||.|.|.|.. |   ....  ||.|..     ....   .  .||.|..|   .||||..|  ..   . |     ||.|.|||.  ||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLD

TINS----EQALSPKIIKNLMWQLLNGIFYMHSADIIHRDIKPSNILLNKNCTLKLAD
   .    .|.|..| . .  ||  .|  | .|  .||||.   |.|...| . | .|
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICD
Kinase 4173.AA TyrKc 2360-2659 23 6.3e-13 -13.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 2360-2659
Range on HMM: 1-280/280
Sequence Identity: 23% (76 aa)

YQIVKRIGDGAYGVVFKAIDKSKNNEIVAIKKVS-DAFLDPRDAKRILREIKLLKFC--NHPNIIKLKDIIKPE--MPTGY---KDIYLVLEYME-IDLD
 .  | .| ||.|.|.|.. |    . ||.|..  ||       . ..||.....    .||||..|  ..  .      .   . ...|.|||.  ||.
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---FMYIEPLMIVMEYMPHGDLK

KTINSEQA-LSPKIIKNLMWQLLNGIFYMHSADIIHRDIKPSNILLNKNCTLKLADMNLARKFDVE-QSSITEQQISLNLYFTTY--VVT--RPYR--AP
. . . .  |..|   . .||  .|  | ||  .||||.   |.|...| | | .|  |.|. . . |.       |   | ..         |.|  ||
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-----ESKDYYRKKEHKGGKTMLPIRWMAP

EILLSTEN-YSKPIDIWSAGCIFAEMMGRKTIFKGNSYVNQLDRIIAIMGKPDFDKLSY--KVDENLKEYIKQL-QEKQPEN-----FYEIYKSHDPLAI
| .   .. ..   |.|| |    |.. .                    |..         . .. . ||.||    .||.|     |      .| .  
ECI--NYGKFTTKSDVWSFGVCMWEIFTY--------------------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQ

DLLYKMLAFDPKERWTVEQCLYHEYF
 .  .  ..||..| | ...  ||.|
-IMKQCWHEDPEDRPTFSEI--HECF