Gene 18512 (Tetrahymena)
18512
Sequence
Protein domains of 18512.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 18512.AA | ERK | 40-327 | 58 | 5.70000000001e-217 | 727.09 | In-house | 1-307 (307) | Show / Hide |
Range on Protein: 40-327 Range on HMM: 1-307/307 Sequence Identity: 58% (180 aa) YRILEKIGQGAYGVVSAAIDQV-----KRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLT-HENVIGLESILLPKSREEFDDIYCVSELMETDLQQIIK |.|...||.|||||| .|||. ... |||||||.|||..||.||||||.||||... |||.|.|. |..|.|.|...|||||.|||||||.|||. YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN SDQQLTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLAR----SVAN----TKNDLTDYVTTRWYRPPELLLSWTDYTCAMDV |.|.|..|||..|.||||.|||||||||||||||||.|.||||||||||||||||| |... ..|..|.||.|||||.||..|||..||.|||. SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI WSVGIIFAELIKRKPLLPGSSSSDQLLRIFDLIGTP-LENEIQMIPYDEYRKFIRELPK--REPKQFEKIFSKAP--KEALDLLKKMLTFDFNKRITVEE ||.|.||||...||||.|| .. .|. |||..|||| |...|.|......|.|..||. |.||..|.||..|. ..|.|||.|||.||..||||||| WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE ALKHPYL .|.|||. CLEHPYF |
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Kinase | 18512.AA | MAPK | 40-327 | 53 | 6.30000000001e-189 | 633.93 | In-house | 1-328 (328) | Show / Hide |
Range on Protein: 40-327 Range on HMM: 1-328/328 Sequence Identity: 53% (175 aa) YRILEKIGQGAYGVVSAAIDQV------KRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLL-THENVIGLESILLP------KSREEFDDIYCVSELMET |.||..||||||||| .|||. . | ||||||...|. ...|||.||.|||| . |||.|.| |. | .|.|||.|||.|.||||| YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET DLQQIIKSDQQLTQDHCKFFIYQILRG--LKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANTKN--------------DLTDYVTTRWYRPP ||.|||||.|.|. ||...|.|||||| |||||||||||||||| |.|||.||||||||||||||...... ..|.||.||||| | DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP ELLLS--WTDYTCAMDVWSVGIIFAELIK-RKPLLPGSSSSDQLLRIFDLIGTPLENEIQMIP-YDEYRKFIREL---PKREPKQFEKIFSK----APKE |..|. |..|| |.|.|||| ||||... ||||.||... ||. .|....||| | || |. ....|..|. | ||. .|..||.|.. | . EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ ALDLLKKMLTFDFNKRITVEEALKHPYL |.|||.|||.|| .||||||||| |||. AIDLLEKMLVFDPDKRITVEEALQHPYF |
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Kinase | 18512.AA | CMGC | 40-327 | 28 | 1.1e-138 | 458.77 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 40-327 Range on HMM: 1-513/513 Sequence Identity: 28% (145 aa) YRILEKIGQGAYGVVSAAIDQVKRKS--------------VAIKKIEKAFDQRIYTK----------RTLRELKLLRLLT-----------------HEN | |..|||.|.|||| ..|. . |||||| ..| . | |.|||.|.|. | |.| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VIGLESILLPKS--REEFD----------DIYCVSELMETDLQQIIKSDQ---------QLTQDH------------CKFFI------YQILRGLK--YI ...| |. .| ..|.. ..| | |.|..|| |.||. | |.. | .|.|. |||||||| |. IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HSAN--VIHRDLKPRNLLVNSNCDL--------------------KICDFGLARSVANTKND---------------------LTDYVTTRWYRPPELLL ||.. .||||||| |.|.|.||.| |||||||||.. . ... .|.|| |||||.||.|| HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL SW---------TDYTCAMDVWSVGIIFAELIKR--------KPLLPGSSS-----------SDQLLRIFDLIGTP----------------LENEIQMIP .| ..||...|.|||| ||||.. . ||| ||.|. ||| .||...||| |. ..||. GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK --------------------YDEYRKFIRE---LPKREPKQFEKIFSK-----------------------------------APKEALDLLKKMLTFDF .. .|..|. .|.. || ....| . ....|.|||||||..| LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP NKRITVEEALKHPYL .||||.|.||.|||. DKRITAEQALQHPYF |
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Kinase | 18512.AA | p38 | 40-327 | 48 | 4.4e-136 | 458.4 | In-house | 1-289 (289) | Show / Hide |
Range on Protein: 40-327 Range on HMM: 1-289/289 Sequence Identity: 48% (142 aa) YRILEKIGQGAYGVVSAAIDQVKRKS---VAIKKIEKAFDQRIYTKRTLRELKLLRLLTHENVIGLESILLP--KSREEFDDIYCVSELMETDLQQIIKS |. |. .|.|||| |..|.|. .. |||||. . | . |. ||| |||.||... |||||.| . | .|...| |.| |...|..||..|.|. YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC DQQLTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANTKNDLTDYVTTRWYRPPELLLSWTDYTCAMDVWSVGIIFAE |.|. || .| .|||||||||||||..||||||| |. || .|.|.| |||||| . ...|.|| ||||| || .|.| .|| . |.|||| | || -QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR---HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAE LIKRKPLLPGSSSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNKRITVEEALKHPYL || ...| ||. ||| || ..||| | .| | .| | .|. .|... . |...|..| |.||| ||| | ||||.|||..|||. LITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF |
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Kinase | 18512.AA | ERK5 | 40-327 | 51 | 1.9e-127 | 429.71 | In-house | 1-295 (295) | Show / Hide |
Range on Protein: 40-327 Range on HMM: 1-295/295 Sequence Identity: 51% (153 aa) YRILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLTHENVIGLESILLPKS-REEFDDIYCVSELMETDLQQIIKSDQQL |.|.||||.||||||..|. . . |||||| |||. |||.||||.|| |.|.| . || || |. |.| | .||| || ||| |.| . YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF TQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLAR-----SVANTKNDLTDYVTTRWYRPPELLLSWTDYTCAMDVWSVGIIFA | .| ..|.|||||||||.|||.|||||||| ||||| ||.||| |||.|| | .. . .|.|| ||||| |||..| ||| |.|||||| || TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG ELIKRKPLLPGSSSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRE-LPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNKRITVEEALKHPYL |.| |. . || .|| | . .|.| || . | . .. . .| |.||..||.. || . ||||| .|| |. .|||| .||.||.| EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL |
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Kinase | 18512.AA | ERK1 | 40-327 | 50 | 4.8e-117 | 395.14 | In-house | 1-289 (289) | Show / Hide |
Range on Protein: 40-327 Range on HMM: 1-289/289 Sequence Identity: 50% (148 aa) YRILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLTHENVIGLESILLPKSREEFDDIYCVSELMETDLQQIIKSDQQLT | |. ||.||||.|..|.|.|... |||||| |. | .|||||.|.| |||.|... |. .. |.. |.| | .|||||| ...|. |.| YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS QDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANTKND----LTDYVTTRWYRPPELLLSWTDYTCAMDVWSVGIIFAEL || .|.|||||||||||||||.|||||| |||.| |||||||||||| .| . | ||.|| ||||| ||..| || ..|.|||| | ||. NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM IKRKPLLPGSSSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNKRITVEEALKHPYL . .|. || ||| | ..| | ..... | . | ... || .. ....| || . ||||| ||||| .||||||||| |||| LSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL |
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Kinase | 18512.AA | ERK7 | 40-327 | 40 | 1.9e-109 | 369.92 | In-house | 1-292 (292) | Show / Hide |
Range on Protein: 40-327 Range on HMM: 1-292/292 Sequence Identity: 40% (119 aa) YRILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLT-HENVIGLESILLPKSREEFDDIYCVSELMETDLQQIIKSDQQL | |....|.||||.| |.|. .. ||.||| || .. || || .|. . |.|.| | .. . ||| | | ||||| .|. . | YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDR---DIYLVFEFMETDLHAVIRKGNIL TQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANTK------NDLTDYVTTRWYRPPELLLSWTDYTCAMDVWSVGIIF | .. .||.|| .||.||.||||||||| |.|..|.| .|.||||||||.|... .||.|| ||||| || ||. . || . | ||.| | KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL AELIKRKPLLPGSSSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNKRITVEEALKHPYL .|... ||. ||.| .|. .| ..|. | . .|. | . . . .......|...... .....|.||||..| | .||.|.|.||.||| GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV |
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Kinase | 18512.AA | nmo | 41-327 | 45 | 1.7e-106 | 328.56 | In-house | 2-292 (292) | Show / Hide |
Range on Protein: 41-327 Range on HMM: 2-292/292 Sequence Identity: 45% (134 aa) RILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLTHENVIGLESILLPKSREEFDDIYCVSELMETDLQQIIKSDQQLTQ . || ||.||| . | | ||.||. . | . . .|| ||||.| |.||. . || | . |..|| | ||| || .|| | |.|. QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS DHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSV-ANTKNDLTDYVTTRWYRPPELLLSWTDYTCAMDVWSVGIIFAELIKRK || | |.|||||||||.||||..|||.|| |||||||| |||||||||| ... ..| | | .|| ||.|. || |.|.|||| |||||..|. DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRR PLLPGSSSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREP--KQFEKIFS--KAPKEALDLLKKMLTFDFNKRITVEEALKHPYL | | .|| | ||.||| .... . . . |...| .. .. | .| || .||..|| || .||| ...||.|||| ILFQAQSPIQQLQMITDLLGTPSMEDMKYA-CEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL |
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Kinase | 18512.AA | CDK | 40-327 | 35 | 2.7e-97 | 311.82 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 40-327 Range on HMM: 1-284/284 Sequence Identity: 35% (115 aa) YRILEKIGQGAYGVVSAAIDQVKR-----KSVAIKKIEKAF-----DQRIYTKRTLRELKLLRLLTHENVIGLESILLPKSRE----EF--DDIYCVSEL | .|||||.|.|||| |.|. . ||.||| . ..|| .||. | |.|.. | . . |... . .| | | YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY METDLQQIIKSDQQLTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCD-----LKICDFGLARSVAN------TKNDLTDYVTTRWYRPPEL |..|| .... .| ...|.|||| |.|| ...|||||| |.|.|.| ||| |||||| . . .| | |.|||.||| MDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPEL LLSWTDYT--CAMDVWSVGIIFAELIK---RKPLLPGSSSSDQLLRIFDLIGTPLENEIQ-MIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKK || ..|. .. |.|||| ||||.. ||||.||.| ||| .||...||| |. . . .| ||| | LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLNK MLTFDFNKRITVEEALKHPYL ||..| .|||. |.||.|||. MLCYDPKKRISAEQALQHPYF |
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Kinase | 18512.AA | S_TKc | 40-327 | 29 | 2.8e-93 | 317.1 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 40-327 Range on HMM: 1-231/231 Sequence Identity: 29% (90 aa) YRILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLTHENVIGLESILLPKSREEFDDIYCVSELMET---DLQQIIKSDQ |.||.|||.||.|.| ... . ||||.| ....||...|. |.|.. | . |..| | |.... || ..||. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG Q------LTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANTKNDLTDYVTTRWYRPPELLLSWTDYTC-AMDVWSVG .. |..|..|||...|.|.|| ..||||||| |.|... .||||||||| . | .. |.||..||.| |.. . |.||.| RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG IIFAELIKRKPLLPGSSSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNKRITVEEALK------ .|..|.. ..|. | |. ..|..|| ..||.|...|.|..| .||.|. |||. CILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK -HPYL ||.. CHPWF |
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Kinase | 18512.AA | Pkinase | 40-327 | 31 | 3.7e-90 | 310.62 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 40-327 Range on HMM: 1-293/293 Sequence Identity: 31% (96 aa) YRILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLR--ELKLLRLLTHENVIGLESILLPKSREEFDDIYCVSELMET-----DLQQII |.|..|||.|..|.| .... .| ||.|.|.| . .. .| |..... | |.|.. | . |.|| | |..| || .| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI K--SDQQL--TQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDL----KICDFGLARSV-ANTKNDLTDYVTTRWYRPPELLLSWTDYTCAM . .. . . ..|||..|||||||.|.|| ..||||||| |.|...|... ||||||||. . . .|... |.||..||.... ..|. . STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV DVWSVGIIFAELIKRKPLLPGS----SSSDQLLRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNKRITVE |.||.|.|..|.. ..|. ||. . ||. .|. |.||. ... |.. .| . . . ... ....|..|..|..|..| .||.| | DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE EALKHPYL ..|.||.. QILQHPWF |
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Kinase | 18512.AA | MAPK-Unclassified | 40-191 | 49 | 7.3e-77 | 261.66 | In-house | 1-159 (575) | Show / Hide |
Range on Protein: 40-191 Range on HMM: 1-159/575 Sequence Identity: 49% (78 aa) YRILEKIGQGAYGVVSAAIDQVK-RKSVAIKKIEKAFDQRIYTKRTLRELKLLRLLTHENVIGLESILLPKSREE--FDDIYCVSELMET---DLQQIIK | . ||.||||.| |.| . |||||. ..| . .||.|||. .|| | |.|.| . |. .|. . ||||| | ..|.| || |||| YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK SDQ-QLTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSV |.| . | . |.|||||||||.|||..||||||| |||.| .| ..|||||..||. SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSI |
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Kinase | 18512.AA | MAPK-Unclassified | 192-327 | 33 | 1.3e-47 | 164.52 | In-house | 399-575 (575) | Show / Hide |
Range on Protein: 192-327 Range on HMM: 399-575/575 Sequence Identity: 33% (59 aa) ANTKNDLTDYVTTRWYRPPELLLSWTDYTCAMDVWSVGIIFAELIKR-----------KPLLPGSS--------------------SSDQLLRIFDLIGT .... ..| || ||||| ||..|| .|. . | ||.| ||||.. . .||.||.. ..||. ||| |. CHHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGM PLENEIQMIPYDEYRKFIRELPKREPKQFE-KIFSKAP---------KEALDLLKKMLTFDFNKRITVEEALKHPYL | | .. | | ||.|. . . | | .|.||| |..|...||| |. .|||| ..||.||| PPEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF |
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Kinase | 18512.AA | Pkinase_Tyr | 40-227 | 29 | 8.7e-18 | 60.87 | Pfam | 1-199 (270) | Show / Hide |
Range on Protein: 40-227 Range on HMM: 1-199/270 Sequence Identity: 29% (61 aa) YRILEKIGQGAYGVVSAAIDQ----VKRKSVAIKKIEKAFDQRI-YTKRTLRELKLLRLL-THENVIGLESILLPKSREEFDDIYCVSELMET-DLQQII ....|.|.||.|.| .. .. ||.|.. ... . . .||.|... | |.|.. | . ..... || | |.|. || ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYL KS----DQQLTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANTKNDLTDYVTT-------RWYRPPELLLSWTDYTC .. .|.|| . . .|| .|. | .| | ||||| || ||..| ||||||||| . .. | |... .|. .|| . .| RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTT AMDVWS . |||| KSDVWS |
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Kinase | 18512.AA | TyrKc | 40-327 | 23 | 4.3e-15 | 21.29 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 40-327 Range on HMM: 1-280/280 Sequence Identity: 23% (72 aa) YRILEKIGQGAYGVVSAAIDQVKRKSVAIKKIEKAFDQRIYTKRTLRELKLLRLL--THENVIGLESILLPKSREEF---DDIYCVSELMET-DLQQIIK . ..|.| ||.|.| .. ||.|.. . . .||..... | |.|.. | . . ..| | . .. | |.|. ||.. .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR SDQQ-LTQDHCKFFIYQILRGLKYIHSANVIHRDLKPRNLLVNSNCDLKICDFGLARSVANT-------KND------LTDY-VTTRWYRPPELLLSWTD . . |. .. | .|| .| |.|| |.||||| || ||..| ||.||||.| . . . ... . ||. .|| . KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK YTCAMDVWSVGIIFAELIKRKPLLPGSSSSDQL----LRIFDLIGTPLENEIQMIPYDEYRKFIRELPKREPKQFEKIFSKAPKEALDLLKKMLTFDFNK .| . |||| |. |. . | . . ...| . . ..| . | . | .|.| .. |. .| .. FTTKSDVWSFGVCMWEIFTY-----GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------FVCCPDEMYQIMKQCWHEDPED RITVEEALKHPYL | | .| | .. RPTFSEI--HECF |