Gene 13785 (Tetrahymena)
13785
Sequence
Protein domains of 13785.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 13785.AA | ERK | 52-334 | 40 | 5.3e-157 | 527.89 | In-house | 1-307 (307) | Show / Hide |
Range on Protein: 52-334 Range on HMM: 1-307/307 Sequence Identity: 40% (128 aa) YRILKQIGFG-FNPTFTAIDQE-----YGQKVIIEVIKIENDDLIYMNQLIRQIKIENHFK-HENISSNLHIMMES-----KNLYIVREFIDTDLHRVNF |.|.||||.| ......|||.| ||||.|..|....|..||.....|.||...||| ||||.....|||.. ...|.|.|...||||.... YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN SKQELTDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRFIGTNFPNE-----------IYSQYITSDYFLSPQQILNLPKNLSKTDI |.|||.|||.|||.||||..|...||.||.|..|. ||||.|.||||||..|........ ....|...... .|...|...|. ...|| SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI WHVGVIILGLINRDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEELLQYQDYKGLYQYIIKYSK-----KSWQDVFPDAN--PLLCDLLDKMLVFNEDK |..|.|. ....|...|. |..|.. ||.||..||||..|| |||........||..... |.|...||.|| |. .|||.|||||..|| WSCGCIFAEMLGRKPLFP------GKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDK RYTVKECLQHPYF |.||.|||.|||| RITVEECLEHPYF |
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Kinase | 13785.AA | Ciliate-E7 | 52-334 | 47 | 1.5e-133 | 450.02 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 52-334 Range on HMM: 1-290/290 Sequence Identity: 47% (139 aa) YRILKQIGFGFNPTF--TAIDQEYGQKVIIEVIKIENDDLIYMNQLIRQIKIENHFKHENIS-SNLHIMMESKNLYIVREFIDTDLHRVNFSKQELTDDH | |.. | . | .||.||.||..| .|. |. | | . |. .|..||. ||.| .|.|..||..|.|.|..| .| | . .|.|.|||.| YQIKREIWYDTYIYFCKAYIDREYQQKQFIYYIFYEQCYLKYIIKAIEIQKFLNHENHEKIYNFNFHSYMEINNMYVVSDFMQTNLKYITQSRQQLTDEH IQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRFIG--TNFPNEIYSQYITSDYFLSPQQILNLPKNLSKTDIWHVGVIILGLINRDTFFS |..| |||| || ..|||..||||| |..| |||.||| ||. |||.|| ..|| |..||. |. .. ..|||||||||.|.| ||.| ||| IKWFMYQILRALHYIHSQKIYHTQLTPRFIQINQNCDIKISDFIWCIGNFPHEINKKYINKNYYMSPYYIVEQMETFSKTDIWHVGCIFLELIQRYKFFS NLSNQLGGGYLGLINAIFSYIGTPSGE--ELLQYQDYKGLYQYII---KYSKKSWQDVFPDANPLLCDLLDKMLVFNEDKRYTVKECLQHPYF ..| |.| ..| ..| .. | |..| .|. | | |.|||..|| ||||||||||||||||||||..|||||||||| DFCC---HDYNGVITQYFYFCGSQNEEDLDLKYYKQYNRQYNQLKMPKQYCKQSWQVQFPNANPLLCDLLDKMLVFNEDKRFNVKECLQHPYF |
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Kinase | 13785.AA | MAPK | 52-334 | 35 | 2e-105 | 356.56 | In-house | 1-328 (328) | Show / Hide |
Range on Protein: 52-334 Range on HMM: 1-328/328 Sequence Identity: 35% (120 aa) YRILKQIGFG-FNPTFTAIDQE------YGQKVIIEVIKIENDDLIYMNQLIRQIKIENHF-KHENISSNLHIMMES-----------KNLYIVREFIDT |.|||.||.| . . |||.. .|.|| | | ...... .| ||. .|| .|||| . |.|.. . . .|||.|. .| YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET DLHRVNFSKQELTDDHIQYFTYQILSA--LFFLHSQNVYHTQLRLSNILLNKNCDLKISRF----IGTNFPNEIY-------------SQYITSDYFLSP |||.. | |.|.|||||||.|||| . |...|| || | | ||||.|.|||||| | . .. .... ..|.. . .| DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP QQILN--LPKNLSKTDIWHVGVIILGLIN-RDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEELLQYQD-YKGLYQYII------KYSKKSWQDVFPD- .|| . .. . |.|.|| | ... | ..| | |. .| |....||| ||..|. .. ..|| || ||.|...||. EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFP------GKDYIDQWNLIMEVLGTP-SEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNA ---ANPLLCDLLDKMLVFNEDKRYTVKECLQHPYF |||. .|||.|||||. |||.||.|.|||||| NFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF |
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Kinase | 13785.AA | CMGC | 52-334 | 18 | 1e-64 | 211.2 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 52-334 Range on HMM: 1-513/513 Sequence Identity: 18% (96 aa) YRILKQIGFG-FNPTFTAID--------------QEYGQKVIIEVIKIENDDLIYMN----------QLIRQIKIENHFK-----------------HEN | |.|.|| | . . ..| |....| | || . . . . .| ||| |.. |.| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN ISSNLHIMMESK-----------------NLYIVREFIDTDLHRVNFSKQ---------ELTDDH------------IQYFT------YQILSA--LFFL | . . | . .. .||.| |..|.||... ..| .|.. | |.||. |||| . |... IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HSQN--VYHTQLRLSNILLNKNCDL--------------------KISRF---IGTNFP---------------------NEIYSQYITSDYFLSPQQIL ||.. . |. | .|||.|.||.| || | .. . |. |..|. . . .| .| HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL NL---------PKNLSKTDIWHVGVIILGLINR--------DTFFSNLSNQ-----LGGGYLGLINAIFSYIGTPS---------------GEELLQYQD . . .. |.| || |. .... ...| |.. | .. .. || .|||. || .. . GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK --------------------YKGLYQYIIK------YSKKSWQDVFPD-----------------------------------ANPLLCDLLDKMLVFNE ... ..|| . . .|.|...||. ..|.. |||.|||... LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP DKRYTVKECLQHPYF ||| |....|||||| DKRITAEQALQHPYF |
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Kinase | 13785.AA | ERK5 | 52-334 | 31 | 3e-41 | 143.34 | In-house | 1-295 (295) | Show / Hide |
Range on Protein: 52-334 Range on HMM: 1-295/295 Sequence Identity: 31% (95 aa) YRILKQIGFG-FNPTFTAIDQEYGQKVIIEVIKIENDDLIYMNQLIRQIKIENHFKHENISSNLHIMM------ESKNLYIVREFIDTDLHRVNFSKQEL |.|. .|| | . |. . ||.| | | | . .| .|| ||.|.|| |.| | |. |.| . .. ||| . | | . YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF TDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRF-----IGTNFPNE---IYSQYITSDYFLSPQQILNLPKNLSKTDIWHVGVIIL | .|| || |||| | ..|| .| | |. ||.| | ||.||| | . | |.. .|. .. | .. . |.| || |. TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG GLINRDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEELLQYQDYKGLYQYIIK----YSKKSWQDVFPDANPLLCDLLDKMLVFNEDKRYTVKECLQHP .| | .| | |. .. | .|.|. ..| .| |. | | |. |.| | . ||| .||.| .| || . |||| EMIARRQMFP------GKNYIHQLQLIMMVLGMPP-PHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHP YF . FL |
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Kinase | 13785.AA | ERK1 | 52-334 | 34 | 5.8e-37 | 129.13 | In-house | 1-289 (289) | Show / Hide |
Range on Protein: 52-334 Range on HMM: 1-289/289 Sequence Identity: 34% (103 aa) YRILKQIGFG-FNPTFTAIDQEYGQKVIIEVIKIENDDLIYMNQLIRQIKIENHFKHENISSNLHIMMES-----KNLYIVREFIDTDLHRVNFSKQELT | |. || | . |.|. .|.| | | . | .| ||| . |||||| |. . . .||| . ..||| .. |.| YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKL-LKTQHLS DDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRF--IGTNFPNE----IYSQYITSDYFLSPQQILNLPKNLSKTDIWHVGVIILGLI ||| || |||| | ..|| || | |. ||.|||. ||||| | |. |. .. | .|| ||| || |. .. NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML NRDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEEL--LQYQDYKGLYQYIIKYSKKSWQDVFPDANPLLCDLLDKMLVFNEDKRYTVKECLQHPYF | | || .| | . .| || ..| . . . | . .| .|. .||.| . ||||||| || .|| || | | ||| SNRPIFP------GKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL |
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Kinase | 13785.AA | p38 | 117-334 | 33 | 7.7e-33 | 109.37 | In-house | 77-289 (289) | Show / Hide |
Range on Protein: 117-334 Range on HMM: 77-289/289 Sequence Identity: 33% (73 aa) MMESKNLYIVREFIDTDLHRVNFSKQELTDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRFIGTNFPNEIYSQYITSDYFLSPQQI |.. .. |.| .| ..||... | |.|||||. |||| .| . || .. | | ||| .| .|.|.| | . .|. ...| . MNDFQDVYMVTHFMGADLNNI-MKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIM LNLPKNLSKTDIWHVGVIILGLINRDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEEL--LQYQDYKGLYQYIIKYSKKSWQDVFPDANPLLCDLLDKM || . . ||| || |. || . | | | .. .. | . .|||. | . .| . . | . .. .. ..||. |||. |||.|| LNWMHYTQTVDIWSVGCIMAELITGRTLFP------GDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKM LVFNEDKRYTVKECLQHPYF |. .||| |..| .||||| LELDPDKRITAEEAMQHPYF |
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Kinase | 13785.AA | S_TKc | 52-334 | 21 | 1e-27 | 99.35 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 52-334 Range on HMM: 1-231/231 Sequence Identity: 21% (65 aa) YRILKQIGFG-FNPTFTAIDQEYGQKVIIEVIKIENDDLIYMNQLIRQIKIENHFKHENISSNLHIMMESKNLYIVREFIDT---DLHRVNFSKQE---- |.||..|| | | . ... . |..| | .|| ....| |.| . .|.|| . .. . ..||.| |..|. ||... ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --LTDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKI-----SRFIGTNFPNEIYSQYITSDYFLSPQQILNLPKNLS-KTDIWHVGVII .. |.....|||..|| ..||... | | .||||.. .|| .|.. . .. . ....| . . | |.| .|.|. FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL LGLINRDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEELLQYQDYKGLYQYIIKYSKKSWQDVFPDANPLLCDLLDKMLVFNEDKRYTVKECLQ----- .. . . |. ....| || | ..|...|.|... .||.|. |.|| YEMLCGYPPFP------------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI --HPYF ||.| KCHPWF |
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Kinase | 13785.AA | nmo | 53-245 | 30 | 2.2e-26 | 77.62 | In-house | 2-204 (292) | Show / Hide |
Range on Protein: 53-245 Range on HMM: 2-204/292 Sequence Identity: 30% (62 aa) RILKQIGFG-FNPTFTAIDQEYGQKVIIEVIKIENDDLIYMNQLIRQIKIENHFKHENISSNLHIMMESKN-----LYIVREFIDTDLHRVNFSKQELTD . . ||.| | .. | |..| . . .|. | .|. |||.|. | | |. . .|.| | . |||.. | |.|. QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS DHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRFIGTNFPNEIYSQYITSD----YFLSPQQILNLPKNLSKTDIWHVGVIILGLINRD ||.. | |||| | .||| |. | .. |.|.| || ||| | .. |. .| . |. | .. . | ||| || | |. | DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRR TFF | ILF |
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Kinase | 13785.AA | ERK7 | 106-191 | 39 | 1.7e-16 | 52.62 | In-house | 57-144 (292) | Show / Hide |
Range on Protein: 106-191 Range on HMM: 57-144/292 Sequence Identity: 39% (35 aa) KHENISSNLHIMMESKN--LYIVREFIDTDLHRVNFSKQELTDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKISRF .|.|| . . .. . . .|.| || .|||| | . | | | || ||.| |. ..|| || | |. |||||. .| .|. | CHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDF |
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Kinase | 13785.AA | Pkinase | 52-189 | 23 | 4.8e-15 | 54.27 | Pfam | 1-154 (293) | Show / Hide |
Range on Protein: 52-189 Range on HMM: 1-154/293 Sequence Identity: 23% (36 aa) YRILKQIGFG-FNPTFTAIDQEYGQKVIIEVIKIENDDLIYMNQLIR--QIKIENHFKHENISSNLHIMMESKNLYIVREFIDT-----DLHRVNF--SK |.|...|| | | . .... .|..| . .|| .... ...| |.| ....|.|| ..........|.| |. . ||... .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH QEL--TDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDL----KIS . ...... . ||||..| ..||... | | ..|||...|... ||. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC |
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Kinase | 13785.AA | MAPK-Unclassified | 97-188 | 37 | 2.8e-13 | 43.88 | In-house | 48-150 (575) | Show / Hide |
Range on Protein: 97-188 Range on HMM: 48-150/575 Sequence Identity: 37% (39 aa) RQIKIENHFKHENISSNLHIMM--ESKN-----LYIVREFIDT---DLHRVNFSKQ-ELTDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCD | | | . |.|| | . | .| .||| .. | ||| . | | . . |||||.|||| | ||| .. | | ||.|.| .| REIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCS LKI ..| VRI |
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Kinase | 13785.AA | ERK7 | 227-334 | 25 | 1.7e-11 | 35.24 | In-house | 189-292 (292) | Show / Hide |
Range on Protein: 227-334 Range on HMM: 189-292/292 Sequence Identity: 25% (28 aa) DIWHVGVIILGLINRDTFFSNLSNQLGGGYLGLINAIFSYIGTPSGEEL--LQYQDYKGLYQYIIKYSKKSWQDVFPDANPLLCDLLDKMLVFNEDKRYT | | .| |. .. | | . |. | |. |. |.. .. . . . ... .|. ....|.. . ||| ..|||| .|| | DMWSIGCILGEMLRGKPMFP------GTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLT VKECLQHPYF ....||||| AEQALQHPYV |
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Kinase | 13785.AA | MAPK-Unclassified | 296-334 | 32 | 2.1e-10 | 33.33 | In-house | 527-575 (575) | Show / Hide |
Range on Protein: 296-334 Range on HMM: 527-575/575 Sequence Identity: 32% (16 aa) WQDVFPDANP----------LLCDLLDKMLVFNEDKRYTVKECLQHPYF . | .. ..| . |...|||.|| ||.| . |.|||| FTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF |
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Kinase | 13785.AA | nmo | 309-334 | 50 | 3.7e-10 | 26.81 | In-house | 267-292 (292) | Show / Hide |
Range on Protein: 309-334 Range on HMM: 267-292/292 Sequence Identity: 50% (13 aa) DLLDKMLVFNEDKRYTVKECLQHPYF .|| .||.|. ||| .|. |.||| HLLCRMLHFDPDKRISCKDALAHPYL |
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Kinase | 13785.AA | Pkinase | 299-334 | 27 | 5.8e-09 | 32.78 | Pfam | 259-293 (293) | Show / Hide |
Range on Protein: 299-334 Range on HMM: 259-293/293 Sequence Identity: 27% (10 aa) VFPDANPLLCDLLDKMLVFNEDKRYTVKECLQHPYF . . ... ..|.....| .. ||.| ...||||.| F-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 13785.AA | TyrKc | 52-252 | 15 | 3.8e-05 | -139.35 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 52-252 Range on HMM: 1-280/280 Sequence Identity: 15% (47 aa) YRILKQIG--------FGFNPTFTAIDQEYGQKVIIEV-IKIENDDLIYMNQLIRQIKIENHF--KHENISSNLHIMMES-------KNLYIVREFIDT- . .|..| | |.| .| ..| . ..| ..| .. .|.|| . . ... . |.|| |. . ITLGKKLGEGAFGEVYKGTWK--------------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG DLHRVNFSKQE-LTDDHIQYFTYQILSALFFLHSQNVYHTQLRLSNILLNKNCDLKI-----SRFI-------------------GTN--FP-------- ||. .... |. .. .| .|| . .|||.|. | | |.|...| || ||.| |.. .| DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC --NEIYSQ----------------YITSDYF------LSPQQILNLPKNLSKTDIWHVG-------------VIILGLINRDT----FFSNLSNQL ... | . | .|.|..... |. .. . . |.. ..| ||.. .. INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |