Gene 2636 (Tetrahymena)

2636

Species: Tetrahymena
Alias: 3746.m00320, 2636, PreTt02636, 299, 198.m00056, TTHERM_01016020
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
2636.AA Protein None 372 None Fasta, JSON
2636.kin_dom Protein Kinase Domain None 290 None Fasta, JSON
2636.NA RNA None 1119 None Fasta, JSON

Protein domain

Protein domains of 2636.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2636.AA GSK 75-364 37 4.1e-168 518.05 In-house 1-328 (328) Show / Hide 
Range on Protein: 75-364
Range on HMM: 1-328/328
Sequence Identity: 37% (122 aa)

YEIKRVIGSGSFGYVFEAYDN----NNQRT----VALKRIQKVGKKL-SREYEILLDI---KDCDYVVKMIDLYYSK---TDDNKLIQN-IVFEYMENNL
||...|||.||||.|..||.|    .....    || |....  .   .||..|. ..   .... .|...  .|..   .|.|....| .|.|||...|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPN-IVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTL

EDHISKFNKSKKVIPEQTVKEYAYQILKGLQYIHSKGIAHRDLKPDNILLN-DDGKVKICDFGGSKYIDE--KGKNTPYIVSRYYRAPELILCITKYNQK
...| ...|.|...|....| |.||...||.|.||.||.|||.||.|||.. |.|..|||||| .|....  . .|..||.||||||||||...|.|...
YQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQ

IDMWSFGCILGELVTTFPLFQGKTEGDQLFSIFKVLGSPTKEEFQKFSERVPFDKKIFDEFQTYEPQNLRK-------------------MFFYIKDIDN
||.||.||...|.....|||.|... |||. |.|.||.||||..|.. .. |. |. ...||...|....|                   ||........
IDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQ

-LMDLITKCLQYLPENRITADEALQHPFF
 ..|||.|||.| |..|....||..||||
DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 2636.AA CMGC 75-364 23 1.1e-118 391.87 In-house 1-513 (513) Show / Hide 
Range on Protein: 75-364
Range on HMM: 1-513/513
Sequence Identity: 23% (121 aa)

YEIKRVIGSGSFGYVFEAYD--------------NNNQRTVALKRIQKVGKKLS----------------REYEILLDIK----------------DCDY
||| ..||.|..| |....|              ..... ||.|.| ..  .                  || .||  ..                .  .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVKMIDLYYSKTDDNKL------------IQNIVFEYMENNLEDHISKFNKS------------------------KKVIPEQTVKEYAYQILKGLQ--Y
.||..| .|.| .|...              ..|||||...| . | . ..                         .| ..   .. |.||||.||   |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IHSKG--IAHRDLKPDNILLNDD--------------------GKVKICDFGGSKYIDEKGK----------------------NTPYIVSRYYRAPELI
.||..  | |||||| |||.|..                    |..|||||| ......  .                      .|.|.|.|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LCI---------TKYNQKIDMWSFGCILGELVTT--------FPLFQGKTE-----------GDQLFSIFKVLGSPT---------------KEEFQKFS
|           ..|...|||||.|||..|..|          |||.|..|            |||| ||||||.||               .||. ...
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

ERVPFDKKI-----------FDE-----------FQTYEPQNLRKMFFYIK---------------------------------DIDNLMDLITKCLQYL
.   ..|..           ..|           |... |......|  ..                                 . . . ||. |.||| 
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PENRITADEALQHPFF
|..||||..|||||.|
PDKRITAEQALQHPYF
Kinase 2636.AA S_TKc 75-364 31 1.7e-91 311.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 75-364
Range on HMM: 1-231/231
Sequence Identity: 31% (96 aa)

YEIKRVIGSGSFGYVFEAYDNNNQRTVALKRIQKVGKKLSREYEILLDIKDCDYVVKMIDLYYSKTDDNKLIQNIVFEYMEN---NLEDHISKFNKSK--
||| |.||.|.|| |. ..... .| ||.|.|    ... || .||    .....||..| ...          .|.||...   .| |.| | .. .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

KVIPEQTVKEYAYQILKGLQYIHSKGIAHRDLKPDNILLNDDGKVKICDFGGSKYIDEKGKNTPYIVSRYYRAPELILCITKYNQ-KIDMWSFGCILGEL
...|| ... |.|||...|.|.||.|| ||||||.||||..   .|||||| .. .      | ......|.|||..    .|.  |.|.||.|||| |.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

VTTFPLFQGKTEGDQLFSIFKVLGSPTKEEFQKFSERVPFDKKIFDEFQTYEPQNLRKMFFYIKDIDNLMDLITKCLQYLPENRITADEALQ-------H
..  |.|.      |.. .||..|                                          . . |.| ||||. ||.|.|| ||||       |
LCGYPPFP------QMQMMFKKIG-----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PFF
|.|
PWF
Kinase 2636.AA CDK 75-364 32 2e-90 289.5 In-house 1-284 (284) Show / Hide 
Range on Protein: 75-364
Range on HMM: 1-284/284
Sequence Identity: 32% (106 aa)

YEIKRVIGSGSFGYVFEAYDNNNQ-----RTVALKRI-------QKVGKKLS----REYEILLDIKDCDYVVKMIDLYYSKTDD--------NKLIQNIV
||.   || |..| |. | | ...     . ||||.|       .. .  ..    ||  .| ..  ....|| .| ...|..|        |||   .|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLY--MV

FEYMENNLEDHISKFNKSKKVIPEQTVKEYAYQILKGLQYIHSKGIAHRDLKPDNILLNDDGK-----VKICDFGGSKYID-------EKGKNTPYIVSR
||||.  |   ..             .| | .|.|.|| |.||..| |||||| |||.|..|.     .|| ||| ..          .  . |. .| .
FEYMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTL

YYRAPELILCITKYN--QKIDMWSFGCILGELVT---TFPLFQGKTEGDQLFSIFKVLGSPTKEEFQKFSERVPFDKKIFDEFQTYEPQNLRKMFFYIKD
 |||||| |  ..|.    |||||.|||..|..|     |||.|..| |||| ||...|.|| .    ...   .                         
WYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------

IDNLMDLITKCLQYLPENRITADEALQHPFF
     ||. |.|.| |..||.|..|||||.|
-----DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 2636.AA Pkinase 75-364 30 2.6e-83 287.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 75-364
Range on HMM: 1-293/293
Sequence Identity: 30% (97 aa)

YEIKRVIGSGSFGYVFEAYDNNNQRTVALKRIQKVGKKLSR--------EYEILLDIKDCDYVVKMIDLYYSKTDDNKLIQNIVFEYMENNLEDHISKF-
|.|.|.||||||| |..... .....||.|.| |...| .         | .|.. . .....|...| ...   ....   .|.||.|. |. ... | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---KDHIY--MVMEYCEGGLY-VMDLFD

---NKSKKVI--PEQTVKEYAYQILKGLQYIHSKGIAHRDLKPDNILLNDDGKV----KICDFGGSKY--IDEKGKNTPYIVSRYYRAPELILCITKYNQ
    ......  .|...| |.||||.||.|.||.|| ||||||.|||....| .    |||||| .|   .  .. .| . ....|.|||.|.  ..| .
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KIDMWSFGCILGELVTTFPLFQGK----TEGDQLFSIFKVLGSPTKEEFQKF-----SERVPFDKKIFDEFQTYEPQNLRKMFFYIKDIDNLMDLITKCL
|.||||.|||| |...  |.|.|.    .  ||.. |....| |.......      .. ... .                ..| ..  ... |.|..||
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-----------F-HWTF-HNWSEECKDFIKWCL

QYLPENRITADEALQHPFF
.. |. |.||...||||.|
CKDPKKRPTAEQILQHPWF
Kinase 2636.AA CDC2 75-364 34 8.2e-79 241.74 In-house 1-301 (301) Show / Hide 
Range on Protein: 75-364
Range on HMM: 1-301/301
Sequence Identity: 34% (107 aa)

YEIKRVIGSGSFGYVFEAYDNNNQRTVALKRIQKVGKKLS--------REYEILLDIKDCDYVVKMIDLYYSKTDDNKLIQNIVFEYMENNLEDHISKFN
|.  . || |..| |. . |.  .. ||||.|                ||  .| ..|| . .||  | ...    |||   .||||.. .|     . .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ----NKLY--MVFEYLDMDLKKYMDMSI

KSKKVIPEQTVKEYAYQILKGLQYIHSKGIAHRDLKPDNILLNDDGKVKICDFGGSKYIDEKGKN-TPY--IVSRYYRAPELILCITKYNQKIDMWSFGC
...|..|.|.||.|.||||.|. . |...| ||||||.|||....|..|| ||| .. .    .. |.   .| . |||||. |   .|.  .||||.||
PKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGC

ILGEL---VTTFPLFQGKTEGDQLFSIFKVLGSPTKEEFQKFSERVPFDKKIFDEFQTYEPQNLRKM-----FFYIKDIDNLMDLITKCLQYLPENRITA
|. |.   ||  |||.|. | |||| ||..||.|. ....  ..   . |  | ....  .... ..      . .   .. .||. . ||| |..||.|
IFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDY-KNTFPRWKPQDLSKICPNNQKKKNQ-SCLDPEGIDLLMQMLQYDPQKRISA

DEALQHPFF
.||||||.|
KEALQHPYF
Kinase 2636.AA RCK 149-364 37 1.1e-78 249.26 In-house 77-298 (298) Show / Hide 
Range on Protein: 149-364
Range on HMM: 77-298/298
Sequence Identity: 37% (86 aa)

IVFEYMENNLEDHISKFNKSKKVIPEQT--VKEYAYQILKGLQYIHSKGIAHRDLKPDNILLND---------DGKVKICDFGGSKYIDEKGKNTPYIVS
.|||||..||   .  | ...| .||..  .| . ||||.|| ..|..|. |||||| ||....         .. .||.||| .. |  |  .| |. .
FVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVST

RYYRAPELILCITKYNQKIDMWSFGCILGELVTTFPLFQGKTEGDQLFSIFKVLGSPTKEEFQKFSERVPFDKKIFDEFQTYEPQNLRKMFFYIKDIDNL
|.|||||..|  |.|| ..|.|..|||  || . .||| |  | ||.| | ||.|.|.|..  .... .   .. |. |. .....| . .  .    ..
RWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLA--SQMNFN-FPQCKGMPLKQLIPNCS--QDC

MDLITKCLQYLPENRITADEALQHPFF
..|..|.||. |. |||| .|||||.|
IELMEKMLQWDPQKRITAQQALQHPYF
Kinase 2636.AA MAPK 149-364 36 4.9e-68 232.34 In-house 93-328 (328) Show / Hide 
Range on Protein: 149-364
Range on HMM: 93-328/328
Sequence Identity: 36% (89 aa)

IVFEYMENNLEDHISKFNKSKKVIPEQTVKEYAYQILKG--LQYIHSKGIAHRDLKPDNILLNDDGKVKICDFGGSKYIDEK---GKN------------
||.|.|| .|     .  || .   .. ..   ||||.|  |.|||| .. |||||| |||.| .. .|||||| .  || .    ..            
IVMELMETDL----HQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHM

TPYIVSRYYRAPELILC--ITKYNQKIDMWSFGCILGELVT-TFPLFQGKTEGDQLFSIFKVLGSPTKEEFQKFS--ERVPFDKKIFDEF---QTYEPQN
|.|.. |.|||||..|    ..|....|||| |||..|..|   |||.||   ||.. |..|||.|..|  |. .  |..   .. .  .   . | ...
TEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHA---RNYIQSLGNLPKYPKKP

LRKMFFYIK--DIDNLMDLITKCLQYLPENRITADEALQHPFF
..|||        .   ||. | |.  |. |||..||||||.|
WEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 2636.AA DYRK 149-364 36 2.5e-64 220.05 In-house 78-320 (320) Show / Hide 
Range on Protein: 149-364
Range on HMM: 78-320/320
Sequence Identity: 36% (90 aa)

IVFEYMENNLEDHISKFNKSKKVIPEQTVKEYAYQILKGLQYIHSK-GIAHRDLKPDNILLNDD---GKVKICDFGGSKYIDEKGKNTPYIVSRYYRAPE
|||| .. || . . |.|. ..... . |. .|.|||..| ..|..  | | ||||.||.|..      .|..||| | ....  . ..||.||.|||||
IVFELLSMNLYEFL-KNNHFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ--RIYTYIQSRFYRAPE

LILCITKYNQKIDMWSFGCILGELVTTFPLFQGKTEGDQLFSIFKVLGSPTKEEFQK--------FSER--------VPFDKKIFDEFQT----------
 ... ..|. .|||||.|||| ||.|  |||.|..| |||  |  ||| |.|. ..|        | ..        ..  .|| |.  |          
-VILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQ

YEPQNLR--KMFFYIKDIDNLMDLITKCLQYLPENRITADEALQHPFF
. |.. |  ....  .| ... |.|.||||. |..|||. .|||||.|
RRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 2636.AA ERK 182-364 38 3.6e-61 209.52 In-house 115-307 (307) Show / Hide 
Range on Protein: 182-364
Range on HMM: 115-307/307
Sequence Identity: 38% (76 aa)

YQILKGLQYIHSKGIAHRDLKPDNILLNDDGKVKICDFGGSKYID-EKGKN--------TPYIVSRYYRAPELILCITKYNQKIDMWSFGCILGELVTTF
|||| || |||| .. |||||| |||.| ..  ||||||..  .| .  .|        | |...|.|||||..|  .||....|.|| |||. |..   
YQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRK

PLFQGKTEGDQLFSIFKVLGSP-TKEEFQKF-SERVPFDKKIFDEFQT--YEPQNLRKMFFYIKDID---NLMDLITKCLQYLPENRITADEALQHPFF
|||.||   .|.. ||...|.| ..|..|.. ||..   .|   ...   ..|... ..|   .. .      ||. | |.  |. |||..|.|.||.|
PLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENA---WKYIKNLPNPVRPPKPWENIF---PNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase 2636.AA ERK7 75-364 31 6.1e-61 207.06 In-house 1-292 (292) Show / Hide 
Range on Protein: 75-364
Range on HMM: 1-292/292
Sequence Identity: 31% (96 aa)

YEIKRVIGSGSFGYVFEAYDNNNQRTVALKRI------QKVGKKLSREYEILLDIKDCDYVVKMIDLYYSKTDDNKLIQNIVFEYMENNLEDHISKFNKS
|||.. .| | .| |  |||   . .||||.|      |    .  ||  .| .... . ....|.    . | .. |  .|||.||  |   | | |  
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI--RADNDRDIY-LVFEFMETDLHAVIRKGN--

KKVIPEQTVKEYAYQILKGLQYIHSKGIAHRDLKPDNILLNDDGKVKICDFG-----GSKY--IDEKGKNTPYIVSRYYRAPELILCITKYNQKIDMWSF
  .. .  ..   ||.|. ..|.||  . |||||| ||||. .  ||.||||     ...    ....  | |.  | |||||  |  ..| . .|||| 
--ILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSI

GCILGELVTTFPLFQGKTEGDQLFSIFKVLGSPTKEEFQKFSERVPFDKKIFDEFQTYEPQNLRKMFFYIKDIDNLMDLITKCLQYLPENRITADEALQH
||||||...  |.|.|    .|.  | .... ||.|. .       .  .. .. .. ... | .|.   .  |. .||. . |.. |..|.||..||||
GCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAI--GSHYAWNMLEQMNQQKRKTLDQMMP--QCCDDAIDLLKRLLVFNPKKRLTAEQALQH

PFF
|. 
PYV
Kinase 2636.AA MAPK-Unclassified 129-220 41 4.4e-23 79.95 In-house 61-154 (575) Show / Hide 
Range on Protein: 129-220
Range on HMM: 61-154/575
Sequence Identity: 41% (40 aa)

VVKMIDLYYSKTDDN---KLIQNIVFEYMENNLEDHISKFNKSKK-VIPEQTVKEYAYQILKGLQYIHSKGIAHRDLKPDNILLNDDGKVKICDFG
...  | .| | . |   . |  || .||.. | | . .  ||      .| ..   ||||.|| |.|| .|.|||||| |.|.| |. |.|||||
IIQIQDIFYNKELHNQEFDDIY-IVMDYMQTSLFD-LHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFG
Kinase 2636.AA MAPK-Unclassified 232-297 30 4.2e-21 72.65 In-house 406-502 (575) Show / Hide 
Range on Protein: 232-297
Range on HMM: 406-502/575
Sequence Identity: 30% (30 aa)

TPYIVSRYYRAPELILCITKYNQKIDMWSFGCILGELVTT-----------FPLFQGKT--------------------EGDQLFSIFKVLGSPTKE
| |.| |.|||||..|    |  ..|.|| |||..|..              ||| |..                      ||.. || .||.| .|
TQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEE
Kinase 2636.AA Pkinase_Tyr 75-220 27 5.9e-16 54.65 Pfam 1-156 (270) Show / Hide 
Range on Protein: 75-220
Range on HMM: 1-156/270
Sequence Identity: 27% (43 aa)

YEIKRVIGSGSFGYVFEAYDN----NNQRTVALKRI-QKVGKK------LSREYEILLDIKDCDYVVKMIDLYYSKTDDNKLIQNIVFEYMEN-NLEDHI
 .. ...|.|.|| |.... .    |.. .|| | . ..  ..      . || .|.  . ... .|...   ... . |     ||.|||.. .| |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYL

SKFNKSKKVIPEQTVKEYAYQILKGLQYIHSKGIAHRDLKPDNILLNDDGKVKICDFG
 |   .|. .. ..  ....|| ||..| .||.. ||||   |.|......|||||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 2636.AA TyrKc 75-364 22 8.9e-15 16.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 75-364
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)

YEIKRVIGSGSFGYVFEAYDNNNQRTVALKRIQ--KVGKKLSREYEILLDI-KDCDYVVKMIDLYYSKTDD-------NKLIQNIVFEYMEN-NLEDHIS
 . ....|.| || |...  .   ..|| | ..  .  . . || .|.  . .. . .|.   ||   |..         |   ||.|||.. .| |.. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVR---LYGVCTQQGRNFMYIEPLM--IVMEYMPHGDLKDYLR

KFNKSKKVIPEQTVKEYAYQILKGLQYIHSKGIAHRDLKPDNILLNDDGKVKICDFGGSKYIDEK---GKNTPYIVSRY---YR--------APELILCI
|  .    .. ..  ....|| .| .|.|||.. ||||   |.|..... |||.||| |..|...   | .. |....     .        ||| |   
KHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NY

TKYNQKIDMWSFGCILGELVTT-FPLFQGKTEGDQLFSIFKVLGSPTKEEFQKFSER----VPFDKKIFDEFQTYEPQNLRKMFFYIKDIDNLMDLITKC
 |.. | | ||||  . |. |   .   | ..     | . |.    . .  .  .                            |     | . .....|
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F-VCCPDEMYQIMKQC

LQYLPENRITADEALQHPFF
 .. ||.| |  |   | .|
WHEDPEDRPTFSEI--HECF
Kinase 2636.AA MAPK 75-109 31 1.1e-10 32.94 In-house 1-41 (328) Show / Hide 
Range on Protein: 75-109
Range on HMM: 1-41/328
Sequence Identity: 31% (13 aa)

YEIKRVIGSGSFGYVFEAYDNN------NQRTVALKRIQKV
|.| . ||.|..| |. |.|.       ....||.|.|...
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRP
Kinase 2636.AA MAPK-Unclassified 339-364 57 8.9e-10 31.01 In-house 550-575 (575) Show / Hide 
Range on Protein: 339-364
Range on HMM: 550-575/575
Sequence Identity: 57% (15 aa)

DLITKCLQYLPENRITADEALQHPFF
|.. | ||. |  |||||.||.||.|
DFVQKMLQFNPWKRITADQALEHPYF
Kinase 2636.AA DYRK 75-104 46 9.3e-10 32.92 In-house 1-30 (320) Show / Hide 
Range on Protein: 75-104
Range on HMM: 1-30/320
Sequence Identity: 46% (14 aa)

YEIKRVIGSGSFGYVFEAYDNNNQRTVALK
|||  .||.|||| |. ..|....  ||.|
YEILEYIGKGSFGQVVKCWDHKTNEMVAIK
Kinase 2636.AA MAPK-Unclassified 75-109 38 1.3e-09 30.41 In-house 1-36 (575) Show / Hide 
Range on Protein: 75-109
Range on HMM: 1-36/575
Sequence Identity: 38% (14 aa)

YEIKRVIGSGSFGYVFEAYDNNN-QRTVALKRIQKV
|| . .||||..| | .| |. |  . || |.. ..
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHI
Kinase 2636.AA ERK 75-109 32 2e-06 19.89 In-house 1-40 (307) Show / Hide 
Range on Protein: 75-109
Range on HMM: 1-40/307
Sequence Identity: 32% (13 aa)

YEIKRVIGSGSFGYVFEAYDNN-----NQRTVALKRIQKV
|.|   || |..| |. | |..     .. .|| | |...
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENA
Kinase 2636.AA RCK 75-105 32 2e-06 16.16 In-house 1-31 (298) Show / Hide 
Range on Protein: 75-105
Range on HMM: 1-31/298
Sequence Identity: 32% (10 aa)

YEIKRVIGSGSFGYVFEAYDNNNQRTVALKR
| | . .| |..| |..| .  ..  || |.
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKK