Gene 13176 (Tetrahymena)

13176

Species: Tetrahymena
Alias: TTHERM_00066860, 4.m00575, 450, 3707.m00213, PreTt13176, 13176
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: PITSLRE

Sequence

Name Sequence Type Origin Length Description Download
13176.AA Protein None 420 None Fasta, JSON
13176.kin_dom Protein Kinase Domain None 288 None Fasta, JSON
13176.NA RNA None 1263 None Fasta, JSON

Protein domain

Protein domains of 13176.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13176.AA PITSLRE 86-373 59 2.2e-222 745.06 In-house 1-295 (295) Show / Hide 
Range on Protein: 86-373
Range on HMM: 1-295/295
Sequence Identity: 59% (175 aa)

YQKLNKIHEGVYGVVYRAVDKLTGEIIAIKKTKIDRKKEKEGFPITSIREFN-ILMALRHENIVAVKRVVMGTDLDSIYMIMEYMEHELKDVIENHH---
.|.||.||||.|||||||.||.|.||.|.|..|..|.||||||||||.||.| |||||.|.|||.||..|||...|.|||.|||.||.||...||..   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

DEFQEPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNKGQLKICDFGLGRRWQGN-KPYTLNVVTMWYRAPEVLLGQDKYTTALDMWSVGCIFGEL
..|....||.|.||||.|........||||||||||.||..||.||||||||.|..... ||||..|||.||||||.|||..||.|..|||||||||.|.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ITKDQLFKGKNETNQIECIFNAMGGPTERSWPGWTEFKHSKLFK-DRNYPSECTLNEKIG--NRISQTGYKLLCQMLTLNPKERITATKALQDPWF
||...||.||.|..||.|||..||.|||..||||||..|.|... ...|| ...|.....  |.||.||..||.||||.|||.||||..||..|||
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYP-YNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 13176.AA CDK 86-373 40 5.9e-154 496.06 In-house 1-284 (284) Show / Hide 
Range on Protein: 86-373
Range on HMM: 1-284/284
Sequence Identity: 40% (132 aa)

YQKLNKIHEGVYGVVYRAVDKLTG-----EIIAIKKTKIDR---KKEKEGFPITSIREFNILMALRHENIVAVKRVVMGTDLD---------SIYMIMEY
|.||.|| || |||||.| ||.||     .|.|.|| ...    ..||||||||.||| ..|. | |.||| .. |... ..|         ..||..||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MEHELKDVIENHHDEFQEPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNKGQ-----LKICDFGLGRRWQG-------NKPYTLNVVTMWYRAPE
|.| || ...          ||.. .||| |.... ...|||||||..|||.||.|.     ||| |||| | ..        |..|| .|||.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLLGQDKYT--TALDMWSVGCIFGELIT---KDQLFKGKNETNQIECIFNAMGGPTERSWPGWTEFKHSKLFKDRNYPSECTLNEKIGNRISQTGYKLLC
.|||. .|.  |. |||||||||.|..|   .  || |..|..|...||. .| ||| .|||.|.. .                             ||.
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLN

QMLTLNPKERITATKALQDPWF
.||...|| ||.|. |||.|.|
KMLCYDPKKRISAEQALQHPYF
Kinase 13176.AA CMGC 86-373 25 4.5e-127 419.94 In-house 1-513 (513) Show / Hide 
Range on Protein: 86-373
Range on HMM: 1-513/513
Sequence Identity: 25% (130 aa)

YQKLNKIHEGVYGVVYRAVDKLTG--------------EIIAIKKTKIDRKKE--------KEGFPITSIREFNILMALR-----------------HEN
|....|| || |||||...||.|.              ||.|||| | .  .|        |.||||...||  ||. |.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVAVKRVVMGTDLD---------------SIYMIMEYMEHELKDVIENHHD--------EFQEPQ------------IKSLV------QQLLLGMD--FL
||  . ...  . |               ..|...|||.| |...|.|...        .. | .            ||...      .|.| |..  ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

QKKK--IMHRDLKTSNILYNNK--------------------GQLKICDFGLGRRWQGN----------------------KPYTLNVVTMWYRAPEVLL
 ...  |.||||| .||| |..                    |.|||||||| |    .                      .||| .|||.||||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GQ---------DKYTTALDMWSVGCIFGELITK--------DQLFKGKNE-----------TNQIECIFNAMGGPT---------------ERSWPG---
|          ..|||. |||||||||.|..|.        . ||.|..|            .|...||. .| ||               |. ||.   
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

-------------------WTEFKHSKLFKDRNYP--SECTLNEKIGN----------------------------------RISQTGYKLLCQMLTLNP
                   |.||   .... ...|     ...... .                                  .... .  ||..||...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

KERITATKALQDPWF
..||||  ||| |.|
DKRITAEQALQHPYF
Kinase 13176.AA CDC2 86-373 41 2.3e-110 340.48 In-house 1-301 (301) Show / Hide 
Range on Protein: 86-373
Range on HMM: 1-301/301
Sequence Identity: 41% (125 aa)

YQKLNKIHEGVYGVVYRAVDKLTGEIIAIKKTKIDRKKEKEGFPITSIREFNILMALR-HENIVAVKRVVMGTDLDSIYMIMEYMEHELKDVIE---NHH
|||..|| || |||||.. |. |..|.|.|| ....  | .|.| |.|||  .| .|. |.|||  . |..     ..||. ||... ||   .      
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

DEFQEPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNKGQLKICDFGLGRRWQGN-KPYT--LNVVTMWYRAPEVLLGQDKYTTALDMWSVGCIFG
.....  .||.  |.| |..|.  ..||||||| .||| ..||..|| ||||.|  . . ..||   .||| ||||||.|||. .|.|. ||||.|||| 
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EL---ITKDQLFKGKNETNQIECIFNAMGGPTERSWPGWTEFKHSKL----FKDRNYPSECTLNEKIGNR--ISQTGYKLLCQMLTLNPKERITATKALQ
|.   .||  || |. |  |.  ||  .| |.| .||| |.... |     .|  .  . |  | |  |   . ..|  || ||| ..|  ||.| .|||
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

DPWF
 |.|
HPYF
Kinase 13176.AA CDK7 86-373 38 2.3e-101 270.69 In-house 1-288 (288) Show / Hide 
Range on Protein: 86-373
Range on HMM: 1-288/288
Sequence Identity: 38% (113 aa)

YQKLNKIHEGVYGVVYRAVDKLTGEIIAIKKTK--IDRKKEKEGFPITSIREFNILMALRHENIVAVKRVVMGTDLDSIYMIMEYMEHELKDVIENHHDE
|.|. .| || ...||.| |. ||.|.|||| |    |   | |   | |||  ||  ..|.|..    . |   ...|......|.  |  ||.     
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFM--HKSNIQLVFDFMDWDLEVVIKDKSII

FQEPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNKGQLKICDFGLGRRWQG-NKPYTLNVVTMWYRAPEVLLGQDKYTTALDMWSVGCIFGELIT
.    ||.   ..|.|. .. .  | |||||  | | |  ||||| |||| | .   |. || .||| |||||| | |   |.|. ||||||||| ||. 
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML

KDQLFKGKNETNQIECIFNAMGGPTERSWPGWTEFKHSKLFKDRNYPSECTLNEKIGNRISQTGYKLLCQMLTLNPKERITATKALQDPWF
    . | ..  |.. ||...| |||. ||. ....    |||   .|   |. .|    |.    |.| |.|.|| .|.|.| .|. | |
RVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLR-HIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 13176.AA CRK7 86-373 37 2.6e-101 342.9 In-house 1-343 (343) Show / Hide 
Range on Protein: 86-373
Range on HMM: 1-343/343
Sequence Identity: 37% (128 aa)

YQKLNKIHEGVYGVVYRAVDKLTGEIIAIKKTKIDRKKE---KEGFPITSIREFNILMALRHENIVAVKRVVMG--------TDLDSIYMIMEYMEHELK
|.... | || || || |..| |||..| || . |   |   |||||||.|||  ||  | |.|||  | .|           .  |.||. ||| | | 
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMD--NEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLM

DVIENH-HDEFQEPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNKGQLKICDFGLGRRWQGNK---PYTLNVVTMWYRAPEVLLGQDKY------
   |.    .| . |.|..  |||.||| . ||...|||.| ||||.||.|..|| |||| | .  .    |||  |.| |||.|| |||  .|      
GLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHIL

--------------------------------TTALDMWSVGCIFGELITKDQLFKGKNETNQIECIFNAMGGPTERSWPGWTEFKHSKLFKDRNYPSEC
                                ... ||||.|||.||| ||  .|.|.||  |.| |.  .| |.  .||  ..    . .| .      
KELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRR

TLNEKI--GN--RISQTGYKLLCQMLTLNPKERITATKALQDPWF
 ..| .   .   ...    || .||.|.|| |.||. .|| .||
LREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase 13176.AA CDK10 86-373 43 2.5e-96 326.31 In-house 1-285 (285) Show / Hide 
Range on Protein: 86-373
Range on HMM: 1-285/285
Sequence Identity: 43% (125 aa)

YQKLNKIHEGVYGVVYRAVDKLTGEIIAIKKTKIDRKKEKEGFPITSIREFNILMALRHENIVAVKRVVMGTDLDSIYMIMEYMEHELKDVIENHHDEFQ
. |||.. || ||.|||| |  . ||.|.|| ..|  |||.| || ..||  .|. .|||||| .. ||.|  ||||...|.| | .|  ...|    | 
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMD--KEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFT

EPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNKGQLKICDFGLGRRW-QGNKPYTLNVVTMWYRAPEVLLGQDKYTTALDMWSVGCIFGELITKD
| |.| .. |.| |. .| .. ..||||| ||.|   || .|. |||| |..    || |  .||.||||||.|||  . |||.||| |||| |||. . 
ETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHK

QLFKGKNETNQIECIFNAMGGPTERSWPGWTEFKHSKLFKDRNYPSECTLNEKIGNRISQTGYKLLCQMLTLNPKERITATKALQDPWF
 |. |  |  ||. | . .| | |  |||...    . |  .  |    | .|  . .||.| .||  ..  |||.| ||  .|.  .|
PLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNN-LKHKF-HWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase 13176.AA CDK5 86-373 38 3e-94 298.22 In-house 1-287 (287) Show / Hide 
Range on Protein: 86-373
Range on HMM: 1-287/287
Sequence Identity: 38% (113 aa)

YQKLNKIHEGVYGVVYRAVDKLTGEIIAIKKTKIDRKKEKEGFPITSIREFNILMALRHENIVAVKRVVMGTDLDSIYMIMEYMEHELKDVIENHHDEFQ
|.|..|| || ||.||.| .| |.||.|.|. ..|   | || | | |||  .|  |.|.|||    |.       . .. |..   ||  ...  .| .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLD--SEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSE--KKLTLVFEFCDQDLKKYMDSCNGEMD

EPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNKGQLKICDFGLGRRWQ-GNKPYTLNVVTMWYRAPEVLLGQDKYTTALDMWSVGCIFGELI-TK
 . |||.  ||| |. |  .....|||||  | | | .|.||  |||| |      . |.  |||.|||.| ||.|  .|.|  ||||.|||| |.. . 
MHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAG

DQLFKGKNETNQIECIFNAMGGPTERSWPGWTEFKHSK--LFKDRNYPSECTLNEKIGNRISQTGYKLLCQMLTLNPKERITATKALQDPWF
  || | ....|   ||  || |.| .||. |.    |    .   || . .. . . .  ...|  || .|| .||..||.| .||. |.|
RPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 13176.AA S_TKc 86-373 28 1.2e-90 308.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 86-373
Range on HMM: 1-231/231
Sequence Identity: 28% (87 aa)

YQKLNKIHEGVYGVVYRAVDKLTGEIIAIKKTKIDRKKEKEGFPITSIREFNILMALRHENIVAVKRVVMGTDLDSIYMIMEYMEH---ELKDVIENHHD
|..|.|| .| .|.||....| ||.| |||. |           .. .|| .||.  .|.|||  . |      |..||.|||...   .|.|.|...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

E-----FQEPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNKGQLKICDFGLGRRWQGNKPYTLNVVTMWYRAPEVLLGQDKYTT-ALDMWSVGCI
.     | | .......|........ ...|.||||| .||| ..  ..||||||| |.       |  ..| ||.|||||    .|.. . |.||.|||
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

FGELITKDQLFKGKNETNQIECIFNAMGGPTERSWPGWTEFKHSKLFKDRNYPSECTLNEKIGNRISQTGYKLLCQMLTLNPKERITATKALQ-------
. |...   .|       |.. .|. .|                                      |. .  .....|. .|..|.|| .|||       
LYEMLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

DPWF
.|||
HPWF
Kinase 13176.AA Pkinase 86-373 33 8.3e-89 306.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 86-373
Range on HMM: 1-293/293
Sequence Identity: 33% (103 aa)

YQKLNKIHEGVYGVVYRAVDKLTGEIIAIKKTKIDRKKEKEGFPITSIR--EFNILMALRHENIVAVKRVVMGTDLDSIYMIMEYMEHELKDVIENH---
|... || .| .|.||....| ||.| |.|. | .  .||.....| .|  |  |.  |.|.|||  .....    |.|||.|||.|. |. |.. .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYI

----HDEF--QEPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNKGQL----KICDFGLGRR--WQGNKPYTLNVVTMWYRAPEVLLGQDKYTTAL
    |  |  .| ..|. . |.| |.... ...|.||||| .|||..|.|..    ||||||| .   .  |  .|  ..| ||.||||..|. .|... 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DMWSVGCIFGELITKDQLFKGK----NETNQIECIFNAMGGPTERSWPGWTEFKHSKLFKDRNYPSECTLNEKIGNRISQTGYKLLCQMLTLNPKERITA
||||.|||. |....  .|.|.    |  .|...|.. ||.|....|| | .   .. |..   .   . ...   ..|... .... .|...||.|.||
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

TKALQDPWF
. .||.|||
EQILQHPWF
Kinase 13176.AA CDK4 86-373 38 5.2e-75 255.5 In-house 1-290 (290) Show / Hide 
Range on Protein: 86-373
Range on HMM: 1-290/290
Sequence Identity: 38% (113 aa)

YQKLNKIHEGVYGVVYRAVDKLTGEIIAIKKTKIDRKKEKEGFPITSIREFNI---LMALRHENIVAVKRVVMGTDLDS----IYMIMEYMEHELKDVIE
||... | || || |||| |  || ..| |. .|  . |  | |.  |||  .   | .. | |||  . |    | |     | |..|  .  |.. ..
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

NHHD-EFQEPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNKGQLKICDFGLGRRWQGNKPYTLNVVTMWYRAPEVLLGQDKYTTALDMWSVGCIF
.       ...|| .  ||| |.|||    | |||||  ||| .  |..|. |||| |        |  |||.||||||||| |  | |  |||||||||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGCIF

GELITKDQLFKGKNETNQIECIFNAMGGPTERSWPGWTEFKHSKLFKDRNYPSECTLNEKIGNRISQTGYKLLCQMLTLNPKERITATKALQDPWF
 |.     || |..| .| . ||  || |.|  ||     . . |  |   .   .  ...   ... |  || .||. |.. |..| ..|| |.|
AEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWP-----RDVSLPWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase 13176.AA MAPK 86-308 35 1.4e-64 220.86 In-house 1-256 (328) Show / Hide 
Range on Protein: 86-308
Range on HMM: 1-256/328
Sequence Identity: 35% (91 aa)

YQKLNKIHEGVYGVVYRAVDKL------TGEIIAIKKTKIDRKKEKEGFPITSIREFNILMAL-RHENIVAVKRVVMG------TDL---DSIYMIMEYM
|| | .| .| ||||  |.||.      .|...|||  || |  ... .    .||  .|  . .||||. .. . .        .|   . ||..||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIK--KISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELM

EHELKDVIENHHDEFQEPQIKSLVQQLLLG--MDFLQKKKIMHRDLKTSNILYNNKGQLKICDFGLGRRWQGNKPY---------------TLNVVTMWY
|. |  .|.    .  .  |.... |.| |  . ..    . ||||| |||| |  ..|||||||| | .  .. .               | .|.| ||
ETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWY

RAPEVLLG--QDKYTTALDMWSVGCIFGELIT-KDQLFKGKNETNQIECIFNAMGGPTE
||||..|.   ..||.| |||||||||.|..|   .||.||.  .|...|.. .| |.|
RAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSE
Kinase 13176.AA Pkinase_Tyr 86-233 31 2.4e-17 59.38 Pfam 1-157 (270) Show / Hide 
Range on Protein: 86-233
Range on HMM: 1-157/270
Sequence Identity: 31% (51 aa)

YQKLNKIHEGVYGVVYRAVDK----LTGEIIAIKKTKIDRKKE---KEGFPITSIREFNILMAL-RHENIVAVKRVVM-GTDLDSIYMIMEYMEH-ELKD
 ... |. || .|.||... |     |.   |.|. | .  .|   .| |    .|| .|.. | .|.|||    |..   .  .||..||||.|  |.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

VIENH---HDEFQEPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNKGQLKICDFGL
   .|    . .  ... .  .|   ||..|  |.. |||| . |.| ..... |||||||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL
Kinase 13176.AA TyrKc 86-371 20 3.3e-15 23.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 86-371
Range on HMM: 1-280/280
Sequence Identity: 20% (67 aa)

YQKLNKIHEGVYGVVYRAVDKLTGEIIAIKKTKIDRKKEKEGFPITSIREFNILMAL--RHENIVAVKRVVMGT-----DLDSIYMIMEYMEH-ELKDVI
 ... |. || .|.||... |   .  |.|. | |    .| |    .|| .|.. |  .|.|||.   |..         . ....||||.|  ||| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDF----MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

ENHHDEFQEPQIKSLVQQLLLGMDFLQKKKIMHRDLKTSNILYNNKGQLKICDFGLGRRWQGN-------KPYTLNV--VTM------WYRAPEVLLGQD
 .|..... ..  |   |   ||..| .|.. |||| . |.|...... ||.|||| | .          . |.      .       |. |||..  ..
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI--NY

K-YTTALDMWSVGCI-----------FGEL----ITKDQLFKGKNETNQIECIFN----AMGGPTERSWPGWTEFKHSKLFKDRNYPSECTLNEKIGNRI
. .||. | || |               .     .. .....   . .  ..  |    .                                      . 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------------F-VCC

SQTGYKLLCQMLTLNPKERITATKALQDP
..  |..  |    .|..| | .   .. 
PDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 13176.AA MAPK 349-373 52 1.7e-09 28.79 In-house 304-328 (328) Show / Hide 
Range on Protein: 349-373
Range on HMM: 304-328/328
Sequence Identity: 52% (13 aa)

LLCQMLTLNPKERITATKALQDPWF
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LLEKMLVFDPDKRITVEEALQHPYF