Gene 2101 (Tetrahymena)

2101

Species: Tetrahymena
Alias: PreTt02101, TTHERM_01080590, 3798.m00214, 222.m00057, 2101, 269
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
2101.AA Protein None 331 None Fasta, JSON
2101.kin_dom Protein Kinase Domain None 282 None Fasta, JSON
2101.NA RNA None 996 None Fasta, JSON

Protein domain

Protein domains of 2101.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2101.AA CDK-Unclassified 16-297 38 1.1e-164 545.87 In-house 1-324 (324) Show / Hide 
Range on Protein: 16-297
Range on HMM: 1-324/324
Sequence Identity: 38% (125 aa)

YKIQCKVAEGAFGSVFKAIKQNTQQIVAIKDLFFNQNK-----------RSKQIVEREVSIMQDLNDHPNIVKLIDYQISNNKCS-------------LV
|..|||..||.||.|.|||...||..||||....|..|           .||....||.|..|..|.. || |..|   ....||             .|
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHM-NIIKFMDMHYDHDRCSKNPYYDNLHPSFYMV

MEYIDYDLKQFIESQVYPLSHSKIKRIAFQLLTGLSFIHSKGIIHRDLKPSNILITNQF-----IVKIGDFGSAIKEE----------QRK-DKQFSIEG
|||..|..    .. .|.||   |.. . |.| |. ..|...|.|||.||.||.|||..     ..||.|||.|....          ... ..|.|...
MEYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQV

FTRWYKSPEQLFGSREYNYEIDIWSFACIYAEIIQGYPLFSGNNEIEQIAKISDLLGNPCEENWPSIVKMPDYGKILFKQKQKKN---LSTLFSQASEKE
.||||..||.||||..|....|||||.|||||..||.|.|.|..||||...|...||.|||..||....||||.||.||.|||..   .......|||..
STRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASENN

IEFLNSMLKYDNRPTAEQLLQSEYF
.||...|....||......||...|
CEFQMVMYQPYNRWKCMEILQHPWF
Kinase 2101.AA CDK 16-297 35 2.9e-129 415.79 In-house 1-284 (284) Show / Hide 
Range on Protein: 16-297
Range on HMM: 1-284/284
Sequence Identity: 35% (113 aa)

YKIQCKVAEGAFGSVFKAIKQNTQ-----QIVAIKDLFFNQN----K--RSKQIVEREVSIMQDLNDHPNIVKLIDYQISN-----------NKCSLVME
|.. .|. ||..| |.||. ..|.     ||||.| .   ..    .     .   ||.|....|  |||||||.|  ...           || ..|.|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

YIDYDLKQFIESQVYPLSHSKIKRIAFQLLTGLSFIHSKGIIHRDLKPSNILITNQFI-----VKIGDFGSAIKEEQR-----KDKQFSIEGFTRWYKSP
|.|.|||....          || . .||| ||...||..|.||||||.||||.|. .     .||.||| | .   .     . . .. |  |.|| .|
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

EQLFGSREYN--YEIDIWSFACIYAEIIQ---GYPLFSGNNEIEQIAKISDLLGNPCEENWPSIVKMPDYGKILFKQKQKKNLSTLFSQASEKEIEFLNS
| |.||..|.   .||.||. || ||...   . ||| |..||.|. ||....| |.|.|||...|.|||                         ..||.
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNK

MLKYD--NRPTAEQLLQSEYF
|| ||  .| .||| ||..||
MLCYDPKKRISAEQALQHPYF
Kinase 2101.AA CMGC 16-297 23 5.9e-117 386.08 In-house 1-513 (513) Show / Hide 
Range on Protein: 16-297
Range on HMM: 1-513/513
Sequence Identity: 23% (123 aa)

YKIQCKVAEGAFGSVFKAIKQNTQ--------------QIVAIKDLFFNQNKRSKQ----------IVEREVSIMQDLN----------------DHPNI
|.|  |. ||..| |.|.. ..|.              .||||| .. ..... ..          .  ||..|.. ||                .|.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLIDYQISNN-----------------KCSLVMEYIDYDLKQFIESQVY--------PLSHSK------------IKRIA------FQLLTGLS--FIH
|||.|.  ..|                 .  ||.||.|.||.|.|...          |||. .            || .       .|.|.||   ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SKG--IIHRDLKPSNILITNQ--------------------FIVKIGDFGSAIKEEQRKDK--------------------QFSIEGFTRWYKSPEQLFG
|..  ||||||||.||||...                    ...||.|||.| ......|.                    ... .  ||||..|| |.|
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

SREYN---------YEIDIWSFACIYAEIIQG--------YPLFSGNNE-----------IEQIAKISDLLGNPC---------------EENWPSIVKM
...|.         ..||.||..|| ||...|        .||| |..|           |.|..|| ..||.|.               ||.||...|.
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PDYGKIL-------------------------FKQKQKKNLSTLFSQ-----------------------------------ASEKEIEFLNSMLKYD--
|.| | .                         |.....|... ||                                     .... |..|. ||.||  
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

NRPTAEQLLQSEYF
.|.|||| || .||
KRITAEQALQHPYF
Kinase 2101.AA S_TKc 16-297 28 4e-83 283.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-297
Range on HMM: 1-231/231
Sequence Identity: 28% (86 aa)

YKIQCKVAEGAFGSVFKAIKQNTQQIVAIKDLFFNQNKRSKQIVEREVSIMQDLNDHPNIVKLIDYQISNNKCSLVMEYIDY---DLKQFIESQVYP---
|.|  |. .||||.|.|... .|..||||| .         . ..||..|..   .|||||||.|.  . ..  .||||.|    ||...|... ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSHSKIKRIAFQLLTGLSFIHSKGIIHRDLKPSNILITNQFIVKIGDFGSAIKEEQRKDKQFSIEGFTRWYKSPEQLFGSREYNY-EIDIWSFACIYA
  ..   ..... |.. .| ..||.|||||||||.|||...   .||.|||.| .         .    |.|| .|| |     |.. ..|.||. || .
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY

EIIQGYPLFSGNNEIEQIAKISDLLGNPCEENWPSIVKMPDYGKILFKQKQKKNLSTLFSQASEKEIEFLNSMLKYD--NRPTAEQLLQ-------SEYF
| . |||.|.      |.... ...|                                    |.  ..|.. .|..|  .|||| ..||        ..|
EMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2101.AA CDK5 16-297 36 7.8e-80 251.85 In-house 1-287 (287) Show / Hide 
Range on Protein: 16-297
Range on HMM: 1-287/287
Sequence Identity: 36% (105 aa)

YKIQCKVAEGAFGSVFKAIKQNTQQIVAIKDLFFNQN---KRSKQIVEREVSIMQDLNDHPNIVKLIDYQISNNKCSLVMEYIDYDLKQFIESQVYPLSH
|.   |. || .| |.||  ..|. |||.|    ...     |  |  ||..... |  |.||| |.|   |..|  || |..| ||| ...|    .. 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAI--REICLLKELK-HKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDM

SKIKRIAFQLLTGLSFIHSKGIIHRDLKPSNILITNQFIVKIGDFGSAIKEEQRKDKQFSIEGFTRWYKSPEQLFGSREYNYEIDIWSFACIYAEII-QG
  || . .||| ||.| |.. . |||||| | ||  . . | .||| |        . .| |  | ||  |  |.||. |.  ||.||  ||.||..  |
HIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLA-RAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAG

YPLFSGNNEIEQIAKISDLLGNPCEENWPSIVKMPDYG---KILFKQKQKKNLSTLFSQASEKEIEFLNSMLKYD--NRPTAEQLLQSEYF
 ||| ||.. .|  .| ...| |||..|||| |.|||    . . .   .. .. .  . .||  ..|. ||...   | .|.. |.  ||
RPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 2101.AA Pkinase 16-297 33 1.5e-74 258.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-297
Range on HMM: 1-293/293
Sequence Identity: 33% (101 aa)

YKIQCKVAEGAFGSVFKAIKQNTQQIVAIKDLFFNQNKRSKQIVER---EVSIMQDLNDHPNIVKLIDYQISNNKCSLVMEYIDY-----DLKQFIE-SQ
|.|  |. .|.||.|.|.....|..|||.| .    .| .|..  |   |..||. | .|||||.|.|.  ..... .|||| .      ||. .|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

VYPL--SHSKIKRIAFQLLTGLSFIHSKGIIHRDLKPSNILITNQFIV----KIGDFGSAIK-EEQRKDKQFSIEGFTRWYKSPEQLFGSREYNYEIDIW
  ..  |   .|... |.| || ..||.|||||||||.|||| |.  .    ||.|||.| . .   ..  ..    |.|| .|| . |...| ...|.|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFACIYAEIIQGYPLFSGN----NEIEQIAKISDLLGNPCEENWPSIVKMPDYGKILFKQKQKKNLSTLFSQASEKEIEFLNSMLKYDN--RPTAEQLLQ
|. || .| . |.|.|.|     | ..|...|   .| | ...||    ....  . . .   . ..|.   .||  ..|....|..|   ||||||.||
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

SEYF
...|
HPWF
Kinase 2101.AA MAPK 16-297 31 1.3e-72 247.53 In-house 1-328 (328) Show / Hide 
Range on Protein: 16-297
Range on HMM: 1-328/328
Sequence Identity: 31% (106 aa)

YKIQCKVAEGAFGSVFKAIKQN------TQQIVAIKDLF--FNQNKRSKQIVEREVSIMQDLNDHPNIVKLIDYQISN-----NKCS------LVMEYID
|.|. .. .||.| |..|| .       ....|||| ..  |.     | .  ||. ... ...|.||.||.|          |  .      .|||. .
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTY-REIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELME

YDLKQFIESQVYPLSHSKIKRIAFQLLTG--LSFIHSKGIIHRDLKPSNILITNQFIVKIGDFGSAIKEEQR-----KDKQFSIEGF----------TRW
 || | |.||  |||.  |. . .|.| |  | .||| ..|||||||||||..    .||.||| | ....      ..... .  |          |||
TDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HC-FQKMHMTEYVATRW

YKSPEQLFG--SREYNYEIDIWSFACIYAEIIQ-GYPLFSGNNEIEQIAKISDLLGNPCEENWPSIV--KMP-DYGKIL--FKQKQKKNLSTLFSQ----
| .|| ...  ...|.  .|.||  || || .. . ||| |.. |.|. .| ..||.| || .  |   ... .| . |  .....||.....|.     
YRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFN

ASEKEIEFLNSMLKYD--NRPTAEQLLQSEYF
|. . | .|  ||  |   | |.|. || .||
ANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 2101.AA CDK7 61-297 34 3.7e-70 185.87 In-house 51-288 (288) Show / Hide 
Range on Protein: 61-297
Range on HMM: 51-288/288
Sequence Identity: 34% (84 aa)

REVSIMQDLNDHPNIVKLIDYQISNNKCSLVMEYIDYDLKQFIESQVYPLSHSKIKRIAFQLLTGLSFIHSKGIIHRDLKPSNILITNQFIVKIGDFGSA
||. | | .  |.|.. |||        .||....| ||   |. .   |  . || .. ..| || . |   | |||||| | |.    ..||.||| |
REIKILQEMQ-HDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLA

IKEEQRKDKQFSIEGFTRWYKSPEQLFGSREYNYEIDIWSFACIYAEIIQGYPLFSGNNEIEQIAKISDLLGNPCEENWPSIVKMPDYGKILFKQKQK--
 .      . ..    |||| .|| ||| | |   .|.||  || || .   | . | ..| |. .|   || | ||.|| . .|.||  | ||.     
-RFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY--IKFKDFPGYS

-KNLSTLFSQASEKEIEFLNSMLKYD--NRPTAEQLLQSEYF
   |  .|. ||.  ....  |.  .  .| |. | |...||
RTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 2101.AA PITSLRE 61-297 36 1.6e-52 180.81 In-house 49-295 (295) Show / Hide 
Range on Protein: 61-297
Range on HMM: 49-295/295
Sequence Identity: 36% (91 aa)

REVS-IMQDLNDHPNIVKLIDYQISNNKCS--LVMEYIDYDLKQFIESQV---YPLSHSKIKRIAFQLLTGLSFIHSKGIIHRDLKPSNILITNQFIVKI
||.. |   |. |||||..    .  |. .  .||||.. |||  .|       | . . ||    ||| | .. |.. |.||||| ||.|.... | ||
REINMILMALQ-HPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKI

GDFGSAIKEEQRKDKQFSIEGFTRWYKSPEQLFGSREYNYEIDIWSFACIYAEIIQGYPLFSGNNEIEQIAKISDLLGNPCEENWPSIVKMPDYGKIL-F
.||| |  | .   | ..    | || .|| | |...|   .|.||  || ||.|.. ||| |..||.|| .|  ..| | |  || . ..|   ..  |
CDFGLA-REYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNF

KQKQKKNLSTLFS---QASEKEIEFLNSMLKYD--NRPTAEQLLQSEYF
..    ||  .|      |.   . || || |.  || ||.. |. ..|
PHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 2101.AA CDC2 16-158 39 7.5e-50 151.1 In-house 1-148 (301) Show / Hide 
Range on Protein: 16-158
Range on HMM: 1-148/301
Sequence Identity: 39% (59 aa)

YKIQCKVAEGAFGSVFKAIKQNTQQIVAIKDLFFNQNKRS----KQIVEREVSIMQDLNDHPNIVKLIDYQISNNKCSLVMEYIDYDLKQFIE-SQV--Y
|.   |. || .| |.|.. . |.||||.|     |.         .. || |....|.|||||||| | ... ||  .| ||.|.|||.. . |..  .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAI-REISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNK

PLSHSKIKRIAFQLLTGLSFIHSKGIIHRDLKPSNILITNQFIVKIGDFG
... ...| ...|.| |..| |...|.||||||.|||| ..  .||.|||
HMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFG
Kinase 2101.AA RCK 16-160 33 8.2e-44 136.72 In-house 1-161 (298) Show / Hide 
Range on Protein: 16-160
Range on HMM: 1-161/298
Sequence Identity: 33% (55 aa)

YKIQCKVAEGAFGSVFKAIKQNTQQIVAIKDLFFNQNKRSKQIVE-REVSIMQDLNDHPNIVKLIDYQISNN--KCSLVMEYIDYDLKQFIES---QVYP
|.|  .. .|..|.|.||..  |..||||| .  .  .  ... . ||.  .  || ||||.||..  . |.    ..|.|| | .| |....      .
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKY

LSHSK--IKRIAFQLLTGLSFIHSKGIIHRDLKPSNILITN---------QFIVKIGDFGSA
|. ..  || | .|.| ||...|..|. |||||| ||..|.         |...||.|||..
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLC
Kinase 2101.AA RCK 177-297 39 7.6e-35 107.79 In-house 176-298 (298) Show / Hide 
Range on Protein: 177-297
Range on HMM: 176-298/298
Sequence Identity: 39% (48 aa)

TRWYKSPEQLFGSREYNYEIDIWSFACIYAEIIQGYPLFSGNNEIEQIAKISDLLGNPCEENWPSIVKMPDYGKILFKQKQKKNLSTLFSQASEKEIEFL
|||| .|| |  .  ||. .|||.. || .|.    ||| |..|| || || . .| |. . ||  .|      . | |... .|..|....|   || .
TRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELM

NSMLKYD--NRPTAEQLLQSEYF
. ||..|   |.||.|.||  ||
EKMLQWDPQKRITAQQALQHPYF
Kinase 2101.AA CDC2 177-297 36 1.1e-33 100.51 In-house 168-301 (301) Show / Hide 
Range on Protein: 177-297
Range on HMM: 168-301/301
Sequence Identity: 36% (49 aa)

TRWYKSPEQLFGSREYNYEIDIWSFACIYAEI---IQGYPLFSGNNEIEQIAKISDLLGNPCEENWPSIVKMPDYGKILFKQKQKKNLSTLFSQ------
|.|| .|| |.|.. |. ..|.||. || ||.   ..  |||.|  ||.|. ||   || | |..||.. ..||| |  | . ....||... .      
TLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDY-KNTFPRWKPQDLSKICPNNQKKKN

---ASEKEIEFLNSMLKYD--NRPTAEQLLQSEYF
   . .. |. |..|| ||  .| .|.. ||  ||
QSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 2101.AA CDK4 16-158 35 1.2e-32 109.2 In-house 1-155 (290) Show / Hide 
Range on Protein: 16-158
Range on HMM: 1-155/290
Sequence Identity: 35% (56 aa)

YKIQCKVAEGAFGSVFKAIKQNTQQIVAIKDLFFNQNKR---SKQIVEREVSIMQDLN--DHPNIVKLID-YQISNNKC-----SLVMEYIDYDLKQFIE
|.    . |||.| |..|    | ..|| |      .       . . ||.|.|  |.  .|||||||.|  . .          .|.| .| ||.....
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

SQVYP--LSHSKIKRIAFQLLTGLSFIHSKGIIHRDLKPSNILITNQFIVKIGDFG
 .. |  ..   ||.. .|||.|. | ||  |||||||| |||.| .  ||. |||
-KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFG
Kinase 2101.AA CDK4 177-297 36 1.5e-28 94.92 In-house 172-290 (290) Show / Hide 
Range on Protein: 177-297
Range on HMM: 172-290/290
Sequence Identity: 36% (45 aa)

TRWYKSPEQLFGSREYNYEIDIWSFACIYAEIIQGYPLFSGNNEIEQIAKISDLLGNPCEENWPSIVKMPDYGKILFKQKQKKNLSTLFSQASEKEIEFL
| || .|| |  |  ||  .|.|| .|| ||.    ||| |..| .|  || |. | | |. ||. | .|      |.|.. ...  .  . ..  ...|
TLWYRAPEVLLQS-YYNTPVDMWSVGCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP---WDHFPQRHPRPFKDFCPHMCKQGDDLL

NSMLKYD--NRPTAEQLLQSEYF
. || |.   |..|.| ||  ||
QKMLCYNHHKRMSAYQCLQHPYF
Kinase 2101.AA Pkinase_Tyr 16-158 32 3e-22 75.99 Pfam 1-156 (270) Show / Hide 
Range on Protein: 16-158
Range on HMM: 1-156/270
Sequence Identity: 32% (51 aa)

YKIQCKVAEGAFGSVFKAIKQ----NTQQIVAIKDLFFNQNKRSKQ-----IVEREVSIMQDLNDHPNIVKLIDYQI-SNNK--CSLVMEYIDY-DLKQF
 ..  |  |||||.|.|..      ||.. ||.| |  ...  ..|       . |..||  | .|||||.|.   .         .||||  . ||. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IESQ---VYPLSHSKIKRIAFQLLTGLSFIHSKGIIHRDLKPSNILITNQFIVKIGDFG
  ..     ||... .  ...|   |... .||..|||||   |.|.|....|||.|||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 2101.AA TyrKc 16-297 22 1.1e-14 15.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-297
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)

YKIQCKVAEGAFGSVFKAIKQNTQQIVAIKDLFFNQNKRSKQIVEREVSIMQDL-NDHPNIVKLIDYQISN-------NKCSLVMEYIDY-DLKQFIESQ
 .   |  ||||| |.|..     . ||.| |  .     ..   || .||  |  .|||||.|. . ..            .|||| .. |||... . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

VYPLSHSKIKRIAFQLLTGLSFIHSKGIIHRDLKPSNILITNQFIVKIGDFGSAIKEEQR-------KDKQF----SIE--GFTRWYKSPEQLFGSREYN
   |....   ...|   | ...|||..|||||   |.|......|||.||| . . .         . .      .       ||. .|| .   ....
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFT

YEIDIWSFACIYAEII-QGYPLFSG-----NNEIEQIAKISDLLGNPCEEN----WPSIVKMPDYGKILFKQKQKKNLSTLFSQASEKEIEFLNSML---
 . |.|||     ||   | .  .|      . .| |... .    |. .|                              |    .   |  . |.   
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------F---VCCPDEMYQIMKQCW

--KYDNRPTAEQLLQSEYF
  . ..||| ...   |.|
HEDPEDRPTFSEI--HECF
Kinase 2101.AA CDK7 16-45 46 3.6e-10 22.84 In-house 1-30 (288) Show / Hide 
Range on Protein: 16-45
Range on HMM: 1-30/288
Sequence Identity: 46% (14 aa)

YKIQCKVAEGAFGSVFKAIKQNTQQIVAIK
|..  .. || |. |.||  ..| ||||||
YEKIKHIGEGQFATVYKACDHQTGQIVAIK
Kinase 2101.AA PITSLRE 16-45 33 6e-06 17.83 In-house 1-30 (295) Show / Hide 
Range on Protein: 16-45
Range on HMM: 1-30/295
Sequence Identity: 33% (10 aa)

YKIQCKVAEGAFGSVFKAIKQNTQQIVAIK
...  ...||..| |..|    |  |||.|
FQCLNRIHEGTYGVVYRAKDKRTDEIVALK