Gene 6298 (Tetrahymena)

6298

Species: Tetrahymena
Alias: 3719.m00124, 6298, PreTt06298, 58.m00270, 371, TTHERM_00483640
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
6298.AA Protein None 315 None Fasta, JSON
6298.kin_dom Protein Kinase Domain None 288 None Fasta, JSON
6298.NA RNA None 948 None Fasta, JSON

Protein domain

Protein domains of 6298.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6298.AA CDC2 14-301 57 2.5e-207 643.93 In-house 1-301 (301) Show / Hide 
Range on Protein: 14-301
Range on HMM: 1-301/301
Sequence Identity: 57% (176 aa)

YQKIKKIGEGTYGKVFQAKDLKTDQIVALKKVKNDYEEIGDEGIPSTALREISCLKALD-HPNVVKLVDVVYIMKKNKLYLVFEYIDYDLKAYQK----K
||||.||||||||.|...||..|.|||||||.. ..|. || |.||||.|||||||.|. |||.||| ||...   ||||.||||.|.||| |..    |
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGD-GVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPK

IGKIPEQTVKSYMHQILKGIEHCHSRRIFHRDLKPQNILVNNKGDIKIADFGLGKIFGIPLNTIT--HEVETLWYRAPEILLGDKLYSLPVDVWSIGCIF
  ..|.|.|||||.|||.|...||.|||.||||||||||...||.||||||||.. ||||..|.|  |||.||||||||||||.| ||.|||.|||||||
NKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIF

AEL---IIGHPLFHGDSEIDQIFKIFQFFGTPKSSKLEGTYNLKYWSNLFPRFKSQKDEILKPI-------IETDPQAADLLVKLIDIEPAKRISVSQAL
||.   .  .|||||||||||.||||...|||......| ..|... | |||.| |. ... |        ...||.. ||| ... ..|.||||. .||
AEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEAL

KHPYF
.||||
QHPYF
Kinase 6298.AA CDK 14-301 48 2.2e-165 533.2 In-house 1-284 (284) Show / Hide 
Range on Protein: 14-301
Range on HMM: 1-284/284
Sequence Identity: 48% (154 aa)

YQKIKKIGEGTYGKVFQAKDLKTD-----QIVALKKVKNDYE--EIGDEGIPSTALREISCLKALDHPNVVKLVDVVYIMK---------KNKLYLVFEY
|.|..||||||||.|. |.|..|.     |||||||.. . |  |. .||.|.||.||||.|| | |||.||| ||.. ..         .||||.||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

IDYDLKAYQKKIGKIPEQTVKSYMHQILKGIEHCHSRRIFHRDLKPQNILVNNKGD-----IKIADFGLGKIFGI------PLNTITHEVETLWYRAPEI
.|.||| | .         .|.||.|.|.|...|||..| ||||||||||.||.|      .||||||| ..|||      |..| |||| ||||||||.
MDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPEL

LLGDKLYS--LPVDVWSIGCIFAELII---GHPLFHGDSEIDQIFKIFQFFGTPKSSKLEGTYNLKYWSNLFPRFKSQKDEILKPIIETDPQAADLLVKL
|||.| ||   |.|.||.||||||..    . |||.|||||||.||||...|||  .   |   | ..                          ||| |.
LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNKM

IDIEPAKRISVSQALKHPYF
   .|.|||| .|||.||||
LCYDPKKRISAEQALQHPYF
Kinase 6298.AA CMGC 14-301 28 1.8e-139 461.48 In-house 1-513 (513) Show / Hide 
Range on Protein: 14-301
Range on HMM: 1-513/513
Sequence Identity: 28% (148 aa)

YQKIKKIGEGTYGKVFQAKD--------------LKTDQIVALKKVKNDYEEIG------DEGIPSTALREISCLKAL-----------------DHPNV
|..||||||||||.|....|               .|..|||.||.||. .|..       .|.|..|||||..|| |                 .|.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLVDVVYIMK---------------KNKLYLVFEYIDYDLKAYQKKIG---------KIPEQT------------VKSYM------HQILKGIE--HCH
||| |..|  .                |.|||||||.|.||. | |.           . .|              .|..|      .|||.|..  .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SRR--IFHRDLKPQNILVNNK--------------------GDIKIADFGLGKIFGIP---------------------LNTITHEVETLWYRAPEILLG
|..  |.||||||.|||.|..                    | .||.|||| ......                     . ..||.| |.||||||||||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

DKLYS---------LPVDVWSIGCIFAELIIG--------HPLFHGDSE-----------IDQIFKIFQFFGTPK---------------SSKLEGTYNL
.| |.          |.|.||.||||||.. |        .|||.|.||           |||.||||. .|||                . .  .  .|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

KYW----------------SNL----------FPRFKSQKDEILKPIIE---------------------------------TDPQAADLLVKLIDIEPA
 ..                |            ||... .. . |.| .                                   |||| ||| |.  ..|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRISVSQALKHPYF
|||...|||.||||
KRITAEQALQHPYF
Kinase 6298.AA CDK5 14-301 46 2.8e-130 414.04 In-house 1-287 (287) Show / Hide 
Range on Protein: 14-301
Range on HMM: 1-287/287
Sequence Identity: 46% (135 aa)

YQKIKKIGEGTYGKVFQAKDLKTDQIVALKKVKNDYEEIGDEGIPSTALREISCLKALDHPNVVKLVDVVYIMKKNKLYLVFEYIDYDLKAYQKKI-GKI
|.|. |||||||| |. |.. .|  |||||.|. | |   |||.||||.|||. || | |.|.| | ||.     .|| ||||..| ||| |  .. |..
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSE---DEGVPSTAIREICLLKELKHKNIVRLHDVIHS--EKKLTLVFEFCDQDLKKYMDSCNGEM

PEQTVKSYMHQILKGIEHCHSRRIFHRDLKPQNILVNNKGDIKIADFGLGKIFGIPLNTITHEVETLWYRAPEILLGDKLYSLPVDVWSIGCIFAELI-I
  ...||.| | |||.. ||.... |||||||| |.| .|  | |||||   |||| .. .||| |||||.| .|.| |.|| ..|.||.||||||..  
DMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANA

GHPLFHGDSEIDQIFKIFQFFGTPKSSKLEGTYNLKYWSNLFPRFKSQKDEI-LKPIIET-DPQAADLLVKLIDIEPAKRISVSQALKHPYF
| ||| | .. || ..||.  |||  .|  .  .|  .  .   . .   .  ...|.   | .  ||| |.. ..|..|||  .||.||||
GRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 6298.AA CDK7 14-235 47 2.1e-108 289.84 In-house 1-222 (288) Show / Hide 
Range on Protein: 14-235
Range on HMM: 1-222/288
Sequence Identity: 47% (107 aa)

YQKIKKIGEGTYGKVFQAKDLKTDQIVALKKVK-NDYEEIGDEGIPSTALREISCLKALDHPNVVKLVDVVYIMKKNKLYLVFEYIDYDLKAYQKKIGKI
|.|||.||||... |. | |..|.|||| ||.|     .  . ||  ||.|||  |. . |.||. |.|.  .|.|  ..|||...| ||    |    |
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDI--FMHKSNIQLVFDFMDWDLEVVIKDKSII

PEQT-VKSYMHQILKGIEHCHSRRIFHRDLKPQNILVNNKGDIKIADFGLGKIFGIPLNTITHEVETLWYRAPEILLGDKLYSLPVDVWSIGCIFAELII
  .  .|.|| ..|.|.|.||   | |||||| | |.|  |..||||||| . .| |    || | | |||||| | | . |   ||.||.|||||||. 
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML

GHPLFHGDSEIDQIFKIFQFFGTP
  | . |||.|||. .|||  |||
RVPYLPGDSDIDQLTRIFQTLGTP
Kinase 6298.AA PITSLRE 14-301 44 3.5e-107 362.38 In-house 1-295 (295) Show / Hide 
Range on Protein: 14-301
Range on HMM: 1-295/295
Sequence Identity: 44% (133 aa)

YQKIKKIGEGTYGKVFQAKDLKTDQIVALKKVKND--YEEIGDEGIPSTALREIS-CLKALDHPNVVKLVDVVYIMKKNKLYLVFEYIDYDLKAYQKKIG
.|.. .|.||||| |. ||| .|| |||||..| .   |    ||.| |.||||.  |.|| |||.|..  .|    ..| |.|.||.. |||    .. 
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEK---EGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMK

------KIPEQTVKSYMHQILKGIEHCHSRRIFHRDLKPQNILVNNKGDIKIADFGLGKIFGIPLNTITHEVETLWYRAPEILLGDKLYSLPVDVWSIGC
      |..|  .|. | | |.|.|| |.  | |||||  |.| ..||  ||.||||.  .| |.  .|  | ||||||||.||| |.|| |||.||.||
RRNQPFKPGE--IKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGC

IFAELIIGHPLFHGDSEIDQIFKIFQFFGTPKSSKLEGTYNLKYWSNLFPRFKSQKDEILKPIIE----TDPQAADLLVKLIDIEPAKRISVSQALKHPY
||||.|.. ||| |.|||||| .||. .|||  .   |   |. | ...  |. ..   |. ..     .  .. ||| ..    |..||. |.|||||.
IFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHW-KMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPW

F
|
F
Kinase 6298.AA S_TKc 14-301 32 1.4e-101 344.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-301
Range on HMM: 1-231/231
Sequence Identity: 32% (100 aa)

YQKIKKIGEGTYGKVFQAKDLKTDQIVALKKVKNDYEEIGDEGIPSTALREISCLKALDHPNVVKLVDVVYIMKKNKLYLVFEYIDY---DLKAYQKKIG
|....|||.|..|||..... ||..|||.|..|             ...|||..||  .|||.||| || .    ..||.|.||.|    ||. | || |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRG

K------IPEQTVKSYMHQILKGIEHCHSRRIFHRDLKPQNILVNNKGDIKIADFGLGKIFGIPLNTITHEVETLWYRAPEILLGDKLYSL-PVDVWSIG
.      .|| ....||.||....|.|||..| ||||||.|||...   |||.|||| ...       |. . |.||.|||.|     |.  ..|.||.|
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG

CIFAELIIGHPLFHGDSEIDQIFKIFQFFGTPKSSKLEGTYNLKYWSNLFPRFKSQKDEILKPIIETDPQAADLLVKLIDIEPAKRISVSQALK------
||..|.. | |.|.   .....||.                                          .|.| |.. |. . .|.||... .||.      
CILYEMLCGYPPFP---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HPYF
 ||.|
CHPWF
Kinase 6298.AA CRK7 14-301 34 2.2e-94 319.86 In-house 1-343 (343) Show / Hide 
Range on Protein: 14-301
Range on HMM: 1-343/343
Sequence Identity: 34% (117 aa)

YQKIKKIGEGTYGKVFQAKDLKTDQIVALKKVKNDYEEIGDEGIPSTALREISCLKALDHPNVVKLVDVVYI------MKKNK--LYLVFEYIDYDLK--
|..|. |||||||.|  ||...| ..||||||. | | |  || | || |||  |. |.|.|.|.| ..|         || |   |.||||.| ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

AYQKKIGKIPEQTVKSYMHQILKGIEHCHSRRIFHRDLKPQNILVNNKGDIKIADFGLGKIFGIPL--NTITHEVETLWYRAPEILLGDKLY--------
   | . .. .| .|..| |.| |.. || . . |||.|  |||.||.| .|||||||   .         |  | |||||.|| |||.. |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------SLPVDVWSIGCIFAELIIGHPLFHGDSEIDQIFKIFQFFGTPKSSKLEGTYNLKYWSNLFPRFKSQKDEI
                                 .|.|| |||..||  . |.| |  |..|. ||..  |.|        . | .|  . |. .  .  .
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPK-RQYNRRL

LKPIIE------TDPQAADLLVKLIDIEPAKRISVSQALKHPYF
..  ..       .... ||| |. .  | ||......| |..|
REEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase 6298.AA PCTAIRE 14-301 42 6.2e-89 301.76 In-house 1-291 (291) Show / Hide 
Range on Protein: 14-301
Range on HMM: 1-291/291
Sequence Identity: 42% (126 aa)

YQKIKKIGEGTYGKVFQAKDLKTDQIVALKKVKNDYEEIGDEGIPSTALREISCLKALDHPNVVKLVDVVYIMKKNKLYLVFEYIDYDLKAYQKKIGKIP
| |. | |||||  |.  .   || .|||| .. ..|    || | || ||.| || | | |.| | |...  .   | |||||.| ||| |    | | 
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHE----EGAPCTAIREVSLLKDLKHANIVTLHDIIHTHH--QLTLVFEYMDMDLKQYMDDCGNIM

E-QTVKSYMHQILKGIEHCHSRRIFHRDLKPQNILVNNKGDIKIADFGLGKIFGIPLNTITHEVETLWYRAPEILLGDKLYSLPVDVWSIGCIFAELIIG
.   || .. |.| |   || |.| |||||||| |.| .|  | ||||| .   .| .|  ||| ||||| |..|.|   || ..|.| .||||.|.  |
NMHNVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTG

HPLFHGDS------EIDQIFKIFQFFGTPKSSKLEG-TYNLKYWSNLFPRFKSQKDEILKPIIE-TDPQAADLLVKLIDIEPAKRISVSQALKHPYF
 ||| |          ||   ||.. |||   .  | . |  . . .|||.. |      | ..    | .||| .|   |. .|.|  .|.|||||
RPLFPGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase 6298.AA Pkinase 14-301 33 4.6e-88 303.68 Pfam 1-293 (293) Show / Hide 
Range on Protein: 14-301
Range on HMM: 1-293/293
Sequence Identity: 33% (104 aa)

YQKIKKIGEGTYGKVFQAKDLKTDQIVALKKVKNDYEEIGDEGIPSTALR--EISCLKALDHPNVVKLVDVVYIMKKNKLYLVFEYIDY-----DLKAYQ
|....|||.|..|.|..... .| .|||.|..| . |   ... . |..|  ||. .| |.|||.|.| |...   |...|.|.|| .      ||..| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHE---KSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYI

K--KIGKI--PEQTVKSYMHQILKGIEHCHSRRIFHRDLKPQNILVNNKGDI----KIADFGLGKIF-GIPLNTITHEVETLWYRAPEILLGDKLYSLPV
.  . |..  .|...|.|| |||.|.|.|||..| ||||||.|||..|.|.|    ||.|||| | |   .    |. . |.||.|||...|.. |. .|
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSIGCIFAELIIGHPLFHGD----SEIDQIFKIFQFFGTPKSSKLEGTYNLKYWSNLFPRFKSQKDEILKPIIETDPQAADLLVKLIDIEPAKRISVS
|.||.|||..|.. |.|.| |.    . .||...|..  |.| ..  . ...  | . .... .    . ... ..... . |.. ....  |.||..  
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHW-H----F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAE

QALKHPYF
|.|.||.|
QILQHPWF
Kinase 6298.AA PFTAIRE 14-301 41 6.7e-87 295.0 In-house 1-287 (287) Show / Hide 
Range on Protein: 14-301
Range on HMM: 1-287/287
Sequence Identity: 41% (122 aa)

YQKIKKIGEGTYGKVFQAKDLKTDQIVALKKVKNDYEEIGDEGIPSTALREISCLKALDHPNVVKLVDVVYIMKKNKLYLVFEYIDYDLKAY-QKKIGKI
|.|..| |||.| .|....   . |.|||| .. . |    || | || || | || | | |.| | |..    |  | .||||.. ||. |  |  | .
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQE----EGTPFTAIREASLLKNLKHANIVCLHDIIHT--KETLTFVFEYVHTDLCQYMDKHPGGM

PEQTVKSYMHQILKGIEHCHSRRIFHRDLKPQNILVNNKGDIKIADFGLGKIFGIPLNTITHEVETLWYRAPEILLGDKLYSLPVDVWSIGCIFAELIIG
  . |. .. | | |   || ||. |||||||| |. ..|  | |||||     .|  |  ||| ||||| | .|||   ||  .|.| .|||| |.. |
HPNNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWG

HPLFHGD-SEIDQIFKIFQFFGTPKSSKLEGTYNL-KYWSNLFP--RFKSQKDEILKPIIETDPQAADLLVKLIDIEPAKRISVSQALKHPYF
 |.| |     ||  |||.  |||.  .  |  .| .|    |.   .|..| .   | |.  |.| ||. |.  .|| .|.|  .|..||||
QPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase 6298.AA CDK4 14-235 47 2.3e-86 293.21 In-house 1-228 (290) Show / Hide 
Range on Protein: 14-235
Range on HMM: 1-228/290
Sequence Identity: 47% (110 aa)

YQKIKKIGEGTYGKVFQAKDLKTDQIVALKKVKNDYEEIGDEGIPSTALREISCLK---ALDHPNVVKLVDVVYIMKKNK----LYLVFEYIDYDLKAYQ
||..  |||| ||.|. | ||.| ..||||.|.   .|    |.|   .|||| ..   ...|||.|||.||   |        . .||| .| ||. | 
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEE-GGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYL

KKIGK--IPEQTVKSYMHQILKGIEHCHSRRIFHRDLKPQNILVNNKGDIKIADFGLGKIFGIPLNTITHEVETLWYRAPEILLGDKLYSLPVDVWSIGC
 |. .  .|..|.|  |||.| |..  || || |||||||||||.  | .|.||||| .|..      |  | ||||||||.||    |  ||| ||.||
DKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQM-ALTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGC

IFAELIIGHPLFHGDSEIDQIFKIFQFFGTP
||||.    ||| | || ||  |||   |.|
IFAEMYCRRPLFCGQSEKDQLHKIFDVMGLP
Kinase 6298.AA Pkinase_Tyr 14-161 31 6.1e-23 78.32 Pfam 1-157 (270) Show / Hide 
Range on Protein: 14-161
Range on HMM: 1-157/270
Sequence Identity: 31% (52 aa)

YQKIKKIGEGTYGKVFQAKDL----KTDQIVALKKVKNDYEEIGDEGIPSTA------LREISCLKAL-DHPNVVKLVDVVY-IMKKNKLYLVFEYIDY-
 ...||.||| .|.|....      .|.. || |..|        ||  . .      .||.. .| | .|||.|.|. |..   . |..|.|.||  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK--------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG

DLKAYQKK----IGKIPEQTVKSYMHQILKGIEHCHSRRIFHRDLKPQNILVNNKGDIKIADFGL
||. | .|     .... ..  .. .|| || |. .|... ||||   |.||.... .||.||||
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL
Kinase 6298.AA TyrKc 14-301 21 6.5e-14 2.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-301
Range on HMM: 1-280/280
Sequence Identity: 21% (70 aa)

YQKIKKIGEGTYGKVFQAKDLKTDQIVALKKVKNDYEEIGDEGIPSTALREISCLKAL--DHPNVVKLVDVVYIMKK-----NKLYLVFEYIDY-DLKAY
 ...||.||| .|.|....     . || |..|.|             .||.. .. |  .|||.|.|. |.   .        |..|.|| .. ||| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

QKKIGK-IPEQTVKSYMHQILKGIEHCHSRRIFHRDLKPQNILVNNKGDIKIADFGLGKIFGIP--------LNTI-----THEVETLWYRAPEILLGDK
 .| .. .. ..  |...|| .| |. ||... ||||   |.||.... .||.|||| .  .            .      .. .  .   ||| .  ..
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYG

LYSLPVDVWSIGCIFAELI-IGHPLFHG-----DSEIDQIFKIFQFFGTPKSSK----LEGTYNLKYWSNLFPRFKSQKDEILKPIIETDPQAADLLVKL
 ..   |||| |    |.   | .   |      | .. | .. | .  |.                                    .  .   ..  . 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------FVCCPDEMYQIMKQC

IDIEPAKRISVSQALKHPYF
 . .|..| . |.   | .|
WHEDPEDRPTFSEI--HECF
Kinase 6298.AA CDK7 276-301 42 4.9e-10 22.46 In-house 263-288 (288) Show / Hide 
Range on Protein: 276-301
Range on HMM: 263-288/288
Sequence Identity: 42% (11 aa)

DLLVKLIDIEPAKRISVSQALKHPYF
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DLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 6298.AA CDK4 273-301 48 2.9e-08 24.21 In-house 262-290 (290) Show / Hide 
Range on Protein: 273-301
Range on HMM: 262-290/290
Sequence Identity: 48% (14 aa)

QAADLLVKLIDIEPAKRISVSQALKHPYF
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QGDDLLQKMLCYNHHKRMSAYQCLQHPYF