Gene 25533 (Tetrahymena)
25533
Sequence
Protein domains of 25533.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 25533.AA | CDC2 | 29-312 | 55 | 6.4e-208 | 645.78 | In-house | 1-301 (301) | Show / Hide |
Range on Protein: 29-312 Range on HMM: 1-301/301 Sequence Identity: 55% (168 aa) FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEG--IPQSALREICILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDYDLKKYLE----TM .....||||||||.|||. |.|||..||.||..|.||.|| .|..|.|||..||.| ||.|||||.|||.| .||..||||.|.|||||.. .. YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN KHLTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLT--HEVETLWYRPPEILLGVKTYSLAIDMWSIGCVFY ||.... .| .|||.|.|..|||||||.|||.|||||||||.||.||||||||..|..|..|.| |||.|||||.|||||| |.||...|||||||.|. KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA EL---MEKKPLFISDSEIEAIFKIFQFHGTPNSETFQGLEDYPYFKSTFPRFHAQDPFIVFKN---------LENDARDLLMQMIALNPLDRISVKQALL |. ..|||||. ||||. .||||...||||..|..|....|..|.||||...||. ....| |.....||||||....| .|||.|.|| EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ HPYF |||| HPYF |
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Kinase | 25533.AA | CDK | 29-312 | 44 | 4.2e-166 | 535.58 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 29-312 Range on HMM: 1-284/284 Sequence Identity: 44% (142 aa) FKCLQKIGEGTYGIVYKGFDTQTN-----TQVAIKKVKLDQ-----EQEGIPQSALREICILKDLSDHQNIVKLRDVIYQIE---------ESKLFLVFE ...|.||||||||.|||. |.||. ||.||..... | ||.|..|.|||..||.| |.|||||.||... . |.||..||| YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE YVDYDLKKYLETMKHLTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGN-----VKIADFGLAKTFQV------PSKTLTHEVETLWYRPPE |.|.|||||.. || .|.|||.||..||...|.|||.|||||||.. |. .||||||||. |.. |..|.|||| |||||.|| YMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE ILLGVKTYS--LAIDMWSIGCVFYELME---KKPLFISDSEIEAIFKIFQFHGTPNSETFQGLEDYPYFKSTFPRFHAQDPFIVFKNLENDARDLLMQMI .||| |.|| .|||||.||.|.|.. .|||| ||||. .||||.. |||. .. |....|.. |||..| LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKML ALNPLDRISVKQALLHPYF ...| ||| .||| |||| CYDPKKRISAEQALQHPYF |
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Kinase | 25533.AA | CMGC | 29-312 | 27 | 9.90000000001e-135 | 445.58 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 29-312 Range on HMM: 1-513/513 Sequence Identity: 27% (140 aa) FKCLQKIGEGTYGIVYKGFDTQTN--------------TQVAIKKVKLDQ---------EQEGIPQSALREICILKDLS----------------DHQNI .....||||||||.|||..|..|| .|||||.|... | .|.|..||||| ||| |. .| || YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI VKLRDVIYQIEES---------------KLFLVFEYVDYDLKKYLETMK---------HLTQHD------------IKLIM------YQLLNGLD--FCH |||.|..| .. .|.|||||.|.||..|.. .. .|.. || .| ||.|.||. .|| VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH QRR--IIHRDIKPQNILIDKA--------------------GNVKIADFGLAKTFQVP---------------------SKTLTHEVETLWYRPPEILLG ... |||||.||.||||.. |..||.|||||. . .. ....||.| |.|||.|||||| SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG VKTYS---------LAIDMWSIGCVFYELMEK--------KPLFISDSE-----------IEAIFKIFQFHGTPN---------------SETFQGLEDY | |. .|||||.||.|.|.. . |||| .|| |. .||||. |||. .|.. . .. WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL PYF---------------KST-----------FPRFHAQDPFIVFKNLEN-----------------------------------DARDLLMQMIALNPL |.. .| ||... .. .|... | .|.|||..| ..| PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD DRISVKQALLHPYF .||...||| |||| KRITAEQALQHPYF |
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Kinase | 25533.AA | CDK5 | 29-312 | 47 | 9.90000000001e-134 | 425.16 | In-house | 1-287 (287) | Show / Hide |
Range on Protein: 29-312 Range on HMM: 1-287/287 Sequence Identity: 47% (137 aa) FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEGIPQSALREICILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDYDLKKYLETMK-HLTQ .. . ||||||||.|||. . .| ||.|.|.||.| ||.| .|.||||.|| | |.||| | ||| | || ||||..| |||||.. .. . . YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKEL-KHKNIVRLHDVIHS--EKKLTLVFEFCDQDLKKYMDSCNGEMDM HDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLTHEVETLWYRPPEILLGVKTYSLAIDMWSIGCVFYELM-EKK | || .||||| || |||.... ||| |||| || | |. | |||||| | .| .. .||| ||||||| .|.| |.|| |||||.||.| |.. . HIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGR PLFISDSEIEAIFKIFQFHGTPNSETFQGLEDYPYFK---STFPRFHAQD-PFIVFKNLENDARDLLMQMIALNPLDRISVKQALLHPYF ||| .. . ..||. |||. .. .. . | .| .| ..|. . ..|. .||| .|. .|| ||| |.|| |||| PLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF |
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Kinase | 25533.AA | S_TKc | 29-312 | 29 | 5.4e-100 | 339.43 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 29-312 Range on HMM: 1-231/231 Sequence Identity: 29% (89 aa) FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEGIPQSALREICILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDY---DLKKYLETMKH- .. |.|||.|..| |||. .. |. .||||..| ....||| ||| .| ||||| ||.. ..|..|.||.| ||..|.. ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH -----LTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLTHEVETLWYRPPEILLGVKTYSL-AIDMWSIGCV .. ... .|||....|..||...|||||.||.|||.|. ..||.|||||. . |. . |.||..||.| |. ..|.||.||. GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI FYELMEKKPLFISDSEIEAIFKIFQFHGTPNSETFQGLEDYPYFKSTFPRFHAQDPFIVFKNLENDARDLLMQMIALNPLDRISVKQALL-------HPY .||.. .|.| .....||. .|.|..... .| .|... .|| ||. LYEMLCGYPPFP---QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW F | F |
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Kinase | 25533.AA | PFTAIRE | 29-312 | 42 | 1.1e-97 | 330.88 | In-house | 1-287 (287) | Show / Hide |
Range on Protein: 29-312 Range on HMM: 1-287/287 Sequence Identity: 42% (125 aa) FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEGIPQSALREICILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDYDLKKYLETMKH-LTQ .. |.| |||.| ||||. .. || | ..|.|| || | | || ||.| | ||| | |.| | | .|||||. ||..|.. . YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQE-EGTPFTAIREASLLKNLK-HANIVCLHDIIHTKE--TLTFVFEYVHTDLCQYMDKHPGGMHP HDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLTHEVETLWYRPPEILLGVKTYSLAIDMWSIGCVFYELMEKKP . ..| ..||| || .|||||. |||.|||| || ..| | |||||| |||.| ||| ||||||| .||| || .||| .||.| |.| .| NNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQP LFISD-SEIEAIFKIFQFHGTPNSETFQGLEDYPYFKSTFPR--FHAQDPF-IVFKNLE--NDARDLLMQMIALNPLDRISVKQALLHPYF .| . |||. |||. .|. | | .| | |. .. .. .. ..| ||.|.| ..| ||.| ..|. |||| AFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF |
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Kinase | 25533.AA | Pkinase | 29-312 | 31 | 5.5e-96 | 329.99 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 29-312 Range on HMM: 1-293/293 Sequence Identity: 31% (96 aa) FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEGIPQSALR--EICILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDY-----DLKKYLE- .....|||.|..| |||. . |. .||.|..|.. | .. .|...| ||.|.| | .| |||.|.|. . .... .|.||.. ||. |.. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST -TMKHL--TQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNV----KIADFGLAKTF-QVPSKTLTHEVETLWYRPPEILLGVKTYSLAIDM . . . ...| .|||.| ||..||...|||||.||.|||||. |.. ||.|||||| | .. .|. . |.||..||...| . |. ..|| WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM WSIGCVFYELMEKKPLFISD----SEIEAIFKIFQFHGTPNSETFQGLEDYPYFKSTFPRFHAQDPFIVFKNLENDARDLLMQMIALNPLDRISVKQALL ||.||..||.. ..|.| .. . .. ...|.. |.|... .. . . .||. ... .. . . .|.. ...|.. .....| .|.. .|.| WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ HPYF ||.| HPWF |
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Kinase | 25533.AA | PCTAIRE | 29-312 | 42 | 8.6e-96 | 324.54 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 29-312 Range on HMM: 1-291/291 Sequence Identity: 42% (125 aa) FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEGIPQSALREICILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDYDLKKYLE-TMKHLTQ .. | | ||||| |||. |. || | ..| . .|| | | ||. |||| | ||| | |.|.. . | ||||| | |||.|.. . YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRL-EHEEGAPCTAIREVSLLKDLK-HANIVTLHDIIHT--HHQLTLVFEYMDMDLKQYMDDCGNIMNM HDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLTHEVETLWYRPPEILLGVKTYSLAIDMWSIGCVFYELMEKKP |..||...||| ||..||.|.| ||| |||| ||. | | ||||||. ||.|| ||| |||||||..|.| || |||| .||.|||. .| HNVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRP LFISDS------EIEAIFKIFQFHGTPNSETFQGLEDYPYFKS-TFPRFHAQDPFIVFKNLE---NDARDLLMQMIALNPLDRISVKQALLHPYF || . ||.. ||| .| | . . |.. |||. .| . |. . ||| .. . . |.| .|..|||| LFPGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF |
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Kinase | 25533.AA | CRK7 | 29-312 | 34 | 5.5e-92 | 311.9 | In-house | 1-343 (343) | Show / Hide |
Range on Protein: 29-312 Range on HMM: 1-343/343 Sequence Identity: 34% (119 aa) FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQE---QEGIPQSALREICILKDLSDHQNIVKLRDVIYQ------IEESK--LFLVFEYVDYDLKK .. .. ||||||| ||| ...|. .|| |||..| | .|| | | ||| ||. | .|||||.|.... . | ..||||.| || YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQL-NHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMG YLETM--KHLTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPS--KTLTHEVETLWYRPPEILLGVKTY------- || .| . .| .| ||| |.| ||.. ..||||| |||.. |.||||||||| . . . .| | |||||||| ||| . | LLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILK -------------------------------SLAIDMWSIGCVFYELMEKKPLFISDSEIEAIFKIFQFHGTPNSETFQGLEDYPYFKSTFPRF----HA .||||| || . ||. |||.| |.. . ||.. |.|| . . . |... |. ELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRL QDPFI-VFK--NLENDARDLLMQMIALNPLDRISVKQALLHPYF |. .| .. .. ||| .| .|.| |......| |..| REEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF |
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Kinase | 25533.AA | PITSLRE | 29-249 | 45 | 1.5e-90 | 307.16 | In-house | 1-227 (295) | Show / Hide |
Range on Protein: 29-249 Range on HMM: 1-227/295 Sequence Identity: 45% (104 aa) FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLD--QEQEGIPQSALREIC-ILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDYDLKKYLETMK-- |.|| .|.|||||.||.. |..|. ||.|..|.. .| ||.| .|||| ||. | | |||... .. | ..|.|||. ||| .|.|| FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMAL-QHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRR --HLTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLTHEVETLWYRPPEILLGVKTYSLAIDMWSIGCVFYE . || | |||.| .. | |.||| | |.|. .|. ||.||||| .. | | .| | ||||| ||.||| |.|| ..||||.||.| | NQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAE LMEKKPLFISDSEIEAIFKIFQFHGTPN .. .|||| .|||. | .||. |||. FITMKPLFQGKSEIDQINCIFKEMGTPT |
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Kinase | 25533.AA | CDK4 | 29-312 | 39 | 7.1e-89 | 301.56 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 29-312 Range on HMM: 1-290/290 Sequence Identity: 39% (119 aa) FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQE--GIPQSALREICILKDL--SDHQNIVKLRDVIYQIEESK----LFLVFEYVDYDLKKYLE ..|.. |||| ||.||. |..| || |.|. . | |.|.| .||| ... | ..| ||||| || ... . .||| .| ||. ||. YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD TMKH--LTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLTHEVETLWYRPPEILLGVKTYSLAIDMWSIGCV . . . || .| ||| |.|| | |||||| ||||||. | ||.||||||... . || | ||||| ||.|| .| .||||.||. KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGCI FYELMEKKPLFISDSEIEAIFKIFQFHGTPNSETFQGLEDYP----YFKSTFPRFHAQDPFIVFKNLENDARDLLMQMIALNPLDRISVKQALLHPYF | |. .||| || . ||| |.| . .| | . || |.. . . ... . ||| .| |. |.| |.| |||| FAEMYCRRPLFCGQSEKDQLHKIFDVMGLP------PEDDWPRDVSLPWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF |
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Kinase | 25533.AA | MAPK | 29-312 | 31 | 1.6e-87 | 297.1 | In-house | 1-328 (328) | Show / Hide |
Range on Protein: 29-312 Range on HMM: 1-328/328 Sequence Identity: 31% (103 aa) FKCLQKIGEGTYGIVYKGFDTQ------TNTQVAIKKVK--LDQEQEGIPQSALREICILKDLSDHQNIVKLRDVIYQ-----IEE----SKLFLVFEYV .. |..||.| ||.| . .|. ....|||||. . .. ..||| .|. . .| ||.||.|... .. . .|.|. YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK--RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELM DYDLKKYLETMKHLTQHDIKLIMYQLLNG--LDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQV-PSKT-------------LTHEVETLWYR . || . ......|. . |. .|||.|.| | . | ..||||.|| |||... . .||.||||| .. .. .| | | ||| ETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYR PPEILLG--VKTYSLAIDMWSIGCVFYELME-KKPLFISDSEIEAIFKIFQFHGTPNSETFQGLE-D---YPYFKS-TFPRFHAQDPF-IVFKN----LE |||.|. . |. |.||||.|| | |.. |||| .. |. ...|... ||| | | .. . . |..| ... . . |. .|.| APEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN NDARDLLMQMIALNPLDRISVKQALLHPYF .|.||| .| ...| .||.|..|| |||| PQAIDLLEKMLVFDPDKRITVEEALQHPYF |
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Kinase | 25533.AA | Pkinase_Tyr | 29-177 | 32 | 3e-28 | 96.3 | Pfam | 1-160 (270) | Show / Hide |
Range on Protein: 29-177 Range on HMM: 1-160/270 Sequence Identity: 32% (54 aa) FKCLQKIGEGTYGIVYKGFDT----QTNTQVAIKKVKLDQEQEGIPQSA------LREICILKDLSDHQNIVKLRDVIYQIEES-KLFLVFEYVDY-DLK . ..|.||| .| |||| . .|...||.|..| || ... .||. |.| | .|.|||.| |.. .|. ....|.||. . ||. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL KYLETM----KHLTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKT .|| . ..|| .|. . .| .|... .....||||. |.|... . |||.|||||.. DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD |
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Kinase | 25533.AA | TyrKc | 29-312 | 23 | 1.4e-15 | 29.22 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 29-312 Range on HMM: 1-280/280 Sequence Identity: 23% (73 aa) FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEGIPQSALREICILKDL-SDHQNIVKLRDVIYQIEE-----SKLFLVFEYVDY-DLKKYLET . ..|.||| .|.|||| . .|||.|..| | . .||. |.. | .|.|||.| |. | .. |..|.||... |||.|| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK MKH-LTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTF-----------QVPSKT--LTHEVETLWYRPPEILLGVKTYS .. |. | ...| .| .. |....||||. |.|... . |||.||||.. .|. .. . . .|| . .... HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT LAIDMWSIGCVFYELME--KKPLF------ISDSEIEAIFKIFQFHGTPNS----ETFQGLEDYPYFKSTFPRFHAQDPFIVFKNLENDARDLLMQMIAL . | || | . .|.. ..| .|..|. . | | . | . .. | . TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------FVCCPDEMYQIMKQCWHE NPLDRISVKQALLHPYF .| || . .. | .| DPEDRPTFSEI--HECF |
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Kinase | 25533.AA | PITSLRE | 287-312 | 53 | 5e-08 | 25.52 | In-house | 270-295 (295) | Show / Hide |
Range on Protein: 287-312 Range on HMM: 270-295/295 Sequence Identity: 53% (14 aa) DLLMQMIALNPLDRISVKQALLHPYF ||| || .|| ||. .|| ||.| DLLNQMLTYNPKNRITASDALKHPWF |