Gene 23583 (Tetrahymena)

23583

Species: Tetrahymena
Alias: TTHERM_00394590, 42.m00317, 218, 23583, PreTt23583, 3813.m01536
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
23583.AA Protein None 335 None Fasta, JSON
23583.kin_dom Protein Kinase Domain None 289 None Fasta, JSON
23583.NA RNA None 1008 None Fasta, JSON

Protein domain

Protein domains of 23583.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23583.AA CDC2 14-302 37 1.3e-156 485.24 In-house 1-301 (301) Show / Hide 
Range on Protein: 14-302
Range on HMM: 1-301/301
Sequence Identity: 37% (115 aa)

YLRIKKINEGSFGKIILCELVDQKGQYCVLKKFKVTQQSAID---ELSIKEIYYMKKLD-HPNLVKSDDIFKIKKSYNGQDFFEQLYMHLPYYLEMSEVP
| .|.||.||..|... |. ....  ...|||....|....|   . .|.||...|.|. |||.|| .|....   .. ...||.|.|.|..|..||...
YQKIEKIGEGTYGVVYKCKDMQTNQ-IVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPK

RENLSVEAIKILIKQLIEAVHFLHQKKIIHRDIKPSNIFLDKTGKLLLGDMGISRDFPENKDQELTG-NTITRLYRPPEILFGCKKYNETVDLWSLGCTI
.........| ...|....|||.||..|.|||.||.||..||.|.. ..|.|..|.|. ......|. ...|..||.||||.|||.|. .||.||.||..
NKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIF

AEFFMD-HKKYFFQGKSEIDQLCKVFEIRGSANEQNWPGCTELP-YYMDFGELNQKDLSSLLPK---------APKECIEIIDSLLQLCPQKRAKIEDII
||.||| .||..|.|.||||||.|.|.|.|..|||.|||.|.|| |...|......|||...|.         ...|.|......||..|||| ......
AEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEAL

QNKWL
|....
QHPYF
Kinase 23583.AA CDK 14-302 29 2.8e-107 344.32 In-house 1-284 (284) Show / Hide 
Range on Protein: 14-302
Range on HMM: 1-284/284
Sequence Identity: 29% (94 aa)

YLRIKKINEGSFGKIILCELVDQK----GQYCVLKKFKVTQQ------SAIDELSIKEIYYMKKLDHPNLVKSDDIFKIKKS---------YNGQDFFEQ
| ...|| ||..|.   .   ...    ||.. |||... ..        .   .| || ..|.| ||| ||  |..  |..          . .  || 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LYMHLPYYLEMSEVPRENLSVEAIKILIKQLIEAVHFLHQKKIIHRDIKPSNIFLDKTGK-----LLLGDMGISRDFPEN-----KDQELTGNTITRLYR
. . |  |..             || ...||....|..|...|.|||.||.|| ....|.     | ..|.| .| |  .     . ...| . .|. ||
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

PPEILFGCKKYN--ETVDLWSLGCTIAEFFMD-HKKYFFQGKSEIDQLCKVFEIRGSANEQNWPGCTELPYYMDFGELNQKDLSSLLPKAPKECIEIIDS
.||.|.|.|.|.   ..|.||.|| .||.|.| ..|..|.|.||||||.|.|.| |. .|.||||.|.||.|                       . ...
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------DLLNK

LLQLCPQKRAKIEDIIQNKWL
.|...|.|| . |.  | ...
MLCYDPKKRISAEQALQHPYF
Kinase 23583.AA CMGC 14-302 18 6.4e-84 275.51 In-house 1-513 (513) Show / Hide 
Range on Protein: 14-302
Range on HMM: 1-513/513
Sequence Identity: 18% (95 aa)

YLRIKKINEGSFGKIILCELVD-------------QKGQYCVLKKFKVTQQSAIDEL-----------SIKEIYYMKKL-----------------DHPN
|  |||| ||..|.   |   .             . .... .||.|  .   ....           .. || ..|.|                 .|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVKSDDIFKIKKSY---------------NGQDFFEQLYMHLPYYLEMSEVP------------------------RENLSVEAIKILIKQLIEAVH--F
.||  |||. |.|                .    || . . |  |...   .                          .... .|.  ..|......  .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LHQKK--IIHRDIKPSNIFLDKT--------------------GKLLLGDMGISRDFPENKDQ--------------------ELTGNTITRLYRPPEIL
.|...  |||||.||.|| ....                    |.| ..| | .| . ...|.                     .| .  || ||.||||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FGC---------KKYNETVDLWSLGCTIAEFFMD------HKKYFFQGKSE-----------IDQLCKVFEIRGSAN---------------EQNWPGCT
.|.         ..|....| ||.|| .|| ..       ..|..|.|.||           |||| | |.. |. .               |..||...
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

ELPYYMD---------------------------FGELNQKDLSSLLPK-----------------------------------APKECIEIIDSLLQLC
.||.|                             |.. . |....| |.                                   .....|. .. .||. 
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PQKRAKIEDIIQNKWL
|.|| ..|.. |  ..
PDKRITAEQALQHPYF
Kinase 23583.AA CDK7 118-302 27 4e-49 128.7 In-house 104-288 (288) Show / Hide 
Range on Protein: 118-302
Range on HMM: 104-288/288
Sequence Identity: 27% (52 aa)

IKILIKQLIEAVHFLHQKKIIHRDIKPSNIFLDKTGKLLLGDMGISRDFPENKDQELTGNTITRLYRPPEILFGCKKYNETVDLWSLGCTIAEFFMDHKK
||   ...   . ..|.  | |||.|| |  ... |.| ..| |  | ..    . .| . .|| || || ||| . |   ||.|| || .||       
IKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYG-SPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML--RV

YFFQGKSEIDQLCKVFEIRGSANEQNWPGCTELPYYMDFGELNQ---KDLSSLLPKAPKECIEIIDSLLQLCPQKRAKIEDIIQNKWL
 .. | |.|||| ..|.. |  .|..||. .... |. | .        |  .   |. . .. .  .. . |.|| .  .  . .  
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 23583.AA S_TKc 14-302 22 1.8e-48 168.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-302
Range on HMM: 1-231/231
Sequence Identity: 22% (68 aa)

YLRIKKINEGSFGKIILCELVDQKGQYCVLKKFKVTQQSAIDELSIKEIYYMKKLDHPNLVKSDDIFKIKKSYNGQDFFEQLYMHLPYYL----EMSEVP
|  ..|| .|.|||  .|  ..  |... .|. |        |  ..||  .|| .|||.||  |.|            . ||| . |      .. .. 
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD----------DHLYMVMEYCDGDLGDLFDYI

REN--------LSVEAIKILIKQLIEAVHFLHQKKIIHRDIKPSNIFLDKTGKLLLGDMGISRDFPENKDQELTGNTITRLYRPPEILFGCKKYNE-TVD
...        ..   .. ...|...|. ..|...|||||.||.||.||.   . ..| |..| .        |    |. |..||.|    .|.   .|
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCD

LWSLGCTIAEFFMDHKKYFFQGKSEIDQLCKVFEIRGSANEQNWPGCTELPYYMDFGELNQKDLSSLLPKAPKECIEIIDSLLQLCPQKRAKIEDIIQ--
 ||.||...|..    .  |.   ..... |.                                       ..|....|. .||  |.||  . .. |  
WWSCGCILYEMLC--GYPPFP---QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

-----NKWL
       |.
WDIKCHPWF
Kinase 23583.AA CDK-Unclassified 107-302 30 2.5e-48 157.01 In-house 112-324 (324) Show / Hide 
Range on Protein: 107-302
Range on HMM: 112-324/324
Sequence Identity: 30% (65 aa)

EVPRENLSVEAIKILIKQLIEAVHFLHQKKIIHRDIKPSNIFLDKTG-----KLLLGDMGISRDFP----------ENK-DQELTGNTITRLYRPPEILF
...| |||   |.   .|..|   .|| .||.||||||.|| .. ..     .| ..| |....              . .|. . .  || || ||.||
HNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVSTRWYRAPELLF

GCKKYNETVDLWSLGCTIAEFFMDHKKYFFQGKSEIDQLCKVFEIRGSANEQNWPGCTELPYYMDFGELNQKDLS--SLLPKAPKEC-IEIIDSLLQLCP
| |.|.  || ||.|| .||.|   .|  |||..||.|. ..| . |. .| .||  . .| |    . .   .    . ||  ..  ....  .. . |
GSKCYDTGVDIWSFGCIYAEWF--QGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASENNCEFQMVMYQP

QKRAKIEDIIQNKWL
 .| | . | |  |.
YNRWKCMEILQHPWF
Kinase 23583.AA Pkinase 14-302 25 9.7e-47 166.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 14-302
Range on HMM: 1-293/293
Sequence Identity: 25% (80 aa)

YLRIKKINEGSFGKIILCELVDQKGQYCVLKKFKVTQQSAIDELSIK--EIYYMKKLDHPNLVKSDDIFKIKKSYNGQDFFEQLYMHLPYYLEMS----E
| ...|| .||||.  .|  ..   ...| .  |... |  |.  ..  ||..||.|.||| |.  |.|              .|| .. |.|.     .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---------KDHIYMVME-YCEGGLYVMD

VP-------RENL--SVEAIKILIKQLIEAVHFLHQKKIIHRDIKPSNIFLDKTGKL----LLGDMGISRDFPENKDQELTGNTITRLYRPPEILFGCKK
         . ..  | . .|  ..|..... ..|...|||||.||.||..|..| .     ..| |... | . ... .|. . |. |..||.. |...
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

YNETVDLWSLGCTIAEFFMDHKKYFFQGK----SEIDQLCKVFEIRGSANEQNWPGCTELPYYMDFGELNQKDLSSLLPKAPKECIEIIDSLLQLCPQKR
|   || ||.||...|..   ..  |.|.    . .||. ....|.|  .. .||   . .|.. |     . .. . .....||...|...|...|.||
YGPKVDMWSCGCILYEMLC--GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHW-HF-HWTF-HNWSEECKDFIKWCLCKDPKKR

AKIEDIIQNKWL
  .|.| | .|.
PTAEQILQHPWF
Kinase 23583.AA CDK5 14-302 26 1.5e-44 138.37 In-house 1-287 (287) Show / Hide 
Range on Protein: 14-302
Range on HMM: 1-287/287
Sequence Identity: 26% (80 aa)

YLRIKKINEGSFGKIILCELVDQKGQYCVLKKFKVTQQ-SAIDELSIKEIYYMKKLDHPNLVKSDDIFKIKKSYNGQDFFEQLYMHLPYYLEMSEVPREN
| .. || || .| ..   .  . . .  ||. .  .    .    | ||  .| | |.| |   |.    |       || .   |  |..  ..   .
YEKMEKIGEGTYG-TVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKL--TLVFEFCDQDLKKYMDSCNG---E

LSVEAIKILIKQLIEAVHFLHQKKIIHRDIKPSNIFLDKTGKLLLGDMGISRDF--PENKDQELTGNTITRLYRPPEILFGCKKYNETVDLWSLGCTIAE
.. . || .. ||   . | |.... ||| || |    | |.| |.| |  | |  | .     .   .|  |||| .|.| |.|.  .|.|| || .||
MDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRC---YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAE

FFMDHKKYFFQGKSEIDQLCKVFEIRGSANEQNWPGCTELPYYM----DFGELNQKD-LSSLLPKAPKECIEIIDSLLQLCPQKRAKIEDIIQNKWL
  ..  .  | | .. ||| ..|.| |. .| .||. |.|| |     ..   . .  .... ||  ..  ..   .||. |..|   .. ..  . 
-MANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 23583.AA CRK7 112-302 29 4.5e-39 132.28 In-house 108-343 (343) Show / Hide 
Range on Protein: 112-302
Range on HMM: 108-343/343
Sequence Identity: 29% (71 aa)

NLSVEAIKILIKQLIEAVHFLHQKKIIHRDIKPSNIFLDKTGKLLLGDMGISRDF-PENKDQELTGNTITRLYRPPEILFGCKKY---------------
. | . .| . ||| | .  .|.|...||||| ||| ..  |.. . | |  | . .|.| . .|   ||  ||||| | | ..|               
HFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKELIRNIKS

-----------------------NETVDLWSLGCTIAEFFMDHKKYFFQGKSEIDQLCKVFEIRGSANEQNWPGCTELPYYMDFGELN------QKDLS-
                       .  .| || ||  .| |   ||  |||. |..|| |...| || | .|||  ..||.. ..           .. . 
IQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFT--KKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLREEFYH

---SLLPKAPKECIEIIDSLLQLCPQKRAKIEDIIQNKWL
   . ..  ||||    | .| | |.||   |.  |  |.
HKKPVFM--PKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase 23583.AA PITSLRE 118-251 44 8e-39 135.3 In-house 108-238 (295) Show / Hide 
Range on Protein: 118-251
Range on HMM: 108-238/295
Sequence Identity: 44% (60 aa)

IKILIKQLIEAVHFLHQKKIIHRDIKPSNIFLDKTGKLLLGDMGISRDFPENKDQELTGNTITRLYRPPEILFGCKKYNETVDLWSLGCTIAEFFMDHKK
|| |. ||  .|...| ..|.||| | ||. .   | | ..| |  | . ..    .| . .|  || ||.| |||||   ||.|| ||  ||| .  .|
IKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSP-IKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFIT--MK

YFFQGKSEIDQLCKVFEIRGSANEQNWPGCTELP
  |||||||||. ..|   |  .|. ||| ||||
PLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELP
Kinase 23583.AA Ciliate-E2-Unclassified 14-302 21 4.7e-36 122.55 In-house 1-352 (352) Show / Hide 
Range on Protein: 14-302
Range on HMM: 1-352/352
Sequence Identity: 21% (82 aa)

YLRIKKINEGSFGKIILCELVDQKGQY------CVLKKFKVTQQSAID--ELSIKEIYYMKKLDHPN---------LVKSDDIFKIKKSYNGQDF-----
|  ||.|..|.|||. .|.  .|| ||      .. ...|. |.   |   ...||.  .|| .| .         |. ....|..|. |  ||      
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

-FEQL-YMHLPYYLE-------------MSEVPRENLSVEAIK-----ILIKQLIEAVHFLHQKK-IIHRDIKPSNIFLDKTG---KLLLGDMGISRDFP
  |.. . .| .|..             ..   |. .. ...|      ...|....  .||.|. ||||||||.||..|. |   .. . | |||.   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

EN--------------KDQELTGNTITRLYR----PPEILFGCKKYNET---VDLWSLGCTIAEFFMDHKKYFFQGKS------------------EIDQ
.|              |.|... .. |  |     .||.| |.. ....   .| ||||. .  ..|   .| |....                  .. |
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL--YEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

LCKVFEIRGSANE-QNWPGCTELPYYMDFGELNQKDLSSLLPKAPKECIE-IIDSLLQLCPQKRAKIEDIIQNKWL
 .|  .|  .  . |.                     .  ...  |..|. .. ..|. .| ||  .|.|..  |.
NIKQKNIQFPKFPWQQ--------------------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 23583.AA Ciliate-E2 14-302 18 1.7e-35 119.34 In-house 1-365 (365) Show / Hide 
Range on Protein: 14-302
Range on HMM: 1-365/365
Sequence Identity: 18% (78 aa)

YLRIKKINEGSFGKIILCELVDQKGQY-----------------CVLKKFKVTQQSAIDELSI-KEIYYMK----------------KLDHPNLVKSDDI
|  |||| .|.||.. .|.   .. |.                 .  |.. . ...  .  .| .||. |.                .|.|||..|  . 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FKIKKS---------YNGQDFFE------QLYMHLPYYLEMSEVPRENLSVEAIKILIKQLIE---------------AVHFLHQKK-IIHRDIKPSNIF
|. |.          ..|.| |.      .   | .      .   .... . || ..||...               |...||.|. ||||||||.||.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE-----K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL

LDKTGKLLLGDMGISRDFPENKDQELTGNTI-------------------------------TRLYRPPEILFGCKK--------YNETVDLWSLGCTIA
.     . . |.|.|... .. ....  . .                               |  | .|||| | |         |.. .|.||||... 
F-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL-

EFFMDHKKYFFQGKSEIDQLCKVFEIRGSANEQNWPGCTELPYYMDFGELNQKDLSSLLP-------------------KAPKECIEIIDS----LLQLC
 ..|  .|. |                                     . ..|.    .|                   | ..||. .|      .||  
-YEMLFGKPPF-------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKD

PQKRAK-IEDIIQNKWL
|.||   .|.|....|.
PEKRITGWEQILNHPWF
Kinase 23583.AA TyrKc 14-301 17 5.9e-10 -61.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-301
Range on HMM: 1-280/280
Sequence Identity: 17% (56 aa)

YLRIKKINEGSFGKIILCELVDQKGQYCVLKKFKVTQQSAIDELSIKEIYYMKKL--DHPNLVKSDDIFKIKKSYNGQDFF---EQLYMHLPY-------
   .||. || ||.. ....     . .  |. |      . .. ..|.  |.||  .|||.|.   .   ..       |   |.|.. . |       
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRN-----FMYIEPLMIVMEYMPHGDLK

-YLEMSEVPRENLSVEAIKILIKQLIEAVHFLHQKKIIHRDIKPSNIFLDKTGKLLLGDMGISRDFPEN-------KDQEL----TGNT-ITRLYRPPEI
 ||  ..     |...       |  .   .||.|..||||.   |. ... .    .| | |||  .        .         |.| .     .|| 
DYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LFGCKKYNETVDLWSLGCTIAEFFMDHKKYFFQ------GKSEIDQLCKVFEIRGSANE----QNWPGCTELPYYMDFGELNQKDLSSLLPKAPKECIEI
.. . |...  | || | .. | | . ..            .|. .. |  . .    .                            .  . .|.|  .|
INYG-KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------F--VCCPDEMYQI

IDSLLQLCPQKRAKIEDIIQNKW
. .  .  | .|   ..|   ..
MKQCWHEDPEDRPTFSEI-HECF
Kinase 23583.AA CDK7 14-80 31 0.000452 6.26 In-house 1-71 (288) Show / Hide 
Range on Protein: 14-80
Range on HMM: 1-71/288
Sequence Identity: 31% (23 aa)

YLRIKKINEGSFGKIILCELVDQKGQYCVLKKFK-VTQQSA----IDELSIKEIYYMKKLDHPNLVKSDDIF
|  ||.| || |. . .  .. | ||    || | .  .|     |.   | || . . . |.| .   |||
YEKIKHIGEGQFATVYKA-CDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIF
Kinase 23583.AA Pkinase_Tyr 14-75 24 0.001181 13.0 Pfam 1-68 (270) Show / Hide 
Range on Protein: 14-75
Range on HMM: 1-68/270
Sequence Identity: 24% (17 aa)

YLRIKKINEGSFGKIILCELV---DQKGQYCVLKKFKVTQQSA---IDELSIKEIYYMKKL-DHPNLVK
   .||. ||.||.. ....    |.... .  |. | .  .    .... ..|.  ||.| .|||.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF-MREAKIMKQLGHHPNIVR
Kinase 23583.AA CRK7 14-28 40 0.243488 0.14 In-house 1-15 (343) Show / Hide 
Range on Protein: 14-28
Range on HMM: 1-15/343
Sequence Identity: 40% (6 aa)

YLRIKKINEGSFGKI
|..|. | || .|..
YEMIMQIGEGTYGQV
Kinase 23583.AA Pkinase_Tyr 131-142 50 1.342987 2.65 Pfam 126-137 (270) Show / Hide 
Range on Protein: 131-142
Range on HMM: 126-137/270
Sequence Identity: 50% (6 aa)

FLHQKKIIHRDI
.|..|..||||.
YLESKNCIHRDL