Gene 21599 (Tetrahymena)

21599

Species: Tetrahymena
Alias: PreTt21599, TTHERM_00411810, 3714.m00112, 407, 44.m00266, 21599
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
21599.AA Protein None 318 None Fasta, JSON
21599.kin_dom Protein Kinase Domain None 289 None Fasta, JSON
21599.NA RNA None 957 None Fasta, JSON

Protein domain

Protein domains of 21599.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21599.AA CDC2 11-299 60 6.2e-215 667.74 In-house 1-301 (301) Show / Hide 
Range on Protein: 11-299
Range on HMM: 1-301/301
Sequence Identity: 60% (184 aa)

YEKLLKVGEGTYGEVYKAKDIQSSEIVALKKIKLENEDEG--VPSTALREISILKELQPHPNIVCMHEVIYQPQEKKLYLVFEFVDQDLKKFLDQYRKDK
|.|. |.||||||.|||.|| |. .|||||||.||.||||  |||||.||||.||||..|||||. |.||.|   .|||.|||..|.||||..|.. . .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

KLQLRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNILIDAKGNIKIADFGLARAFGVPIKTLT--HEVETLWYRAPEILLGQKAYSLGVDIWSLGCIF
  .. |  .|  |||||.|..|||.|||.||||||||||||.||||||||||||||||.||.|.|  |||.||||||||||||.| ||..||.||.||||
-KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIF

HEM---VEKRALFMGDSEIDQIFKIFQYHGTPTEQTWPALKECPYFKPIYPRFKTADPKTYFKN---------FCDKGFDLIQQMIALDPAKRISVKDAL
.||   |.|..||.|||||||.||||...|||.||||| ....|..|. .||.|. |......|          ...|.||..||...||.||||.|.||
AEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEAL

RHPYF
.||||
QHPYF
Kinase 21599.AA CDK 11-299 49 7.69999999999e-181 583.49 In-house 1-284 (284) Show / Hide 
Range on Protein: 11-299
Range on HMM: 1-284/284
Sequence Identity: 49% (160 aa)

YEKLLKVGEGTYGEVYKAKDIQSS-----EIVALKKIKLEN-----EDEGVPSTALREISILKELQPHPNIVCMHEVIYQPQ---------EKKLYLVFE
|||| |.||||||.||||.| |.      .|||||||..||     |.||.|.||.||||.||||  |||||. |.|... .         |.|||.|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

FVDQDLKKFLDQYRKDKKLQLRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNILIDAKGN-----IKIADFGLARAFGV------PIKTLTHEVETLW
..|.||||..|              || .|.|.|.||..|||..|.|||||||||||. .|.     .||||||||||||.      |..|.|||| |||
YMDHDLKKYMD--------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLW

YRAPEILLGQKAYS--LGVDIWSLGCIFHEMVE---KRALFMGDSEIDQIFKIFQYHGTPTEQTWPALKECPYFKPIYPRFKTADPKTYFKNFCDKGFDL
|||||.|||.| ||   ..|.||.|||| ||.    ...||.|||||||.||||.  |||||..|| ... |..                        ||
YRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DL

IQQMIALDPAKRISVKDALRHPYF
...| ..||.|||| ..|| ||||
LNKMLCYDPKKRISAEQALQHPYF
Kinase 21599.AA CDK5 11-299 51 3.5e-152 484.48 In-house 1-287 (287) Show / Hide 
Range on Protein: 11-299
Range on HMM: 1-287/287
Sequence Identity: 51% (151 aa)

YEKLLKVGEGTYGEVYKAKDIQSSEIVALKKIKLENEDEGVPSTALREISILKELQPHPNIVCMHEVIYQPQEKKLYLVFEFVDQDLKKFLDQYRKDKKL
|||. |.|||||| ||||.. .. ||||||...|..|||||||||.|||..||||. |.||| .| ||    |||| |||||.||||||..|.       
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELK-HKNIVRLHDVIH--SEKKLTLVFEFCDQDLKKYMDSCNG----

QLRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNILIDAKGNIKIADFGLARAFGVPIKTLTHEVETLWYRAPEILLGQKAYSLGVDIWSLGCIFHEMV
.. .  || .||| | || |||.... |||||||| ||  .|. | ||||||||||.|... .||| |||||.| .|.| | ||  .|.|| |||| ||.
EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMA

-EKRALFMGDSEIDQIFKIFQYHGTPTEQTWPALKECPYFKPIYPRFKTADPKTYFKNFC----DKGFDLIQQMIALDPAKRISVKDALRHPYF
   | || | .. || ..||.  |||.| .||.. . | .||    .   .... ... .     || || |.|. ..|..||| |.||.||||
NAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 21599.AA CMGC 11-299 28 2.8e-144 477.56 In-house 1-513 (513) Show / Hide 
Range on Protein: 11-299
Range on HMM: 1-513/513
Sequence Identity: 28% (144 aa)

YEKLLKVGEGTYGEVYKAKD--------------IQSSEIVALKKIKLEN---------EDEGVPSTALREISILKELQ----------------PHPNI
||.. |.||||||.|||..|              ... ||||.||||..          | .|.|..|||||.|||.|.                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VCMHEVIYQPQEK---------------KLYLVFEFVDQDLKKFLDQYRKD----KKLQLRPYQ------------IKLMM------YQILNGLN--FCH
|......| ....               .||||||..|.||.........|    ... | . .            || .|      ||||.||.  .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SRR--IIHRDLKPQNILIDAK--------------------GNIKIADFGLARAFGVP---------------------IKTLTHEVETLWYRAPEILLG
|..  ||||||||.||||. .                    |..||.||||||.....                      ...||.| |.||||||||||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

QKAYS---------LGVDIWSLGCIFHEMVEK--------RALFMGDSE-----------IDQIFKIFQYHGTPT---------------EQTWPALKEC
 | |.          ..|.||.|||| ||. .        . || |.||           |||.||||.  ||||               |..||  .. 
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PYF---------------KPI-----------YPRFKTADPKTYFKNFC-----------------------------------DKGFDLIQQMIALDPA
|..               ...           .|...  . |  |...                                    ....||...|  .||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRISVKDALRHPYF
|||....||.||||
KRITAEQALQHPYF
Kinase 21599.AA CDK7 11-299 42 9.20000000001e-127 339.74 In-house 1-288 (288) Show / Hide 
Range on Protein: 11-299
Range on HMM: 1-288/288
Sequence Identity: 42% (126 aa)

YEKLLKVGEGTYGEVYKAKDIQSSEIVALKKIK----LENEDEGVPSTALREISILKELQPHPNIVCMHEVIYQPQEKKLYLVFEFVDQDLKKFLDQYRK
|||. ..|||... |||| | |. .||| ||||     .  . |.  ||.||| ||.|.| |.|.. .  ..   .   ..|||.| | ||        |
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQ-HDNVIGLIDIFM--HKSNIQLVFDFMDWDLEVVI----K

DKKLQLRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNILIDAKGNIKIADFGLARAFGVPIKTLTHEVETLWYRAPEILLGQKAYSLGVDIWSLGCIF
||.. | |  ||  | ..| || .||   | |||||| | |..  | .|||||||||..| | . .|| | | |||||| | | . |  |||.|| ||||
DKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIF

HEMVEKRALFMGDSEIDQIFKIFQYHGTPTEQTWPALKECP-YFK-PIYPRFKTADPKTYFKNFCDKGFDLIQQMIALDPAKRISVKDALRHPYF
 |       . |||.|||. .|||  |||||..|| . . . | |  ..| .     . .|    |   ||.. | ...| ||..  ..| .|||
AELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 21599.AA PITSLRE 11-299 47 1.2e-121 410.45 In-house 1-295 (295) Show / Hide 
Range on Protein: 11-299
Range on HMM: 1-295/295
Sequence Identity: 47% (140 aa)

YEKLLKVGEGTYGEVYKAKDIQSSEIVALKKIKLE--NEDEGVPSTALREIS-ILKELQPHPNIVCMHEVIYQPQEKKLYLVFEFVDQDLKKFLDQYRKD
...| ...|||||.||.||| .  ||||||..|.|   | || | |.||||. ||..|| |||||   |..      | |.|.|.|. |||  ..  .. 
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQ-HPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRR

KKLQLRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNILIDAKGNIKIADFGLARAFGVPIKTLTHEVETLWYRAPEILLGQKAYSLGVDIWSLGCIFH
.. .  | .|| .| | |.|  . |.  |.|||||  |.|.  ||. ||.|||||| .| ||| .|  | ||||||||.|||.| ||  ||.|| |||| 
NQ-PFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFA

EMVEKRALFMGDSEIDQIFKIFQYHGTPTEQTWPALKECPYFKPIY--PRFKTADPKTYFK---NFCDKGFDLIQQMIALDPAKRISVKDALRHPYF
|.. .. || |.|||||| .||.  |||||. ||. .| | .| .   |  .    .  |.      | |||| .||  ..|..||.  ||| ||.|
EFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 21599.AA PFTAIRE 11-299 44 3.1e-108 365.89 In-house 1-287 (287) Show / Hide 
Range on Protein: 11-299
Range on HMM: 1-287/287
Sequence Identity: 44% (130 aa)

YEKLLKVGEGTYGEVYKAKDIQSSEIVALKKIKLENEDEGVPSTALREISILKELQPHPNIVCMHEVIYQPQEKKLYLVFEFVDQDLKKFLDQYRKDKKL
|||| | |||.|  |||.. .    .|||| |.|. ..||.| || || | ||.|. | ||||.| .|    .. | .|||.|. ||....|.       
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQ-QEEGTPFTAIREASLLKNLK-HANIVCLHDIIH--TKETLTFVFEYVHTDLCQYMDKHPG----

QLRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNILIDAKGNIKIADFGLARAFGVPIKTLTHEVETLWYRAPEILLGQKAYSLGVDIWSLGCIFHEMV
 . |  ..| ..| | || .|| ||. |||||||| || ..|  | ||||||||  || .|  ||| ||||| | .|||   ||  .|.|  |||| ||.
GMHPNNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMM

EKRALFMGD-SEIDQIFKIFQYHGTPTEQTWPALKECPYFKPIYPR--FKTADPKTYFKNFCD---KGFDLIQQMIALDPAKRISVKDALRHPYF
  ...| |     ||  |||.  |||||.|||   . | .||   |  | . ..     .  .   ...||...|  . | .|.| ..|. ||||
WGQPAFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase 21599.AA PCTAIRE 11-299 43 8.4e-104 351.15 In-house 1-291 (291) Show / Hide 
Range on Protein: 11-299
Range on HMM: 1-291/291
Sequence Identity: 43% (130 aa)

YEKLLKVGEGTYGEVYKAKDIQSSEIVALKKIKLENEDEGVPSTALREISILKELQPHPNIVCMHEVIYQPQEKKLYLVFEFVDQDLKKFLDQYRKDKKL
| || | |||||  ||| .      .|||| |.|| | || | || ||.| ||.|. | ||| .| .|.  ... | ||||. |.|||...|.       
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLK-HANIVTLHDIIH--THHQLTLVFEYMDMDLKQYMDDCGN----

QLRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNILIDAKGNIKIADFGLARAFGVPIKTLTHEVETLWYRAPEILLGQKAYSLGVDIWSLGCIFHEMV
 .    .||...|.| || .|| |.| |||||||| ||. .|  | ||||||||  || ||  ||| ||||| |..|.|   ||  .|.|  |||| || 
IMNMHNVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMC

EKRALFMGDS------EIDQIFKIFQYHGTPTEQTWPALKECPYFKP-IYPRFKTADPKTYFKNFC---DKGFDLIQQMIALDPAKRISVKDALRHPYF
  |.|| |          ||   ||.  |||.|.|||  |  . |..  .||..     .    .     .. ||....  . . .|.|  .|..||||
TGRPLFPGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase 21599.AA Pkinase 11-299 35 3.3e-102 350.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 11-299
Range on HMM: 1-293/293
Sequence Identity: 35% (108 aa)

YEKLLKVGEGTYGEVYKAKDIQSSEIVALKKIKLENEDEGVPSTALR--EISILKELQPHPNIVCMHEVIYQPQEKKLYLVFEFVDQDLKKFLDQYRKDK
|... |.|.|..|.|||.... ...|||.|.||...|..... |..|  ||.|.|.|. ||||| .... .   ....|.|.|... .|.  .| ..  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIS

---KLQL--RPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNILIDAKGNI----KIADFGLARAF-GVPIKTLTHEVETLWYRAPEILLGQKAYSLGVD
   .  .   . ..| .||||| ||..|||..||||||||.||||| .|.|    ||.|||||. |   .   .|. . |.||.|||...|.. |.  ||
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWSLGCIFHEMVEKRALFMGD----SEIDQIFKIFQYHGTPTEQTWPALKECPYFKPIYPRFKTADPKTYFKNFCDKGFDLIQQMIALDPAKRISVKDAL
.||.|||..||. .| .| |.    . .||...|..  |.|..  || . . .||. ...   .  ..|  .|  . . |.|  ....||.||.. ...|
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQIL

RHPYF
 ||.|
QHPWF
Kinase 21599.AA CDK4 11-299 42 4.7e-102 345.36 In-house 1-290 (290) Show / Hide 
Range on Protein: 11-299
Range on HMM: 1-290/290
Sequence Identity: 42% (126 aa)

YEKLLKVGEGTYGEVYKAKDIQSSEIVALKKIKLENEDE--GVPSTALREISILKELQP--HPNIVCMHEVIYQPQEKK----LYLVFEFVDQDLKKFLD
|...  .||| || ||.| |...  .||||...  ...|  |.|   .||||... |.   |||||   .|  .         . .||| .|.||. .||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

QYRKDKKLQLRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNILIDAKGNIKIADFGLARAFGVPIKTLTHEVETLWYRAPEILLGQKAYSLGVDIWSL
.  .     . | .|| || |.| |. | || |||||||||||||.   | .|.||||||| ..   . ||  | ||||||||.|| |  |   ||.||.
KCPPP---GMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLL-QSYYNTPVDMWSV

GCIFHEMVEKRALFMGDSEIDQIFKIFQYHGTPTEQTWPALKECPYFKPIYPRFKTADPKTYFKNFCDKGFDLIQQMIALDPAKRISVKDALRHPYF
|||| ||   |.|| | || ||  |||   |.|.|. ||  ..       .|  .   .|      |  | ||.|.|   ...||.|   .| ||||
GCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWP--RDVSLPWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase 21599.AA S_TKc 11-299 31 8.3e-102 345.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-299
Range on HMM: 1-231/231
Sequence Identity: 31% (95 aa)

YEKLLKVGEGTYGEVYKAKDIQSSEIVALKKIKLENEDEGVPSTALREISILKELQPHPNIVCMHEVIYQPQEKKLYLVFEFVDQ---DLKKFLDQYRKD
||.| |.|.|..|.|||.... . .|||.|.||          ...|||.|||.   ||||| ...|..    ..||.|.|..|.   ||......... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

KK-LQLRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNILIDAKGNIKIADFGLARAFGVPIKTLTHEVETLWYRAPEILLGQKAYSL-GVDIWSLGCI
..  .. . ... .||||...|..|||..||||||||.|||.|   .|||.|||||| .       |. . |.||.|||.|     |.   .|.||.|||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

FHEMVEKRALFMGDSEIDQIFKIFQYHGTPTEQTWPALKECPYFKPIYPRFKTADPKTYFKNFCDKGFDLIQQMIALDPAKRISVKDALR-------HPY
. ||.  . .|    .....||.                                         . . |.|...   ||.||... .||.       ||.
LYEMLCGYPPFP---QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase 21599.AA CRK7 11-299 33 2.8e-101 342.79 In-house 1-343 (343) Show / Hide 
Range on Protein: 11-299
Range on HMM: 1-343/343
Sequence Identity: 33% (117 aa)

YEKLLKVGEGTYGEVYKAKDIQSSEIVALKKIKLENE---DEGVPSTALREISILKELQPHPNIVCMHEVIYQP-------QEK-KLYLVFEFVDQDLKK
||..  .|||||| |||||. .  |.|||||....||    || | || ||| ||..|. |.||| ..|..          ..|   |.||| .| ||  
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLN-HQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMG

FLDQYRKDKKLQ-LRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNILIDAKGNIKIADFGLARAFGVPI--KTLTHEVETLWYRAPEILLGQKAY---
 |.     | ..   . |.| .| |.| |.. || . ..|||.|  |||.. .|..||||||||| .      . .|  | |||||.|| ||| . |   
LLE----SKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQ

-----------------------------------SLGVDIWSLGCIFHEMVEKRALFMGDSEIDQIFKIFQYHGTPTEQTWPALKECPYFKPIYPRF--
                                      .|.|| |||. |   |...| |  |..|. ||..  |.|. . || . . |... . |.   
HILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQY

KTADPKTYF---K--NFCDKGFDLIQQMIALDPAKRISVKDALRHPYF
..   .      |  ..  . .||  .| .||| ||......|.|..|
NRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase 21599.AA Pkinase_Tyr 11-164 33 4.8e-26 88.82 Pfam 1-160 (270) Show / Hide 
Range on Protein: 11-164
Range on HMM: 1-160/270
Sequence Identity: 33% (56 aa)

YEKLLKVGEGTYGEVYKAKDI----QSSEIVALKKIKLENEDEGVPSTA------LREISILKELQPHPNIVCMHEVIY---QPQEKKLYLVFEFVDQ-D
 ... | ||| .|||||..      .    || |..|     ||  . .      .||..|.|.|  |||||... |..   .|.  ..|.|.|..   |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGD

LKKFLDQYRKDKKLQLRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNILIDAKGNIKIADFGLARA
|...| . | . | .| . ..  | .|| .|... .|...|||||   |.|.. .. .||.||||||.
LLDYLRKHR-EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase 21599.AA TyrKc 11-299 23 1.1e-15 31.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-299
Range on HMM: 1-280/280
Sequence Identity: 23% (75 aa)

YEKLLKVGEGTYGEVYKAKDIQSSEIVALKKIKLENEDEGVPSTALREISILKEL-QPHPNIVCMHEVIYQPQE-----KKLYLVFEFVDQ-DLKKFLDQ
 ... | ||| .|||||.. .   . || |..| .          .||..|...|   |||||... |. |...     . |..|.|...  |||..|  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

YRKDKKLQLRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNILIDAKGNIKIADFGLARAFGVP--------IKT-----LTHEVETLWYRAPEILLGQ
.|..    | . .   ...|| .| .. ||...|||||   |.|..... .||.||||.|. .           ..      .. .  .   ||| .  .
HRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--N

KA-YSLGVDIWSLGCIFHEMVEKRALFMGDSEIDQIFKIFQYHG-----TPTEQTWPALKECPYFKPIYPR-----FKTADPKTYFKNFCDKGFDLIQQM
.  ..   |.|| |    |.        |..          | |      . ..    .|.  |  |. |      |             |. .....| 
YGKFTTKSDVWSFGVCMWEIFT-----YGQQ---------PYPGMIQQMMSNQEVIEYVKQG-YRMPQPPNDYPMSF---------VCCPDEMYQIMKQC

IALDPAKRISVKDALRHPYF
 . ||..| . ..   | .|
WHEDPEDRPTFSEI--HECF