Gene 21071 (Tetrahymena)

21071

Species: Tetrahymena
Alias: TTHERM_00318700, 1083, PreTt21071, 31.m00373, 21071, 3687.m00174
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
21071.AA Protein None 289 None Fasta, JSON
21071.kin_dom Protein Kinase Domain None 261 None Fasta, JSON
21071.NA RNA None 870 None Fasta, JSON

Protein domain

Protein domains of 21071.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21071.AA CDC2 18-199 52 1.8e-129 400.28 In-house 1-196 (301) Show / Hide 
Range on Protein: 18-199
Range on HMM: 1-196/301
Sequence Identity: 52% (104 aa)

YEVLNVIGKGTYGEVFRARDQETHEIVALKKTITKLENDG--IPSSALREISLLKEIN-HENVVVLKDIIIQNNLLYLVFEFCESDLKKFLD----SKTK
|. .. ||.||||.|....|..|..||||||  .. |..|  .||.|.||||.|||.. |.|.| |.|.|.| | ||.|||... ||||..|    ....
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

VAGQFLDALTIKIIRGVAACHTRRIMHRDLKPQNILIDKN------DFGLSRTFCMPIRPYT--KEVVTLWYRPPEILLGALDYCTPIDMWSVGCIM
.  |... ....|..||. ||.|||||||||||||||||.      ||||.|.|..|||.||  .||||||||.||||||. .|.||.||||.|||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIF
Kinase 21071.AA CDK 18-199 45 4e-110 353.55 In-house 1-212 (284) Show / Hide 
Range on Protein: 18-199
Range on HMM: 1-212/284
Sequence Identity: 45% (101 aa)

YEVLNVIGKGTYGEVFRARDQETH-----EIVALKKTITKL-----ENDGIPSSALREISLLKEINHENVVVLKDIIIQN-----------NLLYLVFEF
|| |. || ||||.|..|||..|.     .|||||| ..       | .|.|..|.||||||||. |.|.| |.|.....           | ||.|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CESDLKKFLDSKTKVAGQFLDALTIKIIRGVAACHTRRIMHRDLKPQNILIDKN-----------DFGLSRTFCM------PIRPYTKEVVTLWYRPPEI
.. ||||..|            ..  ..||.. || ..|||||||||||||..|           ||||.| |        |.|.||.||||||||.||.
MDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPEL

LLGALDYC--TPIDMWSVGCIM
|||. .|   |||||||||||.
LLGSKHYSGGTPIDMWSVGCIF
Kinase 21071.AA CDK5 18-199 51 8.7e-93 293.5 In-house 1-189 (287) Show / Hide 
Range on Protein: 18-199
Range on HMM: 1-189/287
Sequence Identity: 51% (101 aa)

YEVLNVIGKGTYGEVFRARDQETHEIVALKKTITKLEND--GIPSSALREISLLKEINHENVVVLKDIIIQNNLLYLVFEFCESDLKKFLDSKTKVAGQF
|| .. || |||| |..||..|||||||||.   .|...  |.||.|.|||.||||. |.|.| | |.|  .. | ||||||  ||||..|| .      
YEKMEKIGEGTYGTVYKARNKETHEIVALKR--VRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG----E

LDALTIK-----IIRGVAACHTRRIMHRDLKPQNILIDKN------DFGLSRTFCMPIRPYTKEVVTLWYRPPEILLGALDYCTPIDMWSVGCIM
.|. .||       .|.| || ....|||||||| || ||      |||| | |  |.| |. |||||||||| .|.|.  | |.|||||.|||.
MDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIF
Kinase 21071.AA CMGC 18-199 29 2.6e-86 283.49 In-house 1-325 (513) Show / Hide 
Range on Protein: 18-199
Range on HMM: 1-325/513
Sequence Identity: 29% (96 aa)

YEVLNVIGKGTYGEVFRARD--------------QETHEIVALK------KTITKL---ENDGIPSSALREISLLKEIN-----------------HENV
||....||.||||.|...||               || ||||.|      ......   | ||.|..|||||..||..|                 |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VVLKDIIIQNN-----------------LLYLVFEFCESDLKKFLDSKTK-VAG-------------------QFLDALT------IKIIRGVA--ACHT
| |.||.  .|                  ||||||... ||....... .   |                   .    ..        |.||..   || 
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHS

RR--IMHRDLKPQNILIDKN--------------------------DFGLSRTFCMP---------------------IRPYTKEVVTLWYRPPEILLGA
..  |.||||||.||||..|                          ||||.| .  .                      |||| .|||.|||.||||||.
HWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGW

---------LDYCTPIDMWSVGCIM
          .|.|||||||||||.
KHYTNHNYSMHYTTPIDMWSVGCIF
Kinase 21071.AA CDK7 18-199 41 2.8e-77 205.25 In-house 1-193 (288) Show / Hide 
Range on Protein: 18-199
Range on HMM: 1-193/288
Sequence Identity: 41% (80 aa)

YEVLNVIGKGTYGEVFRARDQETHEIVALKKTI----TKLENDGIPSSALREISLLKEINHENVVVLKDIIIQNNLLYLVFEFCESDLKKFL-DSKTKVA
|| .  || |... |..|.|..| .||| ||      .    |||  .|.||| .|.|. |.||. | ||. .   ..|||.| . ||     |..    
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

GQFLDALTIKIIRGVAACHTRRIMHRDLKPQNILIDKN------DFGLSRTFCMPIRPYTKEVVTLWYRPPEILLGALDYCTPIDMWSVGCIM
     | .. . .|. .||   | |||||| | |...|      |||| | .  | | ||  ||| ||| || | ||  | | .||||||||.
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIF
Kinase 21071.AA PITSLRE 18-199 44 1.5e-65 224.11 In-house 1-197 (295) Show / Hide 
Range on Protein: 18-199
Range on HMM: 1-197/295
Sequence Identity: 44% (87 aa)

YEVLNVIGKGTYGEVFRARDQETHEIVALKKT-IT-KLENDGIPSSALREIS-LLKEINHENVVVLKDIIIQNNL--LYLVFEFCESDLKKFLDSKTKVA
.. ||.|. ||||.|.||.| .| ||||||.. .  . | .|.|  .||||. .|....|.|.| .| |..  |.   |.|.|. | |||  ..   .  
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

GQFLD----ALTIKIIRGVAACHTRRIMHRDLKPQNILIDKN------DFGLSRTFCMPIRPYTKEVVTLWYRPPEILLGALDYCTPIDMWSVGCIM
 .|.      |..   |||.  |   |||||||  |.|.  .      |||| | .  ||.|||. ||||||| ||.|||.  | ||.||||||||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIF
Kinase 21071.AA S_TKc 18-278 28 2.5e-63 217.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-278
Range on HMM: 1-231/231
Sequence Identity: 28% (82 aa)

YEVLNVIGKGTYGEVFRARDQETHEIVALKKTITKLENDGIPSSALREISLLKEINHENVVVLKDIIIQNNLLYLVFEFCES---DLKKFLDSKTK----
||.|..||||..|.|...|. .|..|||.|.            ...|||..||. .|.|.| |.|..   . ||.|.|.|.    ||....... .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VAGQFLDALTIKIIRGVAACHTRRIMHRDLKPQNILIDK----NDFGLSRTFCMPIRPYTKEVVTLWYRPPEILLGALDYCT-PIDMWSVGCI---MI
          ..  |..... || ..|.||||||.|||.|.     ||||.| .       |  ..|.||..||.|     | . ..|.||.|||   |.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

LGTPTENDWPGIKDLTDYKPTFPRFRPQKLSEMIENIYKKYNQNSEVDIAAVDLLQRLLCYDPIKRITAKSALN-------HIKI
 | |                         . .|...|          .  | |.....|..|| ||.||  ||.       |  .
CGYPPFP---------------------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 21071.AA Pkinase 18-276 25 5.8e-61 213.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 18-276
Range on HMM: 1-293/293
Sequence Identity: 25% (81 aa)

YEVLNVIGKGTYGEVFRARDQETHEIVALKKTITKLENDGIPSSALR--EISLLKEINHENVVVLKDIIIQNNLLYLVFEFCES-----DLKKFLD--SK
|... .||.|..|.|...... | .|||.|.   . |... . ...|  ||...|..||.|.| |.|.   .. .|.|.|.||      ||. ..   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TKV--AGQFLDALTIKIIRGVAACHTRRIMHRDLKPQNILID---KN-------DFGLSRTF-CMPIRPYTKEVVTLWYRPPEILLGALDYCTPIDMWSV
...    . .      |.||.. || ..|.||||||.|||||    .       ||||.. |   . . .|  ..|.||..||...|. .| ...||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCI---MILGTPTENDWPGIKDLTDYKPTFPRFRPQ-------KLSEMIENIYKKYNQNSEVD---------------------IAAVDLLQRLLCYDPI
|||   |..|                    | |. .       ..  . .. ....  ... .                      .. |.. ..||.|| 
GCILYEMLCGR-------------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

KRITAKSALNH--I
||.||. .|.|  .
KRPTAEQILQHPWF
Kinase 21071.AA PCTAIRE 18-198 46 4.3e-60 205.95 In-house 1-187 (291) Show / Hide 
Range on Protein: 18-198
Range on HMM: 1-187/291
Sequence Identity: 46% (89 aa)

YEVLNVIGKGTYGEVFRARDQETHEIVALKKTITKLE-NDGIPSSALREISLLKEINHENVVVLKDIIIQNNLLYLVFEFCESDLKKFLDSKTKVAGQFL
|  |.  | |||  |.. | . |  .||||    .||   | |  | ||.||||.  | |.| | ||| ..  | ||||. ..|||...|      |. .
YIKLDKLGEGTYATVYKCRSKLTDNLVALKE--IRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDD----CGNIM

DALTIKII-----RGVAACHTRRIMHRDLKPQNILIDKN------DFGLSRTFCMPIRPYTKEVVTLWYRPPEILLGALDYCTPIDMWSVGCI
.   .|..     || | || |.|.|||||||| ||.        |||| |   .| . | .||||||||||..|.|  || |.|||| ||||
NMHNVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCI
Kinase 21071.AA PFTAIRE 18-200 41 2.6e-59 203.34 In-house 1-189 (287) Show / Hide 
Range on Protein: 18-200
Range on HMM: 1-189/287
Sequence Identity: 41% (80 aa)

YEVLNVIGKGTYGEVFRARDQETHEIVALKKTITKLENDGIPSSALREISLLKEINHENVVVLKDIIIQNNLLYLVFEFCESDLKKFLDSKTKVAGQFLD
|| |.  | |.|  |.... . .  .||||  |   .. | |  | || ||||.  | |.|.| |||    .| .|||. . ||....|.        ..
YEKLEKLGEGSYATVYKGISCINQQFVALKE-IRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGG----MH

ALTIK-----IIRGVAACHTRRIMHRDLKPQNILIDKN------DFGLSRTFCMPIRPYTKEVVTLWYRPPEILLGALDYCTPIDMWSVGCIMI
   ..      .|| . || ||..|||||||| || .       |||| |    | . | .|||||||||| .|||. .| | .||| ||||..
PNNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFV
Kinase 21071.AA CDK4 18-199 39 4.5e-57 194.3 In-house 1-199 (290) Show / Hide 
Range on Protein: 18-199
Range on HMM: 1-199/290
Sequence Identity: 39% (80 aa)

YEVLNVIGKGTYGEVFRARDQETHEIVALKKTITKLEND--GIPSSALREISLLK---EINHENVVVLKDIIIQ------NNLLYLVFEFCESDLKKFLD
|. .. ||.| || |.|||| .|  .||||.    ....  |.| | .||||...     .| |.| |.|.  .        .. .||| |. ||. .||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

SKTK--VAGQFLDALTIKIIRGVAACHTRRIMHRDLKPQNILIDKN------DFGLSRTFCMPIRPYTKEVVTLWYRPPEILLGALDYCTPIDMWSVGCI
   .  .  .    ..  ..|||   |. || ||||||||||.  .      ||||.|..       |  ||||||| ||.|| .  | ||.||||||||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGCI

M
.
F
Kinase 21071.AA CRK7 18-199 33 8e-56 190.92 In-house 1-243 (343) Show / Hide 
Range on Protein: 18-199
Range on HMM: 1-243/343
Sequence Identity: 33% (82 aa)

YEVLNVIGKGTYGEVFRARDQETHEIVALKKTITKLE---NDGIPSSALREISLLKEINHENVVVLKDIIIQ--------NNL--LYLVFEFCESDLKKF
|| .. || |||| |  |....| |.||||| ... |    .| |  | ||| .|.. ||.|.| ||.|..         .     |.|||    ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LDSK--TKVAGQFLDALTIKIIRGVAACHTRRIMHRDLKPQNILIDKN------DFGLSRTFCMPI--RPYTKEVVTLWYRPPEILLGALDY--------
|.||   . . | .  .   .  |.. || . ..|||.|  |||.. .      |||| | .      ||||  |.|||||||| |||.  |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------CTPIDMWSVGCIM
                               . |||||.|||.
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCIL
Kinase 21071.AA CDC2 200-278 54 1.8e-44 134.25 In-house 224-301 (301) Show / Hide 
Range on Protein: 200-278
Range on HMM: 224-301/301
Sequence Identity: 54% (43 aa)

ILGTPTENDWPGIKDLTDYKPTFPRFRPQKLSEMIENIYKKYNQNSEVDIAAVDLLQRLLCYDPIKRITAKSALNHIKI
|||||.|..|||...|.|||.||||..||.||....|..||.|| |..|  ..|||...|.|||.|||.||.||.|  .
ILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQ-SCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 21071.AA CDK 200-278 34 1.6e-24 75.24 In-house 240-284 (284) Show / Hide 
Range on Protein: 200-278
Range on HMM: 240-284/284
Sequence Identity: 34% (27 aa)

ILGTPTENDWPGIKDLTDYKPTFPRFRPQKLSEMIENIYKKYNQNSEVDIAAVDLLQRLLCYDPIKRITAKSALNHIKI
|.|||||..|||...| ||                                  |||...||||| |||.|. ||.|   
ICGTPTEDNWPGVTKLPDY----------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 21071.AA CMGC 200-278 21 1.7e-23 73.23 In-house 369-513 (513) Show / Hide 
Range on Protein: 200-278
Range on HMM: 369-513/513
Sequence Identity: 21% (31 aa)

ILGTPT---------------ENDWPGIKDLTDYKP--------------T------------FPRFRPQKLSEMIENIYKKYNQNSE------------
.|||||               |..||....| .|..              .            ||...|....... .. .... | .            
VLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIYEE

---------------VDIAAVDLLQRLLCYDPIKRITAKSALNHIKI
                |  |.|||...|.||| |||||. ||.|  .
KFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 21071.AA CDK5 200-278 35 2.6e-18 54.02 In-house 215-287 (287) Show / Hide 
Range on Protein: 200-278
Range on HMM: 215-287/287
Sequence Identity: 35% (28 aa)

ILGTPTENDWPGIKDLTDYKPTFPRFRPQKLSEMIENIYKKYNQNSEVDIAAVDLLQRLLCYDPIKRITAKSALNHIKI
|.|||.|. ||.| .| ||||    . .  . .  ..| .| ...        ||||..| ..| .||.|| ||.|   
IMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEK------GMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 21071.AA CRK7 200-278 29 7.1e-15 47.53 In-house 268-343 (343) Show / Hide 
Range on Protein: 200-278
Range on HMM: 268-343/343
Sequence Identity: 29% (24 aa)

ILGTPTENDWPGIKDLTDYKPTFPRFRPQK--LSEMIENIYKKYNQNSEVDIAAVDLLQRLLCYDPIKRITAKSALNHIKI
| |.|. | || . .|    | .  ..|..   . . |. |.. .  .  . ...|||  .||.|| ||.||. .|.|  .
ICGSPNPNNWPEVMKL----PWWNTMKPKRQYNRRLREEFYHHKKP-VFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase 21071.AA PITSLRE 201-275 31 5.1e-12 40.22 In-house 223-292 (295) Show / Hide 
Range on Protein: 201-275
Range on HMM: 223-292/295
Sequence Identity: 31% (24 aa)

LGTPTENDWPGIKDLTDYKPTFPRFRPQKLSEMIENIY--KKYNQNSEVDIAAVDLLQRLLCYDPIKRITAKSALNH
.|||||  |||...|   | .   |.... .   . .   .. ...      . |||...|.|.| .||||  || |
MGTPTEKIWPGWTELPHWKMMNN-FPHYPYNNLRKRFPAENHISDT------GFDLLNQMLTYNPKNRITASDALKH
Kinase 21071.AA PCTAIRE 200-278 33 1.2e-11 37.29 In-house 219-291 (291) Show / Hide 
Range on Protein: 200-278
Range on HMM: 219-291/291
Sequence Identity: 33% (28 aa)

ILGTPTENDWPGIKDLTDYKP-TFPRFRPQKLSEMIENIYKKYNQNSEVD---IAAVDLLQRLLCYDPIKRITAKSALNHIKI
|||||.|  |||.| . ....  |||.|.| |           | .   |       |||. || | . .|. | .|..|   
ILGTPDEKTWPGVKSNEEFRTYNFPRYREQPL----------INHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase 21071.AA PFTAIRE 201-278 34 9.6e-11 34.05 In-house 215-287 (287) Show / Hide 
Range on Protein: 201-278
Range on HMM: 215-287/287
Sequence Identity: 34% (28 aa)

LGTPTENDWPGIKDLTDYKPTFPR---FRPQKLSEMIENIYKKYNQNSEVDIAAVDLLQRLLCYDPIKRITAKSALNHIKI
||||||. |||.  |  |||   |   ..|.|| .... ||.         . | ||.. .| . | .|. |. |. |   
LGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYI--------PHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase 21071.AA Pkinase_Tyr 18-105 24 1.4e-10 36.46 Pfam 1-98 (270) Show / Hide 
Range on Protein: 18-105
Range on HMM: 1-98/270
Sequence Identity: 24% (25 aa)

YEVLNVIGKGTYGEVFRARDQ----ETHEIVALKKTITKLENDGIPSSA------LREISLLKEI-NHENVVVLKDIII-QNNL--LYLVFEFCES-DLK
 . . ..|.| .|||....      .|.  || |    .| ..|  ...      .||....|.. .|.|.| |  ... |     .|.|.|...  ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK----ML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KFL
..|
DYL
Kinase 21071.AA CDK4 200-278 29 7.4e-10 29.77 In-house 224-290 (290) Show / Hide 
Range on Protein: 200-278
Range on HMM: 224-290/290
Sequence Identity: 29% (23 aa)

ILGTPTENDWPGIKDLTDYKPTFPRFRPQKLSEMIENIYKKYNQNSEVDIAAVDLLQRLLCYDPIKRITAKSALNHIKI
. |.|.| |||  .|       ||  .|... ..   . |           . ||||. |||.. ||..| ..|.|   
VMGLPPEDDWP--RDVSLPWDHFPQRHPRPFKDFCPHMCKQ----------GDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase 21071.AA TyrKc 18-276 19 1e-09 -65.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-276
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)

YEVLNVIGKGTYGEVFRARDQETHEIVALKKTITKLENDGIPSSALREISLLKEI--NHENVVVLKDIIIQN-------NLLYLVFEFCES-DLKKFLDS
 . . ..| | .|||....     . || |.              .||.......  .|.|.| |  ...|          |..|.|...  |||..| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KTKVAGQFLDALTIKIIRGVAAC----HTRRIMHRDLKPQNILIDKN------DFGLSRTF-CM--------PIRP----YTKEVVTLWYRPPEILLGAL
. .    .  .  ...   .|.     | ... ||||   |.|...|      ||||||              .|.     .| .. .   .|| .    
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----

DYC---TPIDMWSVGCIM--ILGTPTENDWPG-IKDLTDYKPTFPRFRPQKLSEMIENIYKKYNQNS-------EVDIAAVDLLQRLLCYDPIKRITAKS
.|.   |  | || |  |  |. |  .  .|| |.             .| . | ... |      .       .   .  .. ..   .|| .| | . 
NYGKFTTKSDVWSFGVCMWEIF-TYGQQPYPGMIQQ---------MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

ALNHI
    .
IHECF
Kinase 21071.AA CDK7 251-275 28 1.1e-07 16.1 In-house 261-285 (288) Show / Hide 
Range on Protein: 251-275
Range on HMM: 261-285/288
Sequence Identity: 28% (7 aa)

AVDLLQRLLCYDPIKRITAKSALNH
..||.....  .|.||.|.  .|..
LLDLMCGMWTMNPCKRWTCTQCLKM
Kinase 21071.AA CDK7 200-218 52 2e-06 12.86 In-house 218-236 (288) Show / Hide 
Range on Protein: 200-218
Range on HMM: 218-236/288
Sequence Identity: 52% (10 aa)

ILGTPTENDWPGIKDLTDY
.|||||| .||..  . ||
TLGTPTEEEWPNMCCMMDY