Gene 3897 (Tetrahymena)
3897
Sequence
Protein domains of 3897.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
---|---|---|---|---|---|---|---|---|---|
Kinase | 3897.AA | CK1-Unclassified | 28-253 | 56 | 6.30000000001e-164 | 487.66 | In-house | 1-244 (244) | Show / Hide |
Range on Protein: 28-253 Range on HMM: 1-244/244 Sequence Identity: 56% (138 aa) FRFIEKIDAGSFGEIYHAKDLDTDTNVAIKLEKTDSKQKLLCYEAKILQFLNNHKNC----IGYPKVYYCSTE--EPYNVMVTELLGPSLEDLFNICGRK .|.||||..|||||||......|...|||||||..||...|||||||.|.|.|..|| .|.||.|.|..| ..||.||..|||||||||||.|.|| YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK FSAKSVALIGLQLIERLEFLHKCYYIHRDIKPDNICIG-LGKNSKTLYLIDFAFSKRFIQ--KDGSHIPFQEGKFFTGTARYAS---------SRRDDLI || | | .|. |.|.|.|.||....|||||||||...| ||||....|.||| .|||.|. |.|.|||..|.|..|||||||| |||||| FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE SLGYSLVYLMRGRLPWQDYKVLQKKEKYEKILEKKQNLNLEQLC |||| |.|. .|.||||. | ||||||||.|.|... .|||| SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC |
|||||||||
Kinase | 3897.AA | CK1 | 28-279 | 50 | 4.90000000001e-149 | 501.41 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 28-279 Range on HMM: 1-271/271 Sequence Identity: 50% (138 aa) FRFIEKIDAGSFGEIYHAKDLDTDTN---VAIKLEKTDSKQKLLCYEAKILQFLNNHKNC----IGYPKVYYCSTE--EPYNVMVTELLGPSLEDLFNIC .|...||..||||.||..... |... ||||||| .||. .|.|||||.. |..| || .|.|..|.| .| . ||.||..|||||||||||.| YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGH-NCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC GRKFSAKSVALIGLQLIERLEFLHKCYYIHRDIKPDNICIGL-GKNSKTLYLIDFAFSKRFIQ-KDGSHIPFQEGKFFTGTARYAS---------SRRDD .|||| | | .|. |.|.|.|..|.. .|||||||||...|. ||.....|.||| ..||... |...|||..|.| .|||||||| ||||| NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD LISLGYSLVYLMRGRLPWQDYKVLQKKEKYEKILEKKQNLNLEQLCAK-LPEELFEYMKYCTSLEFEQKPDYI . |||| |.|. || ||||. | ||.|||||.|||.....||||. .|.|...|..|| .|.||.|||| MESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
|||||||||
Kinase | 3897.AA | CK1 | 28-281 | 32 | 2.9e-103 | 349.36 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 28-281 Range on HMM: 1-339/339 Sequence Identity: 32% (112 aa) FRFIEKIDAGSFG-EIYHA-----KDLDTD-----TNVAIKLEKTDSK--QKLLCYEAKILQFLNNH----------------KNCIGYPKVYYCSTEEP .. ..||. |.|| .||.. ||.... . .|.|.|. .|. . .| .|..... |.. . ...|..|....||. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED --YNVMVTELLGPSLEDLFN---ICGRKFSAKSVALIGLQLIERLEFLHKCYYIHRDIKPDNICIGL------GKNSK--------TLYLIDFAFSK-RF ||.|| .||||.||||.. |.|||| |.. |..|..|.||..| | .|||||||||.|.|. ||. . ..|.||| ... .. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY IQKDGS------------HIPFQE---GKFFTG-TARYAS---------SRRDDLISLGYSLVYLMRGR--LPWQDYKVLQK-------KEKYEKILEKK . |||. |.|. | | |.| ||||.| .||||| |..| |.....| ||||. | | |.|||.| ||| RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK QNLNLEQLCAK-----LPEELFEYMKYCTSLEFEQKPDYIYI .. .. || .|.|. ..|||. ||... .||| .| MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
|||||||||
Kinase | 3897.AA | CK1-D | 28-281 | 48 | 1.4e-101 | 343.76 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 28-281 Range on HMM: 1-261/261 Sequence Identity: 48% (128 aa) FRFIEKIDAGSFGEIYHAKDLDTDTNVAIKLEKTDSKQKLLCYEAKILQFLNNHKNCIGYPKVYYCSTEEPYNVMVTELLGPSLEDLFNICGRKFSAKSV .| || .||||.||| ... |. |||||| .| | .|.|. ... . || |.. .| | ||||| .||||||||||| |.|||| | | YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMM---QGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTV ALIGLQLIERLEFLHKCYYIHRDIKPDNICIGLGKNSKTLYLIDFAFSKRFIQKD-GSHIPFQEGKFFTGTARYAS---------SRRDDLISLGYSLVY ....|.| |.|..| .||||||||| .|||| .. |.||| .||. |||. | | |||||||| |||||| |||| |.| LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMY LMRGRLPWQDYKVLQKKEKYEKILEKKQNLNLEQLCAKLPEELFEYMKYCTSLEFEQKPDYIYI || |||| | |..|||.| ||| . ....||. .|.| .|| || .|.|..||||.|. FNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
|||||||||
Kinase | 3897.AA | CK1-A | 28-281 | 46 | 4.3e-92 | 312.25 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 28-281 Range on HMM: 1-261/261 Sequence Identity: 46% (123 aa) FRFIEKIDAGSFGEIYHAKDLDTDTNVAIKLEKTDSKQKLLCYEAKILQFLNNHKNCIGYPKVYYCSTEEPYNVMVTELLGPSLEDLFNICGRKFSAKSV .| . || .||||.|| . . .||||.|. . . | ||||. . | . |.| |.. . .| ||||| .|||||||||||.| |.|. | | YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRIL---QGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTV ALIGLQLIERLEFLHKCYYIHRDIKPDNICIGLGKNSKTLYLIDFAFSKRFIQKDG-SHIPFQEGKFFTGTARYAS---------SRRDDLISLGYSLVY .. |.| |.|..|. .||||||||| .|.|. |.|||| .|.. . |||..| | |||||||| |||||. |.|| ..| LMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMY LMRGRLPWQDYKVLQKKEKYEKILEKKQNLNLEQLCAKLPEELFEYMKYCTSLEFEQKPDYIYI ||.|||| | || |||||.||| .|||| | |. ||.|| .| ||..|||.|. FNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
|||||||||
Kinase | 3897.AA | CK1-G | 28-281 | 41 | 7.9e-80 | 270.24 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 28-281 Range on HMM: 1-266/266 Sequence Identity: 41% (111 aa) FRFIEKIDAGSFGEIYHAKDLDTDTNVAIKLEKTDSKQKLLCYEAKILQFLNNHKNCIGYPKVYYCSTEEPYNVMVTELLGPSLEDLFNICGRKFSAKSV .| || |.|||.. | . . ||||.| |. | | . . || . . | |.||| . ||.|| .||||||||||..|.|||| |.| YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGI--PQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTV ALIGLQLIERLEFLHKCYYIHRDIKPDNICIGL--GKNSKTLYLIDFAFSKRFIQKD-GSHIPFQEGKFFTGTARYAS---------SRRDDLISLGYSL ... |.|.|.| .|. | ||.|||| || |. .....||| | .| . . |||. | | |||||| | |||||. .|| CMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMF VYLMRGRLPWQDYKVLQKKEKYEKILEKKQNLNLEQLCAK--LPEELFEYMKYCTSLEFEQKPDYIYI | .|| |||| | ||.|.|| ..|...| | || .||.. |..| .|.|. .||| |. MYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
|||||||||
Kinase | 3897.AA | TTBKL | 28-285 | 29 | 7.2e-51 | 170.0 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 28-285 Range on HMM: 1-288/288 Sequence Identity: 29% (86 aa) FRFIEKIDAGSFGEIYHAKDLDT-DTNVAIKLEKTD-SK-QKLLCYEAKILQFLNNHKNCIGYPKVYYCSTEEPYNVMVTELLGPSLEDLFNICGRK--F .. ...|. | ||..||..|. . .. | | ||. .. . . |...| |... ... .||.... .. || || .|.||.| || . .| | WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPN-GSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRF SAKSVALIGLQLIERLEFLHKCYYIHRDIKPDNICIGLGKN----SKTLYLIDFAFSKRFIQKDGSH-----------IPFQE---GKFFTGTARYAS-- |. ... || |... | .| | .||||.|| |.|.|. .. ....||||| ...... |||. . . | || ||.| SDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPN -------SRRDDLISLGYSLVYLMRGRLPWQDYKVLQKKEKYEKILEKKQNLNLEQLCAK------LPEELFEYMKYCTSLEFEQKPDYIYIKNLF .| ||| |. |....|. | |||.. |. ..| ..|.|...|.|. . .| |. . ||. ||.. . ||| .| ..| MHDRKEQGRHDDLWSWMYMIIELHCG-LPWTN------MEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
|||||||||
Kinase | 3897.AA | Worm6 | 28-281 | 27 | 3.7e-42 | 146.36 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 28-281 Range on HMM: 1-279/279 Sequence Identity: 27% (78 aa) FRFIEKIDAGSFGEIYHAKDLDTDTN--VAIKLEK--TDSKQKLLCYEAKILQFLNNHKNCIGYPKVYYCSTEEP--YNVMVTELLGPSLEDLFNIC-GR . .|| |.|| .| ..| .. .. .|.|.|| .| . | |. .|. ...|| | . .|. . . . .| .| .|.|..|.|| . .| WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHK-CRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDR KFSAKSVALIGLQLIERLEFLHKCYYIHRDIKPDNICIGL-----GKNSKTLYLIDFAFSK--RFIQKDGSHIPFQ-EGKFFTGTARYAS---------S ||| |..| .|..| ||.| .||||.|| | ||| ....|.|..|| ... ... |... .. . | || |||. . KFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQC RRDDLISLGYSLVYLMRGRLPWQDYKVLQKKE-KYEKILEKKQNLNLEQLCAKLPE-ELFEYMKYCTSLEFEQKPDYIYI |.||. | | .| . .|.|||. | . .| .... ... ... .. | |. . |.| ... .. .||| .| RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
|||||||||
Kinase | 3897.AA | TTBK | 28-281 | 31 | 9.5e-40 | 138.16 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 28-281 Range on HMM: 1-257/257 Sequence Identity: 31% (85 aa) FRFIEKIDAGSFGEIYHAKDLDTD-TNVAIKLEKTDSKQKLLCYEAKILQFLNNHKNCIGYPKVYYCSTEEPYNVMVTELLGPSLEDLFNICGR-KFSAK . . || | ||||| |||. .. .||||.|. . . | | .|. | . . . | .. .| || .|.| .| || | .|| WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVC---RFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLS SVALIGLQLIERLEFLHKCYYIHRDIKPDNICIG-LGKNSKTLYLIDFAFSKRFIQKDGSHIPFQEGKFFTGTARYAS---------SRRDDLISLGYSL . .|.|... .| | . |||||| | .| . .. . |..|| ... | | | | ||.|||| |.||| || | | TTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML VYLMRGRLPWQDYKVLQKKEKYEKILEKKQNLNLEQLCAKLPEELFEYMKYCTSLEFEQKPDYIYI | . | ||| |. | ... | |. .. | .|.|. .|. ||..| .||| | VEFVQGQLPWR--KIKDK----DQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
|||||||||
Kinase | 3897.AA | CMGC | 28-180 | 15 | 1.3e-21 | 66.91 | In-house | 1-256 (513) | Show / Hide |
Range on Protein: 28-180 Range on HMM: 1-256/513 Sequence Identity: 15% (41 aa) FRFIEKIDAGSFGEIYHAKDLDTDTN--------------VAIK---LEKTDSKQKL-----------LCYEAKILQFLN----------------NHKN . |.|| |..|. | ..| .|. . |||| ... . |.. . | |||. || .|.| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN CIGYPKVYYCSTEEPYN--------------VMVTELLGPSLEDLFNICG---------------------------RKFSAKSVALIGLQLIERLE--F ... ..| . ..... .|.|... .| .. . ..|. . . |... |. . IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY LHKCY--YIHRDIKPDNICIGLGKNS-----------------KTLYLIDFAFSKRFIQ .|. ||||.|| || | . . .| ..|| ... . . CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP |
|||||||||
Kinase | 3897.AA | Pkinase | 28-172 | 25 | 1.4e-20 | 73.88 | Pfam | 1-156 (293) | Show / Hide |
Range on Protein: 28-172 Range on HMM: 1-156/293 Sequence Identity: 25% (41 aa) FRFIEKIDAGSFGEIYHAKDLDTDTNVAIKLEKTDSKQKLLCY------EAKILQFLNNHKNCIGYPKVYYCSTEEPYNVMVTELLGPSLEDLFNIC--- .....|| .||||. |.... .| ||.| | ... . .. |..|.. | ||.| . . |.. ..... ||.|... |. .. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIV---RLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYI ----GRKF--SAKSVALIGLQLIERLEFLHKCYYIHRDIKPDNICIG-LGKNSKTLYLIDF ...| | . . . .|... ||..|.. ||||.||.|| | | .. .. ..|| STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF |
|||||||||
Kinase | 3897.AA | S_TKc | 28-289 | 20 | 3.5e-15 | 45.81 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 28-289 Range on HMM: 1-231/231 Sequence Identity: 20% (57 aa) FRFIEKIDAGSFGEIYHAKDLDTDTNVAIKLEKTDSKQKLLCYEAKILQFLNNHKNCIGYPKVYYCSTEEPYNVMVTELLGP---SLEDLFNICGRK--- .....|| |.||. | ... .|. |||| | . .. | .||. .|.| . . |.. . ||.|... .| |. .||. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --FSAKSVALIGLQLIERLEFLHKCYYIHRDIKPDNICIGLGKNSKTLYLIDFAFSKRFIQKDGSHIPFQEGKFFTGTARYAS------SR-RDDLISLG |. .. . |... ||..|. ||||.||.|| . .. ..|| ..... . | || | . .. . | |.| FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVLGYGKCKCDWWSCG YSLVYLMRGRLPWQDYKVLQKKEKYEKILEKKQNLNLEQLCAKLPEELFEYMKYCTSLEFEQKPDYIYIKN-----LFSEMV | .. |. |.. | .. ..||. ..|. . .. | . |. | . . . . CILYEMLCGYPPFP-----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
Kinase | 3897.AA | TyrKc | 28-285 | 19 | 6.7e-09 | -78.76 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 28-285 Range on HMM: 1-280/280 Sequence Identity: 19% (58 aa) FRFIEKIDAGSFGEIYHAKDLDTDTNVAIKLEKTDSKQKLLCYEAKILQFL-NNHKNCIGYPKVYYCSTEE-------PYNVMVTELLGP-SLEDLFNIC ....|. | |||.|... ..||.| | |. .. .. ||.|. | .|.| . . | . |.. . .|.|. .| | . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIV---RLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH GRKFSAKSVALIGLQLIERLEFLHKCYYIHRDIKPDNICIGLGKNSKTLYLIDFAFSKRFIQKD------GSHIPFQE--GKFFTGTARYAS--SRRDD- ..|.. | . .| . |.||. .||||. |. .| .. | || | |.| | .. . .| |. . | . . .. RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK ----------------LISLGYSLVYLMRGRLPWQDYKVLQKKEKYEKILEKKQNLNLEQL----CAKLPEELFEYMKYCTSLEFEQKPDYIYIKNLF . ..| . . | . . .. |... .. . . .. . . | |.|... || | . |. | |. .| FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCC---PDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
Kinase | 3897.AA | Pkinase | 210-267 | 15 | 0.010144 | 10.7 | Pfam | 197-273 (293) | Show / Hide |
Range on Protein: 210-267 Range on HMM: 197-273/293 Sequence Identity: 15% (12 aa) SLGYSLVYLMRGRLPWQDY----KVLQKKEKYEKILEKKQNLNLEQLCAKL----------------PEELFEYMKYC |.| | ... ||.|... . . .......|.... . ...| . .||. . .|.| SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC |