Gene 3738 (Tetrahymena)
3738
Sequence
Protein domains of 3738.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 3738.AA | CK1-Unclassified | 9-242 | 62 | 5.2e-195 | 580.93 | In-house | 1-244 (244) | Show / Hide |
Range on Protein: 9-242 Range on HMM: 1-244/244 Sequence Identity: 62% (152 aa) YRVGRVIGQGSFCNVKLGYDTQNEDKEVTIKLEEKKSPHLQLLFEAKVYRILQGGL-------GIPNVHWFGQE--GDFNIMVMDNLGPSLEDLFNYCNR |||.. ||||||... .....|.. .|| ||||.|.| | ||..|||....||.| |||...|.||| ||.||||||.||||||||||.||| YRVIEKIGQGSFGEIYKCINMQTN-EEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNR KFSLKTVLMIADQMIERIEYLHTNNFIHRDLKPSDFLIG-LGKQADIIYLIDYGLAKKFRDA-RTTLHIPYQSAKSLTGTARFSSINTHLEIEQSRRDDL |||||||||||||||.|||||| .||||||.|| .||.| |||.....|.||.||.|...|. .| ||||. |.||||||..|||.|| ||||||||| KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL ESIGYCLVYFLKGSLPWIGIKAESRIEKYQKIADKKISTPIEVLC ||.||.|.|||||||||..|||... |||.||...|.|||.| || ESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC |
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Kinase | 3738.AA | CK1 | 9-268 | 63 | 1.3e-190 | 639.53 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 9-268 Range on HMM: 1-271/271 Sequence Identity: 63% (172 aa) YRVGRVIGQGSFCNVKLGYDTQNEDKE--VTIKLEEKKSPHLQLLFEAKVYRILQG------GLGIPNVHWFGQE--GDFNIMVMDNLGPSLEDLFNYCN ||||| ||||||. . ||... .. .| | ||||..|| | ||..|||.|.|||| . |||...|.||| ||.||||||.||||||||||.|| YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN RKFSLKTVLMIADQMIERIEYLHTNNFIHRDLKPSDFLIGL-GKQADIIYLIDYGLAKKFRDARTTLHIPYQSAKSLTGTARFSSINTHLEIEQSRRDDL ||||||||||||||||.||||.|..||||||.|| ||.|. ||.....|.||.||||..||..| ||||. |.||||||. |||||| ||||||||. RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM ESIGYCLVYFLKGSLPWIGIKAESRIEKYQKIADKKISTPIEVLCED-LPEEFITYLKYCRSLKFEEKPDYV ||.||.|.|||.||||| |.||... .||.||..||.|||.|.||.. .|.||..||.|||.|.||||||| ESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | 3738.AA | CK1-D | 9-270 | 62 | 2.3e-151 | 509.16 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 9-270 Range on HMM: 1-261/261 Sequence Identity: 62% (163 aa) YRVGRVIGQGSFCNVKLGYDTQNEDKEVTIKLEEKKSPHLQLLFEAKVYRILQGGLGIPNVHWFGQEGDFNIMVMDNLGPSLEDLFNYCNRKFSLKTVLM ||.|| || ||| .. .| . |... || |||| |. | || .|.|.|...|||.|||...|.|||||.|.|||| ||||||||||||.|||||||||| YRIGRKIGSGSFGDIYHGTNIQTNE-EVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLM IADQMIERIEYLHTNNFIHRDLKPSDFLIGLGKQADIIYLIDYGLAKKFRDARTTLHIPYQSAKSLTGTARFSSINTHLEIEQSRRDDLESIGYCLVYFL .||||| ||||.|..||||||.|| ||.||||. ...|.||.||||..||||| |||| |.||||||. |||||. |||||||||||.|| |.|| LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN KGSLPWIGIKAESRIEKYQKIADKKISTPIEVLCEDLPEEFITYLKYCRSLKFEEKPDYVLI .||||| |.|| . .||..|..||.||.|..||. .|.|| .|. |||.|||..||||. . RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | 3738.AA | CK1-A | 9-270 | 60 | 3e-138 | 465.57 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 9-270 Range on HMM: 1-261/261 Sequence Identity: 60% (158 aa) YRVGRVIGQGSFCNVKLGYDTQNEDKEVTIKLEEKKSPHLQLLFEAKVYRILQGGLGIPNVHWFGQEGDFNIMVMDNLGPSLEDLFNYCNRKFSLKTVLM ||. | || ||| . || ..| . || ||.|..| | ||..||||||||||. |||...|.|.| |.|.|||| ||||||||||.|.|.|..||||| YRLVRKIGSGSFGDIYLGINITNGE-EVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLM IADQMIERIEYLHTNNFIHRDLKPSDFLIGLGKQADIIYLIDYGLAKKFRDARTTLHIPYQSAKSLTGTARFSSINTHLEIEQSRRDDLESIGYCLVYFL .||||| ||||.|. ||||||.|| ||.|.|. ..|||.|||||.||.|| ||||. | ||||||. ||| || ||||||||.||.||...|| LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN KGSLPWIGIKAESRIEKYQKIADKKISTPIEVLCEDLPEEFITYLKYCRSLKFEEKPDYVLI .|.||| |.|| . || || .||.|||||.|| | || |..|||.|.|||.|||. . RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | 3738.AA | CK1-G | 9-270 | 54 | 1.5e-130 | 440.03 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 9-270 Range on HMM: 1-266/266 Sequence Identity: 54% (145 aa) YRVGRVIGQGSFCNVKLGYDTQNEDKEVTIKLEEKKSPHLQLLFEAKVYRILQGGL-GIPNVHWFGQEGDFNIMVMDNLGPSLEDLFNYCNRKFSLKTVL ||||. || |.| . .| | | ||.| || || | . |.|| | |||.|..|||.| .|||||| |||||||||. |.||||.|||. YRVGKKIGCGNFGELFEGKNMYN-NEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVC MIADQMIERIEYLHTNNFIHRDLKPSDFLIGL--GKQADIIYLIDYGLAKKFRDARTTLHIPYQSAKSLTGTARFSSINTHLEIEQSRRDDLESIGYCLV |.| |||.|.||.|. . | || || |||| |.. .|..||.|.||...| .| |||| ||||||||. |||||| |||||||.|..| MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM YFLKGSLPWIGIKAESRIEKYQKIADKKISTPIEVLCED--LPEEFITYLKYCRSLKFEEKPDYVLI ||| ||||| | ||. |.|||| |.| .|.||.||. .||.| |||.| |.|.|.|.||| . YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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Kinase | 3738.AA | CK1 | 9-270 | 36 | 6e-127 | 428.04 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 9-270 Range on HMM: 1-339/339 Sequence Identity: 36% (126 aa) YRVGRVIGQGSFC-NVKLG-----YDTQNE----DKEVTIKLEEKKSP--HLQLLFEAKVYRILQGG-------------------LGIPNVHWFGQEGD ..|.. ||.|.| . .. .|..| ..|. .|.| ||| | ||. |...|..|||| ..| ..|...|.| WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED --FNIMVMDNLGPSLEDLFN---YCNRKFSLKTVLMIADQMIERIEYLHTNNFIHRDLKPSDFLIGL-------------GKQADIIYLIDYGLAK-KFR .|.|||. |||.||||.. ||||||.||.||||.||.|..||.| ..|||||.||. |..|. .......|.||.|.|. |.| DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR DA-----------RTTLHIPYQS---AKSLTG-TARFSSINTHLEIEQSRRDDLESIGYCLVYFLKGS--LPWIGIKAESR-------IEKYQKIADKKI | .| |.|. . .|...| |||. |||.|| .||.|||||.| .|.|...|||. ||| ..|.|.. .||..|..|| DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM STPIEVLCED-----LPEEFITYLKYCRSLKFEEKPDYVLI |||.. ||. .|.|| ...||.||||....||| | STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | 3738.AA | Worm6 | 9-270 | 29 | 3.7e-54 | 186.24 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 9-270 Range on HMM: 1-279/279 Sequence Identity: 29% (83 aa) YRVGRVIGQGSFCNVKLGYDTQNEDK-EVTIKLEE--KKSPHLQLLFEAKVYRIL--QGGLGIPNVHWFGQEGD--FNIMVMDNLGPSLEDLFNYC-NRK . |.. ||.|.| | . |... | .. .|.| ..... .| .|. | . ... . ... |. . || .|| .|..|.|| . .|| WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FSLKTVLMIADQMIERIEYLHTNNFIHRDLKPSDFLIGL-----GKQADIIYLIDYGLAK--KFRDARTTLHIPYQSAKSLTGTARFSSINTHLEIEQSR ||. | | || |..|.|| || . |||||.||. | || .. .||..|.|... |... ..|. | | || |. ... | .||.| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR RDDLESIGYCLVYFLKGSLPWIGIKAESRIEKYQKIADKKI-STPIEVLCEDLPE-EFITYLKYCRSLKFEEKPDYVLI .||.|| | .| ...| ||| ..|.... ||..| ..... .. . . . | || ..| .......||| | KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | 3738.AA | TTBK | 9-270 | 34 | 3.1e-47 | 163.26 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 9-270 Range on HMM: 1-257/257 Sequence Identity: 34% (91 aa) YRVGRVIGQGSFCNVKLGYDTQNEDKEVTIKLEEKKSPHLQLLFEAKVYRILQGGLGIPNVHWFGQEGDFNIMVMDNLGPSLEDLFNYCNR-KFSLKTVL .| . ||.| | . . | .|. .| ||.| . | | | | . ||| . | . .|| |||. .| .| || | .||| | | WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL MIADQMIERIEYLHTNNFIHRDLKPSDFLIG-LGKQADIIYLIDYGLAKKFRDARTTLHIPYQSAKSLTGTARFSSINTHLEIEQSRRDDLESIGYCLVY . |... || | | ||| ||| | .| . .. ..|..|.||| .. | | ..| ||.|. ||| |. | |.||| |. | || RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVA-GFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE FLKGSLPWIGIKAESRIEKYQKIADKKISTPIEVLCEDLPEEFITYLKYCRSLKFEEKPDYVLI |..| ||| || . . . .| .| ...|.|| .... .||..|..|||.|| FVQGQLPWRKIKDKDQVGEMKEKYD------HRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | 3738.AA | TTBKL | 9-274 | 28 | 1.7e-44 | 148.15 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 9-274 Range on HMM: 1-288/288 Sequence Identity: 28% (83 aa) YRVGRVIGQGSFCNVKLGYDTQNEDKEVTIKLEEKKSPHLQ--LLFEAKVYRILQ--GGLGIPNVHWFGQEGDFNIMVMDNLGPSLEDLFNYCNRK--FS ... ..||.| | | .. |... ... | | .. . . .|..| || | .|..|. |...|.| ||| .||.| || . ..| || WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS LKTVLMIADQMIERIEYLHTNNFIHRDLKPSDFLIGLGKQ----ADIIYLIDYGLAKKFRDARTTL----------HIPYQS---AKSLTGTARFSSINT |.. |. | .. . ..| . |||||.||. . .|. .. . ..||||.|.|..... . . . . .. || |. |.| DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HLEIEQSRRDDLESIGYCLVYFLKGSLPWIGIKAESRIEKYQKIADKKISTPIEVLCED------LPEEFITYLKYCRSLKFEEKPDYVLIRRIF |. ||.| ||| | | ......| ||| ... . .||. .| .. |.|. | .| || |. |||.. . ||| |. .| HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEH------MKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | 3738.AA | Pkinase | 9-279 | 20 | 1.1e-25 | 91.95 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 9-279 Range on HMM: 1-293/293 Sequence Identity: 20% (62 aa) YRVGRVIGQGSFCNVKLGYDTQNEDKEVTIKLEEKKSPHL----QLLF--EAKVYRILQGGLGIPNVHWFGQEGDFNIMVMDNLGPSLEDLFNYC----- |..||.||.||| |..... ... .| .| .|.. . ... |... . |. . .|| .| |||. .. |. .. . YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLY-VMDLFDYIST --NRKF--SLKTVLMIADQMIERIEYLHTNNFIHRDLKPSDFLIG-LGKQADIIYLIDYGLAKKFRDARTTLHIPYQSAKSLTGTARFSSINTHL-EIEQ ...| | ... ... |... .||.| ...|||||||. .|| | .... ..| ||||.|. . ... .....|| .. . .. . WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYY SRRDDLESIGYCLVYFLKGSLPWIGI----KAESRIEKYQKIADKKISTPIEVLCEDL----------------PEEFITYLKYCRSLKFEEKPDYVLIR ... | |.| | ..| | .|. | . . ......| ..... ... .|. .||.. .|.| .. .. | .. GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AE RIFKDLFF |... .| QILQHPWF |
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Kinase | 3738.AA | VRK | 81-159 | 40 | 1.1e-16 | 50.34 | In-house | 106-185 (284) | Show / Hide |
Range on Protein: 81-159 Range on HMM: 106-185/284 Sequence Identity: 40% (32 aa) MVMDNLGPSLEDLFN-YCNRKFSLKTVLMIADQMIERIEYLHTNNFIHRDLKPSDFLIGLGKQADIIYLIDYGLAKKFRD |||. .| .|. . .. .|| |||| | .|. |||| |. | |.| . | |. | .| ||.||||| .. . MVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCP |
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Kinase | 3738.AA | S_TKc | 9-279 | 20 | 8.4e-13 | 10.8 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 9-279 Range on HMM: 1-231/231 Sequence Identity: 20% (57 aa) YRVGRVIGQGSFCNVKLGYDTQNEDKEVTIKLEEKKSPHLQLLFEAKVYRILQGGLGIPNVHWFGQEGDFNIMVMDNLGPSLEDLFNYCNRK-------- |...|.||.|.| |...... ...| || ... | .. . . | . . . |. |. |||. .. .| ||| | .. YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP FSLKTVLMIADQMIERIEYLHTNNFIHRDLKPSDFLIGLGKQADIIYLIDYGLAKKFRDARTTLHIPYQSAKSLTGTARFSSINTHLEIEQSR-RDDLES |. .. .. |... .||.| ...|||||||. |. | ..| |||... ... || . . .. . | | FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWS IGYCLVYFLKGSLPWIGIKAESRIEKYQKIADKKISTPIEVLCEDLPEEFITYLKYCRSLKFEEKPDYVLIRR----IFKDLFF .| .| .| | |. . ..|| ..|.. .. | |. | . . | .. .| CGCILYEMLCGYPPFP-----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 3738.AA | VRK | 176-214 | 48 | 5e-08 | 22.28 | In-house | 202-240 (284) | Show / Hide |
Range on Protein: 176-214 Range on HMM: 202-240/284 Sequence Identity: 48% (19 aa) GTARFSSINTHLEIEQSRRDDLESIGYCLVYFLKGSLPW || | |. |. ||| |||. |||. . | |.||| GTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPW |
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Kinase | 3738.AA | TyrKc | 9-274 | 16 | 0.000169 | -149.88 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 9-274 Range on HMM: 1-280/280 Sequence Identity: 16% (53 aa) YRVGRVIGQGSFCNVKLGYDTQNEDKEVTIKLEEKKSPHLQLLFEAKVYRIL---------QGGLGIP--------NVHWFGQE----GDFNIMVMDNLG . |...| | |. | .| . .| .| . . . .. ||.. . | | . .. | || . .. . ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP PSLEDLFNYCNRKFSLKTVLMIADQMIERIEYLHTNNFIHRDLKPSDFLIGLGKQADIIYLIDYGLAKKFRDA-RTTLHIPYQSAK---SLT--GTARFS ...|. | .. | . |||| .|.||||| |.| .. .. | ||... | .. | ..| . | K------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM SINTHLEIEQSRRDDLESIGYC-------------LVY--FLKGSLPWIG-----IKAESRIEKYQKIADKKISTPIEVLCEDL-----PEEFITYLKYC .. |.| |. . . | | |. | .... | .... . . . . .. . |.| . | | AP--------------ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ---EVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQC RSLKFEEKPDYVLIRRIF . |. | |...| WHEDPEDRPTFSEIHECF |
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Kinase | 3738.AA | VRK | 9-20 | 58 | 0.049984 | 2.79 | In-house | 1-12 (284) | Show / Hide |
Range on Protein: 9-20 Range on HMM: 1-12/284 Sequence Identity: 58% (7 aa) YRVGRVIGQGSF .|.|. |||| | WRLGKPIGQGGF |