Gene 25400 (Tetrahymena)
25400
Sequence
Protein domains of 25400.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 25400.AA | CK1-Unclassified | 21-189 | 57 | 3.9e-118 | 350.23 | In-house | 67-244 (244) | Show / Hide |
Range on Protein: 21-189 Range on HMM: 67-244/244 Sequence Identity: 57% (102 aa) VYCFCTQ--GDQNIMVMDLLGPSLEELLDFCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIG-SGNLLNQIFITGLGYSKRYFQ--RDGT .|..... || |||||||||||||.|. .|||.|||||.||.|.|||| |||.|..|||.| | | |||.| .|. .|..| .|.||||.. ..|. MYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGK HIPYREDKSLVGTPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMFVK----KLNTPIQELC ||||||.|.|.|| || |.|.|.||| |||||| || |.||||||||||||..| . | . | |..||...|| HIPYRENKNLTGTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC |
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| Kinase | 25400.AA | CK1 | 21-215 | 56 | 5.3e-115 | 388.35 | In-house | 68-271 (271) | Show / Hide |
Range on Protein: 21-215 Range on HMM: 68-271/271 Sequence Identity: 56% (116 aa) VYCFCTQ--GDQNIMVMDLLGPSLEELLDFCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIGS-GNLLNQIFITGLGYSKRYFQ-RDGTH .|..... || |||||||||||||.|..||||.|||||.||.|.|||| |||.|..|||.| | | |||.| |. .|..| | .||| . ....| MYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQH IPYREDKSLVGTPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMFVK----KLNTPIQELCLG-FPNEFIEYYNYVGKLSFEEK |||||.|.|.|| || |.|.|.||| |||||. || |.|.|||.||||||||| . . . | |..||...|| | |||||..| ||. .|.|||| IPYRENKNLTGTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEK PDYS ||| PDYM |
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| Kinase | 25400.AA | CK1-D | 24-217 | 55 | 1.8e-85 | 290.25 | In-house | 63-261 (261) | Show / Hide |
Range on Protein: 24-217 Range on HMM: 63-261/261 Sequence Identity: 55% (110 aa) FCTQGDQNIMVMDLLGPSLEELLDFCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIGSGNLLNQIFITGLGYSKRYFQRD-GTHIPYRED . .|| |.|||||||||||.| .|.|.|||||.||||.|||. ||||| .||| | | | |||.| | | ..| | .||| ||||||. CGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYREN KSLVGTPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMF----VKKLNTPIQELCLGFPNEFIEYYNYVGKLSFEEKPDYSYC |.| || || |.| | ||| |||||| || | |.|| .||||||||| . . . ||..|.|..|| |.|.|| .| ||. .| |..||||.| KNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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| Kinase | 25400.AA | CK1 | 16-217 | 35 | 2.5e-83 | 283.12 | In-house | 89-339 (339) | Show / Hide |
Range on Protein: 16-217 Range on HMM: 89-339/339 Sequence Identity: 35% (89 aa) HINFLVYCFCTQGDQNIMVMDLLGPSLEELLD---FCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIGS------GNLLN--------QI |. ..|...... |.|||.||||.||.|.. .|||.||.||.||.|.||.. .||.| ..|| |.| |.||..| |. . |. HPCMYWYHGEEDDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQV FITGLGYSK-RYFQRDGT------------HIPYRE---DKSLVG-TPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGS--LPWQGLK---------I .. | .. .| .||. |.|.|| |...| |.||.|.|.| |.|..||||| |.||.||..|||. ||||..| . YMIDFGMARRKYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQV GRRNEMF--VKKLNTPIQELCLG-----FPNEFIEYYNYVGKLSFEEKPDYSYC .. . | ||..||. || . .| || ....|. .|.....||| . EKMKYEFIDEKKMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | 25400.AA | CK1-A | 29-217 | 55 | 3.3e-81 | 276.12 | In-house | 68-261 (261) | Show / Hide |
Range on Protein: 29-217 Range on HMM: 68-261/261 Sequence Identity: 55% (107 aa) DQNIMVMDLLGPSLEELLDFCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIGSGNLLNQIFITGLGYSKRYF-QRDGTHIPYREDKSLVG | |.|||||||||||.| ||.|||..||.||||.||| |||.| ||| | | | |||.| | |..|. | .|.| .| .|||||||| |.| DYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTG TPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMFV----KKLNTPIQELCLGFPNEFIEYYNYVGKLSFEEKPDYSYC | || |.| |.||| |||||. |. |...|| .|.|||||.| . . ||. |||..|| ||| || | ||. .| |||.||| | TARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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| Kinase | 25400.AA | CK1-G | 21-217 | 50 | 2.8e-77 | 261.49 | In-house | 61-266 (266) | Show / Hide |
Range on Protein: 21-217 Range on HMM: 61-266/266 Sequence Identity: 50% (103 aa) VYCFCTQGDQNIMVMDLLGPSLEELLDFCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIG--SGNLLNQIFITGLGYSKRYFQRD-GTHI || | | ||||||||||||| | |.|.|.||.||..|.| |||. .||.| . | | . | ||||| | . . |.| | | | . . || VYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHI PYREDKSLVGTPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMFVK----KLNTPIQELCLG--FPNEFIEYYNYVGKLSFEEK |||| ||| || || | | |.| | |||||. .| .||| ||||||||| | . | | .|.|. || . || .| | || .|.|.|. PYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFEC PDYSYC ||| | PDYDYL |
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| Kinase | 25400.AA | Worm6 | 33-217 | 29 | 5.3e-33 | 115.79 | In-house | 80-279 (279) | Show / Hide |
Range on Protein: 33-217 Range on HMM: 80-279/279 Sequence Identity: 29% (59 aa) MVMDLLGPSLEELLDFC-NRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIGS-----GNLLNQIFITGLGYSK--RYFQRDGTHIPYR-EDK .|| |.|..|..| .. .|.||. | | .|.|... || | . ||.|.. |||| || | . .|.. | .. .| .... .. | .. IVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTAC SLVGTPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNE-MFVKKLNTP---IQELCLG-FPN-EFIEYYNYVGKLSFEEKPDYSYC .||.|| .|. | |.| .|.||. | || .. ...| |||...| . | . .. .. . .. .| .| || . |. ..|....||| .. GFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | 25400.AA | TTBK | 31-217 | 34 | 1.6e-24 | 83.61 | In-house | 71-257 (257) | Show / Hide |
Range on Protein: 31-217 Range on HMM: 71-257/257 Sequence Identity: 34% (66 aa) NIMVMDLLGPSLEEL-LDFCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIG-SGNLLNQIFITGLGYSKRYFQRDGTHIPYREDKSLVGT | |||.|.| .| .| ||| | | | |..| || || | | | | || .| ..... | .| | | || || NYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGT PRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMFVKKLNTPIQELCLGFPNEFIEYYNYVGKLSFEEKPDYSYC || | | | | |.||| |||| |. |..| ||| .| . .| .... | | || . . . | .|..||| VRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRKIKDKDQVGEMKEKYDHRM--LLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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| Kinase | 25400.AA | TTBKL | 106-221 | 26 | 3.7e-23 | 75.1 | In-house | 156-288 (288) | Show / Hide |
Range on Protein: 106-221
Range on HMM: 156-288/288
Sequence Identity: 26% (36 aa)
SKRYFQRDG-----------THIPYRE---DKSLVGTPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMFVKKLNTPIQELCLG
...|. || .. . |. .. ||.||.|.||| . | .| ||| |..| .|....| |||.... . |. .|.|. . |. .
ARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMED--KMEIEHMKKNMKDEDLFKD
------FPNEFIEYYNYVGKLSFEEKPDYSYCQSLF
.| || . . .. |.. . |||.. . .|
MPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
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| Kinase | 25400.AA | VRK | 33-165 | 37 | 4.5e-21 | 64.63 | In-house | 106-240 (284) | Show / Hide |
Range on Protein: 33-165 Range on HMM: 106-240/284 Sequence Identity: 37% (51 aa) MVMDLLGPSLEELLD-FCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIGS-GNLLNQIFITGLGYSKRYFQRDGTHIPYREDKSLV--GT |||. .| .|. ... .. ||| || | || .|. ||.| |. .| | | | .| .| . . | . || . .| | .| ||. || MVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKN-PDQVYLVDYGLAYRY-CPNGKHRQYKEDPRRCHNGT PRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPW . . |. | | |||| || .| ||... | |.||| CEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPW |
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| Kinase | 25400.AA | TTBKL | 31-90 | 33 | 2.1e-08 | 24.57 | In-house | 75-136 (288) | Show / Hide |
Range on Protein: 31-90 Range on HMM: 75-136/288 Sequence Identity: 33% (21 aa) NIMVMDLLGPSLEELL-DFCNRR-FSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIG | ||| |.||.| | . .|.. || |.. .. | . . ..| . || | . |.|. .| NFMVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWG |
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| S_TKc | 25400.AA | S_TKc | 7-239 | 14 | 6.4e-08 | -60.73 | SMART | 11-231 (231) | Show / Hide |
Range on Protein: 7-239
Range on HMM: 11-231/231
Sequence Identity: 14% (41 aa)
NFCISMIRIHIN-----------------------------FLVYCFCTQGDQNIMVMDLLGP---SLEELLDFCNRR-----FSLKTILMLAEQMIQTI
| . .|.. | ..| . | |||.... .| .... ..|. |. .. .. |... .
AFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCAL
EYIHYNNFICRNINPGNFLIGSGNLLNQIFITGLGYSKRYFQRDGTHIPYREDKSLVGTPRYVSLNMHIGIEPSR-RDDLISLFYCLIYFLKGSLPWQGL
||.| ...| | . | | |. . .| |. | .... ....||| |.. . .. . | |. .|. .| | |..
EYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--
KIGRRNEMFVKKLNTPIQELCLGFPNEFIEYYNYVGKLSFEEKPDYSYCQSLFRQCFQK-----MGYEKDSN-------FDWI
..|| | . . . .. |.|.|| .. . . |.
---QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 25400.AA | Pkinase | 22-78 | 21 | 6.8e-05 | 18.38 | Pfam | 66-130 (293) | Show / Hide |
Range on Protein: 22-78 Range on HMM: 66-130/293 Sequence Identity: 21% (14 aa) YCFCTQGDQNIMVMDLLGPSLEELLDFC-------NRRF--SLKTILMLAEQMIQTIEYIHYNNFI |.... .| |||.... |. ..| . ...| | ... . . |... .||.| ...| YDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGII |
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