Gene 20116 (Tetrahymena)

20116

Species: Tetrahymena
Alias: 110.m00089, PreTt20116, 20116, 926, TTHERM_00703400
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
20116.AA Protein None 390 None Fasta, JSON
20116.kin_dom Protein Kinase Domain None 360 None Fasta, JSON
20116.NA RNA None 1173 None Fasta, JSON

Protein domain

Protein domains of 20116.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20116.AA CK1-Unclassified 40-212 65 1.3e-153 456.73 In-house 68-244 (244) Show / Hide 
Range on Protein: 40-212
Range on HMM: 68-244/244
Sequence Identity: 65% (116 aa)

HWYGRD--GDYNILILDLLGPSLEDLFQLCNKKFSLKTVLMIVEQIISRIEQIHAKNFIYRDIKPDNFLIG-TKQKADHIYLIDFGLAKRYRDA-KTGQH
.|.|..  |||||...|||||||||||..||.||||||||||..|.|.|||..| ||||.|||||||||.| . ......|.|||||.|||.|. |||.|
YWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKH

IEQKEGKSFIGTVRYSSINTHLGKEQSRRDDLEAIGYILLYFLRGSLPWQGVKADNKKDKYDKIGEIKMNTPVEELC
|...|.|...|| ||.|||.|||.|||||||||..||.|.|||.||||||..||.|||.||.|| |.||.||||.||
IPYRENKNLTGTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 20116.AA CK1 40-238 61 1.7e-143 483.03 In-house 69-271 (271) Show / Hide 
Range on Protein: 40-238
Range on HMM: 69-271/271
Sequence Identity: 61% (124 aa)

HWYGRD--GDYNILILDLLGPSLEDLFQLCNKKFSLKTVLMIVEQIISRIEQIHAKNFIYRDIKPDNFLIGT-KQKADHIYLIDFGLAKRYRDAKTGQHI
.|.|..  |||||...|||||||||||..||.||||||||||..|.|.||| .| ||||.|||||||||.|.  ......|.|||||||||||.||.|||
YWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHI

EQKEGKSFIGTVRYSSINTHLGKEQSRRDDLEAIGYILLYFLRGSLPWQGVKADNKKDKYDKIGEIKMNTPVEELCKG-FPEYNNDNIFDWSKLNSNNVH
...|.|...||.|| |||||||.|||||||.|..||.|.|||||||||||.||..||.||.||.|.||.||||.|||| ||.......  . .|. .. .
PYRENKNLTGTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKP

KKK
...
DYM
Kinase 20116.AA CK1-G 40-217 58 8.9e-107 361.04 In-house 62-243 (266) Show / Hide 
Range on Protein: 40-217
Range on HMM: 62-243/266
Sequence Identity: 58% (106 aa)

HWYGRDGDYNILILDLLGPSLEDLFQLCNKKFSLKTVLMIVEQIISRIEQIHAKNFIYRDIKPDNFLIG--TKQKADHIYLIDFGLAKRYRDAKTGQHIE
...|  | |||...||||||||||| .|. |||.|||.|.  |.|.|.|..|... ||||.||||||||   ....  |..||||.|| |.| .|.||| 
YYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIP

QKEGKSFIGTVRYSSINTHLGKEQSRRDDLEAIGYILLYFLRGSLPWQGVKADNKKDKYDKIGEIKMNTPVEELCKG--FPE
  | ||  || || |||||||.|||||||.||.| . .||||||||||| |||| | .|.|||. | .|..| ||..  |||
YREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPE
Kinase 20116.AA CK1-D 40-217 63 4.6e-101 342.07 In-house 61-238 (261) Show / Hide 
Range on Protein: 40-217
Range on HMM: 61-238/261
Sequence Identity: 63% (113 aa)

HWYGRDGDYNILILDLLGPSLEDLFQLCNKKFSLKTVLMIVEQIISRIEQIHAKNFIYRDIKPDNFLIGTKQKADHIYLIDFGLAKRYRDAKTGQHIEQK
.|.|..||||....|||||||||||  |..|||||||||. .|.|.||| ||..||| |||||||||.|  .. . .|.||||||||||||.| |||  .
RWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYR

EGKSFIGTVRYSSINTHLGKEQSRRDDLEAIGYILLYFLRGSLPWQGVKADNKKDKYDKIGEIKMNTPVEELCKGFPE
| |.  || || |||||.| |||||||||..||.|.|| ||||||||.|| .|..||..| | ||.|....||||.|.
ENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPS
Kinase 20116.AA CK1-A 40-216 62 2.1e-98 333.2 In-house 61-237 (261) Show / Hide 
Range on Protein: 40-216
Range on HMM: 61-237/261
Sequence Identity: 62% (110 aa)

HWYGRDGDYNILILDLLGPSLEDLFQLCNKKFSLKTVLMIVEQIISRIEQIHAKNFIYRDIKPDNFLIGTKQKADHIYLIDFGLAKRYRDAKTGQHIEQK
.|||.. |||....||||||||||| .|...|..|||||...|.|.||| .| |||| |||||||||.|.     ...||||||||.|||..| |||. .
RWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYR

EGKSFIGTVRYSSINTHLGKEQSRRDDLEAIGYILLYFLRGSLPWQGVKADNKKDKYDKIGEIKMNTPVEELCKGFP
| |  .||.|| ||| ||| |||||||.|..||...|| ||.|||||.|| .|| ||.|| | || ||.|.||||||
EDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFP
Kinase 20116.AA CK1 40-240 38 5.5e-91 308.57 In-house 93-339 (339) Show / Hide 
Range on Protein: 40-240
Range on HMM: 93-339/339
Sequence Identity: 38% (95 aa)

HWYGRDGD--YNILILDLLGPSLEDLFQ---LCNKKFSLKTVLMIVEQIISRIEQIHAKNFIYRDIKPDNFLIGTK-------------QKADHIYLIDF
.||.  .|  ||.....||||.||||..   .||.|||.||.||| .|.....|..| ..||.||||||||..| .             ......|.|||
YWYHGEEDDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDF

GLAK-RYRDA-----------KTGQHIEQKE---GKSFIG-TVRYSSINTHLGKEQSRRDDLEAIGYILLYFLRGS--LPWQGVKADNK-------KDKY
|.|. .|||            ||.||....|    |.|.| |.|| |||.||||||.|||||.. .| |...|.|.  ||||..|. .|       | ||
GMARRKYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKY

DKIGEIKMNTPVEELCKG-----FPEYNNDNIFDWSKLNSNNVHKKKEI
..| | ||.||.. ||..     .|..  . .   ..|.     . ..|
EFIDEKKMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 20116.AA TTBKL 39-188 34 3.9e-39 129.82 In-house 65-232 (288) Show / Hide 
Range on Protein: 39-188
Range on HMM: 65-232/288
Sequence Identity: 34% (58 aa)

LHWYGRDGDYNILILDLLGPSLEDLF-QLCNKK-FSLKTVLMIVEQIISRIEQIHAKNFIYRDIKPDNFLIGTKQK----ADHIYLIDFGLAKRYRDAKT
.|..|. .||| ... |.||.| ||  ...||| ||  |.. |  |..  . |.| . || ||.|| |. .| ...    . |.||||||.|..|..   
CHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDG

GQ----------HIEQKE---GKSFIGTVRYSSINTHLGKEQSRRDDLEAIGYILLYFLRGSLPWQGVK
..          . ....     .| ||.|| |.| |..|||.| ||| .  |.. ... | |||....
EWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNME
Kinase 20116.AA TTBK 43-217 39 5.5e-35 121.09 In-house 65-234 (257) Show / Hide 
Range on Protein: 43-217
Range on HMM: 65-234/257
Sequence Identity: 39% (70 aa)

GRDGDYNILILDLLGPSLEDL-FQLCNKKFSLKTVLMIVEQIISRIEQIHAKNFIYRDIKPDNFLIG-TKQKADHIYLIDFGLAKRYRDAKTGQHIEQKE
||. ..| ....|.| .| ||  .    .||| | | .  ||.  ||.||   |  ||||| || .| . ..   .|..||||| .|  |. |.     |
GRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNAC-GEVRPPRE

GKSFIGTVRYSSINTHLGKEQSRRDDLEAIGYILLYFLRGSLPWQGVKADNKKDKYDKIGEIKMNTPVEELCKGFPE
   | ||||| ||| |. .|  |.|||  . |.|  |. | |||  .     ||| |..||.|       | |  |.
VAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRKI-----KDK-DQVGEMKEKYDHRMLLKHCPH
Kinase 20116.AA Worm6 42-198 32 1.1e-34 121.58 In-house 69-235 (279) Show / Hide 
Range on Protein: 42-198
Range on HMM: 69-235/279
Sequence Identity: 32% (55 aa)

YGRDGD--YNILILDLLGPSLEDLFQLC-NKKFSLKTVLMIVEQIISRIEQIHAKNFIYRDIKPDNFLIGT-----KQKADHIYLIDFGLAK-RYRDAKT
.|. .   .| ... |.|..|.|| . . ..|||. | | | .| . .||. |   || ||.|| || ||        .   ||..|||... .. . | 
RGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKG

GQHIEQK-EGKSFIGTVRYSSINTHLGKEQSRRDDLEAIGYILLYFLRGSLPWQGVKADNKKDKYDK
.. . .. .   | ||||| ... | |.||.|.||.|   | .. ...| |||...|... ..|. |
NELRTPRWTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKK
Kinase 20116.AA Pkinase 44-201 21 2.6e-26 94.14 Pfam 70-232 (293) Show / Hide 
Range on Protein: 44-201
Range on HMM: 70-232/293
Sequence Identity: 21% (38 aa)

RDGDYNILILDLLGPSLEDLFQLC-------NKKF--SLKTVLMIVEQIISRIEQIHAKNFIYRDIKPDNFLIG-TKQKADHIYLIDFGLAKRYRDAKTG
.|.|.  .......  |. .. |.       ...|  | ... ... ||.. .| .|....|.||.||.|.||  . . .... ..|||||| ..     
EDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----

QHIEQKEGKSFIGTVRYSSINTHL-GKEQSRRDDLEAIGYILLYFLRGSLPWQGV----KADNKKDKYDKIGE
 .  .   ..| || .| .   .. |.. ... |  ..| || ..| | .|..|     . .... ....|..
-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMG
Kinase 20116.AA VRK 51-193 33 2.4e-21 65.52 In-house 106-251 (284) Show / Hide 
Range on Protein: 51-193
Range on HMM: 106-251/284
Sequence Identity: 33% (49 aa)

LILDLLGPSLEDLFQ-LCNKKFSLKTVLMIVEQIISRIEQIHAKNFIYRDIKPDNFLIGTKQKADHIYLIDFGLAKRYRDAKTGQHIEQKEG--KSFIGT
.... .| .|. .    ....|| ||||    ...   | .| ..    |||  | | |    .|. ||.|.||| || .   | | . ||.  .   ||
MVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPN--GKHRQYKEDPRRCHNGT

VRYSSINTHLGKEQSRRDDLEAIGYILLYFLRGSLPWQGVKA--DNKK
  . |.  |.|   ||| |||  || ... | |.|||  ..   | .|
CEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEK
Kinase 20116.AA CK1-Unclassified 9-39 70 7.1e-21 58.35 In-house 1-31 (244) Show / Hide 
Range on Protein: 9-39
Range on HMM: 1-31/244
Sequence Identity: 70% (22 aa)

FRVGRKIGAGSFGEIYLGTNIQTEEEVAIKL
.||..|||.|||||||...|.||.|||||||
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKL
Kinase 20116.AA CK1 9-39 69 8.9e-18 57.94 In-house 1-33 (271) Show / Hide 
Range on Protein: 9-39
Range on HMM: 1-33/271
Sequence Identity: 69% (23 aa)

FRVGRKIGAGSFGEIYLGTNIQTEEE--VAIKL
.|||||||.||||.||||.|....||  |||||
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKL
Kinase 20116.AA CK1-D 9-39 80 1.3e-17 58.55 In-house 1-31 (261) Show / Hide 
Range on Protein: 9-39
Range on HMM: 1-31/261
Sequence Identity: 80% (25 aa)

FRVGRKIGAGSFGEIYLGTNIQTEEEVAIKL
.|.|||||.||||.||.||||||.|||||||
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKL
Kinase 20116.AA CK1-G 9-39 54 3.8e-15 47.71 In-house 1-31 (266) Show / Hide 
Range on Protein: 9-39
Range on HMM: 1-31/266
Sequence Identity: 54% (17 aa)

FRVGRKIGAGSFGEIYLGTNIQTEEEVAIKL
.|||.||| |.|||...|.|. . | ||||.
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKF
Kinase 20116.AA S_TKc 9-224 20 1.5e-14 36.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-224
Range on HMM: 1-231/231
Sequence Identity: 20% (55 aa)

FRVGRKIGAGSFGEIYLGTNIQTEEEVAIK----------------------LHWYGRDGDYNILILDLLGPSLEDLFQLCNKK--------FSLKTVLM
....|||| |.||. |..... | ..||||                      |. . .| |.  ....... .| |||..  |.        |.  ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

IVEQIISRIEQIHAKNFIYRDIKPDNFLIGTKQKADHIYLIDFGLAKRYRDAKTGQHIEQKEGKSFIGTVRYSSINTHLGKEQSR-RDDLEAIGYILLYF
.. ||.. .| .| ...|.||.||.| |. .     || ..|||||...              ..|.||  | .         .. . |  ..| ||  .
YMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LRGSLPWQGVKADNKKDKYDKIGEIKMNTPVEELCKGFPEYN----------N-------DNIF
| |  |..     . .  ..|||      .. .. ..  ...          .       .  |
LCGYPPFP-----QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 20116.AA CK1 9-39 30 4.8e-13 41.91 In-house 1-42 (339) Show / Hide 
Range on Protein: 9-39
Range on HMM: 1-42/339
Sequence Identity: 30% (13 aa)

FRVGRKIGAGSFG-EIYLG-----TNIQTE-----EEVAIKL
..|..||| |.|| .||..     .....      ||.|.|.
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKV
Kinase 20116.AA CK1-A 9-39 67 8.6e-12 37.79 In-house 1-31 (261) Show / Hide 
Range on Protein: 9-39
Range on HMM: 1-31/261
Sequence Identity: 67% (21 aa)

FRVGRKIGAGSFGEIYLGTNIQTEEEVAIKL
.|. ||||.||||.|||| ||.  ||||||.
YRLVRKIGSGSFGDIYLGINITNGEEVAIKM
Kinase 20116.AA TTBK 9-39 46 1.5e-11 37.09 In-house 1-32 (257) Show / Hide 
Range on Protein: 9-39
Range on HMM: 1-32/257
Sequence Identity: 46% (15 aa)

FRVGRKIGAGSFGEIYLGTNIQTE-EEVAIKL
 .| .||| | ||||| ....... |.||||.
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKV
Kinase 20116.AA Pkinase 9-38 46 9.6e-09 32.0 Pfam 1-30 (293) Show / Hide 
Range on Protein: 9-38
Range on HMM: 1-30/293
Sequence Identity: 46% (14 aa)

FRVGRKIGAGSFGEIYLGTNIQTEEEVAIK
...|||||.||||. |..... |...||.|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK
Kinase 20116.AA TTBKL 9-38 23 2.6e-08 24.26 In-house 1-30 (288) Show / Hide 
Range on Protein: 9-38
Range on HMM: 1-30/288
Sequence Identity: 23% (7 aa)

FRVGRKIGAGSFGEIYLGTNIQTEEEVAIK
... ..|| | ||..|.. .... ...|..
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAM
Kinase 20116.AA VRK 9-25 58 1e-06 17.82 In-house 1-17 (284) Show / Hide 
Range on Protein: 9-25
Range on HMM: 1-17/284
Sequence Identity: 58% (10 aa)

FRVGRKIGAGSFGEIYL
.|.|..|| | ||.|||
WRLGKPIGQGGFGCIYL
Kinase 20116.AA Pkinase_Tyr 9-38 41 2e-06 22.25 Pfam 1-34 (270) Show / Hide 
Range on Protein: 9-38
Range on HMM: 1-34/270
Sequence Identity: 41% (14 aa)

FRVGRKIGAGSFGEIYLGTNI----QTEEEVAIK
 . |.|.|.|.|||.|.||      .|. .||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK
Kinase 20116.AA Worm6 9-39 30 4.6e-05 14.48 In-house 1-33 (279) Show / Hide 
Range on Protein: 9-39
Range on HMM: 1-33/279
Sequence Identity: 30% (10 aa)

FRVGRKIGAGSFGEIYLGTNIQTEE--EVAIKL
. |..||| |.|| .|. .. .. .  ..|.|.
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKC
Kinase 20116.AA TyrKc 9-199 17 0.000115 -147.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-199
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

FRVGRKIGAGSFGEIYLGTNIQTEEEVAIK----------------LHWYG-------------RDG------DYNILILDLLGP--SLEDLFQLCNKKF
 . |.|.| | |||.|.|| .   ..||.|                .. .|             ...      .  ..|.  . |  .| |  . . .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

SLKTVLMIVEQIISRIEQIHAKNFIYRDIKPDNFLIGTKQKADHIYLIDFGLAKRYRDA----KTGQHIEQKE--GKSFIGTVRYS---SINTH------
..|. | .  || .  | .| ||.| ||.   | |.| ..   ..   ||||..   |       .. . .||  |. .   .|     .||..      
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

--------------LGKEQSR------RDDLEAIGYILLY-FLRGSLP--------------------WQGVKAD--NKKDKYDKI
              .|..          .. |.| |.     ..                        |.   .|  . .. ....
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF