Gene 18951 (Tetrahymena)
18951
Sequence
Protein domains of 18951.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
---|---|---|---|---|---|---|---|---|---|
Kinase | 18951.AA | CK1-Unclassified | 32-264 | 48 | 3.7e-166 | 494.37 | In-house | 1-244 (244) | Show / Hide |
Range on Protein: 32-264 Range on HMM: 1-244/244 Sequence Identity: 48% (119 aa) YRSIDKIGSGSFGEIHKVYDMVDKKLRAVKIEKKDKRGAQGMLLKEAYIMKQMKDCH-------HFPRLIEEMQNDQ--MSFIIMSFLGQNLESLKKKYN || |.|||.||||||.|...| .... |.|.|||... . .|..||.||......| ..|.... .|..| . ...|..||..||.|....| YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK--HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCN -KLSHYTTLLIGTQMVEALELMHGKGFLHRDIKPENFVIG-TEGNHHNIYIIDFGLSKKYI--DLNNKHIPEDNNKGLVGTARYTSINSHRGIEQSRRDD |.|..|.|.|. ||.. .|..| |.|.||||||.||..| ...|||..|||||||||.|| | ..|||| ..||.|.|||||.|||.|.||||||||| RKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDD LEALGYVLIYLAKGELPWQNLTLEKREEKFEQIKHLKIETKLDDLC ||.|||||||..||.|||||.. ....||.|.|. .|. | .. || LESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC |
|||||||||
Kinase | 18951.AA | CK1 | 32-290 | 43 | 2.4e-146 | 492.48 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 32-290 Range on HMM: 1-271/271 Sequence Identity: 43% (118 aa) YRSIDKIGSGSFGEIHKVYDMVDKKLR---AVKIEKKDKRGAQGMLLKEAYIMKQMKD------CHHFPRLIEEMQNDQ--MSFIIMSFLGQNLESLKKK || . |||.||||.|.....| ... . |.|.||.... .. .|..||.|.|.... ||..|... .|..| . ...|..||..||.|... YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSK-HP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNF YN-KLSHYTTLLIGTQMVEALELMHGKGFLHRDIKPENFVIGT-EGNHHNIYIIDFGLSKKYID-LNNKHIPEDNNKGLVGTARYTSINSHRGIEQSRRD .| |.|..|.|.|. ||.. .| .| |.|.||||||.||..|. . ..|..|||||||.|.|.| ...||| .||.|.|||||.|||.| |||||||| CNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRD DLEALGYVLIYLAKGELPWQNLTLEKREEKFEQIKHLKIETKLDDLCKG-LPNSFKTYMEHVKGLSFEQEPKYK |.|.|||||.|...|.||||.|. .....|.|.|. |. | ...|||| .|| | .|......|.||..|.|. DMESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
|||||||||
Kinase | 18951.AA | CK1 | 32-292 | 31 | 2.2e-112 | 379.65 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 32-292 Range on HMM: 1-339/339 Sequence Identity: 31% (107 aa) YRSIDKIGSGSFG-EIHKV-----YDMVDK-----KLRAVKIEKKDKRGAQGMLLKEAYIMKQMKDC-------------------HHFPRLIEEMQNDQ .. . |||.|.|| .|.|| .|| .. . |.|.|.|. .| . .|..|. ..|..... ...|.... .... WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED --MSFIIMSFLGQNLESLKK---KYN-KLSHYTTLLIGTQMVEALELMHGKGFLHRDIKPENFVIGT-------------EGNHHNIYIIDFGLSK-KYI ...|. || |||.|.| | |.| |.| |. ||.|||| || .||.||||||.||..| ...|...|.||||... ||. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR DLNN------------KHIPEDN---NKGLVG-TARYTSINSHRGIEQSRRDDLEALGYVLIYLAKGE--LPWQNLTLEKR-------EEKFEQIKHLKI | .. .|.| . .||..| ||||.|||.|.|.||.|||||....|.||.. ||. |||||.. |.. ..| | |. | DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM ETKLDDLCKG-----LPNSFKTYMEHVKGLSFEQEPKYKFL |... ||.. .| .| ..|.....|... .|.|... STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
|||||||||
Kinase | 18951.AA | CK1-D | 32-292 | 42 | 2.2e-78 | 266.74 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 32-292 Range on HMM: 1-261/261 Sequence Identity: 42% (113 aa) YRSIDKIGSGSFGEIHKVYDMVDKKLRAVKIEKKDKRGAQGMLLKEAYIMKQMKDCHHFPRLIEEMQNDQMSFIIMSFLGQNLESLKKKYN-KLSHYTTL || ||||||||.| .. |.|.| . | | |. . | |. |.. |. . ..| || || | . | | | | YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQ--LHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVL LIGTQMVEALELMHGKGFLHRDIKPENFVIGTEGNHHNIYIIDFGLSKKYIDLN-NKHIPEDNNKGLVGTARYTSINSHRGIEQSRRDDLEALGYVLIYL ... ||. .| .|.. |.||||||.||..| . .|||||||.|.| | . .||| || | ||||| ||| |.|||||||||||.|||||.| MLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF AKGELPWQNLTLEKREEKFEQIKHLKIETKLDDLCKGLPNSFKTYMEHVKGLSFEQEPKYKFL ..| |||| | . .|.|.| |..||.|.||||.|. |..||.... | |.. | | .| NRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
|||||||||
Kinase | 18951.AA | CK1-A | 32-292 | 39 | 1e-76 | 261.19 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 32-292 Range on HMM: 1-261/261 Sequence Identity: 39% (105 aa) YRSIDKIGSGSFGEIHKVYDMVDKKLRAVKIEKKDKRGAQGMLLKEAYIMKQMKDCHHFPRLIEEMQNDQMSFIIMSFLGQNLESLKKKYN-KLSHYTTL || . ||||||||.| . . . |.|.|... | | |. || . .... | .|.. .. . ..| || || | . . . | | YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQ--LIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVL LIGTQMVEALELMHGKGFLHRDIKPENFVIGTEGNHHNIYIIDFGLSKKYIDLNNK-HIPEDNNKGLVGTARYTSINSHRGIEQSRRDDLEALGYVLIYL .. ||. .| .| |.|.||||||.||..|.. ...|||||.||| | . . ||| . | |.||||| ||| | |||||||||.|..|||..| MLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF AKGELPWQNLTLEKREEKFEQIKHLKIETKLDDLCKGLPNSFKTYMEHVKGLSFEQEPKYKFL .|.|||| .. .. |.|.| |. | .. |||| | | ||.....| ||..| | .| NRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
|||||||||
Kinase | 18951.AA | TTBKL | 32-296 | 29 | 4.3e-72 | 242.67 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 32-296 Range on HMM: 1-288/288 Sequence Identity: 29% (88 aa) YRSIDKIGSGSFGEIHKVYDMVDKKLRAVKIEKKDK-RGAQGMLLKEAYIMKQMK--DCHHFPRLIEEMQNDQMSFIIMSFLGQNLESLK--KKYNK-LS .. . .||.| ||.. .| ||.||| .|...| |.. | . .|....... .. |||.... .... .|..|. .| || |. . .| .| WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS HYTTLLIGTQMVEALELMHGKGFLHRDIKPENFVIGTEGN----HHNIYIIDFGLSKKYIDLNN-----------KHIPEDN---NKGLVGTARYTSINS |.. || | ..|| .|| .||.|||.|| |...| ... ...|.||||....|.. .. .. .. | .. || ||.|.| DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HRGIEQSRRDDLEALGYVLIYLAKGELPWQNLTLEKREEKFEQIKHLKIETKLDDLCKG------LPNSFKTYMEHVKGLSFEQEPKYKFLQQSF |.. ||.| ||| .. |..|.|..| |||.|. |. ..| |.| ..|..||.|. .| .| |.|.. |.. ..| | ... | HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNM------EDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
|||||||||
Kinase | 18951.AA | Worm6 | 32-292 | 32 | 4.3e-65 | 222.58 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 32-292 Range on HMM: 1-279/279 Sequence Identity: 32% (90 aa) YRSIDKIGSGSFGEIHKVYDMVDKK--LRAVKIEKKDKRGAQGMLLKEAYIMKQMKDCH--HFPRLIEEMQNDQ--MSFIIMSFLGQNLESLKKKYN--K . |||.|.|| . || | ||| |.| ||. . . .|| |....| | . ||..... . |. .|.| ..| ||. |.| . | WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK LSHYTTLLIGTQMVEALELMHGKGFLHRDIKPENFVIGT-----EGNHHNIYIIDFGLSK--KYIDLNNKHIPED-NNKGLVGTARYTSINSHRGIEQSR .| |.| |. |. ||.| .| ||.|||.|| || || ..||.||..|||... ||.. .|. .. .. | .|| || ....|.|.||.| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR RDDLEALGYVLIYLAKGELPWQNLTLEKREEKFEQIKHLKI-ETKLDDLCKGLPN-SFKTYMEHVKGLSFEQEPKYKFL .||.| |... . .|.|||.... ....|| .. .. .. .. .. | |. |. . ..|.. .| |||. KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
|||||||||
Kinase | 18951.AA | CK1-G | 128-292 | 44 | 6.3e-64 | 215.54 | In-house | 97-266 (266) | Show / Hide |
Range on Protein: 128-292 Range on HMM: 97-266/266 Sequence Identity: 44% (75 aa) TTLLIGTQMVEALELMHGKGFLHRDIKPENFVIGTEGNH--HNIYIIDFGLSKKYIDLN-NKHIPEDNNKGLVGTARYTSINSHRGIEQSRRDDLEALGY |.... .||.. .| .| . . ||.||.|| || ..|. |.|.|||||. |.|||.. ..||| | | ||||| ||| | | |||||||.|||| TVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGH VLIYLAKGELPWQNLTLEKREEKFEQIKHLKIETKLDDLCKG--LPNSFKTYMEHVKGLSFEQEPKYKFL . .| |.|||| | . |... | | .| .|||.. .| | ||.. | |.|. .| | .| MFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
|||||||||
Kinase | 18951.AA | TTBK | 32-292 | 34 | 3.1e-50 | 173.22 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 32-292 Range on HMM: 1-257/257 Sequence Identity: 34% (91 aa) YRSIDKIGSGSFGEIHKVYDMVDK-KLRAVKIEKKDKRGAQGMLLKEAYIMKQMKDCHHFPRLIEEMQNDQMSFIIMSFLGQNLESLKKK--YNKLSHYT . . ||| | |||| ||. . |.|.|. .. | | ..|.. | | | | ||. ...|. .|.|| | | . | | WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQP--KQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLST TLLIGTQMVEALELMHGKGFLHRDIKPENFVIG-TEGNHHNIYIIDFGLSKKYIDLNNKHIPEDNNKGLVGTARYTSINSHRGIEQSRRDDLEALGYVLI || .| |.....| | ||||||||| || .| . . ..|..|||| .|. | . | ||.|| |||.|| | |.||| | |.|. TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLV YLAKGELPWQNLTLEKREEKFEQIKHLKIETKLDDLCKGLPNSFKTYMEHVKGLSFEQEPKYKFL ..| ||| . | .|. ..| . . .| | .| |...|.|.| | .| | |... EFVQGQLPWRKI-----KDK-DQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
|||||||||
Kinase | 18951.AA | CK1-Unique | 32-237 | 22 | 2.5e-31 | 105.85 | In-house | 1-233 (337) | Show / Hide |
Range on Protein: 32-237 Range on HMM: 1-233/337 Sequence Identity: 22% (53 aa) YRSIDKIGSGSFGEIHKVYDMVDK------KLRAVKIEKKDKRGAQGMLLKEAYIMKQMKDCH-------HFPRLIEEMQNDQMSFIIMSFLGQNLESLK . | .||.|..| |.|.. . . . | | . . |. | .|| . | ||. .. | .....|.| ..| ..|... WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC KKYNK----LS----HYTTLLIGTQMVEALELMHGKGFLHRDIKPENFVIGTEG--NHHNIYIIDFGLSKK--YIDLNNKHIPEDNNKGLVGTARYTSIN .. |. . . | | ...| || ||.||..|| |.. .. | .|..|.| ... .. |. . |. .| .. MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS SHRGIEQSRRDDLEALGYVLIYLAKGE--LPWQ .|. |..||||.| . | |. | .. | |. CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK |
|||||||||
Kinase | 18951.AA | Pkinase | 32-257 | 23 | 1.3e-30 | 109.36 | Pfam | 1-236 (293) | Show / Hide |
Range on Protein: 32-257 Range on HMM: 1-236/293 Sequence Identity: 23% (58 aa) YRSIDKIGSGSFGEIHKVYDMVDKKLRAVKIEKKDKRGA--QGMLLK--EAYIMKQMKDCHHFPRLIEEMQNDQMSFIIMSFL--G----QNLESLK-KK |. . ||||||||. | .. . |. |||| ||... . ... |..||| . .. . ||.. ..... ..| .. | . .. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR YNKL--SHYTTLLIGTQMVEALELMHGKGFLHRDIKPENFVIGTEGNHHN---IYIIDFGLSKKYIDLNNKHIPEDNNKGLVGTARYTSINSHR-GIEQS .... | . . .|....|| .| .|..|||.||||. | | |. . |.||||.|.. . . .....|| .| . .| | . . HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG RRDDLEALGYVLIYLAKGELPWQNL----TLEKREEKFEQIKHLKIE .. | ..| .|.... |..|... . .....|.. ... PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLH |
|||||||||
Kinase | 18951.AA | S_TKc | 32-312 | 18 | 6.4e-22 | 80.06 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 32-312 Range on HMM: 1-231/231 Sequence Identity: 18% (56 aa) YRSIDKIGSGSFGEIHKVYDMVDKKLRAVKIEKKDKRGAQGMLLKEAYIMKQMKDCHHFPRLIEEMQNDQMSFIIMSFLGQ---NLESLKKKYNK----- |. ..|||.|.||. .|... .... |.|| | ....| |.|. .. . .|.. .|. . ...| .... .| .. ||... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -LSHYTTLLIGTQMVEALELMHGKGFLHRDIKPENFVIGTEGNHHNIYIIDFGLSKKYIDLNNKHIPEDNNKGLVGTARYTSINSHRGIEQSR-RDDLEA .. .. . |...||| .| .|..|||.|||| . . .| |.||||.... . ..|| | . .. . | . PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWS LGYVLIYLAKGELPWQNLTLEKREEKFEQIKHLKIETKLDDLCKGLPNSFKTYMEHVKGLSFEQEPKYKFLQQSFLRDAK---QIQEEKN-------IPI .| .|. .. |. |.. .. |..|. .| | |... . .| . . | . | CGCILYEMLCGYPPFP-----QMQMMFKKIG-------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPW E F |
|||||||||
Kinase | 18951.AA | TyrKc | 32-256 | 18 | 1e-06 | -114.67 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 32-256 Range on HMM: 1-280/280 Sequence Identity: 18% (55 aa) YRSIDKIGSGSFGEIHK-VYDMVDKKLRAVKIEKKDKRGAQGMLLKEAYIMKQM-KDCHHFPRLIEEMQND-------QMSFIIMSF-----LGQNLESL . ..|.|.| |||..| ... ||| |.|. . ....|| ||.. .. . ||. . . .|.| . | . | . ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH KKKYNKLSHYTTLLIGTQMVEALELMHGKGFLHRDIKPENFVIGTEGNHHNIYIIDFGLSKKYIDL-----NNKHIPEDNNKGLV--GTARYT---SINS ..| |.. . | . .| . | | |.. |||. | .| .. . | |||||.. | . . . || | . .|| RPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY H--------------------RGIEQSR------RDDLEALGYVLIY--LAKGEL-----------PWQNLTL----EKREE--KFEQIKHLKI . .| . .. |.. || . . . .. . |. |. |..| | .. GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF |
|||||||||
Kinase | 18951.AA | CK1-G | 32-63 | 40 | 0.001432 | 7.87 | In-house | 1-32 (266) | Show / Hide |
Range on Protein: 32-63 Range on HMM: 1-32/266 Sequence Identity: 40% (13 aa) YRSIDKIGSGSFGEIHKVYDMVDKKLRAVKIE || ||| |.|||. |. |.|.| YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFE |